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Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins
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| Zeitschriftentitel: | Molecules |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Molecules, 24, 2019, 23, S. 4379 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
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| Schlagwörter: |
| author_facet |
Liu, Yun-Yun Huang, Dan-Ling Dong, Yun Qin, Da-Peng Yan, Yong-Ming Cheng, Yong-Xian Liu, Yun-Yun Huang, Dan-Ling Dong, Yun Qin, Da-Peng Yan, Yong-Ming Cheng, Yong-Xian |
|---|---|
| author |
Liu, Yun-Yun Huang, Dan-Ling Dong, Yun Qin, Da-Peng Yan, Yong-Ming Cheng, Yong-Xian |
| spellingShingle |
Liu, Yun-Yun Huang, Dan-Ling Dong, Yun Qin, Da-Peng Yan, Yong-Ming Cheng, Yong-Xian Molecules Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins Chemistry (miscellaneous) Analytical Chemistry Organic Chemistry Physical and Theoretical Chemistry Molecular Medicine Drug Discovery Pharmaceutical Science |
| author_sort |
liu, yun-yun |
| spelling |
Liu, Yun-Yun Huang, Dan-Ling Dong, Yun Qin, Da-Peng Yan, Yong-Ming Cheng, Yong-Xian 1420-3049 MDPI AG Chemistry (miscellaneous) Analytical Chemistry Organic Chemistry Physical and Theoretical Chemistry Molecular Medicine Drug Discovery Pharmaceutical Science http://dx.doi.org/10.3390/molecules24234379 <jats:p>Two new octanorlanostane-type triterpenes, euphraticanoids A and B (1 and 2), two new trinorsesquiterpenoids, euphraticanoids C and D (3 and 4), and eight known triterpenoids (5, 6, 8–13) along with one steroid (7) were isolated from Populus euphratica resins. The structures of these new compounds, including their absolute configurations, were characterized by spectrocsopic, chemical, and computational methods. Biological evaluation revealed that compounds 4, 7–9, 12, and 13 display neuroprotective activities in H2O2-induced HT-22 cells with 4, 8, and 9 occurring in a concentration-dependent manner and 7, 12, and 13 reaching the maximum effects at 20 μM. Meanwhile, the neuroprotective properties of all isolates were accessed using glutamate-induced SH-SY5Y cells and disclosed that compounds 3, 4, 8, and 9 could dose-dependently protect neural cell injury in a concentration range of 10–40 μM. Finally, a brief structure–activity relationship was briefly discussed.</jats:p> Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins Molecules |
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10.3390/molecules24234379 |
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MDPI AG, 2019 |
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MDPI AG, 2019 |
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| title |
Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins |
| title_unstemmed |
Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins |
| title_full |
Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins |
| title_fullStr |
Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins |
| title_full_unstemmed |
Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins |
| title_short |
Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins |
| title_sort |
neuroprotective norsesquiterpenoids and triterpenoids from populus euphratica resins |
| topic |
Chemistry (miscellaneous) Analytical Chemistry Organic Chemistry Physical and Theoretical Chemistry Molecular Medicine Drug Discovery Pharmaceutical Science |
| url |
http://dx.doi.org/10.3390/molecules24234379 |
| publishDate |
2019 |
| physical |
4379 |
| description |
<jats:p>Two new octanorlanostane-type triterpenes, euphraticanoids A and B (1 and 2), two new trinorsesquiterpenoids, euphraticanoids C and D (3 and 4), and eight known triterpenoids (5, 6, 8–13) along with one steroid (7) were isolated from Populus euphratica resins. The structures of these new compounds, including their absolute configurations, were characterized by spectrocsopic, chemical, and computational methods. Biological evaluation revealed that compounds 4, 7–9, 12, and 13 display neuroprotective activities in H2O2-induced HT-22 cells with 4, 8, and 9 occurring in a concentration-dependent manner and 7, 12, and 13 reaching the maximum effects at 20 μM. Meanwhile, the neuroprotective properties of all isolates were accessed using glutamate-induced SH-SY5Y cells and disclosed that compounds 3, 4, 8, and 9 could dose-dependently protect neural cell injury in a concentration range of 10–40 μM. Finally, a brief structure–activity relationship was briefly discussed.</jats:p> |
