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Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor
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| Zeitschriftentitel: | Cell Transplantation |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Cell Transplantation, 21, 2012, 2-3, S. 559-563 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Maruyama, Michihiro Kenmochi, Takashi Saigo, Kenichi Naotake, Akutsu Iwashita, Chikara Otsuki, Kazunori Ito, Taihei Maruyama, Michihiro Kenmochi, Takashi Saigo, Kenichi Naotake, Akutsu Iwashita, Chikara Otsuki, Kazunori Ito, Taihei |
|---|---|
| author |
Maruyama, Michihiro Kenmochi, Takashi Saigo, Kenichi Naotake, Akutsu Iwashita, Chikara Otsuki, Kazunori Ito, Taihei |
| spellingShingle |
Maruyama, Michihiro Kenmochi, Takashi Saigo, Kenichi Naotake, Akutsu Iwashita, Chikara Otsuki, Kazunori Ito, Taihei Cell Transplantation Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor Transplantation Cell Biology Biomedical Engineering |
| author_sort |
maruyama, michihiro |
| spelling |
Maruyama, Michihiro Kenmochi, Takashi Saigo, Kenichi Naotake, Akutsu Iwashita, Chikara Otsuki, Kazunori Ito, Taihei 0963-6897 1555-3892 SAGE Publications Transplantation Cell Biology Biomedical Engineering http://dx.doi.org/10.3727/096368911x605484 <jats:p> Grafts from non-heart-beating donors (NHBDs) are used because of the limited availability of heart-beating brain-dead donors. These grafts sustain ischemic damage, and the severity of this damage varies among different areas of an organ. This study determined whether the results of islet isolation were correlated with the clinical outcomes of kidney transplantations in cases where both grafts were harvested from the same NHBD. Islets we isolated from the pancreata of 23 NHBDs between February 2004 and March 2007. Forty-six kidneys were also harvested from these NHBDs. The recipients of kidney transplants were divided into the successful isolation ( n = 14) and failed isolation ( n = 32) groups depending on the results of islet isolation. The clinical outcomes of kidney transplantation were compared between the recipients in these two groups. The immediate graft function rate and the 1-year graft survival rate after kidney transplantation in both groups were similar. Hemodialysis after transplantation was required for 6.0 days (SD, 5.2 days) in the successful isolation group and for 12.7 days (13.1 days) in the failed isolation group ( p < 0.05). The serum creatinine concentrations at 1, 3, 6, and 12 months after transplantation were elevated in the failed isolation group ( p < 0.05). The islet yield was inversely correlated with the requirement of hemodialysis (days) and the serum creatinine level at 1 month after transplantation. However, hemodialysis was required for only 7 days in the recipients of six kidneys that were obtained from NHBDs from whom <40,000 IEQ were obtained (extreme failure of islet isolation). The results of islet isolation were found to correlate with the kidney function after transplantation when both grafts are harvested from the same NHBD. However, the marginal conditions of NHBDs affect the results of islet isolation more than they do the posttransplantation kidney function. </jats:p> Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor Cell Transplantation |
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| title |
Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor |
| title_unstemmed |
Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor |
| title_full |
Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor |
| title_fullStr |
Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor |
| title_full_unstemmed |
Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor |
| title_short |
Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor |
| title_sort |
results of islet isolation and their relationship to the clinical outcome of kidney transplantation in cases where both grafts are harvested from the same non-heart-beating donor |
| topic |
Transplantation Cell Biology Biomedical Engineering |
| url |
http://dx.doi.org/10.3727/096368911x605484 |
| publishDate |
2012 |
| physical |
559-563 |
| description |
<jats:p> Grafts from non-heart-beating donors (NHBDs) are used because of the limited availability of heart-beating brain-dead donors. These grafts sustain ischemic damage, and the severity of this damage varies among different areas of an organ. This study determined whether the results of islet isolation were correlated with the clinical outcomes of kidney transplantations in cases where both grafts were harvested from the same NHBD. Islets we isolated from the pancreata of 23 NHBDs between February 2004 and March 2007. Forty-six kidneys were also harvested from these NHBDs. The recipients of kidney transplants were divided into the successful isolation ( n = 14) and failed isolation ( n = 32) groups depending on the results of islet isolation. The clinical outcomes of kidney transplantation were compared between the recipients in these two groups. The immediate graft function rate and the 1-year graft survival rate after kidney transplantation in both groups were similar. Hemodialysis after transplantation was required for 6.0 days (SD, 5.2 days) in the successful isolation group and for 12.7 days (13.1 days) in the failed isolation group ( p < 0.05). The serum creatinine concentrations at 1, 3, 6, and 12 months after transplantation were elevated in the failed isolation group ( p < 0.05). The islet yield was inversely correlated with the requirement of hemodialysis (days) and the serum creatinine level at 1 month after transplantation. However, hemodialysis was required for only 7 days in the recipients of six kidneys that were obtained from NHBDs from whom <40,000 IEQ were obtained (extreme failure of islet isolation). The results of islet isolation were found to correlate with the kidney function after transplantation when both grafts are harvested from the same NHBD. However, the marginal conditions of NHBDs affect the results of islet isolation more than they do the posttransplantation kidney function. </jats:p> |
