Eintrag weiter verarbeiten
Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse
Gespeichert in:
| Zeitschriftentitel: | ISRN Cardiology |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | ISRN Cardiology, 2012, 2012, S. 1-11 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Vasti, Cecilia Witt, Henning Said, Matilde Sorroche, Patricia García-Rivello, Hernán Ruiz-Noppinger, Patricia Hertig, Cecilia M. Vasti, Cecilia Witt, Henning Said, Matilde Sorroche, Patricia García-Rivello, Hernán Ruiz-Noppinger, Patricia Hertig, Cecilia M. |
|---|---|
| author |
Vasti, Cecilia Witt, Henning Said, Matilde Sorroche, Patricia García-Rivello, Hernán Ruiz-Noppinger, Patricia Hertig, Cecilia M. |
| spellingShingle |
Vasti, Cecilia Witt, Henning Said, Matilde Sorroche, Patricia García-Rivello, Hernán Ruiz-Noppinger, Patricia Hertig, Cecilia M. ISRN Cardiology Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse General Medicine |
| author_sort |
vasti, cecilia |
| spelling |
Vasti, Cecilia Witt, Henning Said, Matilde Sorroche, Patricia García-Rivello, Hernán Ruiz-Noppinger, Patricia Hertig, Cecilia M. 2090-5599 Hindawi Limited General Medicine http://dx.doi.org/10.5402/2012/745185 <jats:p>The accumulating evidence demonstrates the essential role of neuregulin-1 signaling in the adult heart, and, moreover, indicates that an impaired neuregulin signaling exacerbates the doxorubicin-mediated cardiac toxicity. Despite this strong data, the specific cardiomyocyte targets of the active erbB2/erbB4 heterodimer remain unknown. In this paper, we examined pathways involved in cardiomyocyte damage as a result of the cardiac sensitization to anthracycline toxicity in the ventricular muscle-specific erbB4 knockout mouse. We performed morphological analyses to evaluate the ventricular remodeling and employed a cDNA microarray to assess the characteristic gene expression profile, verified data by real-time RT-PCR, and then grouped into functional categories and pathways. We confirm the upregulation of genes related to the classical signature of a hypertrophic response, implicating an erbB2-dependent mechanism in doxorubicin-treated erbB4-KO hearts. Our results indicate the remarkable downregulation of IGF-I/PI-3′ kinase pathway and extends our current knowledge by uncovering an altered ubiquitin-proteasome system leading to cardiomyocyte autophagic vacuolization.</jats:p> Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse ISRN Cardiology |
| doi_str_mv |
10.5402/2012/745185 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuNTQwMi8yMDEyLzc0NTE4NQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuNTQwMi8yMDEyLzc0NTE4NQ |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
Hindawi Limited, 2012 |
| imprint_str_mv |
Hindawi Limited, 2012 |
| issn |
2090-5599 |
| issn_str_mv |
2090-5599 |
| language |
English |
| mega_collection |
Hindawi Limited (CrossRef) |
| match_str |
vasti2012doxorubicinandnrg1erbb4deficiencyaffectgeneexpressionprofileinvolvingproteinhomeostasisinmouse |
| publishDateSort |
2012 |
| publisher |
Hindawi Limited |
| recordtype |
ai |
| record_format |
ai |
| series |
ISRN Cardiology |
| source_id |
49 |
| title |
Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse |
| title_unstemmed |
Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse |
| title_full |
Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse |
| title_fullStr |
Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse |
| title_full_unstemmed |
Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse |
| title_short |
Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse |
| title_sort |
doxorubicin and nrg-1/erbb4-deficiency affect gene expression profile: involving protein homeostasis in mouse |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.5402/2012/745185 |
| publishDate |
2012 |
| physical |
1-11 |
| description |
<jats:p>The accumulating evidence demonstrates the essential role of neuregulin-1 signaling in the adult heart, and, moreover, indicates that an impaired neuregulin signaling exacerbates the doxorubicin-mediated cardiac toxicity. Despite this strong data, the specific cardiomyocyte targets of the active erbB2/erbB4 heterodimer remain unknown. In this paper, we examined pathways involved in cardiomyocyte damage as a result of the cardiac sensitization to anthracycline toxicity in the ventricular muscle-specific erbB4 knockout mouse. We performed morphological analyses to evaluate the ventricular remodeling and employed a cDNA microarray to assess the characteristic gene expression profile, verified data by real-time RT-PCR, and then grouped into functional categories and pathways. We confirm the upregulation of genes related to the classical signature of a hypertrophic response, implicating an erbB2-dependent mechanism in doxorubicin-treated erbB4-KO hearts. Our results indicate the remarkable downregulation of IGF-I/PI-3′ kinase pathway and extends our current knowledge by uncovering an altered ubiquitin-proteasome system leading to cardiomyocyte autophagic vacuolization.</jats:p> |
| container_start_page |
1 |
| container_title |
ISRN Cardiology |
| container_volume |
