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| author_facet |
Zhang, Yan Yang, Zhao Zhang, Shuaihua Zhou, Xingtong Zhang, Yan Yang, Zhao Zhang, Shuaihua Zhou, Xingtong |
|---|---|
| author |
Zhang, Yan Yang, Zhao Zhang, Shuaihua Zhou, Xingtong |
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Zhang, Yan Yang, Zhao Zhang, Shuaihua Zhou, Xingtong Crystals Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal Inorganic Chemistry Condensed Matter Physics General Materials Science General Chemical Engineering |
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zhang, yan |
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Zhang, Yan Yang, Zhao Zhang, Shuaihua Zhou, Xingtong 2073-4352 MDPI AG Inorganic Chemistry Condensed Matter Physics General Materials Science General Chemical Engineering http://dx.doi.org/10.3390/cryst9070360 <jats:p>A novel cocrystal of the potent H2 receptor antagonist famotidine (FMT) was synthesized with malonic acid (MAL) to enhance its solubility. The cocrystal structure was characterized by X-ray single crystal diffraction, and the asymmetry unit contains one FMT and one MAL connected via intermolecular hydrogen bonds. The crystal structure is monoclinic with a P21/n space group and unit cell parameters a = 7.0748 (3) Å, b = 26.6502 (9) Å, c = 9.9823 (4) Å, α = 90, β = 104.2228 (12), γ = 90, V = 1824.42 (12) Å3, and Z = 4. The cocrystal had unique thermal, spectroscopic, and powder X-ray diffraction (PXRD) properties that differed from FMT. The solubility of the famotidine-malonic acid cocrystal (FMT-MAL) was 4.2-fold higher than FMT; the FAM-MAL had no change in FMT stability at high temperature, high humidity, or with illumination.</jats:p> Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal Crystals |
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| title |
Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal |
| title_unstemmed |
Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal |
| title_full |
Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal |
| title_fullStr |
Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal |
| title_full_unstemmed |
Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal |
| title_short |
Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal |
| title_sort |
synthesis, crystal structure, and solubility analysis of a famotidine cocrystal |
| topic |
Inorganic Chemistry Condensed Matter Physics General Materials Science General Chemical Engineering |
| url |
http://dx.doi.org/10.3390/cryst9070360 |
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2019 |
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360 |
| description |
<jats:p>A novel cocrystal of the potent H2 receptor antagonist famotidine (FMT) was synthesized with malonic acid (MAL) to enhance its solubility. The cocrystal structure was characterized by X-ray single crystal diffraction, and the asymmetry unit contains one FMT and one MAL connected via intermolecular hydrogen bonds. The crystal structure is monoclinic with a P21/n space group and unit cell parameters a = 7.0748 (3) Å, b = 26.6502 (9) Å, c = 9.9823 (4) Å, α = 90, β = 104.2228 (12), γ = 90, V = 1824.42 (12) Å3, and Z = 4. The cocrystal had unique thermal, spectroscopic, and powder X-ray diffraction (PXRD) properties that differed from FMT. The solubility of the famotidine-malonic acid cocrystal (FMT-MAL) was 4.2-fold higher than FMT; the FAM-MAL had no change in FMT stability at high temperature, high humidity, or with illumination.</jats:p> |
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| author | Zhang, Yan, Yang, Zhao, Zhang, Shuaihua, Zhou, Xingtong |
| author_facet | Zhang, Yan, Yang, Zhao, Zhang, Shuaihua, Zhou, Xingtong, Zhang, Yan, Yang, Zhao, Zhang, Shuaihua, Zhou, Xingtong |
| author_sort | zhang, yan |
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| description | <jats:p>A novel cocrystal of the potent H2 receptor antagonist famotidine (FMT) was synthesized with malonic acid (MAL) to enhance its solubility. The cocrystal structure was characterized by X-ray single crystal diffraction, and the asymmetry unit contains one FMT and one MAL connected via intermolecular hydrogen bonds. The crystal structure is monoclinic with a P21/n space group and unit cell parameters a = 7.0748 (3) Å, b = 26.6502 (9) Å, c = 9.9823 (4) Å, α = 90, β = 104.2228 (12), γ = 90, V = 1824.42 (12) Å3, and Z = 4. The cocrystal had unique thermal, spectroscopic, and powder X-ray diffraction (PXRD) properties that differed from FMT. The solubility of the famotidine-malonic acid cocrystal (FMT-MAL) was 4.2-fold higher than FMT; the FAM-MAL had no change in FMT stability at high temperature, high humidity, or with illumination.</jats:p> |
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| spelling | Zhang, Yan Yang, Zhao Zhang, Shuaihua Zhou, Xingtong 2073-4352 MDPI AG Inorganic Chemistry Condensed Matter Physics General Materials Science General Chemical Engineering http://dx.doi.org/10.3390/cryst9070360 <jats:p>A novel cocrystal of the potent H2 receptor antagonist famotidine (FMT) was synthesized with malonic acid (MAL) to enhance its solubility. The cocrystal structure was characterized by X-ray single crystal diffraction, and the asymmetry unit contains one FMT and one MAL connected via intermolecular hydrogen bonds. The crystal structure is monoclinic with a P21/n space group and unit cell parameters a = 7.0748 (3) Å, b = 26.6502 (9) Å, c = 9.9823 (4) Å, α = 90, β = 104.2228 (12), γ = 90, V = 1824.42 (12) Å3, and Z = 4. The cocrystal had unique thermal, spectroscopic, and powder X-ray diffraction (PXRD) properties that differed from FMT. The solubility of the famotidine-malonic acid cocrystal (FMT-MAL) was 4.2-fold higher than FMT; the FAM-MAL had no change in FMT stability at high temperature, high humidity, or with illumination.</jats:p> Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal Crystals |
| spellingShingle | Zhang, Yan, Yang, Zhao, Zhang, Shuaihua, Zhou, Xingtong, Crystals, Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal, Inorganic Chemistry, Condensed Matter Physics, General Materials Science, General Chemical Engineering |
| title | Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal |
| title_full | Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal |
| title_fullStr | Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal |
| title_full_unstemmed | Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal |
| title_short | Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal |
| title_sort | synthesis, crystal structure, and solubility analysis of a famotidine cocrystal |
| title_unstemmed | Synthesis, Crystal Structure, and Solubility Analysis of a Famotidine Cocrystal |
| topic | Inorganic Chemistry, Condensed Matter Physics, General Materials Science, General Chemical Engineering |
| url | http://dx.doi.org/10.3390/cryst9070360 |