Eintrag weiter verarbeiten
Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation
Gespeichert in:
| Zeitschriftentitel: | The Journal of Neuroscience |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | The Journal of Neuroscience, 25, 2005, 18, S. 4463-4472 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Society for Neuroscience
|
| Schlagwörter: |
| author_facet |
Yu, Wei-Ming Feltri, M. Laura Wrabetz, Lawrence Strickland, Sidney Chen, Zu-Lin Yu, Wei-Ming Feltri, M. Laura Wrabetz, Lawrence Strickland, Sidney Chen, Zu-Lin |
|---|---|
| author |
Yu, Wei-Ming Feltri, M. Laura Wrabetz, Lawrence Strickland, Sidney Chen, Zu-Lin |
| spellingShingle |
Yu, Wei-Ming Feltri, M. Laura Wrabetz, Lawrence Strickland, Sidney Chen, Zu-Lin The Journal of Neuroscience Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation General Neuroscience |
| author_sort |
yu, wei-ming |
| spelling |
Yu, Wei-Ming Feltri, M. Laura Wrabetz, Lawrence Strickland, Sidney Chen, Zu-Lin 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.5032-04.2005 <jats:p>To investigate the function of laminin in peripheral nerve development, we specifically disrupted the<jats:italic>laminin</jats:italic>γ<jats:italic>1</jats:italic>gene in Schwann cells. Disruption of<jats:italic>laminin</jats:italic>γ<jats:italic>1</jats:italic>gene expression resulted in depletion of all other laminin chains known to be expressed in Schwann cells. Schwann cells lacking laminin do not extend processes required for initiating axonal sorting and mediating axon-Schwann cell interaction. They fail to downregulate Oct-6 and arrest at the premyelinating stage. The impaired axon-Schwann cell interaction prevents phosphorylation of β-neuregulin-1 receptors and results in decreased cell proliferation. Postnatally, laminin-null Schwann cells exhibit reduced phosphatidylinositol 3 (PI3)-kinase activity and activation of caspase cascades, leading to apoptosis. Injection of a laminin peptide into mutant sciatic nerves partially restores PI3-kinase activity and reduces apoptotic signals. These results demonstrate the following: (1) that laminin initiates axonal sorting and mediates axon-Schwann cell interactions required for Schwann cell proliferation and differentiation, and (2) that laminin provides a PI3-kinase/Akt-mediated Schwann cell survival signal.</jats:p> Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation The Journal of Neuroscience |
| doi_str_mv |
10.1523/jneurosci.5032-04.2005 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUyMy9qbmV1cm9zY2kuNTAzMi0wNC4yMDA1 |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUyMy9qbmV1cm9zY2kuNTAzMi0wNC4yMDA1 |
| institution |
DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 |
| imprint |
Society for Neuroscience, 2005 |
| imprint_str_mv |
Society for Neuroscience, 2005 |
| issn |
0270-6474 1529-2401 |
| issn_str_mv |
0270-6474 1529-2401 |
| language |
English |
| mega_collection |
Society for Neuroscience (CrossRef) |
| match_str |
yu2005schwanncellspecificablationoflamining1causesapoptosisandpreventsproliferation |
| publishDateSort |
2005 |
| publisher |
Society for Neuroscience |
| recordtype |
ai |
| record_format |
ai |
| series |
The Journal of Neuroscience |
| source_id |
49 |
| title |
Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation |
| title_unstemmed |
Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation |
| title_full |
Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation |
| title_fullStr |
Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation |
| title_full_unstemmed |
Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation |
| title_short |
Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation |
| title_sort |
schwann cell-specific ablation of laminin γ1 causes apoptosis and prevents proliferation |
| topic |
General Neuroscience |
| url |
http://dx.doi.org/10.1523/jneurosci.5032-04.2005 |
| publishDate |
2005 |
| physical |
4463-4472 |
| description |
<jats:p>To investigate the function of laminin in peripheral nerve development, we specifically disrupted the<jats:italic>laminin</jats:italic>γ<jats:italic>1</jats:italic>gene in Schwann cells. Disruption of<jats:italic>laminin</jats:italic>γ<jats:italic>1</jats:italic>gene expression resulted in depletion of all other laminin chains known to be expressed in Schwann cells. Schwann cells lacking laminin do not extend processes required for initiating axonal sorting and mediating axon-Schwann cell interaction. They fail to downregulate Oct-6 and arrest at the premyelinating stage. The impaired axon-Schwann cell interaction prevents phosphorylation of β-neuregulin-1 receptors and results in decreased cell proliferation. Postnatally, laminin-null Schwann cells exhibit reduced phosphatidylinositol 3 (PI3)-kinase activity and activation of caspase cascades, leading to apoptosis. Injection of a laminin peptide into mutant sciatic nerves partially restores PI3-kinase activity and reduces apoptotic signals. These results demonstrate the following: (1) that laminin initiates axonal sorting and mediates axon-Schwann cell interactions required for Schwann cell proliferation and differentiation, and (2) that laminin provides a PI3-kinase/Akt-mediated Schwann cell survival signal.</jats:p> |
| container_issue |
18 |
| container_start_page |
4463 |
| container_title |
The Journal of Neuroscience |
| container_volume |
