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Neurological and neuropsychological outcome after resection of craniopharyngiomas

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Bibliographische Detailangaben
Zeitschriftentitel: Journal of Neurosurgery
Personen und Körperschaften: Giese, Henrik, Haenig, Benjamin, Haenig, Anna, Unterberg, Andreas, Zweckberger, Klaus
In: Journal of Neurosurgery, 132, 2020, 5, S. 1425-1434
Format: E-Article
Sprache: Unbestimmt
veröffentlicht:
Journal of Neurosurgery Publishing Group (JNSPG)
Schlagwörter:
General Medicine
author_facet Giese, Henrik
Haenig, Benjamin
Haenig, Anna
Unterberg, Andreas
Zweckberger, Klaus
Giese, Henrik
Haenig, Benjamin
Haenig, Anna
Unterberg, Andreas
Zweckberger, Klaus
author Giese, Henrik
Haenig, Benjamin
Haenig, Anna
Unterberg, Andreas
Zweckberger, Klaus
spellingShingle Giese, Henrik
Haenig, Benjamin
Haenig, Anna
Unterberg, Andreas
Zweckberger, Klaus
Journal of Neurosurgery
Neurological and neuropsychological outcome after resection of craniopharyngiomas
General Medicine
author_sort giese, henrik
spelling Giese, Henrik Haenig, Benjamin Haenig, Anna Unterberg, Andreas Zweckberger, Klaus 0022-3085 1933-0693 Journal of Neurosurgery Publishing Group (JNSPG) General Medicine http://dx.doi.org/10.3171/2018.10.jns181557 <jats:sec><jats:title>OBJECTIVE</jats:title><jats:p>Craniopharyngiomas are rare and benign tumors of the sellar and/or parasellar region. Primary treatment involves resection followed by adjuvant radiotherapy. While the grade of resection was frequently analyzed following surgery, the neurological outcome and especially neuropsychological deficits and quality of life have been neglected for many decades. Therefore, the authors retrospectively analyzed their patient series and prospectively assessed neuropsychological outcome and quality of life following resection of craniopharyngiomas in adults.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>In total, 71 patients (39 men and 32 women) with a mean age of 49 years were enrolled in the retrospective analysis. In addition, 36 of the 71 patients were included in the prospective arm of the study and underwent neurological and neuropsychological testing as well as quality of life (36-Item Short-Form Health Survey; SF-36) assessment. Factors influencing outcome were identified and correlations calculated.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>Resection was performed mostly using a pterional (41.6%, 47/113 surgical procedures) or bifrontal translamina terminalis (30.1%, 34/113 surgical procedures) approach. Following surgery, visual acuity was significantly improved (&gt; 0.2 diopters) in 32.4% (23/71) of patients, or remained stable in 45.1% (32/71) of patients. During long-term follow up, 80.3% (57/71) of patients developed pituitary insufficiency, particularly involving the corticotropic and thyrotrophic axes. In total, 75% (27/36) of patients showed neuropsychological deviations in at least 1 test item. In particular, attentiveness, cognitive speed, and short-term memory were affected. Referring to the SF-36 score, quality of life was affected in both the mental and physical score in 19.4% (7/36) and 33.3% (12/36), respectively. The risk factors that were identified were a tumor volume larger than 9 cm<jats:sup>3</jats:sup>, tumor extension toward/into the third ventricle or the brainstem, and resection using a bifrontal translamina terminalis or left-sided approach.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>This study demonstrated that resection of craniopharyngiomas is frequently associated with postoperative neuropsychological deficits and hence an impaired quality of life. In addition to tumor size and extension toward/into the third ventricle or the brainstem, selection of the surgical approach may play a crucial role in the patient’s neuropsychological outcome and quality of life.</jats:p></jats:sec> Neurological and neuropsychological outcome after resection of craniopharyngiomas Journal of Neurosurgery
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title Neurological and neuropsychological outcome after resection of craniopharyngiomas
title_unstemmed Neurological and neuropsychological outcome after resection of craniopharyngiomas
title_full Neurological and neuropsychological outcome after resection of craniopharyngiomas
title_fullStr Neurological and neuropsychological outcome after resection of craniopharyngiomas
title_full_unstemmed Neurological and neuropsychological outcome after resection of craniopharyngiomas
title_short Neurological and neuropsychological outcome after resection of craniopharyngiomas
title_sort neurological and neuropsychological outcome after resection of craniopharyngiomas
topic General Medicine
url http://dx.doi.org/10.3171/2018.10.jns181557
publishDate 2020
physical 1425-1434