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| author | Maruyama, Michihiro, Kenmochi, Takashi, Saigo, Kenichi, Naotake, Akutsu, Iwashita, Chikara, Otsuki, Kazunori, Ito, Taihei |
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| description | <jats:p> Grafts from non-heart-beating donors (NHBDs) are used because of the limited availability of heart-beating brain-dead donors. These grafts sustain ischemic damage, and the severity of this damage varies among different areas of an organ. This study determined whether the results of islet isolation were correlated with the clinical outcomes of kidney transplantations in cases where both grafts were harvested from the same NHBD. Islets we isolated from the pancreata of 23 NHBDs between February 2004 and March 2007. Forty-six kidneys were also harvested from these NHBDs. The recipients of kidney transplants were divided into the successful isolation ( n = 14) and failed isolation ( n = 32) groups depending on the results of islet isolation. The clinical outcomes of kidney transplantation were compared between the recipients in these two groups. The immediate graft function rate and the 1-year graft survival rate after kidney transplantation in both groups were similar. Hemodialysis after transplantation was required for 6.0 days (SD, 5.2 days) in the successful isolation group and for 12.7 days (13.1 days) in the failed isolation group ( p < 0.05). The serum creatinine concentrations at 1, 3, 6, and 12 months after transplantation were elevated in the failed isolation group ( p < 0.05). The islet yield was inversely correlated with the requirement of hemodialysis (days) and the serum creatinine level at 1 month after transplantation. However, hemodialysis was required for only 7 days in the recipients of six kidneys that were obtained from NHBDs from whom <40,000 IEQ were obtained (extreme failure of islet isolation). The results of islet isolation were found to correlate with the kidney function after transplantation when both grafts are harvested from the same NHBD. However, the marginal conditions of NHBDs affect the results of islet isolation more than they do the posttransplantation kidney function. </jats:p> |
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| spelling | Maruyama, Michihiro Kenmochi, Takashi Saigo, Kenichi Naotake, Akutsu Iwashita, Chikara Otsuki, Kazunori Ito, Taihei 0963-6897 1555-3892 SAGE Publications Transplantation Cell Biology Biomedical Engineering http://dx.doi.org/10.3727/096368911x605484 <jats:p> Grafts from non-heart-beating donors (NHBDs) are used because of the limited availability of heart-beating brain-dead donors. These grafts sustain ischemic damage, and the severity of this damage varies among different areas of an organ. This study determined whether the results of islet isolation were correlated with the clinical outcomes of kidney transplantations in cases where both grafts were harvested from the same NHBD. Islets we isolated from the pancreata of 23 NHBDs between February 2004 and March 2007. Forty-six kidneys were also harvested from these NHBDs. The recipients of kidney transplants were divided into the successful isolation ( n = 14) and failed isolation ( n = 32) groups depending on the results of islet isolation. The clinical outcomes of kidney transplantation were compared between the recipients in these two groups. The immediate graft function rate and the 1-year graft survival rate after kidney transplantation in both groups were similar. Hemodialysis after transplantation was required for 6.0 days (SD, 5.2 days) in the successful isolation group and for 12.7 days (13.1 days) in the failed isolation group ( p < 0.05). The serum creatinine concentrations at 1, 3, 6, and 12 months after transplantation were elevated in the failed isolation group ( p < 0.05). The islet yield was inversely correlated with the requirement of hemodialysis (days) and the serum creatinine level at 1 month after transplantation. However, hemodialysis was required for only 7 days in the recipients of six kidneys that were obtained from NHBDs from whom <40,000 IEQ were obtained (extreme failure of islet isolation). The results of islet isolation were found to correlate with the kidney function after transplantation when both grafts are harvested from the same NHBD. However, the marginal conditions of NHBDs affect the results of islet isolation more than they do the posttransplantation kidney function. </jats:p> Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor Cell Transplantation |
| spellingShingle | Maruyama, Michihiro, Kenmochi, Takashi, Saigo, Kenichi, Naotake, Akutsu, Iwashita, Chikara, Otsuki, Kazunori, Ito, Taihei, Cell Transplantation, Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor, Transplantation, Cell Biology, Biomedical Engineering |
| title | Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor |
| title_full | Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor |
| title_fullStr | Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor |
| title_full_unstemmed | Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor |
| title_short | Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor |
| title_sort | results of islet isolation and their relationship to the clinical outcome of kidney transplantation in cases where both grafts are harvested from the same non-heart-beating donor |
| title_unstemmed | Results of Islet Isolation and their Relationship to the Clinical Outcome of Kidney Transplantation in Cases where Both Grafts are Harvested from the Same Non-Heart-Beating Donor |
| topic | Transplantation, Cell Biology, Biomedical Engineering |
| url | http://dx.doi.org/10.3727/096368911x605484 |