Eintrag weiter verarbeiten
Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects
Gespeichert in:
| Zeitschriftentitel: | Monaldi Archives for Chest Disease |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Monaldi Archives for Chest Disease, 70, 2016, 3 |
| Format: | E-Article |
| Sprache: | Unbestimmt |
| veröffentlicht: |
PAGEPress Publications
|
| Schlagwörter: |
| author_facet |
Malerba, M. Ragnoli, B. Corradi, M. Malerba, M. Ragnoli, B. Corradi, M. |
|---|---|
| author |
Malerba, M. Ragnoli, B. Corradi, M. |
| spellingShingle |
Malerba, M. Ragnoli, B. Corradi, M. Monaldi Archives for Chest Disease Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects Cardiology and Cardiovascular Medicine Pulmonary and Respiratory Medicine |
| author_sort |
malerba, m. |
| spelling |
Malerba, M. Ragnoli, B. Corradi, M. 2465-1028 1122-0643 PAGEPress Publications Cardiology and Cardiovascular Medicine Pulmonary and Respiratory Medicine http://dx.doi.org/10.4081/monaldi.2008.390 <jats:p>Cigarette smoking is the major factor implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), despite the fact that only susceptible smoking subjects develop this respiratory disease. In the last few years non–invasive techniques such as induced sputum (IS), exhaled nitric oxide (eNO) measurement and exhaled breath condensate (EBC) collection have been successfully established revealing an inflammatory status and oxidative stress indicators in the airways involved in the pathogenesis of several pulmonary diseases. Using these new non-invasive experimental tools recently, several efforts have been made to find new biomarkers in order to assess and monitor early lung damage induced by smoking. Tobacco smoke can acutely reduce eNO levels in healthy smokers and non-smoker subjects so it can play a role in anti-smoking programmes; its increase can be a positive parameter for subjects who are going to stop cigarette smoking and at the same time be used as an anti-smoking indicator. It can be useful to investigate the mechanism of cigarette-induced lung damage in an experimental setting and may potentially be useful for assessing of Environmental Tobacco Smoke (ETS) effects. Markers of oxidative stress have been detected in induced sputum of COPD subjects even though only few studies investigated the use of induced sputum to study smoke effects on the lungs of healthy subjects. Exhaled breath condensate (EBC) obtained by cooling exhaled air under conditions of spontaneous breathing is a promising biological fluid that could provide a real-time assessment of pulmonary pathobiology. The analysis of induced sputum and of exhaled air is feasible and non-invasive, can be useful to identify new biomarkers of exposure or susceptibility in COPD patients to enhance the understanding of airways changes due to current smoking and may be useful to find new biomarkers in order to assess and monitor early lung damage induced by smoke in order to prevent the progression of obstructive disease.</jats:p> Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects Monaldi Archives for Chest Disease |
| doi_str_mv |
10.4081/monaldi.2008.390 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuNDA4MS9tb25hbGRpLjIwMDguMzkw |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuNDA4MS9tb25hbGRpLjIwMDguMzkw |
| institution |
DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 |
| imprint |
PAGEPress Publications, 2016 |
| imprint_str_mv |
PAGEPress Publications, 2016 |
| issn |
2465-1028 1122-0643 |
| issn_str_mv |
2465-1028 1122-0643 |
| language |
Undetermined |
| mega_collection |
PAGEPress Publications (CrossRef) |
| match_str |
malerba2016noninvasivemethodstoassessbiomarkersofexposureandearlystageofpulmonarydiseaseinsmokingsubjects |
| publishDateSort |
2016 |
| publisher |
PAGEPress Publications |
| recordtype |
ai |
| record_format |
ai |
| series |
Monaldi Archives for Chest Disease |
| source_id |
49 |
| title |
Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| title_unstemmed |
Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| title_full |
Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| title_fullStr |
Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| title_full_unstemmed |
Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| title_short |
Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| title_sort |
non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| topic |
Cardiology and Cardiovascular Medicine Pulmonary and Respiratory Medicine |
| url |
http://dx.doi.org/10.4081/monaldi.2008.390 |
| publishDate |
