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Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD
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| Zeitschriftentitel: | The Journal of Neuroscience |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | The Journal of Neuroscience, 28, 2008, 1, S. 3-9 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Society for Neuroscience
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| Schlagwörter: |
| author_facet |
Wu, Jinfang Basha, Md. Riyaz Brock, Brian Cox, David P. Cardozo-Pelaez, Fernando McPherson, Christopher A. Harry, Jean Rice, Deborah C. Maloney, Bryan Chen, Demao Lahiri, Debomoy K. Zawia, Nasser H. Wu, Jinfang Basha, Md. Riyaz Brock, Brian Cox, David P. Cardozo-Pelaez, Fernando McPherson, Christopher A. Harry, Jean Rice, Deborah C. Maloney, Bryan Chen, Demao Lahiri, Debomoy K. Zawia, Nasser H. |
|---|---|
| author |
Wu, Jinfang Basha, Md. Riyaz Brock, Brian Cox, David P. Cardozo-Pelaez, Fernando McPherson, Christopher A. Harry, Jean Rice, Deborah C. Maloney, Bryan Chen, Demao Lahiri, Debomoy K. Zawia, Nasser H. |
| spellingShingle |
Wu, Jinfang Basha, Md. Riyaz Brock, Brian Cox, David P. Cardozo-Pelaez, Fernando McPherson, Christopher A. Harry, Jean Rice, Deborah C. Maloney, Bryan Chen, Demao Lahiri, Debomoy K. Zawia, Nasser H. The Journal of Neuroscience Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD General Neuroscience |
| author_sort |
wu, jinfang |
| spelling |
Wu, Jinfang Basha, Md. Riyaz Brock, Brian Cox, David P. Cardozo-Pelaez, Fernando McPherson, Christopher A. Harry, Jean Rice, Deborah C. Maloney, Bryan Chen, Demao Lahiri, Debomoy K. Zawia, Nasser H. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.4405-07.2008 <jats:p>The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead (Pb) during brain development predetermined the expression and regulation of the amyloid precursor protein (APP) and its amyloidogenic β-amyloid (Aβ) product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 (β-site APP cleaving enzyme 1)] as well as their transcriptional regulator (Sp1) were elevated in aged (23-year-old) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Aβ staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD.</jats:p> Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD The Journal of Neuroscience |
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| title |
Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD |
| title_unstemmed |
Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD |
| title_full |
Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD |
| title_fullStr |
Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD |
| title_full_unstemmed |
Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD |
| title_short |
Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD |
| title_sort |
alzheimer's disease (ad)-like pathology in aged monkeys after infantile exposure to environmental metal lead (pb): evidence for a developmental origin and environmental link for ad |
| topic |
General Neuroscience |
| url |
http://dx.doi.org/10.1523/jneurosci.4405-07.2008 |
| publishDate |
2008 |
| physical |
3-9 |
| description |
<jats:p>The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead (Pb) during brain development predetermined the expression and regulation of the amyloid precursor protein (APP) and its amyloidogenic β-amyloid (Aβ) product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 (β-site APP cleaving enzyme 1)] as well as their transcriptional regulator (Sp1) were elevated in aged (23-year-old) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Aβ staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD.</jats:p> |
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| author | Wu, Jinfang, Basha, Md. Riyaz, Brock, Brian, Cox, David P., Cardozo-Pelaez, Fernando, McPherson, Christopher A., Harry, Jean, Rice, Deborah C., Maloney, Bryan, Chen, Demao, Lahiri, Debomoy K., Zawia, Nasser H. |
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| description | <jats:p>The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead (Pb) during brain development predetermined the expression and regulation of the amyloid precursor protein (APP) and its amyloidogenic β-amyloid (Aβ) product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 (β-site APP cleaving enzyme 1)] as well as their transcriptional regulator (Sp1) were elevated in aged (23-year-old) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Aβ staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD.</jats:p> |
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| spelling | Wu, Jinfang Basha, Md. Riyaz Brock, Brian Cox, David P. Cardozo-Pelaez, Fernando McPherson, Christopher A. Harry, Jean Rice, Deborah C. Maloney, Bryan Chen, Demao Lahiri, Debomoy K. Zawia, Nasser H. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.4405-07.2008 <jats:p>The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead (Pb) during brain development predetermined the expression and regulation of the amyloid precursor protein (APP) and its amyloidogenic β-amyloid (Aβ) product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 (β-site APP cleaving enzyme 1)] as well as their transcriptional regulator (Sp1) were elevated in aged (23-year-old) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Aβ staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD.</jats:p> Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD The Journal of Neuroscience |
| spellingShingle | Wu, Jinfang, Basha, Md. Riyaz, Brock, Brian, Cox, David P., Cardozo-Pelaez, Fernando, McPherson, Christopher A., Harry, Jean, Rice, Deborah C., Maloney, Bryan, Chen, Demao, Lahiri, Debomoy K., Zawia, Nasser H., The Journal of Neuroscience, Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD, General Neuroscience |
| title | Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD |
| title_full | Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD |
| title_fullStr | Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD |
| title_full_unstemmed | Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD |
| title_short | Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD |
| title_sort | alzheimer's disease (ad)-like pathology in aged monkeys after infantile exposure to environmental metal lead (pb): evidence for a developmental origin and environmental link for ad |
| title_unstemmed | Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD |
| topic | General Neuroscience |
| url | http://dx.doi.org/10.1523/jneurosci.4405-07.2008 |