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Growth and Morphogenesis during Early Heart Development in Amniotes
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| Zeitschriftentitel: | Journal of Cardiovascular Development and Disease |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Journal of Cardiovascular Development and Disease, 4, 2017, 4, S. 20 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
|
| Schlagwörter: |
| author_facet |
Ivanovitch, Kenzo Esteban, Isaac Torres, Miguel Ivanovitch, Kenzo Esteban, Isaac Torres, Miguel |
|---|---|
| author |
Ivanovitch, Kenzo Esteban, Isaac Torres, Miguel |
| spellingShingle |
Ivanovitch, Kenzo Esteban, Isaac Torres, Miguel Journal of Cardiovascular Development and Disease Growth and Morphogenesis during Early Heart Development in Amniotes Pharmacology (medical) General Pharmacology, Toxicology and Pharmaceutics |
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ivanovitch, kenzo |
| spelling |
Ivanovitch, Kenzo Esteban, Isaac Torres, Miguel 2308-3425 MDPI AG Pharmacology (medical) General Pharmacology, Toxicology and Pharmaceutics http://dx.doi.org/10.3390/jcdd4040020 <jats:p>In this review, we will focus on the growth and morphogenesis of the developing heart, an aspect of cardiovascular development to which Antoon Moorman and colleagues have extensively contributed. Over the last decades, genetic studies and characterization of regionally regulated gene programs have provided abundant novel insights into heart development essential to understand the basis of congenital heart disease. Heart morphogenesis, however, is inherently a complex and dynamic three-dimensional process and we are far from understanding its cellular basis. Here, we discuss recent advances in studying heart morphogenesis and regionalization under the light of the pioneering work of Moorman and colleagues, which allowed the reinterpretation of regional gene expression patterns under a new morphogenetic framework. Two aspects of early heart formation will be discussed in particular: (1) the initial formation of the heart tube and (2) the formation of the cardiac chambers by the ballooning process. Finally, we emphasize that in addition to analyses based on fixed samples, new approaches including clonal analysis, single-cell sequencing, live-imaging and quantitative analysis of the data generated will likely lead to novel insights in understanding early heart tube regionalization and morphogenesis in the near future.</jats:p> Growth and Morphogenesis during Early Heart Development in Amniotes Journal of Cardiovascular Development and Disease |
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Growth and Morphogenesis during Early Heart Development in Amniotes |
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Growth and Morphogenesis during Early Heart Development in Amniotes |
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Growth and Morphogenesis during Early Heart Development in Amniotes |
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Growth and Morphogenesis during Early Heart Development in Amniotes |
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Growth and Morphogenesis during Early Heart Development in Amniotes |
| title_short |
Growth and Morphogenesis during Early Heart Development in Amniotes |
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growth and morphogenesis during early heart development in amniotes |
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Pharmacology (medical) General Pharmacology, Toxicology and Pharmaceutics |
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http://dx.doi.org/10.3390/jcdd4040020 |
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2017 |
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<jats:p>In this review, we will focus on the growth and morphogenesis of the developing heart, an aspect of cardiovascular development to which Antoon Moorman and colleagues have extensively contributed. Over the last decades, genetic studies and characterization of regionally regulated gene programs have provided abundant novel insights into heart development essential to understand the basis of congenital heart disease. Heart morphogenesis, however, is inherently a complex and dynamic three-dimensional process and we are far from understanding its cellular basis. Here, we discuss recent advances in studying heart morphogenesis and regionalization under the light of the pioneering work of Moorman and colleagues, which allowed the reinterpretation of regional gene expression patterns under a new morphogenetic framework. Two aspects of early heart formation will be discussed in particular: (1) the initial formation of the heart tube and (2) the formation of the cardiac chambers by the ballooning process. Finally, we emphasize that in addition to analyses based on fixed samples, new approaches including clonal analysis, single-cell sequencing, live-imaging and quantitative analysis of the data generated will likely lead to novel insights in understanding early heart tube regionalization and morphogenesis in the near future.</jats:p> |
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| description | <jats:p>In this review, we will focus on the growth and morphogenesis of the developing heart, an aspect of cardiovascular development to which Antoon Moorman and colleagues have extensively contributed. Over the last decades, genetic studies and characterization of regionally regulated gene programs have provided abundant novel insights into heart development essential to understand the basis of congenital heart disease. Heart morphogenesis, however, is inherently a complex and dynamic three-dimensional process and we are far from understanding its cellular basis. Here, we discuss recent advances in studying heart morphogenesis and regionalization under the light of the pioneering work of Moorman and colleagues, which allowed the reinterpretation of regional gene expression patterns under a new morphogenetic framework. Two aspects of early heart formation will be discussed in particular: (1) the initial formation of the heart tube and (2) the formation of the cardiac chambers by the ballooning process. Finally, we emphasize that in addition to analyses based on fixed samples, new approaches including clonal analysis, single-cell sequencing, live-imaging and quantitative analysis of the data generated will likely lead to novel insights in understanding early heart tube regionalization and morphogenesis in the near future.</jats:p> |
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| spelling | Ivanovitch, Kenzo Esteban, Isaac Torres, Miguel 2308-3425 MDPI AG Pharmacology (medical) General Pharmacology, Toxicology and Pharmaceutics http://dx.doi.org/10.3390/jcdd4040020 <jats:p>In this review, we will focus on the growth and morphogenesis of the developing heart, an aspect of cardiovascular development to which Antoon Moorman and colleagues have extensively contributed. Over the last decades, genetic studies and characterization of regionally regulated gene programs have provided abundant novel insights into heart development essential to understand the basis of congenital heart disease. Heart morphogenesis, however, is inherently a complex and dynamic three-dimensional process and we are far from understanding its cellular basis. Here, we discuss recent advances in studying heart morphogenesis and regionalization under the light of the pioneering work of Moorman and colleagues, which allowed the reinterpretation of regional gene expression patterns under a new morphogenetic framework. Two aspects of early heart formation will be discussed in particular: (1) the initial formation of the heart tube and (2) the formation of the cardiac chambers by the ballooning process. Finally, we emphasize that in addition to analyses based on fixed samples, new approaches including clonal analysis, single-cell sequencing, live-imaging and quantitative analysis of the data generated will likely lead to novel insights in understanding early heart tube regionalization and morphogenesis in the near future.</jats:p> Growth and Morphogenesis during Early Heart Development in Amniotes Journal of Cardiovascular Development and Disease |
| spellingShingle | Ivanovitch, Kenzo, Esteban, Isaac, Torres, Miguel, Journal of Cardiovascular Development and Disease, Growth and Morphogenesis during Early Heart Development in Amniotes, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics |
| title | Growth and Morphogenesis during Early Heart Development in Amniotes |
| title_full | Growth and Morphogenesis during Early Heart Development in Amniotes |
| title_fullStr | Growth and Morphogenesis during Early Heart Development in Amniotes |
| title_full_unstemmed | Growth and Morphogenesis during Early Heart Development in Amniotes |
| title_short | Growth and Morphogenesis during Early Heart Development in Amniotes |
| title_sort | growth and morphogenesis during early heart development in amniotes |
| title_unstemmed | Growth and Morphogenesis during Early Heart Development in Amniotes |
| topic | Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics |
| url | http://dx.doi.org/10.3390/jcdd4040020 |