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RabGAPs in skeletal muscle function and exercise
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| Zeitschriftentitel: | Journal of Molecular Endocrinology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Journal of Molecular Endocrinology, 64, 2020, 1, S. R1-R19 |
| Format: | E-Article |
| Sprache: | Unbestimmt |
| veröffentlicht: |
Bioscientifica
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| Schlagwörter: |
| author_facet |
Espelage, Lena Al-Hasani, Hadi Chadt, Alexandra Espelage, Lena Al-Hasani, Hadi Chadt, Alexandra |
|---|---|
| author |
Espelage, Lena Al-Hasani, Hadi Chadt, Alexandra |
| spellingShingle |
Espelage, Lena Al-Hasani, Hadi Chadt, Alexandra Journal of Molecular Endocrinology RabGAPs in skeletal muscle function and exercise Endocrinology Molecular Biology |
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espelage, lena |
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Espelage, Lena Al-Hasani, Hadi Chadt, Alexandra 0952-5041 1479-6813 Bioscientifica Endocrinology Molecular Biology http://dx.doi.org/10.1530/jme-19-0143 <jats:p>The two closely related RabGAPs TBC1D1 and TBC1D4 are key signaling factors of skeletal muscle substrate utilization. In mice, deficiency in both RabGAPs leads to reduced skeletal muscle glucose transport in response to insulin and lower GLUT4 abundance. Conversely, <jats:italic>Tbc1d1</jats:italic> and <jats:italic>Tbc1d4</jats:italic> deficiency results in enhanced lipid use as fuel in skeletal muscle, through yet unknown mechanisms. In humans, variants in <jats:italic>TBC1D1</jats:italic> and <jats:italic>TBC1D4</jats:italic> are linked to obesity, insulin resistance and type 2 diabetes. While the specific function in metabolism of each of the two RabGAPs remains to be determined, TBC1D1 emerges to be controlling exercise endurance and physical capacity, whereas TBC1D4 may rather be responsible for maintaining muscle insulin sensitivity, muscle contraction, and exercise. There is growing evidence that TBC1D1 also plays an important role in skeletal muscle development, since it has been found to be associated to meat production traits in several livestock species. In addition, TBC1D1 protein abundance in skeletal muscle is regulated by both, insulin receptor and insulin-like growth factor-1 (IGF-1) receptor signaling. This review focuses on the specific roles of the two key signaling factors TBC1D1 and TBC1D4 in skeletal muscle metabolism, development and exercise physiology.</jats:p> RabGAPs in skeletal muscle function and exercise Journal of Molecular Endocrinology |
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| title |
RabGAPs in skeletal muscle function and exercise |
| title_unstemmed |
RabGAPs in skeletal muscle function and exercise |
| title_full |
RabGAPs in skeletal muscle function and exercise |
| title_fullStr |
RabGAPs in skeletal muscle function and exercise |
| title_full_unstemmed |
RabGAPs in skeletal muscle function and exercise |
| title_short |
RabGAPs in skeletal muscle function and exercise |
| title_sort |
rabgaps in skeletal muscle function and exercise |
| topic |
Endocrinology Molecular Biology |
| url |
http://dx.doi.org/10.1530/jme-19-0143 |
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2020 |
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R1-R19 |
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<jats:p>The two closely related RabGAPs TBC1D1 and TBC1D4 are key signaling factors of skeletal muscle substrate utilization. In mice, deficiency in both RabGAPs leads to reduced skeletal muscle glucose transport in response to insulin and lower GLUT4 abundance. Conversely, <jats:italic>Tbc1d1</jats:italic> and <jats:italic>Tbc1d4</jats:italic> deficiency results in enhanced lipid use as fuel in skeletal muscle, through yet unknown mechanisms. In humans, variants in <jats:italic>TBC1D1</jats:italic> and <jats:italic>TBC1D4</jats:italic> are linked to obesity, insulin resistance and type 2 diabetes. While the specific function in metabolism of each of the two RabGAPs remains to be determined, TBC1D1 emerges to be controlling exercise endurance and physical capacity, whereas TBC1D4 may rather be responsible for maintaining muscle insulin sensitivity, muscle contraction, and exercise. There is growing evidence that TBC1D1 also plays an important role in skeletal muscle development, since it has been found to be associated to meat production traits in several livestock species. In addition, TBC1D1 protein abundance in skeletal muscle is regulated by both, insulin receptor and insulin-like growth factor-1 (IGF-1) receptor signaling. This review focuses on the specific roles of the two key signaling factors TBC1D1 and TBC1D4 in skeletal muscle metabolism, development and exercise physiology.</jats:p> |
