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HbA1c and Coronary Heart Disease Risk Among Diabetic Patients
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| Zeitschriftentitel: | Diabetes Care |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Diabetes Care, 37, 2014, 2, S. 428-435 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Diabetes Association
|
| Schlagwörter: |
| author_facet |
Zhao, Wenhui Katzmarzyk, Peter T. Horswell, Ronald Wang, Yujie Johnson, Jolene Hu, Gang Zhao, Wenhui Katzmarzyk, Peter T. Horswell, Ronald Wang, Yujie Johnson, Jolene Hu, Gang |
|---|---|
| author |
Zhao, Wenhui Katzmarzyk, Peter T. Horswell, Ronald Wang, Yujie Johnson, Jolene Hu, Gang |
| spellingShingle |
Zhao, Wenhui Katzmarzyk, Peter T. Horswell, Ronald Wang, Yujie Johnson, Jolene Hu, Gang Diabetes Care HbA1c and Coronary Heart Disease Risk Among Diabetic Patients Advanced and Specialized Nursing Endocrinology, Diabetes and Metabolism Internal Medicine |
| author_sort |
zhao, wenhui |
| spelling |
Zhao, Wenhui Katzmarzyk, Peter T. Horswell, Ronald Wang, Yujie Johnson, Jolene Hu, Gang 0149-5992 1935-5548 American Diabetes Association Advanced and Specialized Nursing Endocrinology, Diabetes and Metabolism Internal Medicine http://dx.doi.org/10.2337/dc13-1525 <jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>Clinical trials to date have not provided definitive evidence regarding the effects of glucose lowering with coronary heart disease (CHD) risk among diabetic patients.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>We prospectively investigated the association of HbA1c at baseline and during follow-up with CHD risk among 17,510 African American and 12,592 white patients with type 2 diabetes.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>During a mean follow-up of 6.0 years, 7,258 incident CHD cases were identified. The multivariable-adjusted hazard ratios of CHD associated with different levels of HbA1c at baseline (&lt;6.0 [reference group], 6.0–6.9, 7.0–7.9, 8.0–8.9, 9.0–9.9, 10.0–10.9, and ≥11.0%) were 1.00, 1.07 (95% CI 0.97–1.18), 1.16 (1.04–1.31), 1.15 (1.01–1.32), 1.26 (1.09–1.45), 1.27 (1.09–1.48), and 1.24 (1.10–1.40) (P trend = 0.002) for African Americans and 1.00, 1.04 (0.94–1.14), 1.15 (1.03–1.28), 1.29 (1.13–1.46), 1.41 (1.22–1.62), 1.34 (1.14–1.57), and 1.44 (1.26–1.65) (P trend &lt;0.001) for white patients, respectively. The graded association of HbA1c during follow-up with CHD risk was observed among both African American and white diabetic patients (all P trend &lt;0.001). Each one percentage increase of HbA1c was associated with a greater increase in CHD risk in white versus African American diabetic patients. When stratified by sex, age, smoking status, use of glucose-lowering agents, and income, this graded association of HbA1c with CHD was still present.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>The current study in a low-income population suggests a graded positive association between HbA1c at baseline and during follow-up with the risk of CHD among both African American and white diabetic patients with low socioeconomic status.</jats:p> </jats:sec> HbA1c and Coronary Heart Disease Risk Among Diabetic Patients Diabetes Care |
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American Diabetes Association, 2014 |
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American Diabetes Association, 2014 |
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0149-5992 1935-5548 |
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| title |
HbA1c and Coronary Heart Disease Risk Among Diabetic Patients |
| title_unstemmed |
HbA1c and Coronary Heart Disease Risk Among Diabetic Patients |
| title_full |
HbA1c and Coronary Heart Disease Risk Among Diabetic Patients |
| title_fullStr |
HbA1c and Coronary Heart Disease Risk Among Diabetic Patients |
| title_full_unstemmed |
HbA1c and Coronary Heart Disease Risk Among Diabetic Patients |
| title_short |
HbA1c and Coronary Heart Disease Risk Among Diabetic Patients |