2012 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792330133525233665 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T13:20:12.75Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Doxorubicin+and+NRG-1%2FerbB4-Deficiency+Affect+Gene+Expression+Profile%3A+Involving+Protein+Homeostasis+in+Mouse&rft.date=2012-08-29&genre=article&issn=2090-5599&volume=2012&spage=1&epage=11&pages=1-11&jtitle=ISRN+Cardiology&atitle=Doxorubicin+and+NRG-1%2FerbB4-Deficiency+Affect+Gene+Expression+Profile%3A+Involving+Protein+Homeostasis+in+Mouse&aulast=Hertig&aufirst=Cecilia+M.&rft_id=info%3Adoi%2F10.5402%2F2012%2F745185&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792330133525233665 |
| author | Vasti, Cecilia, Witt, Henning, Said, Matilde, Sorroche, Patricia, García-Rivello, Hernán, Ruiz-Noppinger, Patricia, Hertig, Cecilia M. |
| author_facet | Vasti, Cecilia, Witt, Henning, Said, Matilde, Sorroche, Patricia, García-Rivello, Hernán, Ruiz-Noppinger, Patricia, Hertig, Cecilia M., Vasti, Cecilia, Witt, Henning, Said, Matilde, Sorroche, Patricia, García-Rivello, Hernán, Ruiz-Noppinger, Patricia, Hertig, Cecilia M. |
| author_sort | vasti, cecilia |
| container_start_page | 1 |
| container_title | ISRN Cardiology |
| container_volume | 2012 |
| description | <jats:p>The accumulating evidence demonstrates the essential role of neuregulin-1 signaling in the adult heart, and, moreover, indicates that an impaired neuregulin signaling exacerbates the doxorubicin-mediated cardiac toxicity. Despite this strong data, the specific cardiomyocyte targets of the active erbB2/erbB4 heterodimer remain unknown. In this paper, we examined pathways involved in cardiomyocyte damage as a result of the cardiac sensitization to anthracycline toxicity in the ventricular muscle-specific erbB4 knockout mouse. We performed morphological analyses to evaluate the ventricular remodeling and employed a cDNA microarray to assess the characteristic gene expression profile, verified data by real-time RT-PCR, and then grouped into functional categories and pathways. We confirm the upregulation of genes related to the classical signature of a hypertrophic response, implicating an erbB2-dependent mechanism in doxorubicin-treated erbB4-KO hearts. Our results indicate the remarkable downregulation of IGF-I/PI-3′ kinase pathway and extends our current knowledge by uncovering an altered ubiquitin-proteasome system leading to cardiomyocyte autophagic vacuolization.</jats:p> |
| doi_str_mv | 10.5402/2012/745185 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuNTQwMi8yMDEyLzc0NTE4NQ |
| imprint | Hindawi Limited, 2012 |
| imprint_str_mv | Hindawi Limited, 2012 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 2090-5599 |
| issn_str_mv | 2090-5599 |
| language | English |
| last_indexed | 2024-03-01T13:20:12.75Z |
| match_str | vasti2012doxorubicinandnrg1erbb4deficiencyaffectgeneexpressionprofileinvolvingproteinhomeostasisinmouse |
| mega_collection | Hindawi Limited (CrossRef) |
| physical | 1-11 |
| publishDate | 2012 |
| publishDateSort | 2012 |
| publisher | Hindawi Limited |
| record_format | ai |
| recordtype | ai |
| series | ISRN Cardiology |
| source_id | 49 |
| spelling | Vasti, Cecilia Witt, Henning Said, Matilde Sorroche, Patricia García-Rivello, Hernán Ruiz-Noppinger, Patricia Hertig, Cecilia M. 2090-5599 Hindawi Limited General Medicine http://dx.doi.org/10.5402/2012/745185 <jats:p>The accumulating evidence demonstrates the essential role of neuregulin-1 signaling in the adult heart, and, moreover, indicates that an impaired neuregulin signaling exacerbates the doxorubicin-mediated cardiac toxicity. Despite this strong data, the specific cardiomyocyte targets of the active erbB2/erbB4 heterodimer remain unknown. In this paper, we examined pathways involved in cardiomyocyte damage as a result of the cardiac sensitization to anthracycline toxicity in the ventricular muscle-specific erbB4 knockout mouse. We performed morphological analyses to evaluate the ventricular remodeling and employed a cDNA microarray to assess the characteristic gene expression profile, verified data by real-time RT-PCR, and then grouped into functional categories and pathways. We confirm the upregulation of genes related to the classical signature of a hypertrophic response, implicating an erbB2-dependent mechanism in doxorubicin-treated erbB4-KO hearts. Our results indicate the remarkable downregulation of IGF-I/PI-3′ kinase pathway and extends our current knowledge by uncovering an altered ubiquitin-proteasome system leading to cardiomyocyte autophagic vacuolization.</jats:p> Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse ISRN Cardiology |
| spellingShingle | Vasti, Cecilia, Witt, Henning, Said, Matilde, Sorroche, Patricia, García-Rivello, Hernán, Ruiz-Noppinger, Patricia, Hertig, Cecilia M., ISRN Cardiology, Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse, General Medicine |
| title | Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse |
| title_full | Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse |
| title_fullStr | Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse |
| title_full_unstemmed | Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse |
| title_short | Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse |
| title_sort | doxorubicin and nrg-1/erbb4-deficiency affect gene expression profile: involving protein homeostasis in mouse |
| title_unstemmed | Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse |
| topic | General Medicine |
| url | http://dx.doi.org/10.5402/2012/745185 |