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Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes
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| Zeitschriftentitel: | The Journal of Immunology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | The Journal of Immunology, 197, 2016, 12, S. 4535-4539 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The American Association of Immunologists
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| Schlagwörter: |
| author_facet |
He, Tianyu Brocca-Cofano, Egidio Policicchio, Benjamin B. Sivanandham, Ranjit Gautam, Rajeev Raehtz, Kevin D. Xu, Cuiling Pandrea, Ivona Apetrei, Cristian He, Tianyu Brocca-Cofano, Egidio Policicchio, Benjamin B. Sivanandham, Ranjit Gautam, Rajeev Raehtz, Kevin D. Xu, Cuiling Pandrea, Ivona Apetrei, Cristian |
|---|---|
| author |
He, Tianyu Brocca-Cofano, Egidio Policicchio, Benjamin B. Sivanandham, Ranjit Gautam, Rajeev Raehtz, Kevin D. Xu, Cuiling Pandrea, Ivona Apetrei, Cristian |
| spellingShingle |
He, Tianyu Brocca-Cofano, Egidio Policicchio, Benjamin B. Sivanandham, Ranjit Gautam, Rajeev Raehtz, Kevin D. Xu, Cuiling Pandrea, Ivona Apetrei, Cristian The Journal of Immunology Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes Immunology Immunology and Allergy |
| author_sort |
he, tianyu |
| spelling |
He, Tianyu Brocca-Cofano, Egidio Policicchio, Benjamin B. Sivanandham, Ranjit Gautam, Rajeev Raehtz, Kevin D. Xu, Cuiling Pandrea, Ivona Apetrei, Cristian 0022-1767 1550-6606 The American Association of Immunologists Immunology Immunology and Allergy http://dx.doi.org/10.4049/jimmunol.1601539 <jats:title>Abstract</jats:title> <jats:p>T regulatory cells (Tregs) are critical in shaping the latent HIV/SIV reservoir, as they are preferentially infected, reverse CD4+ T cell activation status, and suppress CTL responses. To reactivate latent virus and boost cell-mediated immune responses, we performed in vivo Treg depletion with Ontak (denileukin diftitox) in two SIVsab-infected controller macaques. Ontak induced significant (&gt;75%) Treg depletion and major CD4+ T cell activation, and only minimally depleted CD8+ T cells. The overall ability of Tregs to control immune responses was significantly impaired despite their incomplete depletion, resulting in both reactivation of latent virus (virus rebound to 103 viral RNA copies/ml plasma in the absence of antiretroviral therapy) and a significant boost of SIV-specific CD8+ T cell frequency, with rapid clearance of reactivated virus. As none of the latency-reversing agents in development have such dual activity, our strategy holds great promise for cure research.</jats:p> Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes The Journal of Immunology |
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10.4049/jimmunol.1601539 |
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Medizin |
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The American Association of Immunologists, 2016 |
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The American Association of Immunologists, 2016 |
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| title |
Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes |
| title_unstemmed |
Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes |
| title_full |
Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes |
| title_fullStr |
Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes |
| title_full_unstemmed |
Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes |
| title_short |
Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes |
| title_sort |
cutting edge: t regulatory cell depletion reactivates latent simian immunodeficiency virus (siv) in controller macaques while boosting siv-specific t lymphocytes |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.4049/jimmunol.1601539 |
| publishDate |
2016 |
| physical |
4535-4539 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>T regulatory cells (Tregs) are critical in shaping the latent HIV/SIV reservoir, as they are preferentially infected, reverse CD4+ T cell activation status, and suppress CTL responses. To reactivate latent virus and boost cell-mediated immune responses, we performed in vivo Treg depletion with Ontak (denileukin diftitox) in two SIVsab-infected controller macaques. Ontak induced significant (&gt;75%) Treg depletion and major CD4+ T cell activation, and only minimally depleted CD8+ T cells. The overall ability of Tregs to control immune responses was significantly impaired despite their incomplete depletion, resulting in both reactivation of latent virus (virus rebound to 103 viral RNA copies/ml plasma in the absence of antiretroviral therapy) and a significant boost of SIV-specific CD8+ T cell frequency, with rapid clearance of reactivated virus. As none of the latency-reversing agents in development have such dual activity, our strategy holds great promise for cure research.</jats:p> |
