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Leukemia in Infants
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| Zeitschriftentitel: | The Oncologist |
|---|---|
| Personen und Körperschaften: | , |
| In: | The Oncologist, 4, 1999, 3, S. 225-240 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
Felix, Carolyn A. Lange, Beverly J. Felix, Carolyn A. Lange, Beverly J. |
|---|---|
| author |
Felix, Carolyn A. Lange, Beverly J. |
| spellingShingle |
Felix, Carolyn A. Lange, Beverly J. The Oncologist Leukemia in Infants Cancer Research Oncology |
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felix, carolyn a. |
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Felix, Carolyn A. Lange, Beverly J. 1083-7159 1549-490X Oxford University Press (OUP) Cancer Research Oncology http://dx.doi.org/10.1634/theoncologist.4-3-225 <jats:title>Abstract</jats:title> <jats:p>Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in infants have in common a high incidence of translocations of the MLL gene at chromosome band 11q23. Similar translocations occur in leukemias associated with chemotherapies that target DNA topoisomerase II. MLL has numerous different partner genes. The role of the many MLL fusion proteins in leukemogenesis is not yet understood. The t(4;11) translocation, the most common translocation in infant ALL, adversely affects the outcome. Additional genetic changes, especially Ikaros alterations, are found in infant ALL. Other forms of myeloid leukemia in infants present as myelodysplastic and myeloproliferative syndromes, which may be associated with constitutional disorders. This review will consider all leukemia in infants, but will focus on leukemias with MLL gene translocations.</jats:p> Leukemia in Infants The Oncologist |
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Oxford University Press (OUP), 1999 |
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Oxford University Press (OUP), 1999 |
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Leukemia in Infants |
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Leukemia in Infants |
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Leukemia in Infants |
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Leukemia in Infants |
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Leukemia in Infants |
| title_short |
Leukemia in Infants |
| title_sort |
leukemia in infants |
| topic |
Cancer Research Oncology |
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http://dx.doi.org/10.1634/theoncologist.4-3-225 |
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1999 |
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225-240 |
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<jats:title>Abstract</jats:title>
<jats:p>Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in infants have in common a high incidence of translocations of the MLL gene at chromosome band 11q23. Similar translocations occur in leukemias associated with chemotherapies that target DNA topoisomerase II. MLL has numerous different partner genes. The role of the many MLL fusion proteins in leukemogenesis is not yet understood. The t(4;11) translocation, the most common translocation in infant ALL, adversely affects the outcome. Additional genetic changes, especially Ikaros alterations, are found in infant ALL. Other forms of myeloid leukemia in infants present as myelodysplastic and myeloproliferative syndromes, which may be associated with constitutional disorders. This review will consider all leukemia in infants, but will focus on leukemias with MLL gene translocations.</jats:p> |
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| description | <jats:title>Abstract</jats:title> <jats:p>Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in infants have in common a high incidence of translocations of the MLL gene at chromosome band 11q23. Similar translocations occur in leukemias associated with chemotherapies that target DNA topoisomerase II. MLL has numerous different partner genes. The role of the many MLL fusion proteins in leukemogenesis is not yet understood. The t(4;11) translocation, the most common translocation in infant ALL, adversely affects the outcome. Additional genetic changes, especially Ikaros alterations, are found in infant ALL. Other forms of myeloid leukemia in infants present as myelodysplastic and myeloproliferative syndromes, which may be associated with constitutional disorders. This review will consider all leukemia in infants, but will focus on leukemias with MLL gene translocations.</jats:p> |
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| imprint | Oxford University Press (OUP), 1999 |
| imprint_str_mv | Oxford University Press (OUP), 1999 |
| institution | DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
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| series | The Oncologist |
| source_id | 49 |
| spelling | Felix, Carolyn A. Lange, Beverly J. 1083-7159 1549-490X Oxford University Press (OUP) Cancer Research Oncology http://dx.doi.org/10.1634/theoncologist.4-3-225 <jats:title>Abstract</jats:title> <jats:p>Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in infants have in common a high incidence of translocations of the MLL gene at chromosome band 11q23. Similar translocations occur in leukemias associated with chemotherapies that target DNA topoisomerase II. MLL has numerous different partner genes. The role of the many MLL fusion proteins in leukemogenesis is not yet understood. The t(4;11) translocation, the most common translocation in infant ALL, adversely affects the outcome. Additional genetic changes, especially Ikaros alterations, are found in infant ALL. Other forms of myeloid leukemia in infants present as myelodysplastic and myeloproliferative syndromes, which may be associated with constitutional disorders. This review will consider all leukemia in infants, but will focus on leukemias with MLL gene translocations.</jats:p> Leukemia in Infants The Oncologist |
| spellingShingle | Felix, Carolyn A., Lange, Beverly J., The Oncologist, Leukemia in Infants, Cancer Research, Oncology |
| title | Leukemia in Infants |
| title_full | Leukemia in Infants |
| title_fullStr | Leukemia in Infants |
| title_full_unstemmed | Leukemia in Infants |
| title_short | Leukemia in Infants |
| title_sort | leukemia in infants |
| title_unstemmed | Leukemia in Infants |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1634/theoncologist.4-3-225 |