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| author | Liu, Yun-Yun, Huang, Dan-Ling, Dong, Yun, Qin, Da-Peng, Yan, Yong-Ming, Cheng, Yong-Xian |
| author_facet | Liu, Yun-Yun, Huang, Dan-Ling, Dong, Yun, Qin, Da-Peng, Yan, Yong-Ming, Cheng, Yong-Xian, Liu, Yun-Yun, Huang, Dan-Ling, Dong, Yun, Qin, Da-Peng, Yan, Yong-Ming, Cheng, Yong-Xian |
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| description | <jats:p>Two new octanorlanostane-type triterpenes, euphraticanoids A and B (1 and 2), two new trinorsesquiterpenoids, euphraticanoids C and D (3 and 4), and eight known triterpenoids (5, 6, 8–13) along with one steroid (7) were isolated from Populus euphratica resins. The structures of these new compounds, including their absolute configurations, were characterized by spectrocsopic, chemical, and computational methods. Biological evaluation revealed that compounds 4, 7–9, 12, and 13 display neuroprotective activities in H2O2-induced HT-22 cells with 4, 8, and 9 occurring in a concentration-dependent manner and 7, 12, and 13 reaching the maximum effects at 20 μM. Meanwhile, the neuroprotective properties of all isolates were accessed using glutamate-induced SH-SY5Y cells and disclosed that compounds 3, 4, 8, and 9 could dose-dependently protect neural cell injury in a concentration range of 10–40 μM. Finally, a brief structure–activity relationship was briefly discussed.</jats:p> |
| doi_str_mv | 10.3390/molecules24234379 |
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| imprint | MDPI AG, 2019 |
| imprint_str_mv | MDPI AG, 2019 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 1420-3049 |
| issn_str_mv | 1420-3049 |
| language | English |
| last_indexed | 2024-03-01T17:10:03.518Z |
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| physical | 4379 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | MDPI AG |
| record_format | ai |
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| series | Molecules |
| source_id | 49 |
| spelling | Liu, Yun-Yun Huang, Dan-Ling Dong, Yun Qin, Da-Peng Yan, Yong-Ming Cheng, Yong-Xian 1420-3049 MDPI AG Chemistry (miscellaneous) Analytical Chemistry Organic Chemistry Physical and Theoretical Chemistry Molecular Medicine Drug Discovery Pharmaceutical Science http://dx.doi.org/10.3390/molecules24234379 <jats:p>Two new octanorlanostane-type triterpenes, euphraticanoids A and B (1 and 2), two new trinorsesquiterpenoids, euphraticanoids C and D (3 and 4), and eight known triterpenoids (5, 6, 8–13) along with one steroid (7) were isolated from Populus euphratica resins. The structures of these new compounds, including their absolute configurations, were characterized by spectrocsopic, chemical, and computational methods. Biological evaluation revealed that compounds 4, 7–9, 12, and 13 display neuroprotective activities in H2O2-induced HT-22 cells with 4, 8, and 9 occurring in a concentration-dependent manner and 7, 12, and 13 reaching the maximum effects at 20 μM. Meanwhile, the neuroprotective properties of all isolates were accessed using glutamate-induced SH-SY5Y cells and disclosed that compounds 3, 4, 8, and 9 could dose-dependently protect neural cell injury in a concentration range of 10–40 μM. Finally, a brief structure–activity relationship was briefly discussed.</jats:p> Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins Molecules |
| spellingShingle | Liu, Yun-Yun, Huang, Dan-Ling, Dong, Yun, Qin, Da-Peng, Yan, Yong-Ming, Cheng, Yong-Xian, Molecules, Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins, Chemistry (miscellaneous), Analytical Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Molecular Medicine, Drug Discovery, Pharmaceutical Science |
| title | Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins |
| title_full | Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins |
| title_fullStr | Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins |
| title_full_unstemmed | Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins |
| title_short | Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins |
| title_sort | neuroprotective norsesquiterpenoids and triterpenoids from populus euphratica resins |
| title_unstemmed | Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins |
| topic | Chemistry (miscellaneous), Analytical Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Molecular Medicine, Drug Discovery, Pharmaceutical Science |
| url | http://dx.doi.org/10.3390/molecules24234379 |