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A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny
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| Zeitschriftentitel: | The Journal of Immunology |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | The Journal of Immunology, 164, 2000, 10, S. 5296-5305 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The American Association of Immunologists
|
| Schlagwörter: |
| author_facet |
Michalová, Věra Murray, Brent W. Sültmann, Holger Klein, Jan Michalová, Věra Murray, Brent W. Sültmann, Holger Klein, Jan |
|---|---|
| author |
Michalová, Věra Murray, Brent W. Sültmann, Holger Klein, Jan |
| spellingShingle |
Michalová, Věra Murray, Brent W. Sültmann, Holger Klein, Jan The Journal of Immunology A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny Immunology Immunology and Allergy |
| author_sort |
michalová, věra |
| spelling |
Michalová, Věra Murray, Brent W. Sültmann, Holger Klein, Jan 0022-1767 1550-6606 The American Association of Immunologists Immunology Immunology and Allergy http://dx.doi.org/10.4049/jimmunol.164.10.5296 <jats:title>Abstract</jats:title><jats:p>In contrast to the human and mouse Mhc, in which the clusters of class I and class II loci reside in close vicinity to one another, in the zebrafish, Danio rerio, they are found in different linkage groups. Chromosome walking using BAC (bacterial artificial chromosome) and PAC (P1 artificial chromosome) clones reveals the zebrafish class I region to occupy a segment of ∼450 kb and to encompass at least 19 loci. These include three class I (Dare-UDA, -UEA, -UFA), five proteasome subunit β (PSMB8, -9A, -9C, -11, -12), two TAPs (TAP2A, TAP2B), and one TAP binding protein (TAPBP). This arrangement contrasts with the arrangements found in human and mouse Mhc, in which the orthologues of the PSMB, TAP, and TAPBP loci reside within the class II region. In addition to this main zebrafish class I contig, a shorter contig of about 150 kb contains two additional class I (UBA, UCA) and at least five other loci. It probably represents a different haplotype of part of the class I region. The previously identified UAA gene shares an identical 5′ part with UEA, but the two genes differ in their 3′ parts. One of them is probably the result of an unequal crossing over. The described organization has implications for the persistence of syntenic relationships, coevolution of loci, and interpretation of the origin of the human/mouse Mhc organization.</jats:p> A Contig Map of the<i>Mhc</i>Class I Genomic Region in the Zebrafish Reveals Ancient Synteny The Journal of Immunology |
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| title |
A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny |
| title_unstemmed |
A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny |
| title_full |
A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny |
| title_fullStr |
A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny |
| title_full_unstemmed |
A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny |
| title_short |
A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny |
| title_sort |
a contig map of the<i>mhc</i>class i genomic region in the zebrafish reveals ancient synteny |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.4049/jimmunol.164.10.5296 |
| publishDate |
2000 |
| physical |
5296-5305 |
| description |
<jats:title>Abstract</jats:title><jats:p>In contrast to the human and mouse Mhc, in which the clusters of class I and class II loci reside in close vicinity to one another, in the zebrafish, Danio rerio, they are found in different linkage groups. Chromosome walking using BAC (bacterial artificial chromosome) and PAC (P1 artificial chromosome) clones reveals the zebrafish class I region to occupy a segment of ∼450 kb and to encompass at least 19 loci. These include three class I (Dare-UDA, -UEA, -UFA), five proteasome subunit β (PSMB8, -9A, -9C, -11, -12), two TAPs (TAP2A, TAP2B), and one TAP binding protein (TAPBP). This arrangement contrasts with the arrangements found in human and mouse Mhc, in which the orthologues of the PSMB, TAP, and TAPBP loci reside within the class II region. In addition to this main zebrafish class I contig, a shorter contig of about 150 kb contains two additional class I (UBA, UCA) and at least five other loci. It probably represents a different haplotype of part of the class I region. The previously identified UAA gene shares an identical 5′ part with UEA, but the two genes differ in their 3′ parts. One of them is probably the result of an unequal crossing over. The described organization has implications for the persistence of syntenic relationships, coevolution of loci, and interpretation of the origin of the human/mouse Mhc organization.</jats:p> |
