Eintrag weiter verarbeiten
Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients
Gespeichert in:
Zeitschriftentitel: | Current Oncology |
---|---|
Personen und Körperschaften: | , , , , , , |
In: | Current Oncology, 17, 2010, 5, S. 22-27 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
MDPI AG
|
author_facet |
Hijal, T. Al Hamad, A.A. Niazi, T. Sultanem, K. Bahoric, B. Vuong, T. Muanza, T. Hijal, T. Al Hamad, A.A. Niazi, T. Sultanem, K. Bahoric, B. Vuong, T. Muanza, T. |
---|---|
author |
Hijal, T. Al Hamad, A.A. Niazi, T. Sultanem, K. Bahoric, B. Vuong, T. Muanza, T. |
spellingShingle |
Hijal, T. Al Hamad, A.A. Niazi, T. Sultanem, K. Bahoric, B. Vuong, T. Muanza, T. Current Oncology Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
author_sort |
hijal, t. |
spelling |
Hijal, T. Al Hamad, A.A. Niazi, T. Sultanem, K. Bahoric, B. Vuong, T. Muanza, T. 1718-7729 MDPI AG http://dx.doi.org/10.3747/co.v17i5.604 <jats:p>Purpose: Radiation-induced dermatitis is a common side effect of breast irradiation, with hypofractionation being a well-known risk factor. In the context of the widespread adoption of hypofractionated breast radiotherapy, we evaluated the effect of hypofractionated radiotherapy on the incidence of skin toxicity in patients receiving adjuvant chemotherapy. Patients and Methods: We retrospectively reviewed the records of patients with breast cancer treated from 2004 to 2006 at a single institution. Patients undergoing lumpectomy with or without adjuvant chemotherapy followed by hypofractionated radiotherapy consisting of 42.4 Gy in 16 fractions were included in the study. Using cosmetic and skin toxicity scales, all patients were evaluated weekly during treatment and at scheduled follow-up visits with the radiation oncologist. Results: During the study period, 162 patients underwent radiotherapy, and 30% of those (n = 48) received chemotherapy. Radiotherapy boost to the tumour bed was more common in the chemotherapy group [n = 20 (42%)] than in the radiotherapy-alone group [n = 30 (26%)]. We observed no statistically significant difference between the groups with regard to acute skin toxicity of grade 3 or higher (2.1% in the chemotherapy group vs. 4.4% in the radiation-alone group, p = 0.67) or of grades 1–2 toxicity (62.5% vs. 51.7% respectively, p = 0.23). There was also no significant difference in late grade 3 or higher skin toxicity between the groups (2.1% vs. 0% respectively, p = 0.30) or in grades 1–2 toxicity (20.8% vs. 25.5% respectively, p = 0.69). Similarly, excellent or good cosmetic result scores were similar in both groups (p = 0.80). Conclusions: In our single-institution review, we observed no adverse effects of chemotherapy in combination with hypofractionated whole-breast irradiation. Further investigations are necessary to better elucidate the effects of chemotherapy on skin toxicity in the context of hypofractionated irradiation.</jats:p> Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients Current Oncology |
doi_str_mv |
10.3747/co.v17i5.604 |
facet_avail |
Online Free |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMzc0Ny9jby52MTdpNS42MDQ |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMzc0Ny9jby52MTdpNS42MDQ |
institution |
DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 |
imprint |
MDPI AG, 2010 |
imprint_str_mv |
MDPI AG, 2010 |
issn |
1718-7729 |
issn_str_mv |
1718-7729 |
language |
English |
mega_collection |
MDPI AG (CrossRef) |
match_str |
hijal2010hypofractionatedradiotherapyandadjuvantchemotherapydonotincreaseradiationinduceddermatitisinbreastcancerpatients |
publishDateSort |
2010 |
publisher |
MDPI AG |
recordtype |
ai |
record_format |
ai |
series |
Current Oncology |
source_id |
49 |
title |
Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
title_unstemmed |
Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
title_full |
Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
title_fullStr |
Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
title_full_unstemmed |
Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
title_short |
Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
title_sort |
hypofractionated radiotherapy and adjuvant chemotherapy do not increase radiation-induced dermatitis in breast cancer patients |
url |
http://dx.doi.org/10.3747/co.v17i5.604 |
publishDate |
2010 |
physical |
22-27 |
description |
