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Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single...

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Zeitschriftentitel: Cancers
Personen und Körperschaften: Akbaba, Sati, Ahmed, Dina, Mock, Andreas, Held, Thomas, Bahadir, Suzan, Lang, Kristin, Syed, Mustafa, Hoerner-Rieber, Juliane, Forster, Tobias, Federspil, Philippe, Herfarth, Klaus, Plinkert, Peter, Debus, Juergen, Adeberg, Sebastian
In: Cancers, 11, 2019, 11, S. 1705
Format: E-Article
Sprache: Englisch
veröffentlicht:
MDPI AG
Schlagwörter:
Cancer Research
Oncology
author_facet Akbaba, Sati
Ahmed, Dina
Mock, Andreas
Held, Thomas
Bahadir, Suzan
Lang, Kristin
Syed, Mustafa
Hoerner-Rieber, Juliane
Forster, Tobias
Federspil, Philippe
Herfarth, Klaus
Plinkert, Peter
Debus, Juergen
Adeberg, Sebastian
Akbaba, Sati
Ahmed, Dina
Mock, Andreas
Held, Thomas
Bahadir, Suzan
Lang, Kristin
Syed, Mustafa
Hoerner-Rieber, Juliane
Forster, Tobias
Federspil, Philippe
Herfarth, Klaus
Plinkert, Peter
Debus, Juergen
Adeberg, Sebastian
author Akbaba, Sati
Ahmed, Dina
Mock, Andreas
Held, Thomas
Bahadir, Suzan
Lang, Kristin
Syed, Mustafa
Hoerner-Rieber, Juliane
Forster, Tobias
Federspil, Philippe
Herfarth, Klaus
Plinkert, Peter
Debus, Juergen
Adeberg, Sebastian
spellingShingle Akbaba, Sati
Ahmed, Dina
Mock, Andreas
Held, Thomas
Bahadir, Suzan
Lang, Kristin
Syed, Mustafa
Hoerner-Rieber, Juliane
Forster, Tobias
Federspil, Philippe
Herfarth, Klaus
Plinkert, Peter
Debus, Juergen
Adeberg, Sebastian
Cancers
Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
Cancer Research
Oncology
author_sort akbaba, sati
spelling Akbaba, Sati Ahmed, Dina Mock, Andreas Held, Thomas Bahadir, Suzan Lang, Kristin Syed, Mustafa Hoerner-Rieber, Juliane Forster, Tobias Federspil, Philippe Herfarth, Klaus Plinkert, Peter Debus, Juergen Adeberg, Sebastian 2072-6694 MDPI AG Cancer Research Oncology http://dx.doi.org/10.3390/cancers11111705 <jats:p>We aimed to evaluate the treatment outcome of primary and postoperative bimodal radiotherapy (RT) including intensity modulated photon radiotherapy (IMRT) and carbon ion radiotherapy (CIRT) for sinonasal adenoid cystic carcinoma (ACC) patients. Medical records of 227 consecutive patients who received either a primary (n = 90, 40%) or postoperative (n = 137, 60%; R2, n = 86, 63%) IMRT with doses between 48 and 56 Gy in 1.8 or 2 Gy fractions and active raster-scanning carbon ion boost with 18 to 24 Gy (RBE, relative biological effectiveness) in 3 Gy (RBE) fractions between 2009 and 2019 up to a median total dose of 80 Gy (EQD2, equivalent dose in 2 Gy single dose fractions, range 71–80 Gy) were reviewed. Results: Median follow-up was 50 months. In univariate and multivariate analysis, no significant difference in local control (LC) could be shown between the two treatment groups (p = 0.33). Corresponding 3-year LC rates were 79% for primary bimodal RT and 82% for postoperative bimodal RT, respectively. T4 stage (p = 0.002) and solid histology (p = 0.005) were identified as independent prognostic factors for decreased LC. Significant worse long-term treatment tolerance was observed for postoperatively irradiated patients with 17% vs. 6% late grade 3 toxicity (p &lt; 0.001). Primary radiotherapy including IMRT and carbon ion boost for dose-escalation results in adequate LC with less long-term grade 3 toxicity compared to postoperative bimodal radiotherapy in sinonasal ACC patients. The high rate of macroscopic tumor disease in the postoperative group makes the interpretation of the beneficial results in LC for primary RT difficult.</jats:p> Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience Cancers
doi_str_mv 10.3390/cancers11111705
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title Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
title_unstemmed Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
title_full Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
title_fullStr Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
