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Aberrant Alternative Splicing Events in Parkinson's Disease
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| Zeitschriftentitel: | Cell Transplantation |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Cell Transplantation, 22, 2013, 4, S. 653-661 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Fu, Ru-Huei Liu, Shih-Ping Huang, Shyh-Jer Chen, Hung-Jen Chen, Pin-Ru Lin, Ya-Hsien Ho, Yu-Chen Chang, Wen-Lin Tsai, Chang-Hai Shyu, Woei-Cherng Lin, Shinn-Zong Fu, Ru-Huei Liu, Shih-Ping Huang, Shyh-Jer Chen, Hung-Jen Chen, Pin-Ru Lin, Ya-Hsien Ho, Yu-Chen Chang, Wen-Lin Tsai, Chang-Hai Shyu, Woei-Cherng Lin, Shinn-Zong |
|---|---|
| author |
Fu, Ru-Huei Liu, Shih-Ping Huang, Shyh-Jer Chen, Hung-Jen Chen, Pin-Ru Lin, Ya-Hsien Ho, Yu-Chen Chang, Wen-Lin Tsai, Chang-Hai Shyu, Woei-Cherng Lin, Shinn-Zong |
| spellingShingle |
Fu, Ru-Huei Liu, Shih-Ping Huang, Shyh-Jer Chen, Hung-Jen Chen, Pin-Ru Lin, Ya-Hsien Ho, Yu-Chen Chang, Wen-Lin Tsai, Chang-Hai Shyu, Woei-Cherng Lin, Shinn-Zong Cell Transplantation Aberrant Alternative Splicing Events in Parkinson's Disease Transplantation Cell Biology Biomedical Engineering |
| author_sort |
fu, ru-huei |
| spelling |
Fu, Ru-Huei Liu, Shih-Ping Huang, Shyh-Jer Chen, Hung-Jen Chen, Pin-Ru Lin, Ya-Hsien Ho, Yu-Chen Chang, Wen-Lin Tsai, Chang-Hai Shyu, Woei-Cherng Lin, Shinn-Zong 0963-6897 1555-3892 SAGE Publications Transplantation Cell Biology Biomedical Engineering http://dx.doi.org/10.3727/096368912x655154 <jats:p> Alternative splicing (AS) using a sole gene to express multiple transcripts with diverse protein coding sequences and/or RNA regulatory elements raises genomic complexities. In the nervous system, several thousand AS events play important roles in ion transportation, receptor recognition, neurotransmission, memory, and learning. Not surprisingly, AS influences human physiology, development, and disease. Many research studies have focused on aberrant AS in nervous system diseases, including Parkinson's disease (PD), the second most common progressive neurodegenerative disorder of the central nervous system. PD affects the lives of several million people globally. It is caused by protein aggregation, such as in Lewy bodies, and the loss of dopamine-containing neurons in the substantia nigra of the midbrain. To our knowledge, six genes, including PARK2, SNCAIP, LRRK2, SNCA, SRRM2, and MAPT, are involved in aberrant AS events in PD patients. In this review, we highlight the relevance of aberrant AS in PD and discuss the use of an aberrant AS profile as a potential diagnostic or prognostic marker for PD and as a possible means of applying therapy. </jats:p> Aberrant Alternative Splicing Events in Parkinson's Disease Cell Transplantation |
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| title |
Aberrant Alternative Splicing Events in Parkinson's Disease |
| title_unstemmed |
Aberrant Alternative Splicing Events in Parkinson's Disease |
| title_full |
Aberrant Alternative Splicing Events in Parkinson's Disease |
| title_fullStr |
Aberrant Alternative Splicing Events in Parkinson's Disease |
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Aberrant Alternative Splicing Events in Parkinson's Disease |
| title_short |
Aberrant Alternative Splicing Events in Parkinson's Disease |
| title_sort |
aberrant alternative splicing events in parkinson's disease |
| topic |
Transplantation Cell Biology Biomedical Engineering |
| url |
http://dx.doi.org/10.3727/096368912x655154 |
| publishDate |
2013 |
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653-661 |
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<jats:p> Alternative splicing (AS) using a sole gene to express multiple transcripts with diverse protein coding sequences and/or RNA regulatory elements raises genomic complexities. In the nervous system, several thousand AS events play important roles in ion transportation, receptor recognition, neurotransmission, memory, and learning. Not surprisingly, AS influences human physiology, development, and disease. Many research studies have focused on aberrant AS in nervous system diseases, including Parkinson's disease (PD), the second most common progressive neurodegenerative disorder of the central nervous system. PD affects the lives of several million people globally. It is caused by protein aggregation, such as in Lewy bodies, and the loss of dopamine-containing neurons in the substantia nigra of the midbrain. To our knowledge, six genes, including PARK2, SNCAIP, LRRK2, SNCA, SRRM2, and MAPT, are involved in aberrant AS events in PD patients. In this review, we highlight the relevance of aberrant AS in PD and discuss the use of an aberrant AS profile as a potential diagnostic or prognostic marker for PD and as a possible means of applying therapy. </jats:p> |
