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Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats
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| Zeitschriftentitel: | The Journal of Neuroscience |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | The Journal of Neuroscience, 25, 2005, 18, S. 4550-4559 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Society for Neuroscience
|
| Schlagwörter: |
| author_facet |
Choi, Howard Liao, Wei-Lee Newton, Kimberly M. Onario, Renna C. King, Allyson M. Desilets, Federico C. Woodard, Eric J. Eichler, Marc E. Frontera, Walter R. Sabharwal, Sunil Teng, Yang D. Choi, Howard Liao, Wei-Lee Newton, Kimberly M. Onario, Renna C. King, Allyson M. Desilets, Federico C. Woodard, Eric J. Eichler, Marc E. Frontera, Walter R. Sabharwal, Sunil Teng, Yang D. |
|---|---|
| author |
Choi, Howard Liao, Wei-Lee Newton, Kimberly M. Onario, Renna C. King, Allyson M. Desilets, Federico C. Woodard, Eric J. Eichler, Marc E. Frontera, Walter R. Sabharwal, Sunil Teng, Yang D. |
| spellingShingle |
Choi, Howard Liao, Wei-Lee Newton, Kimberly M. Onario, Renna C. King, Allyson M. Desilets, Federico C. Woodard, Eric J. Eichler, Marc E. Frontera, Walter R. Sabharwal, Sunil Teng, Yang D. The Journal of Neuroscience Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats General Neuroscience |
| author_sort |
choi, howard |
| spelling |
Choi, Howard Liao, Wei-Lee Newton, Kimberly M. Onario, Renna C. King, Allyson M. Desilets, Federico C. Woodard, Eric J. Eichler, Marc E. Frontera, Walter R. Sabharwal, Sunil Teng, Yang D. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.5135-04.2005 <jats:p>Respiratory dysfunction after cervical spinal cord injury (SCI) has not been examined experimentally using conscious animals, although clinical SCI most frequently occurs in midcervical segments. Here, we report a C5 hemicontusion SCI model in rats with abnormalities that emulate human post-SCI pathophysiology, including spontaneous recovery processes. Post-C5 SCI rats demonstrated deficits in minute ventilation (Ve) responses to a 7% CO<jats:sub>2</jats:sub>challenge that correlated significantly with lesion severities (no injury or 12.5, 25, or 50 mm × 10 g weight drop; New York University impactor;<jats:italic>p</jats:italic>< 0.001) and ipsilateral motor neuron loss (<jats:italic>p</jats:italic>= 0.016). Importantly, C5 SCI resulted in at least 4 weeks of respiratory abnormalities that ultimately recovered afterward. Because serotonin is involved in respiration-related neuroplasticity, we investigated the impact of activating 5-HT<jats:sub>1A</jats:sub>receptors on post-C5 SCI respiratory dysfunction. Treatment with the 5-HT<jats:sub>1A</jats:sub>agonist 8-hydroxy-2-(di-<jats:italic>n</jats:italic>-propylmino)tetralin (8-OH DPAT) (250 μg/kg, i.p.) restored hypercapnic Ve at 2 and 4 weeks after injury (i.e., ∼39.2% increase vs post-SCI baseline;<jats:italic>p</jats:italic>≤ 0.033). Improvements in hypercapnic Ve response after single administration of 8-OH DPAT were dose dependent and lasted for ∼4 h(<jats:italic>p</jats:italic>≤ 0.038 and<jats:italic>p</jats:italic>≤ 0.024, respectively). Treatment with another 5-HT<jats:sub>1A</jats:sub>receptor agonist, buspirone (1.5 mg/kg, i.p.), replicated the results, whereas pretreatment with a 5-HT<jats:sub>1A</jats:sub>-specific antagonist, 4-iodo-<jats:italic>N</jats:italic>-[2-[4(methoxyphenyl)-1-piperazinyl]ethyl]-<jats:italic>N</jats:italic>-2-pyridinyl-benzamide (3 mg/kg, i.p.) given 20 min before 8-OH DPAT negated the effect of 8-OH DPAT. These results imply a potential clinical use of 5-HT<jats:sub>1A</jats:sub>agonists for post-SCI respiratory disorders.</jats:p> Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats The Journal of Neuroscience |
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| title |
Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats |
| title_unstemmed |
Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats |
| title_full |
Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats |
| title_fullStr |
Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats |
| title_full_unstemmed |
Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats |
| title_short |
Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats |
| title_sort |
respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1a agonists in conscious rats |
| topic |
General Neuroscience |
| url |
http://dx.doi.org/10.1523/jneurosci.5135-04.2005 |
| publishDate |
2005 |
| physical |
4550-4559 |
| description |
<jats:p>Respiratory dysfunction after cervical spinal cord injury (SCI) has not been examined experimentally using conscious animals, although clinical SCI most frequently occurs in midcervical segments. Here, we report a C5 hemicontusion SCI model in rats with abnormalities that emulate human post-SCI pathophysiology, including spontaneous recovery processes. Post-C5 SCI rats demonstrated deficits in minute ventilation (Ve) responses to a 7% CO<jats:sub>2</jats:sub>challenge that correlated significantly with lesion severities (no injury or 12.5, 25, or 50 mm × 10 g weight drop; New York University impactor;<jats:italic>p</jats:italic>< 0.001) and ipsilateral motor neuron loss (<jats:italic>p</jats:italic>= 0.016). Importantly, C5 SCI resulted in at least 4 weeks of respiratory abnormalities that ultimately recovered afterward. Because serotonin is involved in respiration-related neuroplasticity, we investigated the impact of activating 5-HT<jats:sub>1A</jats:sub>receptors on post-C5 SCI respiratory dysfunction. Treatment with the 5-HT<jats:sub>1A</jats:sub>agonist 8-hydroxy-2-(di-<jats:italic>n</jats:italic>-propylmino)tetralin (8-OH DPAT) (250 μg/kg, i.p.) restored hypercapnic Ve at 2 and 4 weeks after injury (i.e., ∼39.2% increase vs post-SCI baseline;<jats:italic>p</jats:italic>≤ 0.033). Improvements in hypercapnic Ve response after single administration of 8-OH DPAT were dose dependent and lasted for ∼4 h(<jats:italic>p</jats:italic>≤ 0.038 and<jats:italic>p</jats:italic>≤ 0.024, respectively). Treatment with another 5-HT<jats:sub>1A</jats:sub>receptor agonist, buspirone (1.5 mg/kg, i.p.), replicated the results, whereas pretreatment with a 5-HT<jats:sub>1A</jats:sub>-specific antagonist, 4-iodo-<jats:italic>N</jats:italic>-[2-[4(methoxyphenyl)-1-piperazinyl]ethyl]-<jats:italic>N</jats:italic>-2-pyridinyl-benzamide (3 mg/kg, i.p.) given 20 min before 8-OH DPAT negated the effect of 8-OH DPAT. These results imply a potential clinical use of 5-HT<jats:sub>1A</jats:sub>agonists for post-SCI respiratory disorders.</jats:p> |
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| author | Choi, Howard, Liao, Wei-Lee, Newton, Kimberly M., Onario, Renna C., King, Allyson M., Desilets, Federico C., Woodard, Eric J., Eichler, Marc E., Frontera, Walter R., Sabharwal, Sunil, Teng, Yang D. |
| author_facet | Choi, Howard, Liao, Wei-Lee, Newton, Kimberly M., Onario, Renna C., King, Allyson M., Desilets, Federico C., Woodard, Eric J., Eichler, Marc E., Frontera, Walter R., Sabharwal, Sunil, Teng, Yang D., Choi, Howard, Liao, Wei-Lee, Newton, Kimberly M., Onario, Renna C., King, Allyson M., Desilets, Federico C., Woodard, Eric J., Eichler, Marc E., Frontera, Walter R., Sabharwal, Sunil, Teng, Yang D. |
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| description | <jats:p>Respiratory dysfunction after cervical spinal cord injury (SCI) has not been examined experimentally using conscious animals, although clinical SCI most frequently occurs in midcervical segments. Here, we report a C5 hemicontusion SCI model in rats with abnormalities that emulate human post-SCI pathophysiology, including spontaneous recovery processes. Post-C5 SCI rats demonstrated deficits in minute ventilation (Ve) responses to a 7% CO<jats:sub>2</jats:sub>challenge that correlated significantly with lesion severities (no injury or 12.5, 25, or 50 mm × 10 g weight drop; New York University impactor;<jats:italic>p</jats:italic>< 0.001) and ipsilateral motor neuron loss (<jats:italic>p</jats:italic>= 0.016). Importantly, C5 SCI resulted in at least 4 weeks of respiratory abnormalities that ultimately recovered afterward. Because serotonin is involved in respiration-related neuroplasticity, we investigated the impact of activating 5-HT<jats:sub>1A</jats:sub>receptors on post-C5 SCI respiratory dysfunction. Treatment with the 5-HT<jats:sub>1A</jats:sub>agonist 8-hydroxy-2-(di-<jats:italic>n</jats:italic>-propylmino)tetralin (8-OH DPAT) (250 μg/kg, i.p.) restored hypercapnic Ve at 2 and 4 weeks after injury (i.e., ∼39.2% increase vs post-SCI