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A Toolbox for Predicting G-Quadruplex Formation and Stability
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| Zeitschriftentitel: | Journal of Nucleic Acids |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Journal of Nucleic Acids, 2010, 2010, S. 1-6 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Wong, Han Min Stegle, Oliver Rodgers, Simon Huppert, Julian Leon Wong, Han Min Stegle, Oliver Rodgers, Simon Huppert, Julian Leon |
|---|---|
| author |
Wong, Han Min Stegle, Oliver Rodgers, Simon Huppert, Julian Leon |
| spellingShingle |
Wong, Han Min Stegle, Oliver Rodgers, Simon Huppert, Julian Leon Journal of Nucleic Acids A Toolbox for Predicting G-Quadruplex Formation and Stability Molecular Biology Biochemistry |
| author_sort |
wong, han min |
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Wong, Han Min Stegle, Oliver Rodgers, Simon Huppert, Julian Leon 2090-021X Hindawi Limited Molecular Biology Biochemistry http://dx.doi.org/10.4061/2010/564946 <jats:p>G-quadruplexes are four stranded nucleic acid structures formed around a core of guanines, arranged in squares with mutual hydrogen bonding. Many of these structures are highly thermally stable, especially in the presence of monovalent cations, such as those found under physiological conditions. Understanding of their physiological roles is expanding rapidly, and they have been implicated in regulating gene transcription and translation among other functions. We have built a community-focused website to act as a repository for the information that is now being developed. At its core, this site has a detailed database (QuadDB) of predicted G-quadruplexes in the human and other genomes, together with the predictive algorithm used to identify them. We also provide a QuadPredict server, which predicts thermal stability and acts as a repository for experimental data from all researchers. There are also a number of other data sources with computational predictions. We anticipate that the wide availability of this information will be of use both to researchers already active in this exciting field and to those who wish to investigate a particular gene hypothesis.</jats:p> A Toolbox for Predicting G-Quadruplex Formation and Stability Journal of Nucleic Acids |
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| title |
A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_unstemmed |
A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_full |
A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_fullStr |
A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_full_unstemmed |
A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_short |
A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_sort |
a toolbox for predicting g-quadruplex formation and stability |
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Molecular Biology Biochemistry |
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http://dx.doi.org/10.4061/2010/564946 |
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2010 |
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<jats:p>G-quadruplexes are four stranded nucleic acid structures formed around a core of guanines, arranged in squares with mutual hydrogen bonding. Many of these structures are highly thermally stable, especially in the presence of monovalent cations, such as those found under physiological conditions. Understanding of their physiological roles is expanding rapidly, and they have been implicated in regulating gene transcription and translation among other functions. We have built a community-focused website to act as a repository for the information that is now being developed. At its core, this site has a detailed database (QuadDB) of predicted G-quadruplexes in the human and other genomes, together with the predictive algorithm used to identify them. We also provide a QuadPredict server, which predicts thermal stability and acts as a repository for experimental data from all researchers. There are also a number of other data sources with computational predictions. We anticipate that the wide availability of this information will be of use both to researchers already active in this exciting field and to those who wish to investigate a particular gene hypothesis.</jats:p> |
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| author | Wong, Han Min, Stegle, Oliver, Rodgers, Simon, Huppert, Julian Leon |
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| description | <jats:p>G-quadruplexes are four stranded nucleic acid structures formed around a core of guanines, arranged in squares with mutual hydrogen bonding. Many of these structures are highly thermally stable, especially in the presence of monovalent cations, such as those found under physiological conditions. Understanding of their physiological roles is expanding rapidly, and they have been implicated in regulating gene transcription and translation among other functions. We have built a community-focused website to act as a repository for the information that is now being developed. At its core, this site has a detailed database (QuadDB) of predicted G-quadruplexes in the human and other genomes, together with the predictive algorithm used to identify them. We also provide a QuadPredict server, which predicts thermal stability and acts as a repository for experimental data from all researchers. There are also a number of other data sources with computational predictions. We anticipate that the wide availability of this information will be of use both to researchers already active in this exciting field and to those who wish to investigate a particular gene hypothesis.</jats:p> |
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| spelling | Wong, Han Min Stegle, Oliver Rodgers, Simon Huppert, Julian Leon 2090-021X Hindawi Limited Molecular Biology Biochemistry http://dx.doi.org/10.4061/2010/564946 <jats:p>G-quadruplexes are four stranded nucleic acid structures formed around a core of guanines, arranged in squares with mutual hydrogen bonding. Many of these structures are highly thermally stable, especially in the presence of monovalent cations, such as those found under physiological conditions. Understanding of their physiological roles is expanding rapidly, and they have been implicated in regulating gene transcription and translation among other functions. We have built a community-focused website to act as a repository for the information that is now being developed. At its core, this site has a detailed database (QuadDB) of predicted G-quadruplexes in the human and other genomes, together with the predictive algorithm used to identify them. We also provide a QuadPredict server, which predicts thermal stability and acts as a repository for experimental data from all researchers. There are also a number of other data sources with computational predictions. We anticipate that the wide availability of this information will be of use both to researchers already active in this exciting field and to those who wish to investigate a particular gene hypothesis.</jats:p> A Toolbox for Predicting G-Quadruplex Formation and Stability Journal of Nucleic Acids |
| spellingShingle | Wong, Han Min, Stegle, Oliver, Rodgers, Simon, Huppert, Julian Leon, Journal of Nucleic Acids, A Toolbox for Predicting G-Quadruplex Formation and Stability, Molecular Biology, Biochemistry |
| title | A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_full | A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_fullStr | A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_full_unstemmed | A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_short | A Toolbox for Predicting G-Quadruplex Formation and Stability |
| title_sort | a toolbox for predicting g-quadruplex formation and stability |
| title_unstemmed | A Toolbox for Predicting G-Quadruplex Formation and Stability |
| topic | Molecular Biology, Biochemistry |
| url | http://dx.doi.org/10.4061/2010/564946 |