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Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds
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| Zeitschriftentitel: | Archives Animal Breeding |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Archives Animal Breeding, 61, 2018, 3, S. 311-319 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Copernicus GmbH
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| Schlagwörter: |
| author_facet |
Wei, Zhenyu Wang, Ke Hui, Yiqing Yan, Hailong Zhu, Haijing Qu, Lei Pan, Chuanying Chen, Hong Lan, Xianyong Wei, Zhenyu Wang, Ke Hui, Yiqing Yan, Hailong Zhu, Haijing Qu, Lei Pan, Chuanying Chen, Hong Lan, Xianyong |
|---|---|
| author |
Wei, Zhenyu Wang, Ke Hui, Yiqing Yan, Hailong Zhu, Haijing Qu, Lei Pan, Chuanying Chen, Hong Lan, Xianyong |
| spellingShingle |
Wei, Zhenyu Wang, Ke Hui, Yiqing Yan, Hailong Zhu, Haijing Qu, Lei Pan, Chuanying Chen, Hong Lan, Xianyong Archives Animal Breeding Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds General Medicine |
| author_sort |
wei, zhenyu |
| spelling |
Wei, Zhenyu Wang, Ke Hui, Yiqing Yan, Hailong Zhu, Haijing Qu, Lei Pan, Chuanying Chen, Hong Lan, Xianyong 2363-9822 Copernicus GmbH General Medicine http://dx.doi.org/10.5194/aab-61-311-2018 <jats:p>Abstract. The AT motif-binding factor (ATBF1), also known as zinc finger homeobox 3 (ZFXH3), is necessary for activating the POU1F1 gene; thus, the ATBF1 gene greatly affects the grow traits in animals. The objective of this work was to explore novel indel (insertion/deletion) variations and their associations with growth traits in three native Chinese goat breeds. Two indels within the ATBF1 gene were found in the Shaanbei white cashmere goat (SWCG; n=581), the Guanzhong dairy goat (GZDG; n=334) and the Hainan black goat (HNBG; n=270) for the first time using 12 pairs of primers. Association analysis revealed that the P1-12-bp indel was consistently correlated with the body height of the three breeds, and individuals with ID (insertion/deletion) and DD (deletion/deletion) genotypes had a higher body weight than the II (insertion/insertion) genotype (P=0.036); the P11-6-bp indel was consistently correlated with chest circumference and hip width of the three breeds. Moreover, these two loci were associated with other several growth-related traits in different breeds. Hence, these findings indicated that the goat ATBF1 gene had marked effects on growth traits and the growth-trait-related loci, which would contribute to improving the growth-related traits of local breeds in the goat industry by implementing marker-assisted selection (MAS).</jats:p> Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds Archives Animal Breeding |
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| title |
Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| title_unstemmed |
Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| title_full |
Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| title_fullStr |
Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| title_full_unstemmed |
Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| title_short |
Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| title_sort |
detection of insertion/deletions (indels) of the <i>atbf1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.5194/aab-61-311-2018 |
| publishDate |
2018 |
| physical |
311-319 |
| description |
<jats:p>Abstract. The AT motif-binding factor (ATBF1), also known as zinc finger homeobox 3 (ZFXH3), is necessary for activating the POU1F1 gene; thus, the ATBF1 gene greatly affects the grow traits in animals. The objective of this work was to explore novel indel (insertion/deletion) variations and their associations with growth traits in three native Chinese goat breeds. Two indels within the ATBF1 gene were found in the Shaanbei white cashmere goat (SWCG; n=581), the Guanzhong dairy goat (GZDG; n=334) and the Hainan black goat (HNBG; n=270) for the first time using 12 pairs of primers. Association analysis revealed that the P1-12-bp indel was consistently correlated with the body height of the three breeds, and individuals with ID (insertion/deletion) and DD (deletion/deletion) genotypes had a higher body weight than the II (insertion/insertion) genotype (P=0.036); the P11-6-bp indel was consistently correlated with chest circumference and hip width of the three breeds. Moreover, these two loci were associated with other several growth-related traits in different breeds. Hence, these findings indicated that the goat ATBF1 gene had marked effects on growth traits and the growth-trait-related loci, which would contribute to improving the growth-related traits of local breeds in the goat industry by implementing marker-assisted selection (MAS).</jats:p> |