2016 |
| physical |
|
| description |
<jats:p>Cigarette smoking is the major factor implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), despite the fact that only susceptible smoking subjects develop this respiratory disease. In the last few years non–invasive techniques such as induced sputum (IS), exhaled nitric oxide (eNO) measurement and exhaled breath condensate (EBC) collection have been successfully established revealing an inflammatory status and oxidative stress indicators in the airways involved in the pathogenesis of several pulmonary diseases. Using these new non-invasive experimental tools recently, several efforts have been made to find new biomarkers in order to assess and monitor early lung damage induced by smoking. Tobacco smoke can acutely reduce eNO levels in healthy smokers and non-smoker subjects so it can play a role in anti-smoking programmes; its increase can be a positive parameter for subjects who are going to stop cigarette smoking and at the same time be used as an anti-smoking indicator. It can be useful to investigate the mechanism of cigarette-induced lung damage in an experimental setting and may potentially be useful for assessing of Environmental Tobacco Smoke (ETS) effects. Markers of oxidative stress have been detected in induced sputum of COPD subjects even though only few studies investigated the use of induced sputum to study smoke effects on the lungs of healthy subjects. Exhaled breath condensate (EBC) obtained by cooling exhaled air under conditions of spontaneous breathing is a promising biological fluid that could provide a real-time assessment of pulmonary pathobiology. The analysis of induced sputum and of exhaled air is feasible and non-invasive, can be useful to identify new biomarkers of exposure or susceptibility in COPD patients to enhance the understanding of airways changes due to current smoking and may be useful to find new biomarkers in order to assess and monitor early lung damage induced by smoke in order to prevent the progression of obstructive disease.</jats:p> |
| container_issue |
3 |
| container_start_page |
0 |
| container_title |
Monaldi Archives for Chest Disease |
| container_volume |
70 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792327564074680334 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T12:39:21.825Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Non-invasive+methods+to+assess+biomarkers+of+exposure+and+early+stage+of+pulmonary+disease+in+smoking+subjects&rft.date=2016-01-25&genre=article&issn=1122-0643&volume=70&issue=3&jtitle=Monaldi+Archives+for+Chest+Disease&atitle=Non-invasive+methods+to+assess+biomarkers+of+exposure+and+early+stage+of+pulmonary+disease+in+smoking+subjects&aulast=Corradi&aufirst=M.&rft_id=info%3Adoi%2F10.4081%2Fmonaldi.2008.390&rft.language%5B0%5D=und |
| SOLR | |
| _version_ | 1792327564074680334 |
| author | Malerba, M., Ragnoli, B., Corradi, M. |
| author_facet | Malerba, M., Ragnoli, B., Corradi, M., Malerba, M., Ragnoli, B., Corradi, M. |
| author_sort | malerba, m. |
| container_issue | 3 |
| container_start_page | 0 |
| container_title | Monaldi Archives for Chest Disease |
| container_volume | 70 |
| description | <jats:p>Cigarette smoking is the major factor implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), despite the fact that only susceptible smoking subjects develop this respiratory disease. In the last few years non–invasive techniques such as induced sputum (IS), exhaled nitric oxide (eNO) measurement and exhaled breath condensate (EBC) collection have been successfully established revealing an inflammatory status and oxidative stress indicators in the airways involved in the pathogenesis of several pulmonary diseases. Using these new non-invasive experimental tools recently, several efforts have been made to find new biomarkers in order to assess and monitor early lung damage induced by smoking. Tobacco smoke can acutely reduce eNO levels in healthy smokers and non-smoker subjects so it can play a role in anti-smoking programmes; its increase can be a positive parameter for subjects who are going to stop cigarette smoking and at the same time be used as an anti-smoking indicator. It can be useful to investigate the mechanism of cigarette-induced lung damage in an experimental setting and may potentially be useful for assessing of Environmental Tobacco Smoke (ETS) effects. Markers of oxidative stress have been detected in induced sputum of COPD subjects even though only few studies investigated the use of induced sputum to study smoke effects on the lungs of healthy subjects. Exhaled breath condensate (EBC) obtained by cooling exhaled air under conditions of spontaneous breathing is a promising biological fluid that could provide a real-time assessment of pulmonary pathobiology. The analysis of induced sputum and of exhaled air is feasible and non-invasive, can be useful to identify new biomarkers of exposure or susceptibility in COPD patients to enhance the understanding of airways changes due to current smoking and may be useful to find new biomarkers in order to assess and monitor early lung damage induced by smoke in order to prevent the progression of obstructive disease.</jats:p> |