baseline;<jats:italic>p</jats:italic>≤ 0.033). Improvements in hypercapnic Ve response after single administration of 8-OH DPAT were dose dependent and lasted for ∼4 h(<jats:italic>p</jats:italic>≤ 0.038 and<jats:italic>p</jats:italic>≤ 0.024, respectively). Treatment with another 5-HT<jats:sub>1A</jats:sub>receptor agonist, buspirone (1.5 mg/kg, i.p.), replicated the results, whereas pretreatment with a 5-HT<jats:sub>1A</jats:sub>-specific antagonist, 4-iodo-<jats:italic>N</jats:italic>-[2-[4(methoxyphenyl)-1-piperazinyl]ethyl]-<jats:italic>N</jats:italic>-2-pyridinyl-benzamide (3 mg/kg, i.p.) given 20 min before 8-OH DPAT negated the effect of 8-OH DPAT. These results imply a potential clinical use of 5-HT<jats:sub>1A</jats:sub>agonists for post-SCI respiratory disorders.</jats:p> |
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| spelling | Choi, Howard Liao, Wei-Lee Newton, Kimberly M. Onario, Renna C. King, Allyson M. Desilets, Federico C. Woodard, Eric J. Eichler, Marc E. Frontera, Walter R. Sabharwal, Sunil Teng, Yang D. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.5135-04.2005 <jats:p>Respiratory dysfunction after cervical spinal cord injury (SCI) has not been examined experimentally using conscious animals, although clinical SCI most frequently occurs in midcervical segments. Here, we report a C5 hemicontusion SCI model in rats with abnormalities that emulate human post-SCI pathophysiology, including spontaneous recovery processes. Post-C5 SCI rats demonstrated deficits in minute ventilation (Ve) responses to a 7% CO<jats:sub>2</jats:sub>challenge that correlated significantly with lesion severities (no injury or 12.5, 25, or 50 mm × 10 g weight drop; New York University impactor;<jats:italic>p</jats:italic>< 0.001) and ipsilateral motor neuron loss (<jats:italic>p</jats:italic>= 0.016). Importantly, C5 SCI resulted in at least 4 weeks of respiratory abnormalities that ultimately recovered afterward. Because serotonin is involved in respiration-related neuroplasticity, we investigated the impact of activating 5-HT<jats:sub>1A</jats:sub>receptors on post-C5 SCI respiratory dysfunction. Treatment with the 5-HT<jats:sub>1A</jats:sub>agonist 8-hydroxy-2-(di-<jats:italic>n</jats:italic>-propylmino)tetralin (8-OH DPAT) (250 μg/kg, i.p.) restored hypercapnic Ve at 2 and 4 weeks after injury (i.e., ∼39.2% increase vs post-SCI baseline;<jats:italic>p</jats:italic>≤ 0.033). Improvements in hypercapnic Ve response after single administration of 8-OH DPAT were dose dependent and lasted for ∼4 h(<jats:italic>p</jats:italic>≤ 0.038 and<jats:italic>p</jats:italic>≤ 0.024, respectively). Treatment with another 5-HT<jats:sub>1A</jats:sub>receptor agonist, buspirone (1.5 mg/kg, i.p.), replicated the results, whereas pretreatment with a 5-HT<jats:sub>1A</jats:sub>-specific antagonist, 4-iodo-<jats:italic>N</jats:italic>-[2-[4(methoxyphenyl)-1-piperazinyl]ethyl]-<jats:italic>N</jats:italic>-2-pyridinyl-benzamide (3 mg/kg, i.p.) given 20 min before 8-OH DPAT negated the effect of 8-OH DPAT. These results imply a potential clinical use of 5-HT<jats:sub>1A</jats:sub>agonists for post-SCI respiratory disorders.</jats:p> Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats The Journal of Neuroscience |
| spellingShingle | Choi, Howard, Liao, Wei-Lee, Newton, Kimberly M., Onario, Renna C., King, Allyson M., Desilets, Federico C., Woodard, Eric J., Eichler, Marc E., Frontera, Walter R., Sabharwal, Sunil, Teng, Yang D., The Journal of Neuroscience, Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats, General Neuroscience |
| title | Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats |
| title_full | Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats |
| title_fullStr | Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats |
| title_full_unstemmed | Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats |
| title_short | Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats |
| title_sort | respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1a agonists in conscious rats |
| title_unstemmed | Respiratory Abnormalities Resulting from Midcervical Spinal Cord Injury and their Reversal by Serotonin 1A Agonists in Conscious Rats |
| topic | General Neuroscience |
| url | http://dx.doi.org/10.1523/jneurosci.5135-04.2005 |