Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea

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Bibliographische Detailangaben
Zeitschriftentitel:	Molecules
Personen und Körperschaften:	Sandargo, Birthe, Thongbai, Benjarong, Praditya, Dimas, Steinmann, Eike, Stadler, Marc, Surup, Frank
In:	Molecules, 23, 2018, 10, S. 2697
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	MDPI AG
Schlagwörter:	Chemistry (miscellaneous) Analytical Chemistry Organic Chemistry Physical and Theoretical Chemistry Molecular Medicine Drug Discovery Pharmaceutical Science

Details
Zusammenfassung:	<jats:p>4-Hydroxypleurogrisein, a congener of the anticancer-lead compound pleurotin, as well as six further derivatives were isolated from the basidiomycete Hohenbuehelia grisea, strain MFLUCC 12-0451. The structures were elucidated utilizing high resolution electron spray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectral data and evaluated for their biological activities; for leucopleurotin, we provide Xray data. While most congeners showed moderate antimicrobial and cytotoxic activity, 4-hydroxypleurogrisein emerged as an inhibitor of hepatitis C virus infectivity in mammalian liver cells.</jats:p>
Umfang:	2697
ISSN:	1420-3049
DOI:	10.3390/molecules23102697