Eintrag weiter verarbeiten
Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine
Gespeichert in:
| Zeitschriftentitel: | The Journal of Neuroscience |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | The Journal of Neuroscience, 34, 2014, 10, S. 3493-3508 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Society for Neuroscience
|
| Schlagwörter: |
| author_facet |
Lu, Hai-Feng Wu, Peng-Fei Yang, Yuan-Jian Xiao, Wen Fan, Jun Liu, Jing Li, Yuan-Long Luo, Yi Hu, Zhuang-Li Jin, You Wang, Fang Chen, Jian-Guo Lu, Hai-Feng Wu, Peng-Fei Yang, Yuan-Jian Xiao, Wen Fan, Jun Liu, Jing Li, Yuan-Long Luo, Yi Hu, Zhuang-Li Jin, You Wang, Fang Chen, Jian-Guo |
|---|---|
| author |
Lu, Hai-Feng Wu, Peng-Fei Yang, Yuan-Jian Xiao, Wen Fan, Jun Liu, Jing Li, Yuan-Long Luo, Yi Hu, Zhuang-Li Jin, You Wang, Fang Chen, Jian-Guo |
| spellingShingle |
Lu, Hai-Feng Wu, Peng-Fei Yang, Yuan-Jian Xiao, Wen Fan, Jun Liu, Jing Li, Yuan-Long Luo, Yi Hu, Zhuang-Li Jin, You Wang, Fang Chen, Jian-Guo The Journal of Neuroscience Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine General Neuroscience |
| author_sort |
lu, hai-feng |
| spelling |
Lu, Hai-Feng Wu, Peng-Fei Yang, Yuan-Jian Xiao, Wen Fan, Jun Liu, Jing Li, Yuan-Long Luo, Yi Hu, Zhuang-Li Jin, You Wang, Fang Chen, Jian-Guo 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.2594-13.2014 <jats:p>Many studies have reported a withdrawal-dependent increase in synaptic AMPA receptor (AMPAR) levels in the nucleus accumbens (NAc) of cocaine-sensitized rats; however, the exact relationship between the expression of sensitization and altered AMPAR surface expression in the NAc has not yet been investigated. We demonstrated that the expression of behavioral sensitization was negatively controlled by<jats:italic>N-</jats:italic>ethylmaleimide-sensitive factor (NSF)-GluR2 interactions in the NAc. The upregulation of NSF–GluR2 interactions, which may be resulted by the increase in NSF S-nitrosylation after withdrawal from cocaine, was associated with the changes in the expression of behavioral sensitization. Disruption of NSF–GluR2 interactions in the NAc with a specific peptide, TAT-pep-R845A, increased the locomotor response of rats to cocaine by decreasing GluR2 surface insertion. In contrast, prevention of GluR2-containing AMPARs removal from synapses with Pep2-EVKI attenuated the expression of behavioral sensitization. Similarly, treatment with the nitric oxide donor, S-Nitroso-<jats:italic>N</jats:italic>-acetyl-DL-penicillamine (SNAP), attenuated the expression of locomotor sensitization by promoting GluR2 surface expression. This effect was mediated by the binding of S-nitrosylated NSF to GluR2, which promoted the surface expression of AMPARs. Noticeably, exogenous injection of SNAP into NAc also attenuated the expression of cocaine-induced conditioned place preference. Thus, these results indicate that increased NSF–GluR2 interactions in the NAc after withdrawal from cocaine attenuated the expression of behavioral sensitization and serves as a negative regulatory mechanism in drug-exposed individuals.</jats:p> Interactions between<i>N-</i>Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine The Journal of Neuroscience |
| doi_str_mv |
10.1523/jneurosci.2594-13.2014 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUyMy9qbmV1cm9zY2kuMjU5NC0xMy4yMDE0 |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUyMy9qbmV1cm9zY2kuMjU5NC0xMy4yMDE0 |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Zwi2 |
| imprint |
Society for Neuroscience, 2014 |
| imprint_str_mv |
Society for Neuroscience, 2014 |
| issn |
0270-6474 1529-2401 |
| issn_str_mv |
0270-6474 1529-2401 |
| language |
English |
| mega_collection |
Society for Neuroscience (CrossRef) |
| match_str |
lu2014interactionsbetweennethylmaleimidesensitivefactorandglur2inthenucleusaccumbenscontributetotheexpressionoflocomotorsensitizationtococaine |
| publishDateSort |
2014 |
| publisher |
Society for Neuroscience |
| recordtype |
ai |
| record_format |
ai |
| series |
The Journal of Neuroscience |
| source_id |
49 |
| title |
Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine |
| title_unstemmed |
Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine |
| title_full |
Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine |
| title_fullStr |
Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine |
| title_full_unstemmed |
Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine |
| title_short |
Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine |
| title_sort |
interactions between<i>n-</i>ethylmaleimide-sensitive factor and glur2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine |
