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Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing
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| Zeitschriftentitel: | International Journal of Molecular Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | International Journal of Molecular Sciences, 22, 2021, 9, S. 4959 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
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| Schlagwörter: |
| author_facet |
Courtot, Lilas Bournique, Elodie Maric, Chrystelle Guitton-Sert, Laure Madrid-Mencía, Miguel Pancaldi, Vera Cadoret, Jean-Charles Hoffmann, Jean-Sébastien Bergoglio, Valérie Courtot, Lilas Bournique, Elodie Maric, Chrystelle Guitton-Sert, Laure Madrid-Mencía, Miguel Pancaldi, Vera Cadoret, Jean-Charles Hoffmann, Jean-Sébastien Bergoglio, Valérie |
|---|---|
| author |
Courtot, Lilas Bournique, Elodie Maric, Chrystelle Guitton-Sert, Laure Madrid-Mencía, Miguel Pancaldi, Vera Cadoret, Jean-Charles Hoffmann, Jean-Sébastien Bergoglio, Valérie |
| spellingShingle |
Courtot, Lilas Bournique, Elodie Maric, Chrystelle Guitton-Sert, Laure Madrid-Mencía, Miguel Pancaldi, Vera Cadoret, Jean-Charles Hoffmann, Jean-Sébastien Bergoglio, Valérie International Journal of Molecular Sciences Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis |
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courtot, lilas |
| spelling |
Courtot, Lilas Bournique, Elodie Maric, Chrystelle Guitton-Sert, Laure Madrid-Mencía, Miguel Pancaldi, Vera Cadoret, Jean-Charles Hoffmann, Jean-Sébastien Bergoglio, Valérie 1422-0067 MDPI AG Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis http://dx.doi.org/10.3390/ijms22094959 <jats:p>DNA replication timing (RT), reflecting the temporal order of origin activation, is known as a robust and conserved cell-type specific process. Upon low replication stress, the slowing of replication forks induces well-documented RT delays associated to genetic instability, but it can also generate RT advances that are still uncharacterized. In order to characterize these advanced initiation events, we monitored the whole genome RT from six independent human cell lines treated with low doses of aphidicolin. We report that RT advances are cell-type-specific and involve large heterochromatin domains. Importantly, we found that some major late to early RT advances can be inherited by the unstressed next-cellular generation, which is a unique process that correlates with enhanced chromatin accessibility, as well as modified replication origin landscape and gene expression in daughter cells. Collectively, this work highlights how low replication stress may impact cellular identity by RT advances events at a subset of chromosomal domains.</jats:p> Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing International Journal of Molecular Sciences |
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MDPI AG, 2021 |
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| title |
Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing |
| title_unstemmed |
Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing |
| title_full |
Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing |
| title_fullStr |
Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing |
| title_full_unstemmed |
Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing |
| title_short |
Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing |
| title_sort |
low replicative stress triggers cell-type specific inheritable advanced replication timing |
| topic |
Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis |
| url |
http://dx.doi.org/10.3390/ijms22094959 |
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2021 |
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<jats:p>DNA replication timing (RT), reflecting the temporal order of origin activation, is known as a robust and conserved cell-type specific process. Upon low replication stress, the slowing of replication forks induces well-documented RT delays associated to genetic instability, but it can also generate RT advances that are still uncharacterized. In order to characterize these advanced initiation events, we monitored the whole genome RT from six independent human cell lines treated with low doses of aphidicolin. We report that RT advances are cell-type-specific and involve large heterochromatin domains. Importantly, we found that some major late to early RT advances can be inherited by the unstressed next-cellular generation, which is a unique process that correlates with enhanced chromatin accessibility, as well as modified replication origin landscape and gene expression in daughter cells. Collectively, this work highlights how low replication stress may impact cellular identity by RT advances events at a subset of chromosomal domains.</jats:p> |
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| author | Courtot, Lilas, Bournique, Elodie, Maric, Chrystelle, Guitton-Sert, Laure, Madrid-Mencía, Miguel, Pancaldi, Vera, Cadoret, Jean-Charles, Hoffmann, Jean-Sébastien, Bergoglio, Valérie |
| author_facet | Courtot, Lilas, Bournique, Elodie, Maric, Chrystelle, Guitton-Sert, Laure, Madrid-Mencía, Miguel, Pancaldi, Vera, Cadoret, Jean-Charles, Hoffmann, Jean-Sébastien, Bergoglio, Valérie, Courtot, Lilas, Bournique, Elodie, Maric, Chrystelle, Guitton-Sert, Laure, Madrid-Mencía, Miguel, Pancaldi, Vera, Cadoret, Jean-Charles, Hoffmann, Jean-Sébastien, Bergoglio, Valérie |
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| description | <jats:p>DNA replication timing (RT), reflecting the temporal order of origin activation, is known as a robust and conserved cell-type specific process. Upon low replication stress, the slowing of replication forks induces well-documented RT delays associated to genetic instability, but it can also generate RT advances that are still uncharacterized. In order to characterize these advanced initiation events, we monitored the whole genome RT from six independent human cell lines treated with low doses of aphidicolin. We report that RT advances are cell-type-specific and involve large heterochromatin domains. Importantly, we found that some major late to early RT advances can be inherited by the unstressed next-cellular generation, which is a unique process that correlates with enhanced chromatin accessibility, as well as modified replication origin landscape and gene expression in daughter cells. Collectively, this work highlights how low replication stress may impact cellular identity by RT advances events at a subset of chromosomal domains.</jats:p> |
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| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4 |
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| series | International Journal of Molecular Sciences |
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| spelling | Courtot, Lilas Bournique, Elodie Maric, Chrystelle Guitton-Sert, Laure Madrid-Mencía, Miguel Pancaldi, Vera Cadoret, Jean-Charles Hoffmann, Jean-Sébastien Bergoglio, Valérie 1422-0067 MDPI AG Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis http://dx.doi.org/10.3390/ijms22094959 <jats:p>DNA replication timing (RT), reflecting the temporal order of origin activation, is known as a robust and conserved cell-type specific process. Upon low replication stress, the slowing of replication forks induces well-documented RT delays associated to genetic instability, but it can also generate RT advances that are still uncharacterized. In order to characterize these advanced initiation events, we monitored the whole genome RT from six independent human cell lines treated with low doses of aphidicolin. We report that RT advances are cell-type-specific and involve large heterochromatin domains. Importantly, we found that some major late to early RT advances can be inherited by the unstressed next-cellular generation, which is a unique process that correlates with enhanced chromatin accessibility, as well as modified replication origin landscape and gene expression in daughter cells. Collectively, this work highlights how low replication stress may impact cellular identity by RT advances events at a subset of chromosomal domains.</jats:p> Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing International Journal of Molecular Sciences |
| spellingShingle | Courtot, Lilas, Bournique, Elodie, Maric, Chrystelle, Guitton-Sert, Laure, Madrid-Mencía, Miguel, Pancaldi, Vera, Cadoret, Jean-Charles, Hoffmann, Jean-Sébastien, Bergoglio, Valérie, International Journal of Molecular Sciences, Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing, Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis |
| title | Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing |
| title_full | Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing |
| title_fullStr | Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing |
| title_full_unstemmed | Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing |
| title_short | Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing |
| title_sort | low replicative stress triggers cell-type specific inheritable advanced replication timing |
| title_unstemmed | Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing |
| topic | Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis |
| url | http://dx.doi.org/10.3390/ijms22094959 |