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Specificity, propagation, and memory of pericentric heterochromatin
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| Zeitschriftentitel: | Molecular Systems Biology |
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| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Molecular Systems Biology, 10, 2014, 8 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Springer Science and Business Media LLC
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| Schlagwörter: |
| author_facet |
Müller‐Ott, Katharina Erdel, Fabian Matveeva, Anna Mallm, Jan‐Philipp Rademacher, Anne Hahn, Matthias Bauer, Caroline Zhang, Qin Kaltofen, Sabine Schotta, Gunnar Höfer, Thomas Rippe, Karsten Müller‐Ott, Katharina Erdel, Fabian Matveeva, Anna Mallm, Jan‐Philipp Rademacher, Anne Hahn, Matthias Bauer, Caroline Zhang, Qin Kaltofen, Sabine Schotta, Gunnar Höfer, Thomas Rippe, Karsten |
|---|---|
| author |
Müller‐Ott, Katharina Erdel, Fabian Matveeva, Anna Mallm, Jan‐Philipp Rademacher, Anne Hahn, Matthias Bauer, Caroline Zhang, Qin Kaltofen, Sabine Schotta, Gunnar Höfer, Thomas Rippe, Karsten |
| spellingShingle |
Müller‐Ott, Katharina Erdel, Fabian Matveeva, Anna Mallm, Jan‐Philipp Rademacher, Anne Hahn, Matthias Bauer, Caroline Zhang, Qin Kaltofen, Sabine Schotta, Gunnar Höfer, Thomas Rippe, Karsten Molecular Systems Biology Specificity, propagation, and memory of pericentric heterochromatin Applied Mathematics Computational Theory and Mathematics General Agricultural and Biological Sciences General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology Information Systems |
| author_sort |
müller‐ott, katharina |
| spelling |
Müller‐Ott, Katharina Erdel, Fabian Matveeva, Anna Mallm, Jan‐Philipp Rademacher, Anne Hahn, Matthias Bauer, Caroline Zhang, Qin Kaltofen, Sabine Schotta, Gunnar Höfer, Thomas Rippe, Karsten 1744-4292 1744-4292 Springer Science and Business Media LLC Applied Mathematics Computational Theory and Mathematics General Agricultural and Biological Sciences General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology Information Systems http://dx.doi.org/10.15252/msb.20145377 <jats:title>Abstract</jats:title><jats:p>The cell establishes heritable patterns of active and silenced chromatin via interacting factors that set, remove, and read epigenetic marks. To understand how the underlying networks operate, we have dissected transcriptional silencing in pericentric heterochromatin (<jats:styled-content style="fixed-case">PCH</jats:styled-content>) of mouse fibroblasts. We assembled a quantitative map for the abundance and interactions of 16 factors related to <jats:styled-content style="fixed-case">PCH</jats:styled-content> in living cells and found that stably bound complexes of the histone methyltransferase <jats:styled-content style="fixed-case">SUV</jats:styled-content>39H1/2 demarcate the <jats:styled-content style="fixed-case">PCH</jats:styled-content> state. From the experimental data, we developed a predictive mathematical model that explains how chromatin‐bound <jats:styled-content style="fixed-case">SUV</jats:styled-content>39<jats:styled-content style="fixed-case">H</jats:styled-content>1/2 complexes act as nucleation sites and propagate a spatially confined <jats:styled-content style="fixed-case">PCH</jats:styled-content> domain with elevated histone <jats:styled-content style="fixed-case">H</jats:styled-content>3 lysine 9 trimethylation levels via chromatin dynamics. This “nucleation and looping” mechanism is particularly robust toward transient perturbations and stably maintains the <jats:styled-content style="fixed-case">PCH</jats:styled-content> state. These features make it an attractive model for establishing functional epigenetic domains throughout the genome based on the localized immobilization of chromatin‐modifying enzymes.</jats:p> Specificity, propagation, and memory of pericentric heterochromatin Molecular Systems Biology |
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10.15252/msb.20145377 |
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Springer Science and Business Media LLC |
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Molecular Systems Biology |