| topic |
General Neuroscience |
| url |
http://dx.doi.org/10.1523/jneurosci.2594-13.2014 |
| publishDate |
2014 |
| physical |
3493-3508 |
| description |
<jats:p>Many studies have reported a withdrawal-dependent increase in synaptic AMPA receptor (AMPAR) levels in the nucleus accumbens (NAc) of cocaine-sensitized rats; however, the exact relationship between the expression of sensitization and altered AMPAR surface expression in the NAc has not yet been investigated. We demonstrated that the expression of behavioral sensitization was negatively controlled by<jats:italic>N-</jats:italic>ethylmaleimide-sensitive factor (NSF)-GluR2 interactions in the NAc. The upregulation of NSF–GluR2 interactions, which may be resulted by the increase in NSF S-nitrosylation after withdrawal from cocaine, was associated with the changes in the expression of behavioral sensitization. Disruption of NSF–GluR2 interactions in the NAc with a specific peptide, TAT-pep-R845A, increased the locomotor response of rats to cocaine by decreasing GluR2 surface insertion. In contrast, prevention of GluR2-containing AMPARs removal from synapses with Pep2-EVKI attenuated the expression of behavioral sensitization. Similarly, treatment with the nitric oxide donor, S-Nitroso-<jats:italic>N</jats:italic>-acetyl-DL-penicillamine (SNAP), attenuated the expression of locomotor sensitization by promoting GluR2 surface expression. This effect was mediated by the binding of S-nitrosylated NSF to GluR2, which promoted the surface expression of AMPARs. Noticeably, exogenous injection of SNAP into NAc also attenuated the expression of cocaine-induced conditioned place preference. Thus, these results indicate that increased NSF–GluR2 interactions in the NAc after withdrawal from cocaine attenuated the expression of behavioral sensitization and serves as a negative regulatory mechanism in drug-exposed individuals.</jats:p> |
| container_issue |
10 |
| container_start_page |
3493 |
| container_title |
The Journal of Neuroscience |
| container_volume |
34 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792345637999607808 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:26:41.065Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Interactions+betweenN-Ethylmaleimide-Sensitive+Factor+and+GluR2+in+the+Nucleus+Accumbens+Contribute+to+the+Expression+of+Locomotor+Sensitization+to+Cocaine&rft.date=2014-03-05&genre=article&issn=1529-2401&volume=34&issue=10&spage=3493&epage=3508&pages=3493-3508&jtitle=The+Journal+of+Neuroscience&atitle=Interactions+between%3Ci%3EN-%3C%2Fi%3EEthylmaleimide-Sensitive+Factor+and+GluR2+in+the+Nucleus+Accumbens+Contribute+to+the+Expression+of+Locomotor+Sensitization+to+Cocaine&aulast=Chen&aufirst=Jian-Guo&rft_id=info%3Adoi%2F10.1523%2Fjneurosci.2594-13.2014&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792345637999607808 |
| author | Lu, Hai-Feng, Wu, Peng-Fei, Yang, Yuan-Jian, Xiao, Wen, Fan, Jun, Liu, Jing, Li, Yuan-Long, Luo, Yi, Hu, Zhuang-Li, Jin, You, Wang, Fang, Chen, Jian-Guo |
| author_facet | Lu, Hai-Feng, Wu, Peng-Fei, Yang, Yuan-Jian, Xiao, Wen, Fan, Jun, Liu, Jing, Li, Yuan-Long, Luo, Yi, Hu, Zhuang-Li, Jin, You, Wang, Fang, Chen, Jian-Guo, Lu, Hai-Feng, Wu, Peng-Fei, Yang, Yuan-Jian, Xiao, Wen, Fan, Jun, Liu, Jing, Li, Yuan-Long, Luo, Yi, Hu, Zhuang-Li, Jin, You, Wang, Fang, Chen, Jian-Guo |
| author_sort | lu, hai-feng |
| container_issue | 10 |
| container_start_page | 3493 |
| container_title | The Journal of Neuroscience |
| container_volume | 34 |
| description | <jats:p>Many studies have reported a withdrawal-dependent increase in synaptic AMPA receptor (AMPAR) levels in the nucleus accumbens (NAc) of cocaine-sensitized rats; however, the exact relationship between the expression of sensitization and altered AMPAR surface expression in the NAc has not yet been investigated. We demonstrated that the expression of behavioral sensitization was negatively controlled by<jats:italic>N-</jats:italic>ethylmaleimide-sensitive factor (NSF)-GluR2 interactions in the NAc. The upregulation of NSF–GluR2 interactions, which may be resulted by the increase in NSF S-nitrosylation after withdrawal from cocaine, was associated with the changes in the expression of behavioral sensitization. Disruption of NSF–GluR2 interactions in the NAc with a specific peptide, TAT-pep-R845A, increased the locomotor response of rats to cocaine by decreasing GluR2 surface insertion. In contrast, prevention of GluR2-containing AMPARs removal from synapses with Pep2-EVKI attenuated the expression of behavioral