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Tumor Cell Invasion in Glioblastoma
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| Zeitschriftentitel: | International Journal of Molecular Sciences |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | International Journal of Molecular Sciences, 21, 2020, 6, S. 1932 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
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| author_facet |
Vollmann-Zwerenz, Arabel Leidgens, Verena Feliciello, Giancarlo Klein, Christoph A. Hau, Peter Vollmann-Zwerenz, Arabel Leidgens, Verena Feliciello, Giancarlo Klein, Christoph A. Hau, Peter |
|---|---|
| author |
Vollmann-Zwerenz, Arabel Leidgens, Verena Feliciello, Giancarlo Klein, Christoph A. Hau, Peter |
| spellingShingle |
Vollmann-Zwerenz, Arabel Leidgens, Verena Feliciello, Giancarlo Klein, Christoph A. Hau, Peter International Journal of Molecular Sciences Tumor Cell Invasion in Glioblastoma Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis |
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vollmann-zwerenz, arabel |
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Vollmann-Zwerenz, Arabel Leidgens, Verena Feliciello, Giancarlo Klein, Christoph A. Hau, Peter 1422-0067 MDPI AG Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis http://dx.doi.org/10.3390/ijms21061932 <jats:p>Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16 months. Recent research has revealed novel insights into the outstanding heterogeneity of this type of brain cancer. However, all GBM subtypes share the hallmark feature of aggressive invasion into the surrounding tissue. Invasive glioblastoma cells escape surgery and focal therapies and thus represent a major obstacle for curative therapy. This review aims to provide a comprehensive understanding of glioma invasion mechanisms with respect to tumor-cell-intrinsic properties as well as cues provided by the microenvironment. We discuss genetic programs that may influence the dissemination and plasticity of GBM cells as well as their different invasion patterns. We also review how tumor cells shape their microenvironment and how, vice versa, components of the extracellular matrix and factors from non-neoplastic cells influence tumor cell motility. We further discuss different research platforms for modeling invasion. Finally, we highlight the importance of accounting for the complex interplay between tumor cell invasion and treatment resistance in glioblastoma when considering new therapeutic approaches.</jats:p> Tumor Cell Invasion in Glioblastoma International Journal of Molecular Sciences |
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| title |
Tumor Cell Invasion in Glioblastoma |
| title_unstemmed |
Tumor Cell Invasion in Glioblastoma |
| title_full |
Tumor Cell Invasion in Glioblastoma |
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Tumor Cell Invasion in Glioblastoma |
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Tumor Cell Invasion in Glioblastoma |
| title_short |
Tumor Cell Invasion in Glioblastoma |
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tumor cell invasion in glioblastoma |
| topic |
Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis |
| url |
http://dx.doi.org/10.3390/ijms21061932 |
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2020 |
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1932 |
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<jats:p>Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16 months. Recent research has revealed novel insights into the outstanding heterogeneity of this type of brain cancer. However, all GBM subtypes share the hallmark feature of aggressive invasion into the surrounding tissue. Invasive glioblastoma cells escape surgery and focal therapies and thus represent a major obstacle for curative therapy. This review aims to provide a comprehensive understanding of glioma invasion mechanisms with respect to tumor-cell-intrinsic properties as well as cues provided by the microenvironment. We discuss genetic programs that may influence the dissemination and plasticity of GBM cells as well as their different invasion patterns. We also review how tumor cells shape their microenvironment and how, vice versa, components of the extracellular matrix and factors from non-neoplastic cells influence tumor cell motility. We further discuss different research platforms for modeling invasion. Finally, we highlight the importance of accounting for the complex interplay between tumor cell invasion and treatment resistance in glioblastoma when considering new therapeutic approaches.</jats:p> |
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| description | <jats:p>Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16 months. Recent research has revealed novel insights into the outstanding heterogeneity of this type of brain cancer. However, all GBM subtypes share the hallmark feature of aggressive invasion into the surrounding tissue. Invasive glioblastoma cells escape surgery and focal therapies and thus represent a major obstacle for curative therapy. This review aims to provide a comprehensive understanding of glioma invasion mechanisms with respect to tumor-cell-intrinsic properties as well as cues provided by the microenvironment. We discuss genetic programs that may influence the dissemination and plasticity of GBM cells as well as their different invasion patterns. We also review how tumor cells shape their microenvironment and how, vice versa, components of the extracellular matrix and factors from non-neoplastic cells influence tumor cell motility. We further discuss different research platforms for modeling invasion. Finally, we highlight the importance of accounting for the complex interplay between tumor cell invasion and treatment resistance in glioblastoma when considering new therapeutic approaches.</jats:p> |
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| spelling | Vollmann-Zwerenz, Arabel Leidgens, Verena Feliciello, Giancarlo Klein, Christoph A. Hau, Peter 1422-0067 MDPI AG Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis http://dx.doi.org/10.3390/ijms21061932 <jats:p>Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16 months. Recent research has revealed novel insights into the outstanding heterogeneity of this type of brain cancer. However, all GBM subtypes share the hallmark feature of aggressive invasion into the surrounding tissue. Invasive glioblastoma cells escape surgery and focal therapies and thus represent a major obstacle for curative therapy. This review aims to provide a comprehensive understanding of glioma invasion mechanisms with respect to tumor-cell-intrinsic properties as well as cues provided by the microenvironment. We discuss genetic programs that may influence the dissemination and plasticity of GBM cells as well as their different invasion patterns. We also review how tumor cells shape their microenvironment and how, vice versa, components of the extracellular matrix and factors from non-neoplastic cells influence tumor cell motility. We further discuss different research platforms for modeling invasion. Finally, we highlight the importance of accounting for the complex interplay between tumor cell invasion and treatment resistance in glioblastoma when considering new therapeutic approaches.</jats:p> Tumor Cell Invasion in Glioblastoma International Journal of Molecular Sciences |
| spellingShingle | Vollmann-Zwerenz, Arabel, Leidgens, Verena, Feliciello, Giancarlo, Klein, Christoph A., Hau, Peter, International Journal of Molecular Sciences, Tumor Cell Invasion in Glioblastoma, Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis |
| title | Tumor Cell Invasion in Glioblastoma |
| title_full | Tumor Cell Invasion in Glioblastoma |
| title_fullStr | Tumor Cell Invasion in Glioblastoma |
| title_full_unstemmed | Tumor Cell Invasion in Glioblastoma |
| title_short | Tumor Cell Invasion in Glioblastoma |
| title_sort | tumor cell invasion in glioblastoma |
| title_unstemmed | Tumor Cell Invasion in Glioblastoma |
| topic | Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis |
| url | http://dx.doi.org/10.3390/ijms21061932 |