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Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo
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| Zeitschriftentitel: | The Journal of Neuroscience |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | The Journal of Neuroscience, 25, 2005, 2, S. 343-351 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Society for Neuroscience
|
| Schlagwörter: |
| author_facet |
Wang, Xueyong Li, Yingjie Engisch, Kathrin L. Nakanishi, Stan T. Dodson, Sara E. Miller, Gary W. Cope, Timothy C. Pinter, Martin J. Rich, Mark M. Wang, Xueyong Li, Yingjie Engisch, Kathrin L. Nakanishi, Stan T. Dodson, Sara E. Miller, Gary W. Cope, Timothy C. Pinter, Martin J. Rich, Mark M. |
|---|---|
| author |
Wang, Xueyong Li, Yingjie Engisch, Kathrin L. Nakanishi, Stan T. Dodson, Sara E. Miller, Gary W. Cope, Timothy C. Pinter, Martin J. Rich, Mark M. |
| spellingShingle |
Wang, Xueyong Li, Yingjie Engisch, Kathrin L. Nakanishi, Stan T. Dodson, Sara E. Miller, Gary W. Cope, Timothy C. Pinter, Martin J. Rich, Mark M. The Journal of Neuroscience Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo General Neuroscience |
| author_sort |
wang, xueyong |
| spelling |
Wang, Xueyong Li, Yingjie Engisch, Kathrin L. Nakanishi, Stan T. Dodson, Sara E. Miller, Gary W. Cope, Timothy C. Pinter, Martin J. Rich, Mark M. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.3252-04.2005 <jats:p>Changes in synaptic activity alter quantal size, but the relative roles of presynaptic and postsynaptic cells in these changes are only beginning to be understood. We examined the mechanism underlying increased quantal size after block of synaptic activity at the mammalian neuromuscular junction<jats:italic>in vivo</jats:italic>. We found that changes in neither acetylcholinesterase activity nor acetylcholine receptor density could account for the increase. By elimination, it appears likely that the site of increased quantal size after chronic block of activity is presynaptic and involves increased release of acetylcholine. We used mice with muscle hyperexcitability caused by mutation of the ClC-1 muscle chloride channel to examine the role of postsynaptic activity in controlling quantal size. Surprisingly, quantal size was increased in ClC mice before block of synaptic activity. We examined the mechanism underlying increased quantal size in ClC mice and found that it also appeared to be located presynaptically. When presynaptic activity was completely blocked in both control and ClC mice, quantal size was large in both groups despite the higher level of postsynaptic activity in ClC mice. This suggests that postsynaptic activity does not regulate quantal size at the neuromuscular junction. We propose that presynaptic activity modulates quantal size at the neuromuscular junction by modulating the amount of acetylcholine released from vesicles.</jats:p> Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular Junction<i>In Vivo</i> The Journal of Neuroscience |
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The Journal of Neuroscience |
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49 |
| title |
Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo |
| title_unstemmed |
Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo |
| title_full |
Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo |
| title_fullStr |
Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo |
| title_full_unstemmed |
Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo |
| title_short |
Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo |
| title_sort |
activity-dependent presynaptic regulation of quantal size at the mammalian neuromuscular junction<i>in vivo</i> |
| topic |
General Neuroscience |
| url |
http://dx.doi.org/10.1523/jneurosci.3252-04.2005 |
| publishDate |
2005 |
| physical |
343-351 |
| description |
<jats:p>Changes in synaptic activity alter quantal size, but the relative roles of presynaptic and postsynaptic cells in these changes are only beginning to be understood. We examined the mechanism underlying increased quantal size after block of synaptic activity at the mammalian neuromuscular junction<jats:italic>in vivo</jats:italic>. We found that changes in neither acetylcholinesterase activity nor acetylcholine receptor density could account for the increase. By elimination, it appears likely that the site of increased quantal size after chronic block of activity is presynaptic and involves increased release of acetylcholine. We used mice with muscle hyperexcitability caused by mutation of the ClC-1 muscle chloride channel to examine the role of postsynaptic activity in controlling quantal size. Surprisingly, quantal size was increased in ClC mice before block of synaptic activity. We examined the mechanism underlying increased quantal size in ClC mice and found that it also appeared to be located presynaptically. When presynaptic activity was completely blocked in both control and ClC mice, quantal size was large in both groups despite the higher level of postsynaptic activity in ClC mice. This suggests that postsynaptic activity does not regulate quantal size at the neuromuscular junction. We propose that presynaptic activity modulates quantal size at the neuromuscular junction by modulating the amount of acetylcholine released from vesicles.</jats:p> |