title_full_unstemmed Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
title_short Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
title_sort treatment outcome of 227 patients with sinonasal adenoid cystic carcinoma (acc) after intensity modulated radiotherapy and active raster-scanning carbon ion boost: a 10-year single-center experience
topic Cancer Research
Oncology
url http://dx.doi.org/10.3390/cancers11111705
publishDate 2019
physical 1705
description <jats:p>We aimed to evaluate the treatment outcome of primary and postoperative bimodal radiotherapy (RT) including intensity modulated photon radiotherapy (IMRT) and carbon ion radiotherapy (CIRT) for sinonasal adenoid cystic carcinoma (ACC) patients. Medical records of 227 consecutive patients who received either a primary (n = 90, 40%) or postoperative (n = 137, 60%; R2, n = 86, 63%) IMRT with doses between 48 and 56 Gy in 1.8 or 2 Gy fractions and active raster-scanning carbon ion boost with 18 to 24 Gy (RBE, relative biological effectiveness) in 3 Gy (RBE) fractions between 2009 and 2019 up to a median total dose of 80 Gy (EQD2, equivalent dose in 2 Gy single dose fractions, range 71–80 Gy) were reviewed. Results: Median follow-up was 50 months. In univariate and multivariate analysis, no significant difference in local control (LC) could be shown between the two treatment groups (p = 0.33). Corresponding 3-year LC rates were 79% for primary bimodal RT and 82% for postoperative bimodal RT, respectively. T4 stage (p = 0.002) and solid histology (p = 0.005) were identified as independent prognostic factors for decreased LC. Significant worse long-term treatment tolerance was observed for postoperatively irradiated patients with 17% vs. 6% late grade 3 toxicity (p &lt; 0.001). Primary radiotherapy including IMRT and carbon ion boost for dose-escalation results in adequate LC with less long-term grade 3 toxicity compared to postoperative bimodal radiotherapy in sinonasal ACC patients. The high rate of macroscopic tumor disease in the postoperative group makes the interpretation of the beneficial results in LC for primary RT difficult.</jats:p>
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author Akbaba, Sati, Ahmed, Dina, Mock, Andreas, Held, Thomas, Bahadir, Suzan, Lang, Kristin, Syed, Mustafa, Hoerner-Rieber, Juliane, Forster, Tobias, Federspil, Philippe, Herfarth, Klaus, Plinkert, Peter, Debus, Juergen, Adeberg, Sebastian
author_facet Akbaba, Sati, Ahmed, Dina, Mock, Andreas, Held, Thomas, Bahadir, Suzan, Lang, Kristin, Syed, Mustafa, Hoerner-Rieber, Juliane, Forster, Tobias, Federspil, Philippe, Herfarth, Klaus, Plinkert, Peter, Debus, Juergen, Adeberg, Sebastian, Akbaba, Sati, Ahmed, Dina, Mock, Andreas, Held, Thomas, Bahadir, Suzan, Lang, Kristin, Syed, Mustafa, Hoerner-Rieber, Juliane, Forster, Tobias, Federspil, Philippe, Herfarth, Klaus, Plinkert, Peter, Debus, Juergen, Adeberg, Sebastian
author_sort akbaba, sati
container_issue 11
container_start_page 0
container_title Cancers
container_volume 11
description <jats:p>We aimed to evaluate the treatment outcome of primary and postoperative bimodal radiotherapy (RT) including intensity modulated photon radiotherapy (IMRT) and carbon ion radiotherapy (CIRT) for sinonasal adenoid cystic carcinoma (ACC) patients. Medical records of 227 consecutive patients who received either a primary (n = 90, 40%) or postoperative (n = 137, 60%; R2, n = 86, 63%) IMRT with doses between 48 and 56 Gy in 1.8 or 2 Gy fractions and active raster-scanning carbon ion boost with 18 to 24 Gy (RBE, relative biological effectiveness) in 3 Gy (RBE) fractions between 2009 and 2019 up to a median total dose of 80 Gy (EQD2, equivalent dose in 2 Gy single dose fractions, range 71–80 Gy) were reviewed. Results: Median follow-up was 50 months. In univariate and multivariate analysis, no significant difference in local control (LC) could be shown between the two treatment groups (p = 0.33). Corresponding 3-year LC rates were 