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The Transition from Development to Motor Control Function in the Corticospinal System
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| Zeitschriftentitel: | The Journal of Neuroscience |
|---|---|
| Personen und Körperschaften: | , , |
| In: | The Journal of Neuroscience, 24, 2004, 3, S. 605-614 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Society for Neuroscience
|
| Schlagwörter: |
| author_facet |
Meng, Zhuo Li, Qun Martin, John H. Meng, Zhuo Li, Qun Martin, John H. |
|---|---|
| author |
Meng, Zhuo Li, Qun Martin, John H. |
| spellingShingle |
Meng, Zhuo Li, Qun Martin, John H. The Journal of Neuroscience The Transition from Development to Motor Control Function in the Corticospinal System General Neuroscience |
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meng, zhuo |
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Meng, Zhuo Li, Qun Martin, John H. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.4313-03.2004 <jats:p>During early postnatal development, corticospinal (CS) system stimulation, electrical or transcranial magnetic, is minimally effective in producing muscle contraction, despite having axon terminals that excite spinal neurons. Later, after stimulation becomes more effective, the cortical motor representation develops, and movements the system controls in maturity are expressed. We determined whether development of temporal facilitation (response enhancement produced by the second of a pair of pyramidal tract stimuli, or a higher stimulus multiple of a train of stimuli) correlated with these changes. Facilitation of the monosynaptic CS response was larger in older kittens and adults than younger kittens. When facilitation was strong, strong motor responses were evoked by pyramidal stimulation with small currents and few pulses. With strong facilitation in older kittens, corticospinal axon varicosities colocalize synaptophysin like adults, suggesting a presynaptic mechanism. With effective facilitation, control signals from the cortex can be sufficiently effective to provoke muscle contraction for guiding movements.</jats:p> The Transition from Development to Motor Control Function in the Corticospinal System The Journal of Neuroscience |
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| title |
The Transition from Development to Motor Control Function in the Corticospinal System |
| title_unstemmed |
The Transition from Development to Motor Control Function in the Corticospinal System |
| title_full |
The Transition from Development to Motor Control Function in the Corticospinal System |
| title_fullStr |
The Transition from Development to Motor Control Function in the Corticospinal System |
| title_full_unstemmed |
The Transition from Development to Motor Control Function in the Corticospinal System |
| title_short |
The Transition from Development to Motor Control Function in the Corticospinal System |
| title_sort |
the transition from development to motor control function in the corticospinal system |
| topic |
General Neuroscience |
| url |
http://dx.doi.org/10.1523/jneurosci.4313-03.2004 |
| publishDate |
2004 |
| physical |
605-614 |
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<jats:p>During early postnatal development, corticospinal (CS) system stimulation, electrical or transcranial magnetic, is minimally effective in producing muscle contraction, despite having axon terminals that excite spinal neurons. Later, after stimulation becomes more effective, the cortical motor representation develops, and movements the system controls in maturity are expressed. We determined whether development of temporal facilitation (response enhancement produced by the second of a pair of pyramidal tract stimuli, or a higher stimulus multiple of a train of stimuli) correlated with these changes. Facilitation of the monosynaptic CS response was larger in older kittens and adults than younger kittens. When facilitation was strong, strong motor responses were evoked by pyramidal stimulation with small currents and few pulses. With strong facilitation in older kittens, corticospinal axon varicosities colocalize synaptophysin like adults, suggesting a presynaptic mechanism. With effective facilitation, control signals from the cortex can be sufficiently effective to provoke muscle contraction for guiding movements.</jats:p> |
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| author | Meng, Zhuo, Li, Qun, Martin, John H. |
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| description | <jats:p>During early postnatal development, corticospinal (CS) system stimulation, electrical or transcranial magnetic, is minimally effective in producing muscle contraction, despite having axon terminals that excite spinal neurons. Later, after stimulation becomes more effective, the cortical motor representation develops, and movements the system controls in maturity are expressed. We determined whether development of temporal facilitation (response enhancement produced by the second of a pair of pyramidal tract stimuli, or a higher stimulus multiple of a train of stimuli) correlated with these changes. Facilitation of the monosynaptic CS response was larger in older kittens and adults than younger kittens. When facilitation was strong, strong motor responses were evoked by pyramidal stimulation with small currents and few pulses. With strong facilitation in older kittens, corticospinal axon varicosities colocalize synaptophysin like adults, suggesting a presynaptic mechanism. With effective facilitation, control signals from the cortex can be sufficiently effective to provoke muscle contraction for guiding movements.</jats:p> |
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| series | The Journal of Neuroscience |
| source_id | 49 |
| spelling | Meng, Zhuo Li, Qun Martin, John H. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.4313-03.2004 <jats:p>During early postnatal development, corticospinal (CS) system stimulation, electrical or transcranial magnetic, is minimally effective in producing muscle contraction, despite having axon terminals that excite spinal neurons. Later, after stimulation becomes more effective, the cortical motor representation develops, and movements the system controls in maturity are expressed. We determined whether development of temporal facilitation (response enhancement produced by the second of a pair of pyramidal tract stimuli, or a higher stimulus multiple of a train of stimuli) correlated with these changes. Facilitation of the monosynaptic CS response was larger in older kittens and adults than younger kittens. When facilitation was strong, strong motor responses were evoked by pyramidal stimulation with small currents and few pulses. With strong facilitation in older kittens, corticospinal axon varicosities colocalize synaptophysin like adults, suggesting a presynaptic mechanism. With effective facilitation, control signals from the cortex can be sufficiently effective to provoke muscle contraction for guiding movements.</jats:p> The Transition from Development to Motor Control Function in the Corticospinal System The Journal of Neuroscience |
| spellingShingle | Meng, Zhuo, Li, Qun, Martin, John H., The Journal of Neuroscience, The Transition from Development to Motor Control Function in the Corticospinal System, General Neuroscience |
| title | The Transition from Development to Motor Control Function in the Corticospinal System |
| title_full | The Transition from Development to Motor Control Function in the Corticospinal System |
| title_fullStr | The Transition from Development to Motor Control Function in the Corticospinal System |
| title_full_unstemmed | The Transition from Development to Motor Control Function in the Corticospinal System |
| title_short | The Transition from Development to Motor Control Function in the Corticospinal System |
| title_sort | the transition from development to motor control function in the corticospinal system |
| title_unstemmed | The Transition from Development to Motor Control Function in the Corticospinal System |
| topic | General Neuroscience |
| url | http://dx.doi.org/10.1523/jneurosci.4313-03.2004 |