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Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset
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| Zeitschriftentitel: | Nutrients |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Nutrients, 13, 2021, 5, S. 1738 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
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| Schlagwörter: |
| author_facet |
Milton-Laskibar, Iñaki Marcos-Zambrano, Laura Judith Gómez-Zorita, Saioa Fernández-Quintela, Alfredo Carrillo de Santa Pau, Enrique Martínez, J. Alfredo Portillo, María P. Milton-Laskibar, Iñaki Marcos-Zambrano, Laura Judith Gómez-Zorita, Saioa Fernández-Quintela, Alfredo Carrillo de Santa Pau, Enrique Martínez, J. Alfredo Portillo, María P. |
|---|---|
| author |
Milton-Laskibar, Iñaki Marcos-Zambrano, Laura Judith Gómez-Zorita, Saioa Fernández-Quintela, Alfredo Carrillo de Santa Pau, Enrique Martínez, J. Alfredo Portillo, María P. |
| spellingShingle |
Milton-Laskibar, Iñaki Marcos-Zambrano, Laura Judith Gómez-Zorita, Saioa Fernández-Quintela, Alfredo Carrillo de Santa Pau, Enrique Martínez, J. Alfredo Portillo, María P. Nutrients Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset Food Science Nutrition and Dietetics |
| author_sort |
milton-laskibar, iñaki |
| spelling |
Milton-Laskibar, Iñaki Marcos-Zambrano, Laura Judith Gómez-Zorita, Saioa Fernández-Quintela, Alfredo Carrillo de Santa Pau, Enrique Martínez, J. Alfredo Portillo, María P. 2072-6643 MDPI AG Food Science Nutrition and Dietetics http://dx.doi.org/10.3390/nu13051738 <jats:p>Resveratrol and its 2-methoxy derivative pterostilbene are two phenolic compounds that occur in foodstuffs and feature hepato-protective effects. This study is devoted to analysing and comparing the metabolic effects of pterostilbene and resveratrol on gut microbiota composition in rats displaying NAFLD induced by a diet rich in saturated fat and fructose. The associations among changes induced by both phenolic compounds in liver status and those induced in gut microbiota composition were also analysed. For this purpose, fifty Wistar rats were distributed in five experimental groups: a group of animals fed a standard diet (CC group) and four additional groups fed a high-fat high-fructose diet alone (HFHF group) or supplemented with 15 or 30 mg/kg bw/d of pterostilbene (PT15 and PT30 groups, respectively) or 30 mg/kg bw/d of resveratrol (RSV30 group). The dramatic changes induced by high-fat high-fructose feeding in the gut microbiota were poorly ameliorated by pterostilbene or resveratrol. These results suggest that the specific changes in microbiota composition induced by pterostilbene (increased abundances of Akkermansia and Erysipelatoclostridium, and lowered abundance of Clostridum sensu stricto 1) may not entirely explain the putative preventive effects on steatohepatitis.</jats:p> Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset Nutrients |
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10.3390/nu13051738 |
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| title |
Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset |
| title_unstemmed |
Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset |
| title_full |
Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset |
| title_fullStr |
Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset |
| title_full_unstemmed |
Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset |
| title_short |
Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset |
| title_sort |
gut microbiota induced by pterostilbene and resveratrol in high-fat-high-fructose fed rats: putative role in steatohepatitis onset |
| topic |
Food Science Nutrition and Dietetics |
| url |
http://dx.doi.org/10.3390/nu13051738 |
| publishDate |
2021 |
| physical |
1738 |
| description |
<jats:p>Resveratrol and its 2-methoxy derivative pterostilbene are two phenolic compounds that occur in foodstuffs and feature hepato-protective effects. This study is devoted to analysing and comparing the metabolic effects of pterostilbene and resveratrol on gut microbiota composition in rats displaying NAFLD induced by a diet rich in saturated fat and fructose. The associations among changes induced by both phenolic compounds in liver status and those induced in gut microbiota composition were also analysed. For this purpose, fifty Wistar rats were distributed in five experimental groups: a group of animals fed a standard diet (CC group) and four additional groups fed a high-fat high-fructose diet alone (HFHF group) or supplemented with 15 or 30 mg/kg bw/d of pterostilbene (PT15 and PT30 groups, respectively) or 30 mg/kg bw/d of resveratrol (RSV30 group). The dramatic changes induced by high-fat high-fructose feeding in the gut microbiota were poorly ameliorated by pterostilbene or resveratrol. These results suggest that the specific changes in microbiota composition induced by pterostilbene (increased abundances of Akkermansia and Erysipelatoclostridium, and lowered abundance of Clostridum sensu stricto 1) may not entirely explain the putative preventive effects on steatohepatitis.</jats:p> |