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| author | Espelage, Lena, Al-Hasani, Hadi, Chadt, Alexandra |
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| description | <jats:p>The two closely related RabGAPs TBC1D1 and TBC1D4 are key signaling factors of skeletal muscle substrate utilization. In mice, deficiency in both RabGAPs leads to reduced skeletal muscle glucose transport in response to insulin and lower GLUT4 abundance. Conversely, <jats:italic>Tbc1d1</jats:italic> and <jats:italic>Tbc1d4</jats:italic> deficiency results in enhanced lipid use as fuel in skeletal muscle, through yet unknown mechanisms. In humans, variants in <jats:italic>TBC1D1</jats:italic> and <jats:italic>TBC1D4</jats:italic> are linked to obesity, insulin resistance and type 2 diabetes. While the specific function in metabolism of each of the two RabGAPs remains to be determined, TBC1D1 emerges to be controlling exercise endurance and physical capacity, whereas TBC1D4 may rather be responsible for maintaining muscle insulin sensitivity, muscle contraction, and exercise. There is growing evidence that TBC1D1 also plays an important role in skeletal muscle development, since it has been found to be associated to meat production traits in several livestock species. In addition, TBC1D1 protein abundance in skeletal muscle is regulated by both, insulin receptor and insulin-like growth factor-1 (IGF-1) receptor signaling. This review focuses on the specific roles of the two key signaling factors TBC1D1 and TBC1D4 in skeletal muscle metabolism, development and exercise physiology.</jats:p> |
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| spelling | Espelage, Lena Al-Hasani, Hadi Chadt, Alexandra 0952-5041 1479-6813 Bioscientifica Endocrinology Molecular Biology http://dx.doi.org/10.1530/jme-19-0143 <jats:p>The two closely related RabGAPs TBC1D1 and TBC1D4 are key signaling factors of skeletal muscle substrate utilization. In mice, deficiency in both RabGAPs leads to reduced skeletal muscle glucose transport in response to insulin and lower GLUT4 abundance. Conversely, <jats:italic>Tbc1d1</jats:italic> and <jats:italic>Tbc1d4</jats:italic> deficiency results in enhanced lipid use as fuel in skeletal muscle, through yet unknown mechanisms. In humans, variants in <jats:italic>TBC1D1</jats:italic> and <jats:italic>TBC1D4</jats:italic> are linked to obesity, insulin resistance and type 2 diabetes. While the specific function in metabolism of each of the two RabGAPs remains to be determined, TBC1D1 emerges to be controlling exercise endurance and physical capacity, whereas TBC1D4 may rather be responsible for maintaining muscle insulin sensitivity, muscle contraction, and exercise. There is growing evidence that TBC1D1 also plays an important role in skeletal muscle development, since it has been found to be associated to meat production traits in several livestock species. In addition, TBC1D1 protein abundance in skeletal muscle is regulated by both, insulin receptor and insulin-like growth factor-1 (IGF-1) receptor signaling. This review focuses on the specific roles of the two key signaling factors TBC1D1 and TBC1D4 in skeletal muscle metabolism, development and exercise physiology.</jats:p> RabGAPs in skeletal muscle function and exercise Journal of Molecular Endocrinology |
| spellingShingle | Espelage, Lena, Al-Hasani, Hadi, Chadt, Alexandra, Journal of Molecular Endocrinology, RabGAPs in skeletal muscle function and exercise, Endocrinology, Molecular Biology |
| title | RabGAPs in skeletal muscle function and exercise |
| title_full | RabGAPs in skeletal muscle function and exercise |
| title_fullStr | RabGAPs in skeletal muscle function and exercise |
| title_full_unstemmed | RabGAPs in skeletal muscle function and exercise |
| title_short | RabGAPs in skeletal muscle function and exercise |
| title_sort | rabgaps in skeletal muscle function and exercise |
| title_unstemmed | RabGAPs in skeletal muscle function and exercise |
| topic | Endocrinology, Molecular Biology |
| url | http://dx.doi.org/10.1530/jme-19-0143 |