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Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus
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| Zeitschriftentitel: | The Journal of Neuroscience |
|---|---|
| Personen und Körperschaften: | , |
| In: | The Journal of Neuroscience, 35, 2015, 11, S. 4540-4551 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Society for Neuroscience
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| Schlagwörter: |
| author_facet |
Tang, Zheng-Quan Trussell, Laurence O. Tang, Zheng-Quan Trussell, Laurence O. |
|---|---|
| author |
Tang, Zheng-Quan Trussell, Laurence O. |
| spellingShingle |
Tang, Zheng-Quan Trussell, Laurence O. The Journal of Neuroscience Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus General Neuroscience |
| author_sort |
tang, zheng-quan |
| spelling |
Tang, Zheng-Quan Trussell, Laurence O. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.4825-14.2015 <jats:p>The dorsal cochlear nucleus (DCN) is one of the first stations within the central auditory pathway where the basic computations underlying sound localization are initiated and heightened activity in the DCN may underlie central tinnitus. The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT), is associated with many distinct behavioral or cognitive states, and serotonergic fibers are concentrated in the DCN. However, it remains unclear what is the function of this dense input. Using a combination of<jats:italic>in vitro</jats:italic>electrophysiology and optogenetics in mouse brain slices, we found that 5-HT directly enhances the excitability of fusiform principal cells via activation of two distinct 5-HT receptor subfamilies, 5-HT<jats:sub>2A/2C</jats:sub>R (5-HT<jats:sub>2A/2C</jats:sub>receptor) and 5-HT<jats:sub>7</jats:sub>R (5-HT<jats:sub>7</jats:sub>receptor). This excitatory effect results from an augmentation of hyperpolarization-activated cyclic nucleotide-gated channels (<jats:italic>I</jats:italic><jats:sub>h</jats:sub>or HCN channels). The serotonergic regulation of excitability is G-protein-dependent and involves cAMP and Src kinase signaling pathways. Moreover, optogenetic activation of serotonergic axon terminals increased excitability of fusiform cells. Our findings reveal that 5-HT exerts a potent influence on fusiform cells by altering their intrinsic properties, which may enhance the sensitivity of the DCN to sensory input.</jats:p> Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus The Journal of Neuroscience |
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The Journal of Neuroscience |
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| title |
Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus |
| title_unstemmed |
Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus |
| title_full |
Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus |
| title_fullStr |
Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus |
| title_full_unstemmed |
Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus |
| title_short |
Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus |
| title_sort |
serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus |
| topic |
General Neuroscience |
| url |
http://dx.doi.org/10.1523/jneurosci.4825-14.2015 |
| publishDate |
2015 |
| physical |
4540-4551 |
| description |
<jats:p>The dorsal cochlear nucleus (DCN) is one of the first stations within the central auditory pathway where the basic computations underlying sound localization are initiated and heightened activity in the DCN may underlie central tinnitus. The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT), is associated with many distinct behavioral or cognitive states, and serotonergic fibers are concentrated in the DCN. However, it remains unclear what is the function of this dense input. Using a combination of<jats:italic>in vitro</jats:italic>electrophysiology and optogenetics in mouse brain slices, we found that 5-HT directly enhances the excitability of fusiform principal cells via activation of two distinct 5-HT receptor subfamilies, 5-HT<jats:sub>2A/2C</jats:sub>R (5-HT<jats:sub>2A/2C</jats:sub>receptor) and 5-HT<jats:sub>7</jats:sub>R (5-HT<jats:sub>7</jats:sub>receptor). This excitatory effect results from an augmentation of hyperpolarization-activated cyclic nucleotide-gated channels (<jats:italic>I</jats:italic><jats:sub>h</jats:sub>or HCN channels). The serotonergic regulation of excitability is G-protein-dependent and involves cAMP and Src kinase signaling pathways. Moreover, optogenetic activation of serotonergic axon terminals increased excitability of fusiform cells. Our findings reveal that 5-HT exerts a potent influence on fusiform cells by altering their intrinsic properties, which may enhance the sensitivity of the DCN to sensory input.</jats:p> |