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| author | Milton-Laskibar, Iñaki, Marcos-Zambrano, Laura Judith, Gómez-Zorita, Saioa, Fernández-Quintela, Alfredo, Carrillo de Santa Pau, Enrique, Martínez, J. Alfredo, Portillo, María P. |
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| description | <jats:p>Resveratrol and its 2-methoxy derivative pterostilbene are two phenolic compounds that occur in foodstuffs and feature hepato-protective effects. This study is devoted to analysing and comparing the metabolic effects of pterostilbene and resveratrol on gut microbiota composition in rats displaying NAFLD induced by a diet rich in saturated fat and fructose. The associations among changes induced by both phenolic compounds in liver status and those induced in gut microbiota composition were also analysed. For this purpose, fifty Wistar rats were distributed in five experimental groups: a group of animals fed a standard diet (CC group) and four additional groups fed a high-fat high-fructose diet alone (HFHF group) or supplemented with 15 or 30 mg/kg bw/d of pterostilbene (PT15 and PT30 groups, respectively) or 30 mg/kg bw/d of resveratrol (RSV30 group). The dramatic changes induced by high-fat high-fructose feeding in the gut microbiota were poorly ameliorated by pterostilbene or resveratrol. These results suggest that the specific changes in microbiota composition induced by pterostilbene (increased abundances of Akkermansia and Erysipelatoclostridium, and lowered abundance of Clostridum sensu stricto 1) may not entirely explain the putative preventive effects on steatohepatitis.</jats:p> |
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| spelling | Milton-Laskibar, Iñaki Marcos-Zambrano, Laura Judith Gómez-Zorita, Saioa Fernández-Quintela, Alfredo Carrillo de Santa Pau, Enrique Martínez, J. Alfredo Portillo, María P. 2072-6643 MDPI AG Food Science Nutrition and Dietetics http://dx.doi.org/10.3390/nu13051738 <jats:p>Resveratrol and its 2-methoxy derivative pterostilbene are two phenolic compounds that occur in foodstuffs and feature hepato-protective effects. This study is devoted to analysing and comparing the metabolic effects of pterostilbene and resveratrol on gut microbiota composition in rats displaying NAFLD induced by a diet rich in saturated fat and fructose. The associations among changes induced by both phenolic compounds in liver status and those induced in gut microbiota composition were also analysed. For this purpose, fifty Wistar rats were distributed in five experimental groups: a group of animals fed a standard diet (CC group) and four additional groups fed a high-fat high-fructose diet alone (HFHF group) or supplemented with 15 or 30 mg/kg bw/d of pterostilbene (PT15 and PT30 groups, respectively) or 30 mg/kg bw/d of resveratrol (RSV30 group). The dramatic changes induced by high-fat high-fructose feeding in the gut microbiota were poorly ameliorated by pterostilbene or resveratrol. These results suggest that the specific changes in microbiota composition induced by pterostilbene (increased abundances of Akkermansia and Erysipelatoclostridium, and lowered abundance of Clostridum sensu stricto 1) may not entirely explain the putative preventive effects on steatohepatitis.</jats:p> Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset Nutrients |
| spellingShingle | Milton-Laskibar, Iñaki, Marcos-Zambrano, Laura Judith, Gómez-Zorita, Saioa, Fernández-Quintela, Alfredo, Carrillo de Santa Pau, Enrique, Martínez, J. Alfredo, Portillo, María P., Nutrients, Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset, Food Science, Nutrition and Dietetics |
| title | Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset |
| title_full | Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset |
| title_fullStr | Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset |
| title_full_unstemmed | Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset |
| title_short | Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset |
| title_sort | gut microbiota induced by pterostilbene and resveratrol in high-fat-high-fructose fed rats: putative role in steatohepatitis onset |
| title_unstemmed | Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset |
| topic | Food Science, Nutrition and Dietetics |
| url | http://dx.doi.org/10.3390/nu13051738 |