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| title |
Specificity, propagation, and memory of pericentric heterochromatin |
| title_unstemmed |
Specificity, propagation, and memory of pericentric heterochromatin |
| title_full |
Specificity, propagation, and memory of pericentric heterochromatin |
| title_fullStr |
Specificity, propagation, and memory of pericentric heterochromatin |
| title_full_unstemmed |
Specificity, propagation, and memory of pericentric heterochromatin |
| title_short |
Specificity, propagation, and memory of pericentric heterochromatin |
| title_sort |
specificity, propagation, and memory of pericentric heterochromatin |
| topic |
Applied Mathematics Computational Theory and Mathematics General Agricultural and Biological Sciences General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology Information Systems |
| url |
http://dx.doi.org/10.15252/msb.20145377 |
| publishDate |
2014 |
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<jats:title>Abstract</jats:title><jats:p>The cell establishes heritable patterns of active and silenced chromatin via interacting factors that set, remove, and read epigenetic marks. To understand how the underlying networks operate, we have dissected transcriptional silencing in pericentric heterochromatin (<jats:styled-content style="fixed-case">PCH</jats:styled-content>) of mouse fibroblasts. We assembled a quantitative map for the abundance and interactions of 16 factors related to <jats:styled-content style="fixed-case">PCH</jats:styled-content> in living cells and found that stably bound complexes of the histone methyltransferase <jats:styled-content style="fixed-case">SUV</jats:styled-content>39H1/2 demarcate the <jats:styled-content style="fixed-case">PCH</jats:styled-content> state. From the experimental data, we developed a predictive mathematical model that explains how chromatin‐bound <jats:styled-content style="fixed-case">SUV</jats:styled-content>39<jats:styled-content style="fixed-case">H</jats:styled-content>1/2 complexes act as nucleation sites and propagate a spatially confined <jats:styled-content style="fixed-case">PCH</jats:styled-content> domain with elevated histone <jats:styled-content style="fixed-case">H</jats:styled-content>3 lysine 9 trimethylation levels via chromatin dynamics. This “nucleation and looping” mechanism is particularly robust toward transient perturbations and stably maintains the <jats:styled-content style="fixed-case">PCH</jats:styled-content> state. These features make it an attractive model for establishing functional epigenetic domains throughout the genome based on the localized immobilization of chromatin‐modifying enzymes.</jats:p> |
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| author | Müller‐Ott, Katharina, Erdel, Fabian, Matveeva, Anna, Mallm, Jan‐Philipp, Rademacher, Anne, Hahn, Matthias, Bauer, Caroline, Zhang, Qin, Kaltofen, Sabine, Schotta, Gunnar, Höfer, Thomas, Rippe, Karsten |
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| description | <jats:title>Abstract</jats:title><jats:p>The cell establishes heritable patterns of active and silenced chromatin via interacting factors that set, remove, and read epigenetic marks. To understand how the underlying networks operate, we have dissected transcriptional silencing in pericentric heterochromatin (<jats:styled-content style="fixed-case">PCH</jats:styled-content>) of mouse fibroblasts. We assembled a quantitative map for the abundance and interactions of 16 factors related to <jats:styled-content style="fixed-case">PCH</jats:styled-content> in living cells and found that stably bound complexes of the histone methyltransferase <jats:styled-content style="fixed-case">SUV</jats:styled-content>39H1/2 demarcate the <jats:styled-content style="fixed-case">PCH</jats:styled-content> state. From the experimental data, we developed a predictive mathematical model that explains how chromatin‐bound <jats:styled-content style="fixed-case">SUV</jats:styled-content>39<jats:styled-content style="fixed-case">H</jats:styled-content>1/2 complexes act as nucleation sites and propagate a spatially confined <jats:styled-content style="fixed-case">PCH</jats:styled-content> domain with elevated histone <jats:styled-content style="fixed-case">H</jats:styled-content>3 lysine 9 trimethylation levels via chromatin dynamics. This “nucleation and looping” mechanism is particularly robust toward transient perturbations and stably maintains the <jats:styled-content style="fixed-case">PCH</jats:styled-content> state. These features make it an attractive model for establishing functional epigenetic domains throughout the genome based on the localized immobilization of chromatin‐modifying enzymes.</jats:p> |
