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Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis.
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| Zeitschriftentitel: | Acta Biochimica Polonica |
|---|---|
| Personen und Körperschaften: | , |
| In: | Acta Biochimica Polonica, 50, 2003, 1, S. 49-59 |
| Format: | E-Article |
| Sprache: | Unbestimmt |
| veröffentlicht: |
Frontiers Media SA
|
| Schlagwörter: |
| author_facet |
Kimura, Hideo Esumi, Hiroyasu Kimura, Hideo Esumi, Hiroyasu |
|---|---|
| author |
Kimura, Hideo Esumi, Hiroyasu |
| spellingShingle |
Kimura, Hideo Esumi, Hiroyasu Acta Biochimica Polonica Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. General Biochemistry, Genetics and Molecular Biology |
| author_sort |
kimura, hideo |
| spelling |
Kimura, Hideo Esumi, Hiroyasu 1734-154X 0001-527X Frontiers Media SA General Biochemistry, Genetics and Molecular Biology http://dx.doi.org/10.18388/abp.2003_3713 <jats:p>Physiologically, angiogenesis is tightly regulated, or otherwise it leads to pathological processes, such as tumors, inflammatory diseases, gynecological diseases and diabetic retinopathy. The vascular endothelial growth factor (VEGF) is a potent and critical inducer of angiogenesis. The VEGF gene expression is regulated by a variety of stimuli. Hypoxia is one of the most potent inducers of the VEGF expression. The hypoxia inducible factor 1 (HIF-1) plays as a key transcription factor in hypoxia-mediated VEGF gene upregulation. Nitric oxide (NO) as well as hypoxia is reported to upregulate the VEGF gene by enhancing HIF-1 activity. The Akt/protein kinase B (PKB) pathway may be involved in NO-mediated HIF-1 activation in limited cell lines. There are some reports of negative effects of NO on HIF-1 and VEGF activity. These conflicting data of NO effects may be attributed mainly to the amount of released NO. Indeed, NO can be a positive or negative modulator of the VEGF gene under the same conditions simply by changing its amounts. The VEGF-mediated angiogenesis requires NO production from activated endothelial NO synthase (eNOS). Activation of eNOS by VEGF involves several pathways including Akt/PKB, Ca(2+)/calmodulin, and protein kinase C. The NO-mediated VEGF expression can be regulated by HIF-1 and heme oxygenase 1 (HO-1) activity, and the VEGF-mediated NO production by eNOS can be also modulated by HIF-1 and HO-1 activity, depending upon the amount of produced NO. These reciprocal relations between NO and VEGF may contribute to regulated angiogenesis in normal tissues.</jats:p> Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. Acta Biochimica Polonica |
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| title |
Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| title_unstemmed |
Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| title_full |
Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| title_fullStr |
Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| title_full_unstemmed |
Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| title_short |
Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| title_sort |
reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| topic |
General Biochemistry, Genetics and Molecular Biology |
| url |
http://dx.doi.org/10.18388/abp.2003_3713 |
| publishDate |
2003 |
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49-59 |
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<jats:p>Physiologically, angiogenesis is tightly regulated, or otherwise it leads to pathological processes, such as tumors, inflammatory diseases, gynecological diseases and diabetic retinopathy. The vascular endothelial growth factor (VEGF) is a potent and critical inducer of angiogenesis. The VEGF gene expression is regulated by a variety of stimuli. Hypoxia is one of the most potent inducers of the VEGF expression. The hypoxia inducible factor 1 (HIF-1) plays as a key transcription factor in hypoxia-mediated VEGF gene upregulation. Nitric oxide (NO) as well as hypoxia is reported to upregulate the VEGF gene by enhancing HIF-1 activity. The Akt/protein kinase B (PKB) pathway may be involved in NO-mediated HIF-1 activation in limited cell lines. There are some reports of negative effects of NO on HIF-1 and VEGF activity. These conflicting data of NO effects may be attributed mainly to the amount of released NO. Indeed, NO can be a positive or negative modulator of the VEGF gene under the same conditions simply by changing its amounts. The VEGF-mediated angiogenesis requires NO production from activated endothelial NO synthase (eNOS). Activation of eNOS by VEGF involves several pathways including Akt/PKB, Ca(2+)/calmodulin, and protein kinase C. The NO-mediated VEGF expression can be regulated by HIF-1 and heme oxygenase 1 (HO-1) activity, and the VEGF-mediated NO production by eNOS can be also modulated by HIF-1 and HO-1 activity, depending upon the amount of produced NO. These reciprocal relations between NO and VEGF may contribute to regulated angiogenesis in normal tissues.</jats:p> |
