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The role of basigin in reproduction
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| Zeitschriftentitel: | Reproduction |
|---|---|
| Personen und Körperschaften: | , |
| In: | Reproduction, 159, 2020, 2, S. R97-R109 |
| Format: | E-Article |
| Sprache: | Unbestimmt |
| veröffentlicht: |
Bioscientifica
|
| Schlagwörter: |
| author_facet |
Li, Kailiang Nowak, Romana A Li, Kailiang Nowak, Romana A |
|---|---|
| author |
Li, Kailiang Nowak, Romana A |
| spellingShingle |
Li, Kailiang Nowak, Romana A Reproduction The role of basigin in reproduction Cell Biology Obstetrics and Gynecology Endocrinology Embryology Reproductive Medicine |
| author_sort |
li, kailiang |
| spelling |
Li, Kailiang Nowak, Romana A 1470-1626 1741-7899 Bioscientifica Cell Biology Obstetrics and Gynecology Endocrinology Embryology Reproductive Medicine http://dx.doi.org/10.1530/rep-19-0268 <jats:p>Basigin is a highly glycosylated transmembrane protein that was originally identified as a product of tumor cells. Basigin is a potent inducer of matrix metalloproteinases (MMPs) and angiogenic factors such as vascular endothelial growth factor (VEGF). Basigin is also a chaperone protein for specific metabolite transporters in the plasma cell membrane such as the monocarboxylate transporters and is an important regulator of cell metabolism. Studies in reproductive model systems have demonstrated that basigin is expressed in the testis, ovary, uterus and placenta and is necessary for normal fertility in both males and females. Overexpression of basigin is associated with reproductive diseases including uterine leiomyomas and endometriosis. This review presents an overview of the literature regarding the physiological role of basigin in reproductive tissues and the mechanistic pathways involved in its actions.</jats:p> The role of basigin in reproduction Reproduction |
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Bioscientifica, 2020 |
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2020 |
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Reproduction |
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The role of basigin in reproduction |
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The role of basigin in reproduction |
| title_full |
The role of basigin in reproduction |
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The role of basigin in reproduction |
| title_full_unstemmed |
The role of basigin in reproduction |
| title_short |
The role of basigin in reproduction |
| title_sort |
the role of basigin in reproduction |
| topic |
Cell Biology Obstetrics and Gynecology Endocrinology Embryology Reproductive Medicine |
| url |
http://dx.doi.org/10.1530/rep-19-0268 |
| publishDate |
2020 |
| physical |
R97-R109 |
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<jats:p>Basigin is a highly glycosylated transmembrane protein that was originally identified as a product of tumor cells. Basigin is a potent inducer of matrix metalloproteinases (MMPs) and angiogenic factors such as vascular endothelial growth factor (VEGF). Basigin is also a chaperone protein for specific metabolite transporters in the plasma cell membrane such as the monocarboxylate transporters and is an important regulator of cell metabolism. Studies in reproductive model systems have demonstrated that basigin is expressed in the testis, ovary, uterus and placenta and is necessary for normal fertility in both males and females. Overexpression of basigin is associated with reproductive diseases including uterine leiomyomas and endometriosis. This review presents an overview of the literature regarding the physiological role of basigin in reproductive tissues and the mechanistic pathways involved in its actions.</jats:p> |
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| author | Li, Kailiang, Nowak, Romana A |
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| description | <jats:p>Basigin is a highly glycosylated transmembrane protein that was originally identified as a product of tumor cells. Basigin is a potent inducer of matrix metalloproteinases (MMPs) and angiogenic factors such as vascular endothelial growth factor (VEGF). Basigin is also a chaperone protein for specific metabolite transporters in the plasma cell membrane such as the monocarboxylate transporters and is an important regulator of cell metabolism. Studies in reproductive model systems have demonstrated that basigin is expressed in the testis, ovary, uterus and placenta and is necessary for normal fertility in both males and females. Overexpression of basigin is associated with reproductive diseases including uterine leiomyomas and endometriosis. This review presents an overview of the literature regarding the physiological role of basigin in reproductive tissues and the mechanistic pathways involved in its actions.</jats:p> |
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| imprint | Bioscientifica, 2020 |
| imprint_str_mv | Bioscientifica, 2020 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 1470-1626, 1741-7899 |
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| series | Reproduction |
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| spelling | Li, Kailiang Nowak, Romana A 1470-1626 1741-7899 Bioscientifica Cell Biology Obstetrics and Gynecology Endocrinology Embryology Reproductive Medicine http://dx.doi.org/10.1530/rep-19-0268 <jats:p>Basigin is a highly glycosylated transmembrane protein that was originally identified as a product of tumor cells. Basigin is a potent inducer of matrix metalloproteinases (MMPs) and angiogenic factors such as vascular endothelial growth factor (VEGF). Basigin is also a chaperone protein for specific metabolite transporters in the plasma cell membrane such as the monocarboxylate transporters and is an important regulator of cell metabolism. Studies in reproductive model systems have demonstrated that basigin is expressed in the testis, ovary, uterus and placenta and is necessary for normal fertility in both males and females. Overexpression of basigin is associated with reproductive diseases including uterine leiomyomas and endometriosis. This review presents an overview of the literature regarding the physiological role of basigin in reproductive tissues and the mechanistic pathways involved in its actions.</jats:p> The role of basigin in reproduction Reproduction |
| spellingShingle | Li, Kailiang, Nowak, Romana A, Reproduction, The role of basigin in reproduction, Cell Biology, Obstetrics and Gynecology, Endocrinology, Embryology, Reproductive Medicine |
| title | The role of basigin in reproduction |
| title_full | The role of basigin in reproduction |
| title_fullStr | The role of basigin in reproduction |
| title_full_unstemmed | The role of basigin in reproduction |
| title_short | The role of basigin in reproduction |
| title_sort | the role of basigin in reproduction |
| title_unstemmed | The role of basigin in reproduction |
| topic | Cell Biology, Obstetrics and Gynecology, Endocrinology, Embryology, Reproductive Medicine |
| url | http://dx.doi.org/10.1530/rep-19-0268 |