| doi_str_mv | 10.4081/monaldi.2008.390 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuNDA4MS9tb25hbGRpLjIwMDguMzkw |
| imprint | PAGEPress Publications, 2016 |
| imprint_str_mv | PAGEPress Publications, 2016 |
| institution | DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1 |
| issn | 2465-1028, 1122-0643 |
| issn_str_mv | 2465-1028, 1122-0643 |
| language | Undetermined |
| last_indexed | 2024-03-01T12:39:21.825Z |
| match_str | malerba2016noninvasivemethodstoassessbiomarkersofexposureandearlystageofpulmonarydiseaseinsmokingsubjects |
| mega_collection | PAGEPress Publications (CrossRef) |
| physical | |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher | PAGEPress Publications |
| record_format | ai |
| recordtype | ai |
| series | Monaldi Archives for Chest Disease |
| source_id | 49 |
| spelling | Malerba, M. Ragnoli, B. Corradi, M. 2465-1028 1122-0643 PAGEPress Publications Cardiology and Cardiovascular Medicine Pulmonary and Respiratory Medicine http://dx.doi.org/10.4081/monaldi.2008.390 <jats:p>Cigarette smoking is the major factor implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), despite the fact that only susceptible smoking subjects develop this respiratory disease. In the last few years non–invasive techniques such as induced sputum (IS), exhaled nitric oxide (eNO) measurement and exhaled breath condensate (EBC) collection have been successfully established revealing an inflammatory status and oxidative stress indicators in the airways involved in the pathogenesis of several pulmonary diseases. Using these new non-invasive experimental tools recently, several efforts have been made to find new biomarkers in order to assess and monitor early lung damage induced by smoking. Tobacco smoke can acutely reduce eNO levels in healthy smokers and non-smoker subjects so it can play a role in anti-smoking programmes; its increase can be a positive parameter for subjects who are going to stop cigarette smoking and at the same time be used as an anti-smoking indicator. It can be useful to investigate the mechanism of cigarette-induced lung damage in an experimental setting and may potentially be useful for assessing of Environmental Tobacco Smoke (ETS) effects. Markers of oxidative stress have been detected in induced sputum of COPD subjects even though only few studies investigated the use of induced sputum to study smoke effects on the lungs of healthy subjects. Exhaled breath condensate (EBC) obtained by cooling exhaled air under conditions of spontaneous breathing is a promising biological fluid that could provide a real-time assessment of pulmonary pathobiology. The analysis of induced sputum and of exhaled air is feasible and non-invasive, can be useful to identify new biomarkers of exposure or susceptibility in COPD patients to enhance the understanding of airways changes due to current smoking and may be useful to find new biomarkers in order to assess and monitor early lung damage induced by smoke in order to prevent the progression of obstructive disease.</jats:p> Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects Monaldi Archives for Chest Disease |
| spellingShingle | Malerba, M., Ragnoli, B., Corradi, M., Monaldi Archives for Chest Disease, Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine |
| title | Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| title_full | Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| title_fullStr | Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| title_full_unstemmed | Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| title_short | Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| title_sort | non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| title_unstemmed | Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects |
| topic | Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine |
| url | http://dx.doi.org/10.4081/monaldi.2008.390 |