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Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review
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| Zeitschriftentitel: | Melanoma Management |
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| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , |
| In: | Melanoma Management, 6, 2019, 4, S. MMT33 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Future Medicine Ltd
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| Schlagwörter: |
| author_facet |
Mohr, Peter Kiecker, Felix Soriano, Virtudes Dereure, Olivier Mujika, Karmele Saiag, Philippe Utikal, Jochen Koneru, Rama Robert, Caroline Cuadros, Florencia Chacón, Matias Villarroel, Rodrigo U Najjar, Yana G Kottschade, Lisa Couselo, Eva M Koruth, Roy Guérin, Annie Burne, Rebecca Ionescu-Ittu, Raluca Perrinjaquet, Maurice Zager, Jonathan S Mohr, Peter Kiecker, Felix Soriano, Virtudes Dereure, Olivier Mujika, Karmele Saiag, Philippe Utikal, Jochen Koneru, Rama Robert, Caroline Cuadros, Florencia Chacón, Matias Villarroel, Rodrigo U Najjar, Yana G Kottschade, Lisa Couselo, Eva M Koruth, Roy Guérin, Annie Burne, Rebecca Ionescu-Ittu, Raluca Perrinjaquet, Maurice Zager, Jonathan S |
|---|---|
| author |
Mohr, Peter Kiecker, Felix Soriano, Virtudes Dereure, Olivier Mujika, Karmele Saiag, Philippe Utikal, Jochen Koneru, Rama Robert, Caroline Cuadros, Florencia Chacón, Matias Villarroel, Rodrigo U Najjar, Yana G Kottschade, Lisa Couselo, Eva M Koruth, Roy Guérin, Annie Burne, Rebecca Ionescu-Ittu, Raluca Perrinjaquet, Maurice Zager, Jonathan S |
| spellingShingle |
Mohr, Peter Kiecker, Felix Soriano, Virtudes Dereure, Olivier Mujika, Karmele Saiag, Philippe Utikal, Jochen Koneru, Rama Robert, Caroline Cuadros, Florencia Chacón, Matias Villarroel, Rodrigo U Najjar, Yana G Kottschade, Lisa Couselo, Eva M Koruth, Roy Guérin, Annie Burne, Rebecca Ionescu-Ittu, Raluca Perrinjaquet, Maurice Zager, Jonathan S Melanoma Management Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review Dermatology Oncology |
| author_sort |
mohr, peter |
| spelling |
Mohr, Peter Kiecker, Felix Soriano, Virtudes Dereure, Olivier Mujika, Karmele Saiag, Philippe Utikal, Jochen Koneru, Rama Robert, Caroline Cuadros, Florencia Chacón, Matias Villarroel, Rodrigo U Najjar, Yana G Kottschade, Lisa Couselo, Eva M Koruth, Roy Guérin, Annie Burne, Rebecca Ionescu-Ittu, Raluca Perrinjaquet, Maurice Zager, Jonathan S 2045-0885 2045-0893 Future Medicine Ltd Dermatology Oncology http://dx.doi.org/10.2217/mmt-2019-0015 <jats:p> Aim: To describe treatment patterns among patients with stage III melanoma who underwent surgical excision in years 2011–2016, and assess outcomes among patients who subsequently received systemic adjuvant therapy versus watch-and-wait. Methods: Chart review of 380 patients from 17 melanoma centers in North America, South America and Europe. Results: Of 129 (34%) patients treated with adjuvant therapy, 85% received interferon α-2b and 56% discontinued treatment (mostly due to adverse events). Relapse-free survival was significantly longer for patients treated with adjuvant therapy versus watch-and-wait (hazard ratio = 0.63; p < 0.05). There was considerable heterogeneity in adjuvant treatment schedules and doses. Similar results were found in patients who received interferon-based adjuvant therapy. Conclusion: Adjuvant therapies with better safety/efficacy profiles will improve clinical outcomes in patients with stage III melanoma. </jats:p> Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review Melanoma Management |
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Future Medicine Ltd, 2019 |
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Future Medicine Ltd, 2019 |
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| title |
Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review |
| title_unstemmed |
Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review |
| title_full |
Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review |
| title_fullStr |
Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review |
| title_full_unstemmed |
Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review |
| title_short |
Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review |
| title_sort |
adjuvant therapy versus watch-and-wait post surgery for stage iii melanoma: a multicountry retrospective chart review |
| topic |
Dermatology Oncology |
| url |
http://dx.doi.org/10.2217/mmt-2019-0015 |
| publishDate |
2019 |
| physical |
MMT33 |
| description |
<jats:p> Aim: To describe treatment patterns among patients with stage III melanoma who underwent surgical excision in years 2011–2016, and assess outcomes among patients who subsequently received systemic adjuvant therapy versus watch-and-wait. Methods: Chart review of 380 patients from 17 melanoma centers in North America, South America and Europe. Results: Of 129 (34%) patients treated with adjuvant therapy, 85% received interferon α-2b and 56% discontinued treatment (mostly due to adverse events). Relapse-free survival was significantly longer for patients treated with adjuvant therapy versus watch-and-wait (hazard ratio = 0.63; p < 0.05). There was considerable heterogeneity in adjuvant treatment schedules and doses. Similar results were found in patients who received interferon-based adjuvant therapy. Conclusion: Adjuvant therapies with better safety/efficacy profiles will improve clinical outcomes in patients with stage III melanoma. </jats:p> |
