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The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer
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| Zeitschriftentitel: | International Journal of Molecular Sciences |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | International Journal of Molecular Sciences, 21, 2020, 6, S. 2092 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
|
| Schlagwörter: |
| author_facet |
Indrieri, Alessia Carrella, Sabrina Carotenuto, Pietro Banfi, Sandro Franco, Brunella Indrieri, Alessia Carrella, Sabrina Carotenuto, Pietro Banfi, Sandro Franco, Brunella |
|---|---|
| author |
Indrieri, Alessia Carrella, Sabrina Carotenuto, Pietro Banfi, Sandro Franco, Brunella |
| spellingShingle |
Indrieri, Alessia Carrella, Sabrina Carotenuto, Pietro Banfi, Sandro Franco, Brunella International Journal of Molecular Sciences The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis |
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indrieri, alessia |
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Indrieri, Alessia Carrella, Sabrina Carotenuto, Pietro Banfi, Sandro Franco, Brunella 1422-0067 MDPI AG Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis http://dx.doi.org/10.3390/ijms21062092 <jats:p>MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the regulation of gene expression. Evidence accumulating in the past decades indicate that they are capable of simultaneously modulating diverse signaling pathways involved in a variety of pathophysiological processes. In the present review, we provide a comprehensive overview of the function of a highly conserved group of miRNAs, the miR-181 family, both in physiological as well as in pathological conditions. We summarize a large body of studies highlighting a role for this miRNA family in the regulation of key biological processes such as embryonic development, cell proliferation, apoptosis, autophagy, mitochondrial function, and immune response. Importantly, members of this family have been involved in many pathological processes underlying the most common neurodegenerative disorders as well as different solid tumors and hematological malignancies. The relevance of this miRNA family in the pathogenesis of these disorders and their possible influence on the severity of their manifestations will be discussed. A better understanding of the miR-181 family in pathological conditions may open new therapeutic avenues for devasting disorders such as neurodegenerative diseases and cancer.</jats:p> The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer International Journal of Molecular Sciences |
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| title |
The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer |
| title_unstemmed |
The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer |
| title_full |
The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer |
| title_fullStr |
The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer |
| title_full_unstemmed |
The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer |
| title_short |
The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer |
| title_sort |
the pervasive role of the mir-181 family in development, neurodegeneration, and cancer |
| topic |
Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis |
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http://dx.doi.org/10.3390/ijms21062092 |
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2020 |
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2092 |
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<jats:p>MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the regulation of gene expression. Evidence accumulating in the past decades indicate that they are capable of simultaneously modulating diverse signaling pathways involved in a variety of pathophysiological processes. In the present review, we provide a comprehensive overview of the function of a highly conserved group of miRNAs, the miR-181 family, both in physiological as well as in pathological conditions. We summarize a large body of studies highlighting a role for this miRNA family in the regulation of key biological processes such as embryonic development, cell proliferation, apoptosis, autophagy, mitochondrial function, and immune response. Importantly, members of this family have been involved in many pathological processes underlying the most common neurodegenerative disorders as well as different solid tumors and hematological malignancies. The relevance of this miRNA family in the pathogenesis of these disorders and their possible influence on the severity of their manifestations will be discussed. A better understanding of the miR-181 family in pathological conditions may open new therapeutic avenues for devasting disorders such as neurodegenerative diseases and cancer.</jats:p> |
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| description | <jats:p>MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the regulation of gene expression. Evidence accumulating in the past decades indicate that they are capable of simultaneously modulating diverse signaling pathways involved in a variety of pathophysiological processes. In the present review, we provide a comprehensive overview of the function of a highly conserved group of miRNAs, the miR-181 family, both in physiological as well as in pathological conditions. We summarize a large body of studies highlighting a role for this miRNA family in the regulation of key biological processes such as embryonic development, cell proliferation, apoptosis, autophagy, mitochondrial function, and immune response. Importantly, members of this family have been involved in many pathological processes underlying the most common neurodegenerative disorders as well as different solid tumors and hematological malignancies. The relevance of this miRNA family in the pathogenesis of these disorders and their possible influence on the severity of their manifestations will be discussed. A better understanding of the miR-181 family in pathological conditions may open new therapeutic avenues for devasting disorders such as neurodegenerative diseases and cancer.</jats:p> |
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| spelling | Indrieri, Alessia Carrella, Sabrina Carotenuto, Pietro Banfi, Sandro Franco, Brunella 1422-0067 MDPI AG Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis http://dx.doi.org/10.3390/ijms21062092 <jats:p>MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the regulation of gene expression. Evidence accumulating in the past decades indicate that they are capable of simultaneously modulating diverse signaling pathways involved in a variety of pathophysiological processes. In the present review, we provide a comprehensive overview of the function of a highly conserved group of miRNAs, the miR-181 family, both in physiological as well as in pathological conditions. We summarize a large body of studies highlighting a role for this miRNA family in the regulation of key biological processes such as embryonic development, cell proliferation, apoptosis, autophagy, mitochondrial function, and immune response. Importantly, members of this family have been involved in many pathological processes underlying the most common neurodegenerative disorders as well as different solid tumors and hematological malignancies. The relevance of this miRNA family in the pathogenesis of these disorders and their possible influence on the severity of their manifestations will be discussed. A better understanding of the miR-181 family in pathological conditions may open new therapeutic avenues for devasting disorders such as neurodegenerative diseases and cancer.</jats:p> The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer International Journal of Molecular Sciences |
| spellingShingle | Indrieri, Alessia, Carrella, Sabrina, Carotenuto, Pietro, Banfi, Sandro, Franco, Brunella, International Journal of Molecular Sciences, The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer, Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis |
| title | The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer |
| title_full | The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer |
| title_fullStr | The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer |
| title_full_unstemmed | The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer |
| title_short | The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer |
| title_sort | the pervasive role of the mir-181 family in development, neurodegeneration, and cancer |
| title_unstemmed | The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer |
| topic | Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis |
| url | http://dx.doi.org/10.3390/ijms21062092 |