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| author_facet |
Cuomo, Francesca Altucci, Lucia Cobellis, Gilda Cuomo, Francesca Altucci, Lucia Cobellis, Gilda |
|---|---|
| author |
Cuomo, Francesca Altucci, Lucia Cobellis, Gilda |
| spellingShingle |
Cuomo, Francesca Altucci, Lucia Cobellis, Gilda Cancers Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy Cancer Research Oncology |
| author_sort |
cuomo, francesca |
| spelling |
Cuomo, Francesca Altucci, Lucia Cobellis, Gilda 2072-6694 MDPI AG Cancer Research Oncology http://dx.doi.org/10.3390/cancers11101465 <jats:p>Autophagy is a highly conserved catabolic and energy-generating process that facilitates the degradation of damaged organelles or intracellular components, providing cells with components for the synthesis of new ones. Autophagy acts as a quality control system, and has a pro-survival role. The imbalance of this process is associated with apoptosis, which is a “positive” and desired biological choice in some circumstances. Autophagy dysfunction is associated with several diseases, including neurodegenerative disorders, cardiomyopathy, diabetes, liver disease, autoimmune diseases, and cancer. Here, we provide an overview of the regulatory mechanisms underlying autophagy, with a particular focus on cancer and the autophagy-targeting drugs currently approved for use in the treatment of solid and non-solid malignancies.</jats:p> Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy Cancers |
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10.3390/cancers11101465 |
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Online Free |
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Medizin |
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DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 |
| imprint |
MDPI AG, 2019 |
| imprint_str_mv |
MDPI AG, 2019 |
| issn |
2072-6694 |
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2072-6694 |
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English |
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MDPI AG (CrossRef) |
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cuomo2019autophagyfunctionanddysfunctionpotentialdrugsasanticancertherapy |
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2019 |
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MDPI AG |
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ai |
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ai |
| series |
Cancers |
| source_id |
49 |
| title |
Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy |
| title_unstemmed |
Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy |
| title_full |
Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy |
| title_fullStr |
Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy |
| title_full_unstemmed |
Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy |
| title_short |
Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy |
| title_sort |
autophagy function and dysfunction: potential drugs as anti-cancer therapy |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.3390/cancers11101465 |
| publishDate |
2019 |
| physical |
1465 |
| description |
<jats:p>Autophagy is a highly conserved catabolic and energy-generating process that facilitates the degradation of damaged organelles or intracellular components, providing cells with components for the synthesis of new ones. Autophagy acts as a quality control system, and has a pro-survival role. The imbalance of this process is associated with apoptosis, which is a “positive” and desired biological choice in some circumstances. Autophagy dysfunction is associated with several diseases, including neurodegenerative disorders, cardiomyopathy, diabetes, liver disease, autoimmune diseases, and cancer. Here, we provide an overview of the regulatory mechanisms underlying autophagy, with a particular focus on cancer and the autophagy-targeting drugs currently approved for use in the treatment of solid and non-solid malignancies.</jats:p> |
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| author | Cuomo, Francesca, Altucci, Lucia, Cobellis, Gilda |
| author_facet | Cuomo, Francesca, Altucci, Lucia, Cobellis, Gilda, Cuomo, Francesca, Altucci, Lucia, Cobellis, Gilda |
| author_sort | cuomo, francesca |
| container_issue | 10 |
| container_start_page | 0 |
| container_title | Cancers |
| container_volume | 11 |
| description | <jats:p>Autophagy is a highly conserved catabolic and energy-generating process that facilitates the degradation of damaged organelles or intracellular components, providing cells with components for the synthesis of new ones. Autophagy acts as a quality control system, and has a pro-survival role. The imbalance of this process is associated with apoptosis, which is a “positive” and desired biological choice in some circumstances. Autophagy dysfunction is associated with several diseases, including neurodegenerative disorders, cardiomyopathy, diabetes, liver disease, autoimmune diseases, and cancer. Here, we provide an overview of the regulatory mechanisms underlying autophagy, with a particular focus on cancer and the autophagy-targeting drugs currently approved for use in the treatment of solid and non-solid malignancies.</jats:p> |
| doi_str_mv | 10.3390/cancers11101465 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
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| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMzM5MC9jYW5jZXJzMTExMDE0NjU |
| imprint | MDPI AG, 2019 |
| imprint_str_mv | MDPI AG, 2019 |
| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
| issn | 2072-6694 |
| issn_str_mv | 2072-6694 |
| language | English |
| last_indexed | 2024-03-01T18:05:05.089Z |
| match_str | cuomo2019autophagyfunctionanddysfunctionpotentialdrugsasanticancertherapy |
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| physical | 1465 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | MDPI AG |
| record_format | ai |
| recordtype | ai |
| series | Cancers |
| source_id | 49 |
| spelling | Cuomo, Francesca Altucci, Lucia Cobellis, Gilda 2072-6694 MDPI AG Cancer Research Oncology http://dx.doi.org/10.3390/cancers11101465 <jats:p>Autophagy is a highly conserved catabolic and energy-generating process that facilitates the degradation of damaged organelles or intracellular components, providing cells with components for the synthesis of new ones. Autophagy acts as a quality control system, and has a pro-survival role. The imbalance of this process is associated with apoptosis, which is a “positive” and desired biological choice in some circumstances. Autophagy dysfunction is associated with several diseases, including neurodegenerative disorders, cardiomyopathy, diabetes, liver disease, autoimmune diseases, and cancer. Here, we provide an overview of the regulatory mechanisms underlying autophagy, with a particular focus on cancer and the autophagy-targeting drugs currently approved for use in the treatment of solid and non-solid malignancies.</jats:p> Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy Cancers |
| spellingShingle | Cuomo, Francesca, Altucci, Lucia, Cobellis, Gilda, Cancers, Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy, Cancer Research, Oncology |
| title | Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy |
| title_full | Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy |
| title_fullStr | Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy |
| title_full_unstemmed | Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy |
| title_short | Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy |
| title_sort | autophagy function and dysfunction: potential drugs as anti-cancer therapy |
| title_unstemmed | Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.3390/cancers11101465 |