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| spelling | Müller‐Ott, Katharina Erdel, Fabian Matveeva, Anna Mallm, Jan‐Philipp Rademacher, Anne Hahn, Matthias Bauer, Caroline Zhang, Qin Kaltofen, Sabine Schotta, Gunnar Höfer, Thomas Rippe, Karsten 1744-4292 1744-4292 Springer Science and Business Media LLC Applied Mathematics Computational Theory and Mathematics General Agricultural and Biological Sciences General Immunology and Microbiology General Biochemistry, Genetics and Molecular Biology Information Systems http://dx.doi.org/10.15252/msb.20145377 <jats:title>Abstract</jats:title><jats:p>The cell establishes heritable patterns of active and silenced chromatin via interacting factors that set, remove, and read epigenetic marks. To understand how the underlying networks operate, we have dissected transcriptional silencing in pericentric heterochromatin (<jats:styled-content style="fixed-case">PCH</jats:styled-content>) of mouse fibroblasts. We assembled a quantitative map for the abundance and interactions of 16 factors related to <jats:styled-content style="fixed-case">PCH</jats:styled-content> in living cells and found that stably bound complexes of the histone methyltransferase <jats:styled-content style="fixed-case">SUV</jats:styled-content>39H1/2 demarcate the <jats:styled-content style="fixed-case">PCH</jats:styled-content> state. From the experimental data, we developed a predictive mathematical model that explains how chromatin‐bound <jats:styled-content style="fixed-case">SUV</jats:styled-content>39<jats:styled-content style="fixed-case">H</jats:styled-content>1/2 complexes act as nucleation sites and propagate a spatially confined <jats:styled-content style="fixed-case">PCH</jats:styled-content> domain with elevated histone <jats:styled-content style="fixed-case">H</jats:styled-content>3 lysine 9 trimethylation levels via chromatin dynamics. This “nucleation and looping” mechanism is particularly robust toward transient perturbations and stably maintains the <jats:styled-content style="fixed-case">PCH</jats:styled-content> state. These features make it an attractive model for establishing functional epigenetic domains throughout the genome based on the localized immobilization of chromatin‐modifying enzymes.</jats:p> Specificity, propagation, and memory of pericentric heterochromatin Molecular Systems Biology |
| spellingShingle | Müller‐Ott, Katharina, Erdel, Fabian, Matveeva, Anna, Mallm, Jan‐Philipp, Rademacher, Anne, Hahn, Matthias, Bauer, Caroline, Zhang, Qin, Kaltofen, Sabine, Schotta, Gunnar, Höfer, Thomas, Rippe, Karsten, Molecular Systems Biology, Specificity, propagation, and memory of pericentric heterochromatin, Applied Mathematics, Computational Theory and Mathematics, General Agricultural and Biological Sciences, General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, Information Systems |
| title | Specificity, propagation, and memory of pericentric heterochromatin |
| title_full | Specificity, propagation, and memory of pericentric heterochromatin |
| title_fullStr | Specificity, propagation, and memory of pericentric heterochromatin |
| title_full_unstemmed | Specificity, propagation, and memory of pericentric heterochromatin |
| title_short | Specificity, propagation, and memory of pericentric heterochromatin |
| title_sort | specificity, propagation, and memory of pericentric heterochromatin |
| title_unstemmed | Specificity, propagation, and memory of pericentric heterochromatin |
| topic | Applied Mathematics, Computational Theory and Mathematics, General Agricultural and Biological Sciences, General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, Information Systems |
| url | http://dx.doi.org/10.15252/msb.20145377 |