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Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs
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| Zeitschriftentitel: | Archives Animal Breeding |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Archives Animal Breeding, 61, 2018, 4, S. 379-386 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Copernicus GmbH
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| Schlagwörter: |
| author_facet |
Hwang, Jung Hye An, Sang Mi Yu, Go Eun Park, Da Hye Kang, Deok Gyeong Kim, Tae Wan Park, Hwa Chun Ha, Jeongim Kim, Chul Wook Hwang, Jung Hye An, Sang Mi Yu, Go Eun Park, Da Hye Kang, Deok Gyeong Kim, Tae Wan Park, Hwa Chun Ha, Jeongim Kim, Chul Wook |
|---|---|
| author |
Hwang, Jung Hye An, Sang Mi Yu, Go Eun Park, Da Hye Kang, Deok Gyeong Kim, Tae Wan Park, Hwa Chun Ha, Jeongim Kim, Chul Wook |
| spellingShingle |
Hwang, Jung Hye An, Sang Mi Yu, Go Eun Park, Da Hye Kang, Deok Gyeong Kim, Tae Wan Park, Hwa Chun Ha, Jeongim Kim, Chul Wook Archives Animal Breeding Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs General Medicine |
| author_sort |
hwang, jung hye |
| spelling |
Hwang, Jung Hye An, Sang Mi Yu, Go Eun Park, Da Hye Kang, Deok Gyeong Kim, Tae Wan Park, Hwa Chun Ha, Jeongim Kim, Chul Wook 2363-9822 Copernicus GmbH General Medicine http://dx.doi.org/10.5194/aab-61-379-2018 <jats:p>Abstract. Litter size is an economically important trait in the pig industry. We aimed to identify genetic markers associated with litter size, which can be used in breeding programs for improving reproductive traits. Single-nucleotide polymorphisms (SNPs) of Berkshire pigs in the N-acetyltransferase 9 (NAT9) and Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) genes were from RNA sequencing results, and already exist in the databank (NCBI), and were confirmed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). A total of 272 Berkshire sows were used to examine the genotype, and their association with litter size traits was analyzed. The NAT9 SNP was located in chromosome 12 exon 640 mRNA (A > G) and the MAP3K3 SNP was located in chromosome 12 intron 11 (80, C > T). Association analysis indicated that the GG genotype of NAT9 and the CT genotype of MAP3K3 had the highest values for litter size traits. The GG genotype expressed higher levels of NAT9 mRNA in the endometrium than the other genotypes did, and a positive correlation was found between litter size traits and NAT9, but not MAP3K3 expression level. These results indicate that the NAT9 and MAP3K3 can be used as candidate genes applicable in breeding program for the improvement of litter size traits in Berkshire pigs.</jats:p> Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs Archives Animal Breeding |
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| title |
Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs |
| title_unstemmed |
Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs |
| title_full |
Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs |
| title_fullStr |
Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs |
| title_full_unstemmed |
Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs |
| title_short |
Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs |
| title_sort |
association of single-nucleotide polymorphisms in <i>nat9 </i>and <i>map3k3</i> genes with litter size traits in berkshire pigs |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.5194/aab-61-379-2018 |
| publishDate |
2018 |
| physical |
379-386 |
| description |
<jats:p>Abstract. Litter size is an economically important trait in the pig industry. We aimed to identify genetic markers associated with litter size, which can be used in breeding programs for improving reproductive traits. Single-nucleotide polymorphisms (SNPs) of Berkshire pigs in the N-acetyltransferase 9 (NAT9) and Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) genes were from RNA sequencing results, and already exist in the databank (NCBI), and were confirmed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). A total of 272 Berkshire sows were used to examine the genotype, and their association with litter size traits was analyzed. The NAT9 SNP was located in chromosome 12 exon 640 mRNA (A > G) and the MAP3K3 SNP was located in chromosome 12 intron 11 (80, C > T). Association analysis indicated that the GG genotype of NAT9 and the CT genotype of MAP3K3 had the highest values for litter size traits. The GG genotype expressed higher levels of NAT9 mRNA in the endometrium than the other genotypes did, and a positive correlation was found between litter size traits and NAT9, but not MAP3K3 expression level. These results indicate that the NAT9 and MAP3K3 can be used as candidate genes applicable in breeding program for the improvement of litter size traits in Berkshire pigs.</jats:p> |