25 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792345398820470790 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:22:33.999Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Schwann+Cell-Specific+Ablation+of+Laminin+%CE%B31+Causes+Apoptosis+and+Prevents+Proliferation&rft.date=2005-05-04&genre=article&issn=1529-2401&volume=25&issue=18&spage=4463&epage=4472&pages=4463-4472&jtitle=The+Journal+of+Neuroscience&atitle=Schwann+Cell-Specific+Ablation+of+Laminin+%CE%B31+Causes+Apoptosis+and+Prevents+Proliferation&aulast=Chen&aufirst=Zu-Lin&rft_id=info%3Adoi%2F10.1523%2Fjneurosci.5032-04.2005&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792345398820470790 |
| author | Yu, Wei-Ming, Feltri, M. Laura, Wrabetz, Lawrence, Strickland, Sidney, Chen, Zu-Lin |
| author_facet | Yu, Wei-Ming, Feltri, M. Laura, Wrabetz, Lawrence, Strickland, Sidney, Chen, Zu-Lin, Yu, Wei-Ming, Feltri, M. Laura, Wrabetz, Lawrence, Strickland, Sidney, Chen, Zu-Lin |
| author_sort | yu, wei-ming |
| container_issue | 18 |
| container_start_page | 4463 |
| container_title | The Journal of Neuroscience |
| container_volume | 25 |
| description | <jats:p>To investigate the function of laminin in peripheral nerve development, we specifically disrupted the<jats:italic>laminin</jats:italic>γ<jats:italic>1</jats:italic>gene in Schwann cells. Disruption of<jats:italic>laminin</jats:italic>γ<jats:italic>1</jats:italic>gene expression resulted in depletion of all other laminin chains known to be expressed in Schwann cells. Schwann cells lacking laminin do not extend processes required for initiating axonal sorting and mediating axon-Schwann cell interaction. They fail to downregulate Oct-6 and arrest at the premyelinating stage. The impaired axon-Schwann cell interaction prevents phosphorylation of β-neuregulin-1 receptors and results in decreased cell proliferation. Postnatally, laminin-null Schwann cells exhibit reduced phosphatidylinositol 3 (PI3)-kinase activity and activation of caspase cascades, leading to apoptosis. Injection of a laminin peptide into mutant sciatic nerves partially restores PI3-kinase activity and reduces apoptotic signals. These results demonstrate the following: (1) that laminin initiates axonal sorting and mediates axon-Schwann cell interactions required for Schwann cell proliferation and differentiation, and (2) that laminin provides a PI3-kinase/Akt-mediated Schwann cell survival signal.</jats:p> |
| doi_str_mv | 10.1523/jneurosci.5032-04.2005 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUyMy9qbmV1cm9zY2kuNTAzMi0wNC4yMDA1 |
| imprint | Society for Neuroscience, 2005 |
| imprint_str_mv | Society for Neuroscience, 2005 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1 |
| issn | 0270-6474, 1529-2401 |
| issn_str_mv | 0270-6474, 1529-2401 |
| language | English |
| last_indexed | 2024-03-01T17:22:33.999Z |
| match_str | yu2005schwanncellspecificablationoflamining1causesapoptosisandpreventsproliferation |
| mega_collection | Society for Neuroscience (CrossRef) |
| physical | 4463-4472 |
| publishDate | 2005 |
| publishDateSort | 2005 |
| publisher | Society for Neuroscience |
| record_format | ai |
| recordtype | ai |
| series | The Journal of Neuroscience |
| source_id | 49 |
| spelling | Yu, Wei-Ming Feltri, M. Laura Wrabetz, Lawrence Strickland, Sidney Chen, Zu-Lin 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.5032-04.2005 <jats:p>To investigate the function of laminin in peripheral nerve development, we specifically disrupted the<jats:italic>laminin</jats:italic>γ<jats:italic>1</jats:italic>gene in Schwann cells. Disruption of<jats:italic>laminin</jats:italic>γ<jats:italic>1</jats:italic>gene expression resulted in depletion of all other laminin chains known to be expressed in Schwann cells. Schwann cells lacking laminin do not extend processes required for initiating axonal sorting and mediating axon-Schwann cell interaction. They fail to downregulate Oct-6 and arrest at the premyelinating stage. The impaired axon-Schwann cell interaction prevents phosphorylation of β-neuregulin-1 receptors and results in decreased cell proliferation. Postnatally, laminin-null Schwann cells exhibit reduced phosphatidylinositol 3 (PI3)-kinase activity and activation of caspase cascades, leading to apoptosis. Injection of a laminin peptide into mutant sciatic nerves partially restores PI3-kinase activity and reduces apoptotic signals. These results demonstrate the following: (1) that laminin initiates axonal sorting and mediates axon-Schwann cell interactions required for Schwann cell proliferation and differentiation, and (2) that laminin provides a PI3-kinase/Akt-mediated Schwann cell survival signal.</jats:p> Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation The Journal of Neuroscience |
| spellingShingle | Yu, Wei-Ming, Feltri, M. Laura, Wrabetz, Lawrence, Strickland, Sidney, Chen, Zu-Lin, The Journal of Neuroscience, Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation, General Neuroscience |
| title | Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation |
| title_full | Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation |
| title_fullStr | Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation |
| title_full_unstemmed | Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation |
| title_short | Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation |
| title_sort | schwann cell-specific ablation of laminin γ1 causes apoptosis and prevents proliferation |
| title_unstemmed | Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation |
| topic | General Neuroscience |
| url | http://dx.doi.org/10.1523/jneurosci.5032-04.2005 |