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| author | Wei, Zhenyu, Wang, Ke, Hui, Yiqing, Yan, Hailong, Zhu, Haijing, Qu, Lei, Pan, Chuanying, Chen, Hong, Lan, Xianyong |
| author_facet | Wei, Zhenyu, Wang, Ke, Hui, Yiqing, Yan, Hailong, Zhu, Haijing, Qu, Lei, Pan, Chuanying, Chen, Hong, Lan, Xianyong, Wei, Zhenyu, Wang, Ke, Hui, Yiqing, Yan, Hailong, Zhu, Haijing, Qu, Lei, Pan, Chuanying, Chen, Hong, Lan, Xianyong |
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| description | <jats:p>Abstract. The AT motif-binding factor (ATBF1), also known as zinc finger homeobox 3 (ZFXH3), is necessary for activating the POU1F1 gene; thus, the ATBF1 gene greatly affects the grow traits in animals. The objective of this work was to explore novel indel (insertion/deletion) variations and their associations with growth traits in three native Chinese goat breeds. Two indels within the ATBF1 gene were found in the Shaanbei white cashmere goat (SWCG; n=581), the Guanzhong dairy goat (GZDG; n=334) and the Hainan black goat (HNBG; n=270) for the first time using 12 pairs of primers. Association analysis revealed that the P1-12-bp indel was consistently correlated with the body height of the three breeds, and individuals with ID (insertion/deletion) and DD (deletion/deletion) genotypes had a higher body weight than the II (insertion/insertion) genotype (P=0.036); the P11-6-bp indel was consistently correlated with chest circumference and hip width of the three breeds. Moreover, these two loci were associated with other several growth-related traits in different breeds. Hence, these findings indicated that the goat ATBF1 gene had marked effects on growth traits and the growth-trait-related loci, which would contribute to improving the growth-related traits of local breeds in the goat industry by implementing marker-assisted selection (MAS).</jats:p> |
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| institution | DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15 |
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| spelling | Wei, Zhenyu Wang, Ke Hui, Yiqing Yan, Hailong Zhu, Haijing Qu, Lei Pan, Chuanying Chen, Hong Lan, Xianyong 2363-9822 Copernicus GmbH General Medicine http://dx.doi.org/10.5194/aab-61-311-2018 <jats:p>Abstract. The AT motif-binding factor (ATBF1), also known as zinc finger homeobox 3 (ZFXH3), is necessary for activating the POU1F1 gene; thus, the ATBF1 gene greatly affects the grow traits in animals. The objective of this work was to explore novel indel (insertion/deletion) variations and their associations with growth traits in three native Chinese goat breeds. Two indels within the ATBF1 gene were found in the Shaanbei white cashmere goat (SWCG; n=581), the Guanzhong dairy goat (GZDG; n=334) and the Hainan black goat (HNBG; n=270) for the first time using 12 pairs of primers. Association analysis revealed that the P1-12-bp indel was consistently correlated with the body height of the three breeds, and individuals with ID (insertion/deletion) and DD (deletion/deletion) genotypes had a higher body weight than the II (insertion/insertion) genotype (P=0.036); the P11-6-bp indel was consistently correlated with chest circumference and hip width of the three breeds. Moreover, these two loci were associated with other several growth-related traits in different breeds. Hence, these findings indicated that the goat ATBF1 gene had marked effects on growth traits and the growth-trait-related loci, which would contribute to improving the growth-related traits of local breeds in the goat industry by implementing marker-assisted selection (MAS).</jats:p> Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds Archives Animal Breeding |
| spellingShingle | Wei, Zhenyu, Wang, Ke, Hui, Yiqing, Yan, Hailong, Zhu, Haijing, Qu, Lei, Pan, Chuanying, Chen, Hong, Lan, Xianyong, Archives Animal Breeding, Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds, General Medicine |
| title | Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| title_full | Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| title_fullStr | Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| title_full_unstemmed | Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| title_short | Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| title_sort | detection of insertion/deletions (indels) of the <i>atbf1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| title_unstemmed | Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds |
| topic | General Medicine |
| url | http://dx.doi.org/10.5194/aab-61-311-2018 |