| title_sort |
hba1c and coronary heart disease risk among diabetic patients |
| topic |
Advanced and Specialized Nursing Endocrinology, Diabetes and Metabolism Internal Medicine |
| url |
http://dx.doi.org/10.2337/dc13-1525 |
| publishDate |
2014 |
| physical |
428-435 |
| description |
<jats:sec>
<jats:title>OBJECTIVE</jats:title>
<jats:p>Clinical trials to date have not provided definitive evidence regarding the effects of glucose lowering with coronary heart disease (CHD) risk among diabetic patients.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>RESEARCH DESIGN AND METHODS</jats:title>
<jats:p>We prospectively investigated the association of HbA1c at baseline and during follow-up with CHD risk among 17,510 African American and 12,592 white patients with type 2 diabetes.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>RESULTS</jats:title>
<jats:p>During a mean follow-up of 6.0 years, 7,258 incident CHD cases were identified. The multivariable-adjusted hazard ratios of CHD associated with different levels of HbA1c at baseline (&lt;6.0 [reference group], 6.0–6.9, 7.0–7.9, 8.0–8.9, 9.0–9.9, 10.0–10.9, and ≥11.0%) were 1.00, 1.07 (95% CI 0.97–1.18), 1.16 (1.04–1.31), 1.15 (1.01–1.32), 1.26 (1.09–1.45), 1.27 (1.09–1.48), and 1.24 (1.10–1.40) (P trend = 0.002) for African Americans and 1.00, 1.04 (0.94–1.14), 1.15 (1.03–1.28), 1.29 (1.13–1.46), 1.41 (1.22–1.62), 1.34 (1.14–1.57), and 1.44 (1.26–1.65) (P trend &lt;0.001) for white patients, respectively. The graded association of HbA1c during follow-up with CHD risk was observed among both African American and white diabetic patients (all P trend &lt;0.001). Each one percentage increase of HbA1c was associated with a greater increase in CHD risk in white versus African American diabetic patients. When stratified by sex, age, smoking status, use of glucose-lowering agents, and income, this graded association of HbA1c with CHD was still present.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>CONCLUSIONS</jats:title>
<jats:p>The current study in a low-income population suggests a graded positive association between HbA1c at baseline and during follow-up with the risk of CHD among both African American and white diabetic patients with low socioeconomic status.</jats:p>
</jats:sec> |
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| author | Zhao, Wenhui, Katzmarzyk, Peter T., Horswell, Ronald, Wang, Yujie, Johnson, Jolene, Hu, Gang |
| author_facet | Zhao, Wenhui, Katzmarzyk, Peter T., Horswell, Ronald, Wang, Yujie, Johnson, Jolene, Hu, Gang, Zhao, Wenhui, Katzmarzyk, Peter T., Horswell, Ronald, Wang, Yujie, Johnson, Jolene, Hu, Gang |
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| description | <jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>Clinical trials to date have not provided definitive evidence regarding the effects of glucose lowering with coronary heart disease (CHD) risk among diabetic patients.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>We prospectively investigated the association of HbA1c at baseline and during follow-up with CHD risk among 17,510 African American and 12,592 white patients with type 2 diabetes.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>During a mean follow-up of 6.0 years, 7,258 incident CHD cases were identified. The multivariable-adjusted hazard ratios of CHD associated with different levels of HbA1c at baseline (&lt;6.0 [reference group], 6.0–6.9, 7.0–7.9, 8.0–8.9, 9.0–9.9, 10.0–10.9, and ≥11.0%) were 1.00, 1.07 (95% CI 0.97–1.18), 1.16 (1.04–1.31), 1.15 (1.01–1.32), 1.26 (1.09–1.45), 1.27 (1.09–1.48), and 1.24 (1.10–1.40) (P trend = 0.002) for African Americans and 1.00, 1.04 (0.94–1.14), 1.15 (1.03–1.28), 1.29 (1.13–1.46), 1.41 (1.22–1.62), 1.34 (1.14–1.57), and 1.44 (1.26–1.65) (P trend &lt;0.001) for white patients, respectively. The graded association of HbA1c during follow-up with CHD risk was observed among both African American and white diabetic patients (all P trend &lt;0.001). Each one percentage increase of HbA1c was associated with a greater increase in CHD risk in white versus African American diabetic patients. When stratified by sex, age, smoking status, use of glucose-lowering agents, and income, this graded association of HbA1c with CHD was still present.