Relationship Between MiRKAT and Coefficient of Determination in Similarity Matrix Regression

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Bibliographische Detailangaben
Zeitschriftentitel:	Processes
Personen und Körperschaften:	Zhan, Xiang
In:	Processes, 7, 2019, 2, S. 79
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	MDPI AG
Schlagwörter:	Process Chemistry and Technology Chemical Engineering (miscellaneous) Bioengineering

Details
Zusammenfassung:	<jats:p>The Microbiome Regression-based Kernel Association Test (MiRKAT) is widely used in testing for the association between microbiome compositions and an outcome of interest. The MiRKAT statistic is derived as a variance-component score test in a kernel machine regression-based generalized linear mixed model. In this brief report, we show that the MiRKAT statistic is proportional to the R 2 (coefficient of determination) statistic in a similarity matrix regression, which characterizes the fraction of variability in outcome similarity, explained by microbiome similarity (up to a constant).</jats:p>
Umfang:	79
ISSN:	2227-9717
DOI:	10.3390/pr7020079