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| author | Wang, Xueyong, Li, Yingjie, Engisch, Kathrin L., Nakanishi, Stan T., Dodson, Sara E., Miller, Gary W., Cope, Timothy C., Pinter, Martin J., Rich, Mark M. |
| author_facet | Wang, Xueyong, Li, Yingjie, Engisch, Kathrin L., Nakanishi, Stan T., Dodson, Sara E., Miller, Gary W., Cope, Timothy C., Pinter, Martin J., Rich, Mark M., Wang, Xueyong, Li, Yingjie, Engisch, Kathrin L., Nakanishi, Stan T., Dodson, Sara E., Miller, Gary W., Cope, Timothy C., Pinter, Martin J., Rich, Mark M. |
| author_sort | wang, xueyong |
| container_issue | 2 |
| container_start_page | 343 |
| container_title | The Journal of Neuroscience |
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| description | <jats:p>Changes in synaptic activity alter quantal size, but the relative roles of presynaptic and postsynaptic cells in these changes are only beginning to be understood. We examined the mechanism underlying increased quantal size after block of synaptic activity at the mammalian neuromuscular junction<jats:italic>in vivo</jats:italic>. We found that changes in neither acetylcholinesterase activity nor acetylcholine receptor density could account for the increase. By elimination, it appears likely that the site of increased quantal size after chronic block of activity is presynaptic and involves increased release of acetylcholine. We used mice with muscle hyperexcitability caused by mutation of the ClC-1 muscle chloride channel to examine the role of postsynaptic activity in controlling quantal size. Surprisingly, quantal size was increased in ClC mice before block of synaptic activity. We examined the mechanism underlying increased quantal size in ClC mice and found that it also appeared to be located presynaptically. When presynaptic activity was completely blocked in both control and ClC mice, quantal size was large in both groups despite the higher level of postsynaptic activity in ClC mice. This suggests that postsynaptic activity does not regulate quantal size at the neuromuscular junction. We propose that presynaptic activity modulates quantal size at the neuromuscular junction by modulating the amount of acetylcholine released from vesicles.</jats:p> |
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| imprint_str_mv | Society for Neuroscience, 2005 |
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| last_indexed | 2024-03-01T15:31:34.435Z |
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| physical | 343-351 |
| publishDate | 2005 |
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| publisher | Society for Neuroscience |
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| series | The Journal of Neuroscience |
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| spelling | Wang, Xueyong Li, Yingjie Engisch, Kathrin L. Nakanishi, Stan T. Dodson, Sara E. Miller, Gary W. Cope, Timothy C. Pinter, Martin J. Rich, Mark M. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.3252-04.2005 <jats:p>Changes in synaptic activity alter quantal size, but the relative roles of presynaptic and postsynaptic cells in these changes are only beginning to be understood. We examined the mechanism underlying increased quantal size after block of synaptic activity at the mammalian neuromuscular junction<jats:italic>in vivo</jats:italic>. We found that changes in neither acetylcholinesterase activity nor acetylcholine receptor density could account for the increase. By elimination, it appears likely that the site of increased quantal size after chronic block of activity is presynaptic and involves increased release of acetylcholine. We used mice with muscle hyperexcitability caused by mutation of the ClC-1 muscle chloride channel to examine the role of postsynaptic activity in controlling quantal size. Surprisingly, quantal size was increased in ClC mice before block of synaptic activity. We examined the mechanism underlying increased quantal size in ClC mice and found that it also appeared to be located presynaptically. When presynaptic activity was completely blocked in both control and ClC mice, quantal size was large in both groups despite the higher level of postsynaptic activity in ClC mice. This suggests that postsynaptic activity does not regulate quantal size at the neuromuscular junction. We propose that presynaptic activity modulates quantal size at the neuromuscular junction by modulating the amount of acetylcholine released from vesicles.</jats:p> Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular Junction<i>In Vivo</i> The Journal of Neuroscience |
| spellingShingle | Wang, Xueyong, Li, Yingjie, Engisch, Kathrin L., Nakanishi, Stan T., Dodson, Sara E., Miller, Gary W., Cope, Timothy C., Pinter, Martin J., Rich, Mark M., The Journal of Neuroscience, Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo, General Neuroscience |
| title | Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo |
| title_full | Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo |
| title_fullStr | Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo |
| title_full_unstemmed | Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo |
| title_short | Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo |
| title_sort | activity-dependent presynaptic regulation of quantal size at the mammalian neuromuscular junction<i>in vivo</i> |
| title_unstemmed | Activity-Dependent Presynaptic Regulation of Quantal Size at the Mammalian Neuromuscular JunctionIn Vivo |
| topic | General Neuroscience |
| url | http://dx.doi.org/10.1523/jneurosci.3252-04.2005 |