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| author | Tang, Zheng-Quan, Trussell, Laurence O. |
| author_facet | Tang, Zheng-Quan, Trussell, Laurence O., Tang, Zheng-Quan, Trussell, Laurence O. |
| author_sort | tang, zheng-quan |
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| container_start_page | 4540 |
| container_title | The Journal of Neuroscience |
| container_volume | 35 |
| description | <jats:p>The dorsal cochlear nucleus (DCN) is one of the first stations within the central auditory pathway where the basic computations underlying sound localization are initiated and heightened activity in the DCN may underlie central tinnitus. The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT), is associated with many distinct behavioral or cognitive states, and serotonergic fibers are concentrated in the DCN. However, it remains unclear what is the function of this dense input. Using a combination of<jats:italic>in vitro</jats:italic>electrophysiology and optogenetics in mouse brain slices, we found that 5-HT directly enhances the excitability of fusiform principal cells via activation of two distinct 5-HT receptor subfamilies, 5-HT<jats:sub>2A/2C</jats:sub>R (5-HT<jats:sub>2A/2C</jats:sub>receptor) and 5-HT<jats:sub>7</jats:sub>R (5-HT<jats:sub>7</jats:sub>receptor). This excitatory effect results from an augmentation of hyperpolarization-activated cyclic nucleotide-gated channels (<jats:italic>I</jats:italic><jats:sub>h</jats:sub>or HCN channels). The serotonergic regulation of excitability is G-protein-dependent and involves cAMP and Src kinase signaling pathways. Moreover, optogenetic activation of serotonergic axon terminals increased excitability of fusiform cells. Our findings reveal that 5-HT exerts a potent influence on fusiform cells by altering their intrinsic properties, which may enhance the sensitivity of the DCN to sensory input.</jats:p> |
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| imprint_str_mv | Society for Neuroscience, 2015 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229 |
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| last_indexed | 2024-03-01T18:01:29.548Z |
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| series | The Journal of Neuroscience |
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| spelling | Tang, Zheng-Quan Trussell, Laurence O. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.4825-14.2015 <jats:p>The dorsal cochlear nucleus (DCN) is one of the first stations within the central auditory pathway where the basic computations underlying sound localization are initiated and heightened activity in the DCN may underlie central tinnitus. The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT), is associated with many distinct behavioral or cognitive states, and serotonergic fibers are concentrated in the DCN. However, it remains unclear what is the function of this dense input. Using a combination of<jats:italic>in vitro</jats:italic>electrophysiology and optogenetics in mouse brain slices, we found that 5-HT directly enhances the excitability of fusiform principal cells via activation of two distinct 5-HT receptor subfamilies, 5-HT<jats:sub>2A/2C</jats:sub>R (5-HT<jats:sub>2A/2C</jats:sub>receptor) and 5-HT<jats:sub>7</jats:sub>R (5-HT<jats:sub>7</jats:sub>receptor). This excitatory effect results from an augmentation of hyperpolarization-activated cyclic nucleotide-gated channels (<jats:italic>I</jats:italic><jats:sub>h</jats:sub>or HCN channels). The serotonergic regulation of excitability is G-protein-dependent and involves cAMP and Src kinase signaling pathways. Moreover, optogenetic activation of serotonergic axon terminals increased excitability of fusiform cells. Our findings reveal that 5-HT exerts a potent influence on fusiform cells by altering their intrinsic properties, which may enhance the sensitivity of the DCN to sensory input.</jats:p> Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus The Journal of Neuroscience |
| spellingShingle | Tang, Zheng-Quan, Trussell, Laurence O., The Journal of Neuroscience, Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus, General Neuroscience |
| title | Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus |
| title_full | Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus |
| title_fullStr | Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus |
| title_full_unstemmed | Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus |
| title_short | Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus |
| title_sort | serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus |
| title_unstemmed | Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus |
| topic | General Neuroscience |
| url | http://dx.doi.org/10.1523/jneurosci.4825-14.2015 |