sensitization. Similarly, treatment with the nitric oxide donor, S-Nitroso-<jats:italic>N</jats:italic>-acetyl-DL-penicillamine (SNAP), attenuated the expression of locomotor sensitization by promoting GluR2 surface expression. This effect was mediated by the binding of S-nitrosylated NSF to GluR2, which promoted the surface expression of AMPARs. Noticeably, exogenous injection of SNAP into NAc also attenuated the expression of cocaine-induced conditioned place preference. Thus, these results indicate that increased NSF–GluR2 interactions in the NAc after withdrawal from cocaine attenuated the expression of behavioral sensitization and serves as a negative regulatory mechanism in drug-exposed individuals.</jats:p> |
| doi_str_mv | 10.1523/jneurosci.2594-13.2014 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTUyMy9qbmV1cm9zY2kuMjU5NC0xMy4yMDE0 |
| imprint | Society for Neuroscience, 2014 |
| imprint_str_mv | Society for Neuroscience, 2014 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2 |
| issn | 0270-6474, 1529-2401 |
| issn_str_mv | 0270-6474, 1529-2401 |
| language | English |
| last_indexed | 2024-03-01T17:26:41.065Z |
| match_str | lu2014interactionsbetweennethylmaleimidesensitivefactorandglur2inthenucleusaccumbenscontributetotheexpressionoflocomotorsensitizationtococaine |
| mega_collection | Society for Neuroscience (CrossRef) |
| physical | 3493-3508 |
| publishDate | 2014 |
| publishDateSort | 2014 |
| publisher | Society for Neuroscience |
| record_format | ai |
| recordtype | ai |
| series | The Journal of Neuroscience |
| source_id | 49 |
| spelling | Lu, Hai-Feng Wu, Peng-Fei Yang, Yuan-Jian Xiao, Wen Fan, Jun Liu, Jing Li, Yuan-Long Luo, Yi Hu, Zhuang-Li Jin, You Wang, Fang Chen, Jian-Guo 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.2594-13.2014 <jats:p>Many studies have reported a withdrawal-dependent increase in synaptic AMPA receptor (AMPAR) levels in the nucleus accumbens (NAc) of cocaine-sensitized rats; however, the exact relationship between the expression of sensitization and altered AMPAR surface expression in the NAc has not yet been investigated. We demonstrated that the expression of behavioral sensitization was negatively controlled by<jats:italic>N-</jats:italic>ethylmaleimide-sensitive factor (NSF)-GluR2 interactions in the NAc. The upregulation of NSF–GluR2 interactions, which may be resulted by the increase in NSF S-nitrosylation after withdrawal from cocaine, was associated with the changes in the expression of behavioral sensitization. Disruption of NSF–GluR2 interactions in the NAc with a specific peptide, TAT-pep-R845A, increased the locomotor response of rats to cocaine by decreasing GluR2 surface insertion. In contrast, prevention of GluR2-containing AMPARs removal from synapses with Pep2-EVKI attenuated the expression of behavioral sensitization. Similarly, treatment with the nitric oxide donor, S-Nitroso-<jats:italic>N</jats:italic>-acetyl-DL-penicillamine (SNAP), attenuated the expression of locomotor sensitization by promoting GluR2 surface expression. This effect was mediated by the binding of S-nitrosylated NSF to GluR2, which promoted the surface expression of AMPARs. Noticeably, exogenous injection of SNAP into NAc also attenuated the expression of cocaine-induced conditioned place preference. Thus, these results indicate that increased NSF–GluR2 interactions in the NAc after withdrawal from cocaine attenuated the expression of behavioral sensitization and serves as a negative regulatory mechanism in drug-exposed individuals.</jats:p> Interactions between<i>N-</i>Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine The Journal of Neuroscience |
| spellingShingle | Lu, Hai-Feng, Wu, Peng-Fei, Yang, Yuan-Jian, Xiao, Wen, Fan, Jun, Liu, Jing, Li, Yuan-Long, Luo, Yi, Hu, Zhuang-Li, Jin, You, Wang, Fang, Chen, Jian-Guo, The Journal of Neuroscience, Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine, General Neuroscience |
| title | Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine |
| title_full | Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine |
| title_fullStr | Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine |
| title_full_unstemmed | Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine |
| title_short | Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine |
| title_sort | interactions between<i>n-</i>ethylmaleimide-sensitive factor and glur2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine |
| title_unstemmed | Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine |
| topic | General Neuroscience |
| url | http://dx.doi.org/10.1523/jneurosci.2594-13.2014 |