description <jats:sec><jats:title>OBJECTIVE</jats:title><jats:p>Craniopharyngiomas are rare and benign tumors of the sellar and/or parasellar region. Primary treatment involves resection followed by adjuvant radiotherapy. While the grade of resection was frequently analyzed following surgery, the neurological outcome and especially neuropsychological deficits and quality of life have been neglected for many decades. Therefore, the authors retrospectively analyzed their patient series and prospectively assessed neuropsychological outcome and quality of life following resection of craniopharyngiomas in adults.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>In total, 71 patients (39 men and 32 women) with a mean age of 49 years were enrolled in the retrospective analysis. In addition, 36 of the 71 patients were included in the prospective arm of the study and underwent neurological and neuropsychological testing as well as quality of life (36-Item Short-Form Health Survey; SF-36) assessment. Factors influencing outcome were identified and correlations calculated.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>Resection was performed mostly using a pterional (41.6%, 47/113 surgical procedures) or bifrontal translamina terminalis (30.1%, 34/113 surgical procedures) approach. Following surgery, visual acuity was significantly improved (&gt; 0.2 diopters) in 32.4% (23/71) of patients, or remained stable in 45.1% (32/71) of patients. During long-term follow up, 80.3% (57/71) of patients developed pituitary insufficiency, particularly involving the corticotropic and thyrotrophic axes. In total, 75% (27/36) of patients showed neuropsychological deviations in at least 1 test item. In particular, attentiveness, cognitive speed, and short-term memory were affected. Referring to the SF-36 score, quality of life was affected in both the mental and physical score in 19.4% (7/36) and 33.3% (12/36), respectively. The risk factors that were identified were a tumor volume larger than 9 cm<jats:sup>3</jats:sup>, tumor extension toward/into the third ventricle or the brainstem, and resection using a bifrontal translamina terminalis or left-sided approach.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>This study demonstrated that resection of craniopharyngiomas is frequently associated with postoperative neuropsychological deficits and hence an impaired quality of life. In addition to tumor size and extension toward/into the third ventricle or the brainstem, selection of the surgical approach may play a crucial role in the patient’s neuropsychological outcome and quality of life.</jats:p></jats:sec>
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author Giese, Henrik, Haenig, Benjamin, Haenig, Anna, Unterberg, Andreas, Zweckberger, Klaus
author_facet Giese, Henrik, Haenig, Benjamin, Haenig, Anna, Unterberg, Andreas, Zweckberger, Klaus, Giese, Henrik, Haenig, Benjamin, Haenig, Anna, Unterberg, Andreas, Zweckberger, Klaus
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container_title Journal of Neurosurgery
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description <jats:sec><jats:title>OBJECTIVE</jats:title><jats:p>Craniopharyngiomas are rare and benign tumors of the sellar and/or parasellar region. Primary treatment involves resection followed by adjuvant radiotherapy. While the grade of resection was frequently analyzed following surgery, the neurological outcome and especially neuropsychological deficits and quality of life have been neglected for many decades. Therefore, the authors retrospectively analyzed their patient series and prospectively assessed neuropsychological outcome and quality of life following resection of craniopharyngiomas in adults.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>In total, 71 patients (39 men and 32 women) with a mean age of 49 years were enrolled in the retrospective analysis. In addition, 36 of the 71 patients were included in the prospective arm of the study and underwent neurological and neuropsychological testing as well as quality of life (36-Item Short-Form Health Survey; SF-36) assessment. Factors influencing outcome were identified and correlations calculated.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>Resection was performed mostly using a pterional (41.6%, 47/113 surgical procedures) or bifrontal translamina terminalis (30.1%, 34/113 surgical procedures) approach. Following surgery, visual acuity was significantly improved (&gt; 0.2 diopters) in 32.4% (23/71) of patients, or remained stable in 45.1% (32/71) of patients. During long-term follow up, 80.3% (57/71) of patients developed pituitary insufficiency, particularly involving the corticotropic and thyrotrophic axes. In total, 75% (27/36) of patients showed neuropsychological deviations in at least 1 test item. In particular, attentiveness, cognitive speed, and short-term memory were affected. Referring to the SF-36 score, quality of life was affected in both the mental and physical score in 19.4% (7/36) and 33.3% (12/36), respectively. The risk factors that were identified were a tumor volume larger than 9 cm<jats:sup>3</jats:sup>, tumor extension toward/into the third ventricle or the brainstem, and resection using a bifrontal translamina terminalis or left-sided approach.