<jats:p>Purpose: Radiation-induced dermatitis is a common side effect of breast irradiation, with hypofractionation being a well-known risk factor. In the context of the widespread adoption of hypofractionated breast radiotherapy, we evaluated the effect of hypofractionated radiotherapy on the incidence of skin toxicity in patients receiving adjuvant chemotherapy. Patients and Methods: We retrospectively reviewed the records of patients with breast cancer treated from 2004 to 2006 at a single institution. Patients undergoing lumpectomy with or without adjuvant chemotherapy followed by hypofractionated radiotherapy consisting of 42.4 Gy in 16 fractions were included in the study. Using cosmetic and skin toxicity scales, all patients were evaluated weekly during treatment and at scheduled follow-up visits with the radiation oncologist. Results: During the study period, 162 patients underwent radiotherapy, and 30% of those (n = 48) received chemotherapy. Radiotherapy boost to the tumour bed was more common in the chemotherapy group [n = 20 (42%)] than in the radiotherapy-alone group [n = 30 (26%)]. We observed no statistically significant difference between the groups with regard to acute skin toxicity of grade 3 or higher (2.1% in the chemotherapy group vs. 4.4% in the radiation-alone group, p = 0.67) or of grades 1–2 toxicity (62.5% vs. 51.7% respectively, p = 0.23). There was also no significant difference in late grade 3 or higher skin toxicity between the groups (2.1% vs. 0% respectively, p = 0.30) or in grades 1–2 toxicity (20.8% vs. 25.5% respectively, p = 0.69). Similarly, excellent or good cosmetic result scores were similar in both groups (p = 0.80). Conclusions: In our single-institution review, we observed no adverse effects of chemotherapy in combination with hypofractionated whole-breast irradiation. Further investigations are necessary to better elucidate the effects of chemotherapy on skin toxicity in the context of hypofractionated irradiation.</jats:p> |
container_issue |
5 |
container_start_page |
22 |
container_title |
Current Oncology |
container_volume |
17 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792334211340828675 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T14:25:03.59Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Hypofractionated+Radiotherapy+and+Adjuvant+Chemotherapy+Do+Not+Increase+Radiation-Induced+Dermatitis+in+Breast+Cancer+Patients&rft.date=2010-10-01&genre=article&issn=1718-7729&volume=17&issue=5&spage=22&epage=27&pages=22-27&jtitle=Current+Oncology&atitle=Hypofractionated+Radiotherapy+and+Adjuvant+Chemotherapy+Do+Not+Increase+Radiation-Induced+Dermatitis+in+Breast+Cancer+Patients&aulast=Muanza&aufirst=T.&rft_id=info%3Adoi%2F10.3747%2Fco.v17i5.604&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792334211340828675 |
author | Hijal, T., Al Hamad, A.A., Niazi, T., Sultanem, K., Bahoric, B., Vuong, T., Muanza, T. |
author_facet | Hijal, T., Al Hamad, A.A., Niazi, T., Sultanem, K., Bahoric, B., Vuong, T., Muanza, T., Hijal, T., Al Hamad, A.A., Niazi, T., Sultanem, K., Bahoric, B., Vuong, T., Muanza, T. |
author_sort | hijal, t. |
container_issue | 5 |
container_start_page | 22 |
container_title | Current Oncology |
container_volume | 17 |
description | <jats:p>Purpose: Radiation-induced dermatitis is a common side effect of breast irradiation, with hypofractionation being a well-known risk factor. In the context of the widespread adoption of hypofractionated breast radiotherapy, we evaluated the effect of hypofractionated radiotherapy on the incidence of skin toxicity in patients receiving adjuvant chemotherapy. Patients and Methods: We retrospectively reviewed the records of patients with breast cancer treated from 2004 to 2006 at a single institution. Patients undergoing lumpectomy with or without adjuvant chemotherapy followed by hypofractionated radiotherapy consisting of 42.4 Gy in 16 fractions were included in the study. Using cosmetic and skin toxicity scales, all patients were evaluated weekly during treatment and at scheduled follow-up visits with the radiation oncologist. Results: During the study period, 162 patients underwent radiotherapy, and 30% of those (n = 48) received chemotherapy. Radiotherapy boost to the tumour bed was more common in the chemotherapy group [n = 20 (42%)] than in the radiotherapy-alone group [n = 30 (26%)]. We observed no statistically significant difference between the groups with regard to acute skin toxicity of grade 3 or higher (2.1% in the chemotherapy