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>The current study in a low-income population suggests a graded positive association between HbA1c at baseline and during follow-up with the risk of CHD among both African American and white diabetic patients with low socioeconomic status.</jats:p> </jats:sec> |
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| institution | DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
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| spelling | Zhao, Wenhui Katzmarzyk, Peter T. Horswell, Ronald Wang, Yujie Johnson, Jolene Hu, Gang 0149-5992 1935-5548 American Diabetes Association Advanced and Specialized Nursing Endocrinology, Diabetes and Metabolism Internal Medicine http://dx.doi.org/10.2337/dc13-1525 <jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>Clinical trials to date have not provided definitive evidence regarding the effects of glucose lowering with coronary heart disease (CHD) risk among diabetic patients.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>We prospectively investigated the association of HbA1c at baseline and during follow-up with CHD risk among 17,510 African American and 12,592 white patients with type 2 diabetes.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>During a mean follow-up of 6.0 years, 7,258 incident CHD cases were identified. The multivariable-adjusted hazard ratios of CHD associated with different levels of HbA1c at baseline (&lt;6.0 [reference group], 6.0–6.9, 7.0–7.9, 8.0–8.9, 9.0–9.9, 10.0–10.9, and ≥11.0%) were 1.00, 1.07 (95% CI 0.97–1.18), 1.16 (1.04–1.31), 1.15 (1.01–1.32), 1.26 (1.09–1.45), 1.27 (1.09–1.48), and 1.24 (1.10–1.40) (P trend = 0.002) for African Americans and 1.00, 1.04 (0.94–1.14), 1.15 (1.03–1.28), 1.29 (1.13–1.46), 1.41 (1.22–1.62), 1.34 (1.14–1.57), and 1.44 (1.26–1.65) (P trend &lt;0.001) for white patients, respectively. The graded association of HbA1c during follow-up with CHD risk was observed among both African American and white diabetic patients (all P trend &lt;0.001). Each one percentage increase of HbA1c was associated with a greater increase in CHD risk in white versus African American diabetic patients. When stratified by sex, age, smoking status, use of glucose-lowering agents, and income, this graded association of HbA1c with CHD was still present.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>The current study in a low-income population suggests a graded positive association between HbA1c at baseline and during follow-up with the risk of CHD among both African American and white diabetic patients with low socioeconomic status.</jats:p> </jats:sec> HbA1c and Coronary Heart Disease Risk Among Diabetic Patients Diabetes Care |
| spellingShingle | Zhao, Wenhui, Katzmarzyk, Peter T., Horswell, Ronald, Wang, Yujie, Johnson, Jolene, Hu, Gang, Diabetes Care, HbA1c and Coronary Heart Disease Risk Among Diabetic Patients, Advanced and Specialized Nursing, Endocrinology, Diabetes and Metabolism, Internal Medicine |
| title | HbA1c and Coronary Heart Disease Risk Among Diabetic Patients |
| title_full | HbA1c and Coronary Heart Disease Risk Among Diabetic Patients |
| title_fullStr | HbA1c and Coronary Heart Disease Risk Among Diabetic Patients |
| title_full_unstemmed | HbA1c and Coronary Heart Disease Risk Among Diabetic Patients |
| title_short | HbA1c and Coronary Heart Disease Risk Among Diabetic Patients |
| title_sort | hba1c and coronary heart disease risk among diabetic patients |
| title_unstemmed | HbA1c and Coronary Heart Disease Risk Among Diabetic Patients |
| topic | Advanced and Specialized Nursing, Endocrinology, Diabetes and Metabolism, Internal Medicine |
| url | http://dx.doi.org/10.2337/dc13-1525 |