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| author | Michalová, Věra, Murray, Brent W., Sültmann, Holger, Klein, Jan |
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| description | <jats:title>Abstract</jats:title><jats:p>In contrast to the human and mouse Mhc, in which the clusters of class I and class II loci reside in close vicinity to one another, in the zebrafish, Danio rerio, they are found in different linkage groups. Chromosome walking using BAC (bacterial artificial chromosome) and PAC (P1 artificial chromosome) clones reveals the zebrafish class I region to occupy a segment of ∼450 kb and to encompass at least 19 loci. These include three class I (Dare-UDA, -UEA, -UFA), five proteasome subunit β (PSMB8, -9A, -9C, -11, -12), two TAPs (TAP2A, TAP2B), and one TAP binding protein (TAPBP). This arrangement contrasts with the arrangements found in human and mouse Mhc, in which the orthologues of the PSMB, TAP, and TAPBP loci reside within the class II region. In addition to this main zebrafish class I contig, a shorter contig of about 150 kb contains two additional class I (UBA, UCA) and at least five other loci. It probably represents a different haplotype of part of the class I region. The previously identified UAA gene shares an identical 5′ part with UEA, but the two genes differ in their 3′ parts. One of them is probably the result of an unequal crossing over. The described organization has implications for the persistence of syntenic relationships, coevolution of loci, and interpretation of the origin of the human/mouse Mhc organization.</jats:p> |
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| imprint | The American Association of Immunologists, 2000 |
| imprint_str_mv | The American Association of Immunologists, 2000 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
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| spelling | Michalová, Věra Murray, Brent W. Sültmann, Holger Klein, Jan 0022-1767 1550-6606 The American Association of Immunologists Immunology Immunology and Allergy http://dx.doi.org/10.4049/jimmunol.164.10.5296 <jats:title>Abstract</jats:title><jats:p>In contrast to the human and mouse Mhc, in which the clusters of class I and class II loci reside in close vicinity to one another, in the zebrafish, Danio rerio, they are found in different linkage groups. Chromosome walking using BAC (bacterial artificial chromosome) and PAC (P1 artificial chromosome) clones reveals the zebrafish class I region to occupy a segment of ∼450 kb and to encompass at least 19 loci. These include three class I (Dare-UDA, -UEA, -UFA), five proteasome subunit β (PSMB8, -9A, -9C, -11, -12), two TAPs (TAP2A, TAP2B), and one TAP binding protein (TAPBP). This arrangement contrasts with the arrangements found in human and mouse Mhc, in which the orthologues of the PSMB, TAP, and TAPBP loci reside within the class II region. In addition to this main zebrafish class I contig, a shorter contig of about 150 kb contains two additional class I (UBA, UCA) and at least five other loci. It probably represents a different haplotype of part of the class I region. The previously identified UAA gene shares an identical 5′ part with UEA, but the two genes differ in their 3′ parts. One of them is probably the result of an unequal crossing over. The described organization has implications for the persistence of syntenic relationships, coevolution of loci, and interpretation of the origin of the human/mouse Mhc organization.</jats:p> A Contig Map of the<i>Mhc</i>Class I Genomic Region in the Zebrafish Reveals Ancient Synteny The Journal of Immunology |
| spellingShingle | Michalová, Věra, Murray, Brent W., Sültmann, Holger, Klein, Jan, The Journal of Immunology, A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny, Immunology, Immunology and Allergy |
| title | A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny |
| title_full | A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny |
| title_fullStr | A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny |
| title_full_unstemmed | A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny |
| title_short | A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny |
| title_sort | a contig map of the<i>mhc</i>class i genomic region in the zebrafish reveals ancient synteny |
| title_unstemmed | A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.4049/jimmunol.164.10.5296 |