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| author | Hwang, Jung Hye, An, Sang Mi, Yu, Go Eun, Park, Da Hye, Kang, Deok Gyeong, Kim, Tae Wan, Park, Hwa Chun, Ha, Jeongim, Kim, Chul Wook |
| author_facet | Hwang, Jung Hye, An, Sang Mi, Yu, Go Eun, Park, Da Hye, Kang, Deok Gyeong, Kim, Tae Wan, Park, Hwa Chun, Ha, Jeongim, Kim, Chul Wook, Hwang, Jung Hye, An, Sang Mi, Yu, Go Eun, Park, Da Hye, Kang, Deok Gyeong, Kim, Tae Wan, Park, Hwa Chun, Ha, Jeongim, Kim, Chul Wook |
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| description | <jats:p>Abstract. Litter size is an economically important trait in the pig industry. We aimed to identify genetic markers associated with litter size, which can be used in breeding programs for improving reproductive traits. Single-nucleotide polymorphisms (SNPs) of Berkshire pigs in the N-acetyltransferase 9 (NAT9) and Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) genes were from RNA sequencing results, and already exist in the databank (NCBI), and were confirmed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). A total of 272 Berkshire sows were used to examine the genotype, and their association with litter size traits was analyzed. The NAT9 SNP was located in chromosome 12 exon 640 mRNA (A > G) and the MAP3K3 SNP was located in chromosome 12 intron 11 (80, C > T). Association analysis indicated that the GG genotype of NAT9 and the CT genotype of MAP3K3 had the highest values for litter size traits. The GG genotype expressed higher levels of NAT9 mRNA in the endometrium than the other genotypes did, and a positive correlation was found between litter size traits and NAT9, but not MAP3K3 expression level. These results indicate that the NAT9 and MAP3K3 can be used as candidate genes applicable in breeding program for the improvement of litter size traits in Berkshire pigs.</jats:p> |
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| institution | DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15 |
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| physical | 379-386 |
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| spelling | Hwang, Jung Hye An, Sang Mi Yu, Go Eun Park, Da Hye Kang, Deok Gyeong Kim, Tae Wan Park, Hwa Chun Ha, Jeongim Kim, Chul Wook 2363-9822 Copernicus GmbH General Medicine http://dx.doi.org/10.5194/aab-61-379-2018 <jats:p>Abstract. Litter size is an economically important trait in the pig industry. We aimed to identify genetic markers associated with litter size, which can be used in breeding programs for improving reproductive traits. Single-nucleotide polymorphisms (SNPs) of Berkshire pigs in the N-acetyltransferase 9 (NAT9) and Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) genes were from RNA sequencing results, and already exist in the databank (NCBI), and were confirmed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). A total of 272 Berkshire sows were used to examine the genotype, and their association with litter size traits was analyzed. The NAT9 SNP was located in chromosome 12 exon 640 mRNA (A > G) and the MAP3K3 SNP was located in chromosome 12 intron 11 (80, C > T). Association analysis indicated that the GG genotype of NAT9 and the CT genotype of MAP3K3 had the highest values for litter size traits. The GG genotype expressed higher levels of NAT9 mRNA in the endometrium than the other genotypes did, and a positive correlation was found between litter size traits and NAT9, but not MAP3K3 expression level. These results indicate that the NAT9 and MAP3K3 can be used as candidate genes applicable in breeding program for the improvement of litter size traits in Berkshire pigs.</jats:p> Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs Archives Animal Breeding |
| spellingShingle | Hwang, Jung Hye, An, Sang Mi, Yu, Go Eun, Park, Da Hye, Kang, Deok Gyeong, Kim, Tae Wan, Park, Hwa Chun, Ha, Jeongim, Kim, Chul Wook, Archives Animal Breeding, Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs, General Medicine |
| title | Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs |
| title_full | Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs |
| title_fullStr | Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs |
| title_full_unstemmed | Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs |
| title_short | Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs |
| title_sort | association of single-nucleotide polymorphisms in <i>nat9 </i>and <i>map3k3</i> genes with litter size traits in berkshire pigs |
| title_unstemmed | Association of single-nucleotide polymorphisms in <i>NAT9 </i>and <i>MAP3K3</i> genes with litter size traits in Berkshire pigs |
| topic | General Medicine |
| url | http://dx.doi.org/10.5194/aab-61-379-2018 |