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Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines
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| Zeitschriftentitel: | The Journal of Neuroscience |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | The Journal of Neuroscience, 25, 2005, 5, S. 1159-1168 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Society for Neuroscience
|
| Schlagwörter: |
| author_facet |
Liu, Zhaoping Tearle, Adam W. Nai, Qiang Berg, Darwin K. Liu, Zhaoping Tearle, Adam W. Nai, Qiang Berg, Darwin K. |
|---|---|
| author |
Liu, Zhaoping Tearle, Adam W. Nai, Qiang Berg, Darwin K. |
| spellingShingle |
Liu, Zhaoping Tearle, Adam W. Nai, Qiang Berg, Darwin K. The Journal of Neuroscience Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines General Neuroscience |
| author_sort |
liu, zhaoping |
| spelling |
Liu, Zhaoping Tearle, Adam W. Nai, Qiang Berg, Darwin K. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.3953-04.2005 <jats:p>Rapid trafficking of glutamate receptors contributes importantly to synaptic plasticity, but whether similar trafficking extends to other ionotropic receptors is unknown. Nicotinic acetylcholine receptors containing α7 subunits are widely expressed in the nervous system and allow calcium influx. Because of this, α7-containing receptors regulate diverse events, depending on the signaling pathways available. We find that the receptors codistribute with target soluble<jats:italic>N</jats:italic>-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) postsynaptically and that nicotinic stimulation rapidly induces SNARE-dependent vesicular endocytosis accompanied by receptor internalization. At the same time, a SNARE-dependent process recruits receptors to the cell surface from internal pools. Overall, the trafficking does not markedly change the number of surface receptors or their combined whole-cell response to nicotine. SNARE-dependent trafficking is needed, however, for the receptors to remain capable of activating the transcription factor cAMP response element-binding protein and attendant gene expression when repeatedly challenged. Thus, trafficking appears to be essential for maintaining functional coupling between α7-receptor responses and downstream signaling.</jats:p> Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines The Journal of Neuroscience |
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The Journal of Neuroscience |
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| title |
Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines |
| title_unstemmed |
Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines |
| title_full |
Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines |
| title_fullStr |
Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines |
| title_full_unstemmed |
Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines |
| title_short |
Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines |
| title_sort |
rapid activity-driven snare-dependent trafficking of nicotinic receptors on somatic spines |
| topic |
General Neuroscience |
| url |
http://dx.doi.org/10.1523/jneurosci.3953-04.2005 |
| publishDate |
2005 |
| physical |
1159-1168 |
| description |
<jats:p>Rapid trafficking of glutamate receptors contributes importantly to synaptic plasticity, but whether similar trafficking extends to other ionotropic receptors is unknown. Nicotinic acetylcholine receptors containing α7 subunits are widely expressed in the nervous system and allow calcium influx. Because of this, α7-containing receptors regulate diverse events, depending on the signaling pathways available. We find that the receptors codistribute with target soluble<jats:italic>N</jats:italic>-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) postsynaptically and that nicotinic stimulation rapidly induces SNARE-dependent vesicular endocytosis accompanied by receptor internalization. At the same time, a SNARE-dependent process recruits receptors to the cell surface from internal pools. Overall, the trafficking does not markedly change the number of surface receptors or their combined whole-cell response to nicotine. SNARE-dependent trafficking is needed, however, for the receptors to remain capable of activating the transcription factor cAMP response element-binding protein and attendant gene expression when repeatedly challenged. Thus, trafficking appears to be essential for maintaining functional coupling between α7-receptor responses and downstream signaling.</jats:p> |
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| author | Liu, Zhaoping, Tearle, Adam W., Nai, Qiang, Berg, Darwin K. |
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| description | <jats:p>Rapid trafficking of glutamate receptors contributes importantly to synaptic plasticity, but whether similar trafficking extends to other ionotropic receptors is unknown. Nicotinic acetylcholine receptors containing α7 subunits are widely expressed in the nervous system and allow calcium influx. Because of this, α7-containing receptors regulate diverse events, depending on the signaling pathways available. We find that the receptors codistribute with target soluble<jats:italic>N</jats:italic>-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) postsynaptically and that nicotinic stimulation rapidly induces SNARE-dependent vesicular endocytosis accompanied by receptor internalization. At the same time, a SNARE-dependent process recruits receptors to the cell surface from internal pools. Overall, the trafficking does not markedly change the number of surface receptors or their combined whole-cell response to nicotine. SNARE-dependent trafficking is needed, however, for the receptors to remain capable of activating the transcription factor cAMP response element-binding protein and attendant gene expression when repeatedly challenged. Thus, trafficking appears to be essential for maintaining functional coupling between α7-receptor responses and downstream signaling.</jats:p> |
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| spelling | Liu, Zhaoping Tearle, Adam W. Nai, Qiang Berg, Darwin K. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.3953-04.2005 <jats:p>Rapid trafficking of glutamate receptors contributes importantly to synaptic plasticity, but whether similar trafficking extends to other ionotropic receptors is unknown. Nicotinic acetylcholine receptors containing α7 subunits are widely expressed in the nervous system and allow calcium influx. Because of this, α7-containing receptors regulate diverse events, depending on the signaling pathways available. We find that the receptors codistribute with target soluble<jats:italic>N</jats:italic>-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) postsynaptically and that nicotinic stimulation rapidly induces SNARE-dependent vesicular endocytosis accompanied by receptor internalization. At the same time, a SNARE-dependent process recruits receptors to the cell surface from internal pools. Overall, the trafficking does not markedly change the number of surface receptors or their combined whole-cell response to nicotine. SNARE-dependent trafficking is needed, however, for the receptors to remain capable of activating the transcription factor cAMP response element-binding protein and attendant gene expression when repeatedly challenged. Thus, trafficking appears to be essential for maintaining functional coupling between α7-receptor responses and downstream signaling.</jats:p> Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines The Journal of Neuroscience |
| spellingShingle | Liu, Zhaoping, Tearle, Adam W., Nai, Qiang, Berg, Darwin K., The Journal of Neuroscience, Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines, General Neuroscience |
| title | Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines |
| title_full | Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines |
| title_fullStr | Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines |
| title_full_unstemmed | Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines |
| title_short | Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines |
| title_sort | rapid activity-driven snare-dependent trafficking of nicotinic receptors on somatic spines |
| title_unstemmed | Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines |
| topic | General Neuroscience |
| url | http://dx.doi.org/10.1523/jneurosci.3953-04.2005 |