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| description | <jats:p>Physiologically, angiogenesis is tightly regulated, or otherwise it leads to pathological processes, such as tumors, inflammatory diseases, gynecological diseases and diabetic retinopathy. The vascular endothelial growth factor (VEGF) is a potent and critical inducer of angiogenesis. The VEGF gene expression is regulated by a variety of stimuli. Hypoxia is one of the most potent inducers of the VEGF expression. The hypoxia inducible factor 1 (HIF-1) plays as a key transcription factor in hypoxia-mediated VEGF gene upregulation. Nitric oxide (NO) as well as hypoxia is reported to upregulate the VEGF gene by enhancing HIF-1 activity. The Akt/protein kinase B (PKB) pathway may be involved in NO-mediated HIF-1 activation in limited cell lines. There are some reports of negative effects of NO on HIF-1 and VEGF activity. These conflicting data of NO effects may be attributed mainly to the amount of released NO. Indeed, NO can be a positive or negative modulator of the VEGF gene under the same conditions simply by changing its amounts. The VEGF-mediated angiogenesis requires NO production from activated endothelial NO synthase (eNOS). Activation of eNOS by VEGF involves several pathways including Akt/PKB, Ca(2+)/calmodulin, and protein kinase C. The NO-mediated VEGF expression can be regulated by HIF-1 and heme oxygenase 1 (HO-1) activity, and the VEGF-mediated NO production by eNOS can be also modulated by HIF-1 and HO-1 activity, depending upon the amount of produced NO. These reciprocal relations between NO and VEGF may contribute to regulated angiogenesis in normal tissues.</jats:p> |
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| spelling | Kimura, Hideo Esumi, Hiroyasu 1734-154X 0001-527X Frontiers Media SA General Biochemistry, Genetics and Molecular Biology http://dx.doi.org/10.18388/abp.2003_3713 <jats:p>Physiologically, angiogenesis is tightly regulated, or otherwise it leads to pathological processes, such as tumors, inflammatory diseases, gynecological diseases and diabetic retinopathy. The vascular endothelial growth factor (VEGF) is a potent and critical inducer of angiogenesis. The VEGF gene expression is regulated by a variety of stimuli. Hypoxia is one of the most potent inducers of the VEGF expression. The hypoxia inducible factor 1 (HIF-1) plays as a key transcription factor in hypoxia-mediated VEGF gene upregulation. Nitric oxide (NO) as well as hypoxia is reported to upregulate the VEGF gene by enhancing HIF-1 activity. The Akt/protein kinase B (PKB) pathway may be involved in NO-mediated HIF-1 activation in limited cell lines. There are some reports of negative effects of NO on HIF-1 and VEGF activity. These conflicting data of NO effects may be attributed mainly to the amount of released NO. Indeed, NO can be a positive or negative modulator of the VEGF gene under the same conditions simply by changing its amounts. The VEGF-mediated angiogenesis requires NO production from activated endothelial NO synthase (eNOS). Activation of eNOS by VEGF involves several pathways including Akt/PKB, Ca(2+)/calmodulin, and protein kinase C. The NO-mediated VEGF expression can be regulated by HIF-1 and heme oxygenase 1 (HO-1) activity, and the VEGF-mediated NO production by eNOS can be also modulated by HIF-1 and HO-1 activity, depending upon the amount of produced NO. These reciprocal relations between NO and VEGF may contribute to regulated angiogenesis in normal tissues.</jats:p> Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. Acta Biochimica Polonica |
| spellingShingle | Kimura, Hideo, Esumi, Hiroyasu, Acta Biochimica Polonica, Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis., General Biochemistry, Genetics and Molecular Biology |
| title | Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| title_full | Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| title_fullStr | Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| title_full_unstemmed | Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| title_short | Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| title_sort | reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| title_unstemmed | Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. |
| topic | General Biochemistry, Genetics and Molecular Biology |
| url | http://dx.doi.org/10.18388/abp.2003_3713 |