79% for primary bimodal RT and 82% for postoperative bimodal RT, respectively. T4 stage (p = 0.002) and solid histology (p = 0.005) were identified as independent prognostic factors for decreased LC. Significant worse long-term treatment tolerance was observed for postoperatively irradiated patients with 17% vs. 6% late grade 3 toxicity (p &lt; 0.001). Primary radiotherapy including IMRT and carbon ion boost for dose-escalation results in adequate LC with less long-term grade 3 toxicity compared to postoperative bimodal radiotherapy in sinonasal ACC patients. The high rate of macroscopic tumor disease in the postoperative group makes the interpretation of the beneficial results in LC for primary RT difficult.</jats:p>
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spelling Akbaba, Sati Ahmed, Dina Mock, Andreas Held, Thomas Bahadir, Suzan Lang, Kristin Syed, Mustafa Hoerner-Rieber, Juliane Forster, Tobias Federspil, Philippe Herfarth, Klaus Plinkert, Peter Debus, Juergen Adeberg, Sebastian 2072-6694 MDPI AG Cancer Research Oncology http://dx.doi.org/10.3390/cancers11111705 <jats:p>We aimed to evaluate the treatment outcome of primary and postoperative bimodal radiotherapy (RT) including intensity modulated photon radiotherapy (IMRT) and carbon ion radiotherapy (CIRT) for sinonasal adenoid cystic carcinoma (ACC) patients. Medical records of 227 consecutive patients who received either a primary (n = 90, 40%) or postoperative (n = 137, 60%; R2, n = 86, 63%) IMRT with doses between 48 and 56 Gy in 1.8 or 2 Gy fractions and active raster-scanning carbon ion boost with 18 to 24 Gy (RBE, relative biological effectiveness) in 3 Gy (RBE) fractions between 2009 and 2019 up to a median total dose of 80 Gy (EQD2, equivalent dose in 2 Gy single dose fractions, range 71–80 Gy) were reviewed. Results: Median follow-up was 50 months. In univariate and multivariate analysis, no significant difference in local control (LC) could be shown between the two treatment groups (p = 0.33). Corresponding 3-year LC rates were 79% for primary bimodal RT and 82% for postoperative bimodal RT, respectively. T4 stage (p = 0.002) and solid histology (p = 0.005) were identified as independent prognostic factors for decreased LC. Significant worse long-term treatment tolerance was observed for postoperatively irradiated patients with 17% vs. 6% late grade 3 toxicity (p &lt; 0.001). Primary radiotherapy including IMRT and carbon ion boost for dose-escalation results in adequate LC with less long-term grade 3 toxicity compared to postoperative bimodal radiotherapy in sinonasal ACC patients. The high rate of macroscopic tumor disease in the postoperative group makes the interpretation of the beneficial results in LC for primary RT difficult.</jats:p> Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience Cancers
spellingShingle Akbaba, Sati, Ahmed, Dina, Mock, Andreas, Held, Thomas, Bahadir, Suzan, Lang, Kristin, Syed, Mustafa, Hoerner-Rieber, Juliane, Forster, Tobias, Federspil, Philippe, Herfarth, Klaus, Plinkert, Peter, Debus, Juergen, Adeberg, Sebastian, Cancers, Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience, Cancer Research, Oncology
title Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
title_full Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
title_fullStr Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
title_full_unstemmed Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
title_short Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
title_sort treatment outcome of 227 patients with sinonasal adenoid cystic carcinoma (acc) after intensity modulated radiotherapy and active raster-scanning carbon ion boost: a 10-year single-center experience
title_unstemmed Treatment Outcome of 227 Patients with Sinonasal Adenoid Cystic Carcinoma (ACC) after Intensity Modulated Radiotherapy and Active Raster-Scanning Carbon Ion Boost: A 10-Year Single-Center Experience
topic Cancer Research, Oncology
url http://dx.doi.org/10.3390/cancers11111705