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>This study demonstrated that resection of craniopharyngiomas is frequently associated with postoperative neuropsychological deficits and hence an impaired quality of life. In addition to tumor size and extension toward/into the third ventricle or the brainstem, selection of the surgical approach may play a crucial role in the patient’s neuropsychological outcome and quality of life.</jats:p></jats:sec>
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spelling Giese, Henrik Haenig, Benjamin Haenig, Anna Unterberg, Andreas Zweckberger, Klaus 0022-3085 1933-0693 Journal of Neurosurgery Publishing Group (JNSPG) General Medicine http://dx.doi.org/10.3171/2018.10.jns181557 <jats:sec><jats:title>OBJECTIVE</jats:title><jats:p>Craniopharyngiomas are rare and benign tumors of the sellar and/or parasellar region. Primary treatment involves resection followed by adjuvant radiotherapy. While the grade of resection was frequently analyzed following surgery, the neurological outcome and especially neuropsychological deficits and quality of life have been neglected for many decades. Therefore, the authors retrospectively analyzed their patient series and prospectively assessed neuropsychological outcome and quality of life following resection of craniopharyngiomas in adults.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>In total, 71 patients (39 men and 32 women) with a mean age of 49 years were enrolled in the retrospective analysis. In addition, 36 of the 71 patients were included in the prospective arm of the study and underwent neurological and neuropsychological testing as well as quality of life (36-Item Short-Form Health Survey; SF-36) assessment. Factors influencing outcome were identified and correlations calculated.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>Resection was performed mostly using a pterional (41.6%, 47/113 surgical procedures) or bifrontal translamina terminalis (30.1%, 34/113 surgical procedures) approach. Following surgery, visual acuity was significantly improved (&gt; 0.2 diopters) in 32.4% (23/71) of patients, or remained stable in 45.1% (32/71) of patients. During long-term follow up, 80.3% (57/71) of patients developed pituitary insufficiency, particularly involving the corticotropic and thyrotrophic axes. In total, 75% (27/36) of patients showed neuropsychological deviations in at least 1 test item. In particular, attentiveness, cognitive speed, and short-term memory were affected. Referring to the SF-36 score, quality of life was affected in both the mental and physical score in 19.4% (7/36) and 33.3% (12/36), respectively. The risk factors that were identified were a tumor volume larger than 9 cm<jats:sup>3</jats:sup>, tumor extension toward/into the third ventricle or the brainstem, and resection using a bifrontal translamina terminalis or left-sided approach.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>This study demonstrated that resection of craniopharyngiomas is frequently associated with postoperative neuropsychological deficits and hence an impaired quality of life. In addition to tumor size and extension toward/into the third ventricle or the brainstem, selection of the surgical approach may play a crucial role in the patient’s neuropsychological outcome and quality of life.</jats:p></jats:sec> Neurological and neuropsychological outcome after resection of craniopharyngiomas Journal of Neurosurgery
spellingShingle Giese, Henrik, Haenig, Benjamin, Haenig, Anna, Unterberg, Andreas, Zweckberger, Klaus, Journal of Neurosurgery, Neurological and neuropsychological outcome after resection of craniopharyngiomas, General Medicine
title Neurological and neuropsychological outcome after resection of craniopharyngiomas
title_full Neurological and neuropsychological outcome after resection of craniopharyngiomas
title_fullStr Neurological and neuropsychological outcome after resection of craniopharyngiomas
title_full_unstemmed Neurological and neuropsychological outcome after resection of craniopharyngiomas
title_short Neurological and neuropsychological outcome after resection of craniopharyngiomas
title_sort neurological and neuropsychological outcome after resection of craniopharyngiomas
title_unstemmed Neurological and neuropsychological outcome after resection of craniopharyngiomas
topic General Medicine
url http://dx.doi.org/10.3171/2018.10.jns181557