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| author | Mohr, Peter, Kiecker, Felix, Soriano, Virtudes, Dereure, Olivier, Mujika, Karmele, Saiag, Philippe, Utikal, Jochen, Koneru, Rama, Robert, Caroline, Cuadros, Florencia, Chacón, Matias, Villarroel, Rodrigo U, Najjar, Yana G, Kottschade, Lisa, Couselo, Eva M, Koruth, Roy, Guérin, Annie, Burne, Rebecca, Ionescu-Ittu, Raluca, Perrinjaquet, Maurice, Zager, Jonathan S |
| author_facet | Mohr, Peter, Kiecker, Felix, Soriano, Virtudes, Dereure, Olivier, Mujika, Karmele, Saiag, Philippe, Utikal, Jochen, Koneru, Rama, Robert, Caroline, Cuadros, Florencia, Chacón, Matias, Villarroel, Rodrigo U, Najjar, Yana G, Kottschade, Lisa, Couselo, Eva M, Koruth, Roy, Guérin, Annie, Burne, Rebecca, Ionescu-Ittu, Raluca, Perrinjaquet, Maurice, Zager, Jonathan S, Mohr, Peter, Kiecker, Felix, Soriano, Virtudes, Dereure, Olivier, Mujika, Karmele, Saiag, Philippe, Utikal, Jochen, Koneru, Rama, Robert, Caroline, Cuadros, Florencia, Chacón, Matias, Villarroel, Rodrigo U, Najjar, Yana G, Kottschade, Lisa, Couselo, Eva M, Koruth, Roy, Guérin, Annie, Burne, Rebecca, Ionescu-Ittu, Raluca, Perrinjaquet, Maurice, Zager, Jonathan S |
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| description | <jats:p> Aim: To describe treatment patterns among patients with stage III melanoma who underwent surgical excision in years 2011–2016, and assess outcomes among patients who subsequently received systemic adjuvant therapy versus watch-and-wait. Methods: Chart review of 380 patients from 17 melanoma centers in North America, South America and Europe. Results: Of 129 (34%) patients treated with adjuvant therapy, 85% received interferon α-2b and 56% discontinued treatment (mostly due to adverse events). Relapse-free survival was significantly longer for patients treated with adjuvant therapy versus watch-and-wait (hazard ratio = 0.63; p < 0.05). There was considerable heterogeneity in adjuvant treatment schedules and doses. Similar results were found in patients who received interferon-based adjuvant therapy. Conclusion: Adjuvant therapies with better safety/efficacy profiles will improve clinical outcomes in patients with stage III melanoma. </jats:p> |
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| spelling | Mohr, Peter Kiecker, Felix Soriano, Virtudes Dereure, Olivier Mujika, Karmele Saiag, Philippe Utikal, Jochen Koneru, Rama Robert, Caroline Cuadros, Florencia Chacón, Matias Villarroel, Rodrigo U Najjar, Yana G Kottschade, Lisa Couselo, Eva M Koruth, Roy Guérin, Annie Burne, Rebecca Ionescu-Ittu, Raluca Perrinjaquet, Maurice Zager, Jonathan S 2045-0885 2045-0893 Future Medicine Ltd Dermatology Oncology http://dx.doi.org/10.2217/mmt-2019-0015 <jats:p> Aim: To describe treatment patterns among patients with stage III melanoma who underwent surgical excision in years 2011–2016, and assess outcomes among patients who subsequently received systemic adjuvant therapy versus watch-and-wait. Methods: Chart review of 380 patients from 17 melanoma centers in North America, South America and Europe. Results: Of 129 (34%) patients treated with adjuvant therapy, 85% received interferon α-2b and 56% discontinued treatment (mostly due to adverse events). Relapse-free survival was significantly longer for patients treated with adjuvant therapy versus watch-and-wait (hazard ratio = 0.63; p < 0.05). There was considerable heterogeneity in adjuvant treatment schedules and doses. Similar results were found in patients who received interferon-based adjuvant therapy. Conclusion: Adjuvant therapies with better safety/efficacy profiles will improve clinical outcomes in patients with stage III melanoma. </jats:p> Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review Melanoma Management |
| spellingShingle | Mohr, Peter, Kiecker, Felix, Soriano, Virtudes, Dereure, Olivier, Mujika, Karmele, Saiag, Philippe, Utikal, Jochen, Koneru, Rama, Robert, Caroline, Cuadros, Florencia, Chacón, Matias, Villarroel, Rodrigo U, Najjar, Yana G, Kottschade, Lisa, Couselo, Eva M, Koruth, Roy, Guérin, Annie, Burne, Rebecca, Ionescu-Ittu, Raluca, Perrinjaquet, Maurice, Zager, Jonathan S, Melanoma Management, Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review, Dermatology, Oncology |
| title | Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review |
| title_full | Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review |
| title_fullStr | Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review |
| title_full_unstemmed | Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review |
| title_short | Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review |
| title_sort | adjuvant therapy versus watch-and-wait post surgery for stage iii melanoma: a multicountry retrospective chart review |
| title_unstemmed | Adjuvant therapy versus watch-and-wait post surgery for stage III melanoma: a multicountry retrospective chart review |
| topic | Dermatology, Oncology |
| url | http://dx.doi.org/10.2217/mmt-2019-0015 |