group vs. 4.4% in the radiation-alone group, p = 0.67) or of grades 1–2 toxicity (62.5% vs. 51.7% respectively, p = 0.23). There was also no significant difference in late grade 3 or higher skin toxicity between the groups (2.1% vs. 0% respectively, p = 0.30) or in grades 1–2 toxicity (20.8% vs. 25.5% respectively, p = 0.69). Similarly, excellent or good cosmetic result scores were similar in both groups (p = 0.80). Conclusions: In our single-institution review, we observed no adverse effects of chemotherapy in combination with hypofractionated whole-breast irradiation. Further investigations are necessary to better elucidate the effects of chemotherapy on skin toxicity in the context of hypofractionated irradiation.</jats:p> |
doi_str_mv | 10.3747/co.v17i5.604 |
facet_avail | Online, Free |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMzc0Ny9jby52MTdpNS42MDQ |
imprint | MDPI AG, 2010 |
imprint_str_mv | MDPI AG, 2010 |
institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
issn | 1718-7729 |
issn_str_mv | 1718-7729 |
language | English |
last_indexed | 2024-03-01T14:25:03.59Z |
match_str | hijal2010hypofractionatedradiotherapyandadjuvantchemotherapydonotincreaseradiationinduceddermatitisinbreastcancerpatients |
mega_collection | MDPI AG (CrossRef) |
physical | 22-27 |
publishDate | 2010 |
publishDateSort | 2010 |
publisher | MDPI AG |
record_format | ai |
recordtype | ai |
series | Current Oncology |
source_id | 49 |
spelling | Hijal, T. Al Hamad, A.A. Niazi, T. Sultanem, K. Bahoric, B. Vuong, T. Muanza, T. 1718-7729 MDPI AG http://dx.doi.org/10.3747/co.v17i5.604 <jats:p>Purpose: Radiation-induced dermatitis is a common side effect of breast irradiation, with hypofractionation being a well-known risk factor. In the context of the widespread adoption of hypofractionated breast radiotherapy, we evaluated the effect of hypofractionated radiotherapy on the incidence of skin toxicity in patients receiving adjuvant chemotherapy. Patients and Methods: We retrospectively reviewed the records of patients with breast cancer treated from 2004 to 2006 at a single institution. Patients undergoing lumpectomy with or without adjuvant chemotherapy followed by hypofractionated radiotherapy consisting of 42.4 Gy in 16 fractions were included in the study. Using cosmetic and skin toxicity scales, all patients were evaluated weekly during treatment and at scheduled follow-up visits with the radiation oncologist. Results: During the study period, 162 patients underwent radiotherapy, and 30% of those (n = 48) received chemotherapy. Radiotherapy boost to the tumour bed was more common in the chemotherapy group [n = 20 (42%)] than in the radiotherapy-alone group [n = 30 (26%)]. We observed no statistically significant difference between the groups with regard to acute skin toxicity of grade 3 or higher (2.1% in the chemotherapy group vs. 4.4% in the radiation-alone group, p = 0.67) or of grades 1–2 toxicity (62.5% vs. 51.7% respectively, p = 0.23). There was also no significant difference in late grade 3 or higher skin toxicity between the groups (2.1% vs. 0% respectively, p = 0.30) or in grades 1–2 toxicity (20.8% vs. 25.5% respectively, p = 0.69). Similarly, excellent or good cosmetic result scores were similar in both groups (p = 0.80). Conclusions: In our single-institution review, we observed no adverse effects of chemotherapy in combination with hypofractionated whole-breast irradiation. Further investigations are necessary to better elucidate the effects of chemotherapy on skin toxicity in the context of hypofractionated irradiation.</jats:p> Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients Current Oncology |
spellingShingle | Hijal, T., Al Hamad, A.A., Niazi, T., Sultanem, K., Bahoric, B., Vuong, T., Muanza, T., Current Oncology, Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
title | Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
title_full | Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
title_fullStr | Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
title_full_unstemmed | Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
title_short | Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
title_sort | hypofractionated radiotherapy and adjuvant chemotherapy do not increase radiation-induced dermatitis in breast cancer patients |
title_unstemmed | Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients |
url | http://dx.doi.org/10.3747/co.v17i5.604 |