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| author | He, Tianyu, Brocca-Cofano, Egidio, Policicchio, Benjamin B., Sivanandham, Ranjit, Gautam, Rajeev, Raehtz, Kevin D., Xu, Cuiling, Pandrea, Ivona, Apetrei, Cristian |
| author_facet | He, Tianyu, Brocca-Cofano, Egidio, Policicchio, Benjamin B., Sivanandham, Ranjit, Gautam, Rajeev, Raehtz, Kevin D., Xu, Cuiling, Pandrea, Ivona, Apetrei, Cristian, He, Tianyu, Brocca-Cofano, Egidio, Policicchio, Benjamin B., Sivanandham, Ranjit, Gautam, Rajeev, Raehtz, Kevin D., Xu, Cuiling, Pandrea, Ivona, Apetrei, Cristian |
| author_sort | he, tianyu |
| container_issue | 12 |
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| container_title | The Journal of Immunology |
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| description | <jats:title>Abstract</jats:title> <jats:p>T regulatory cells (Tregs) are critical in shaping the latent HIV/SIV reservoir, as they are preferentially infected, reverse CD4+ T cell activation status, and suppress CTL responses. To reactivate latent virus and boost cell-mediated immune responses, we performed in vivo Treg depletion with Ontak (denileukin diftitox) in two SIVsab-infected controller macaques. Ontak induced significant (&gt;75%) Treg depletion and major CD4+ T cell activation, and only minimally depleted CD8+ T cells. The overall ability of Tregs to control immune responses was significantly impaired despite their incomplete depletion, resulting in both reactivation of latent virus (virus rebound to 103 viral RNA copies/ml plasma in the absence of antiretroviral therapy) and a significant boost of SIV-specific CD8+ T cell frequency, with rapid clearance of reactivated virus. As none of the latency-reversing agents in development have such dual activity, our strategy holds great promise for cure research.</jats:p> |
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| spelling | He, Tianyu Brocca-Cofano, Egidio Policicchio, Benjamin B. Sivanandham, Ranjit Gautam, Rajeev Raehtz, Kevin D. Xu, Cuiling Pandrea, Ivona Apetrei, Cristian 0022-1767 1550-6606 The American Association of Immunologists Immunology Immunology and Allergy http://dx.doi.org/10.4049/jimmunol.1601539 <jats:title>Abstract</jats:title> <jats:p>T regulatory cells (Tregs) are critical in shaping the latent HIV/SIV reservoir, as they are preferentially infected, reverse CD4+ T cell activation status, and suppress CTL responses. To reactivate latent virus and boost cell-mediated immune responses, we performed in vivo Treg depletion with Ontak (denileukin diftitox) in two SIVsab-infected controller macaques. Ontak induced significant (&gt;75%) Treg depletion and major CD4+ T cell activation, and only minimally depleted CD8+ T cells. The overall ability of Tregs to control immune responses was significantly impaired despite their incomplete depletion, resulting in both reactivation of latent virus (virus rebound to 103 viral RNA copies/ml plasma in the absence of antiretroviral therapy) and a significant boost of SIV-specific CD8+ T cell frequency, with rapid clearance of reactivated virus. As none of the latency-reversing agents in development have such dual activity, our strategy holds great promise for cure research.</jats:p> Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes The Journal of Immunology |
| spellingShingle | He, Tianyu, Brocca-Cofano, Egidio, Policicchio, Benjamin B., Sivanandham, Ranjit, Gautam, Rajeev, Raehtz, Kevin D., Xu, Cuiling, Pandrea, Ivona, Apetrei, Cristian, The Journal of Immunology, Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes, Immunology, Immunology and Allergy |
| title | Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes |
| title_full | Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes |
| title_fullStr | Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes |
| title_full_unstemmed | Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes |
| title_short | Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes |
| title_sort | cutting edge: t regulatory cell depletion reactivates latent simian immunodeficiency virus (siv) in controller macaques while boosting siv-specific t lymphocytes |
| title_unstemmed | Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.4049/jimmunol.1601539 |