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| author | Fu, Ru-Huei, Liu, Shih-Ping, Huang, Shyh-Jer, Chen, Hung-Jen, Chen, Pin-Ru, Lin, Ya-Hsien, Ho, Yu-Chen, Chang, Wen-Lin, Tsai, Chang-Hai, Shyu, Woei-Cherng, Lin, Shinn-Zong |
| author_facet | Fu, Ru-Huei, Liu, Shih-Ping, Huang, Shyh-Jer, Chen, Hung-Jen, Chen, Pin-Ru, Lin, Ya-Hsien, Ho, Yu-Chen, Chang, Wen-Lin, Tsai, Chang-Hai, Shyu, Woei-Cherng, Lin, Shinn-Zong, Fu, Ru-Huei, Liu, Shih-Ping, Huang, Shyh-Jer, Chen, Hung-Jen, Chen, Pin-Ru, Lin, Ya-Hsien, Ho, Yu-Chen, Chang, Wen-Lin, Tsai, Chang-Hai, Shyu, Woei-Cherng, Lin, Shinn-Zong |
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| description | <jats:p> Alternative splicing (AS) using a sole gene to express multiple transcripts with diverse protein coding sequences and/or RNA regulatory elements raises genomic complexities. In the nervous system, several thousand AS events play important roles in ion transportation, receptor recognition, neurotransmission, memory, and learning. Not surprisingly, AS influences human physiology, development, and disease. Many research studies have focused on aberrant AS in nervous system diseases, including Parkinson's disease (PD), the second most common progressive neurodegenerative disorder of the central nervous system. PD affects the lives of several million people globally. It is caused by protein aggregation, such as in Lewy bodies, and the loss of dopamine-containing neurons in the substantia nigra of the midbrain. To our knowledge, six genes, including PARK2, SNCAIP, LRRK2, SNCA, SRRM2, and MAPT, are involved in aberrant AS events in PD patients. In this review, we highlight the relevance of aberrant AS in PD and discuss the use of an aberrant AS profile as a potential diagnostic or prognostic marker for PD and as a possible means of applying therapy. </jats:p> |
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| spelling | Fu, Ru-Huei Liu, Shih-Ping Huang, Shyh-Jer Chen, Hung-Jen Chen, Pin-Ru Lin, Ya-Hsien Ho, Yu-Chen Chang, Wen-Lin Tsai, Chang-Hai Shyu, Woei-Cherng Lin, Shinn-Zong 0963-6897 1555-3892 SAGE Publications Transplantation Cell Biology Biomedical Engineering http://dx.doi.org/10.3727/096368912x655154 <jats:p> Alternative splicing (AS) using a sole gene to express multiple transcripts with diverse protein coding sequences and/or RNA regulatory elements raises genomic complexities. In the nervous system, several thousand AS events play important roles in ion transportation, receptor recognition, neurotransmission, memory, and learning. Not surprisingly, AS influences human physiology, development, and disease. Many research studies have focused on aberrant AS in nervous system diseases, including Parkinson's disease (PD), the second most common progressive neurodegenerative disorder of the central nervous system. PD affects the lives of several million people globally. It is caused by protein aggregation, such as in Lewy bodies, and the loss of dopamine-containing neurons in the substantia nigra of the midbrain. To our knowledge, six genes, including PARK2, SNCAIP, LRRK2, SNCA, SRRM2, and MAPT, are involved in aberrant AS events in PD patients. In this review, we highlight the relevance of aberrant AS in PD and discuss the use of an aberrant AS profile as a potential diagnostic or prognostic marker for PD and as a possible means of applying therapy. </jats:p> Aberrant Alternative Splicing Events in Parkinson's Disease Cell Transplantation |
| spellingShingle | Fu, Ru-Huei, Liu, Shih-Ping, Huang, Shyh-Jer, Chen, Hung-Jen, Chen, Pin-Ru, Lin, Ya-Hsien, Ho, Yu-Chen, Chang, Wen-Lin, Tsai, Chang-Hai, Shyu, Woei-Cherng, Lin, Shinn-Zong, Cell Transplantation, Aberrant Alternative Splicing Events in Parkinson's Disease, Transplantation, Cell Biology, Biomedical Engineering |
| title | Aberrant Alternative Splicing Events in Parkinson's Disease |
| title_full | Aberrant Alternative Splicing Events in Parkinson's Disease |
| title_fullStr | Aberrant Alternative Splicing Events in Parkinson's Disease |
| title_full_unstemmed | Aberrant Alternative Splicing Events in Parkinson's Disease |
| title_short | Aberrant Alternative Splicing Events in Parkinson's Disease |
| title_sort | aberrant alternative splicing events in parkinson's disease |
| title_unstemmed | Aberrant Alternative Splicing Events in Parkinson's Disease |
| topic | Transplantation, Cell Biology, Biomedical Engineering |
| url | http://dx.doi.org/10.3727/096368912x655154 |