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Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks
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| Zeitschriftentitel: | Cells |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Cells, 9, 2020, 11, S. 2443 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
MDPI AG
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| Schlagwörter: |
| author_facet |
Bär, Isabel Ast, Volker Meyer, Daria König, Rainer Rauner, Martina Hofbauer, Lorenz C. Müller, Jörg P. Bär, Isabel Ast, Volker Meyer, Daria König, Rainer Rauner, Martina Hofbauer, Lorenz C. Müller, Jörg P. |
|---|---|
| author |
Bär, Isabel Ast, Volker Meyer, Daria König, Rainer Rauner, Martina Hofbauer, Lorenz C. Müller, Jörg P. |
| spellingShingle |
Bär, Isabel Ast, Volker Meyer, Daria König, Rainer Rauner, Martina Hofbauer, Lorenz C. Müller, Jörg P. Cells Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks General Medicine |
| author_sort |
bär, isabel |
| spelling |
Bär, Isabel Ast, Volker Meyer, Daria König, Rainer Rauner, Martina Hofbauer, Lorenz C. Müller, Jörg P. 2073-4409 MDPI AG General Medicine http://dx.doi.org/10.3390/cells9112443 <jats:p>Acute myeloid leukaemia (AML) is a haematopoietic malignancy caused by a combination of genetic and epigenetic lesions. Activation of the oncoprotein FLT3 ITD (Fms-like tyrosine kinase with internal tandem duplications) represents a key driver mutation in 25–30% of AML patients. FLT3 is a class III receptor tyrosine kinase, which plays a role in cell survival, proliferation, and differentiation of haematopoietic progenitors of lymphoid and myeloid lineages. Mutant FLT3 ITD results in an altered signalling quality, which causes cell transformation. Recent evidence indicates an effect of FLT3 ITD on bone homeostasis in addition to haematological aberrations. Using gene expression data repositories of FLT3 ITD-positive AML patients, we identified activated cytokine networks that affect the formation of the haematopoietic niche by controlling osteoclastogenesis and osteoblast functions. In addition, aberrant oncogenic FLT3 signalling of osteogenesis-specific cytokines affects survival of AML patients and may be used for prognosis. Thus, these data highlight the intimate crosstalk between leukaemic and osteogenic cells within the osteohaematopoietic niche.</jats:p> Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks Cells |
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MDPI AG, 2020 |
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| title |
Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks |
| title_unstemmed |
Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks |
| title_full |
Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks |
| title_fullStr |
Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks |
| title_full_unstemmed |
Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks |
| title_short |
Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks |
| title_sort |
aberrant bone homeostasis in aml is associated with activated oncogenic flt3-dependent cytokine networks |
| topic |
General Medicine |
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http://dx.doi.org/10.3390/cells9112443 |
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2020 |
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2443 |
| description |
<jats:p>Acute myeloid leukaemia (AML) is a haematopoietic malignancy caused by a combination of genetic and epigenetic lesions. Activation of the oncoprotein FLT3 ITD (Fms-like tyrosine kinase with internal tandem duplications) represents a key driver mutation in 25–30% of AML patients. FLT3 is a class III receptor tyrosine kinase, which plays a role in cell survival, proliferation, and differentiation of haematopoietic progenitors of lymphoid and myeloid lineages. Mutant FLT3 ITD results in an altered signalling quality, which causes cell transformation. Recent evidence indicates an effect of FLT3 ITD on bone homeostasis in addition to haematological aberrations. Using gene expression data repositories of FLT3 ITD-positive AML patients, we identified activated cytokine networks that affect the formation of the haematopoietic niche by controlling osteoclastogenesis and osteoblast functions. In addition, aberrant oncogenic FLT3 signalling of osteogenesis-specific cytokines affects survival of AML patients and may be used for prognosis. Thus, these data highlight the intimate crosstalk between leukaemic and osteogenic cells within the osteohaematopoietic niche.</jats:p> |
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| author | Bär, Isabel, Ast, Volker, Meyer, Daria, König, Rainer, Rauner, Martina, Hofbauer, Lorenz C., Müller, Jörg P. |
| author_facet | Bär, Isabel, Ast, Volker, Meyer, Daria, König, Rainer, Rauner, Martina, Hofbauer, Lorenz C., Müller, Jörg P., Bär, Isabel, Ast, Volker, Meyer, Daria, König, Rainer, Rauner, Martina, Hofbauer, Lorenz C., Müller, Jörg P. |
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| description | <jats:p>Acute myeloid leukaemia (AML) is a haematopoietic malignancy caused by a combination of genetic and epigenetic lesions. Activation of the oncoprotein FLT3 ITD (Fms-like tyrosine kinase with internal tandem duplications) represents a key driver mutation in 25–30% of AML patients. FLT3 is a class III receptor tyrosine kinase, which plays a role in cell survival, proliferation, and differentiation of haematopoietic progenitors of lymphoid and myeloid lineages. Mutant FLT3 ITD results in an altered signalling quality, which causes cell transformation. Recent evidence indicates an effect of FLT3 ITD on bone homeostasis in addition to haematological aberrations. Using gene expression data repositories of FLT3 ITD-positive AML patients, we identified activated cytokine networks that affect the formation of the haematopoietic niche by controlling osteoclastogenesis and osteoblast functions. In addition, aberrant oncogenic FLT3 signalling of osteogenesis-specific cytokines affects survival of AML patients and may be used for prognosis. Thus, these data highlight the intimate crosstalk between leukaemic and osteogenic cells within the osteohaematopoietic niche.</jats:p> |
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| spelling | Bär, Isabel Ast, Volker Meyer, Daria König, Rainer Rauner, Martina Hofbauer, Lorenz C. Müller, Jörg P. 2073-4409 MDPI AG General Medicine http://dx.doi.org/10.3390/cells9112443 <jats:p>Acute myeloid leukaemia (AML) is a haematopoietic malignancy caused by a combination of genetic and epigenetic lesions. Activation of the oncoprotein FLT3 ITD (Fms-like tyrosine kinase with internal tandem duplications) represents a key driver mutation in 25–30% of AML patients. FLT3 is a class III receptor tyrosine kinase, which plays a role in cell survival, proliferation, and differentiation of haematopoietic progenitors of lymphoid and myeloid lineages. Mutant FLT3 ITD results in an altered signalling quality, which causes cell transformation. Recent evidence indicates an effect of FLT3 ITD on bone homeostasis in addition to haematological aberrations. Using gene expression data repositories of FLT3 ITD-positive AML patients, we identified activated cytokine networks that affect the formation of the haematopoietic niche by controlling osteoclastogenesis and osteoblast functions. In addition, aberrant oncogenic FLT3 signalling of osteogenesis-specific cytokines affects survival of AML patients and may be used for prognosis. Thus, these data highlight the intimate crosstalk between leukaemic and osteogenic cells within the osteohaematopoietic niche.</jats:p> Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks Cells |
| spellingShingle | Bär, Isabel, Ast, Volker, Meyer, Daria, König, Rainer, Rauner, Martina, Hofbauer, Lorenz C., Müller, Jörg P., Cells, Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks, General Medicine |
| title | Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks |
| title_full | Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks |
| title_fullStr | Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks |
| title_full_unstemmed | Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks |
| title_short | Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks |
| title_sort | aberrant bone homeostasis in aml is associated with activated oncogenic flt3-dependent cytokine networks |
| title_unstemmed | Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks |
| topic | General Medicine |
| url | http://dx.doi.org/10.3390/cells9112443 |