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Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses
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| Zeitschriftentitel: | The Journal of Neuroscience |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | The Journal of Neuroscience, 33, 2013, 41, S. 16158-16169 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Society for Neuroscience
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| Schlagwörter: |
| author_facet |
Wu, Wendy W. Bryant, Damani N. Dorsa, Daniel M. Adelman, John P. Maylie, James Wu, Wendy W. Bryant, Damani N. Dorsa, Daniel M. Adelman, John P. Maylie, James |
|---|---|
| author |
Wu, Wendy W. Bryant, Damani N. Dorsa, Daniel M. Adelman, John P. Maylie, James |
| spellingShingle |
Wu, Wendy W. Bryant, Damani N. Dorsa, Daniel M. Adelman, John P. Maylie, James The Journal of Neuroscience Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses General Neuroscience |
| author_sort |
wu, wendy w. |
| spelling |
Wu, Wendy W. Bryant, Damani N. Dorsa, Daniel M. Adelman, John P. Maylie, James 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.2001-13.2013 <jats:p>Premature and long-term ovarian hormone loss following ovariectomy (OVX) is associated with cognitive impairment. This condition is prevented by estradiol (E<jats:sub>2</jats:sub>) therapy when initiated shortly following OVX but not after substantial delay. To determine whether these clinical findings are correlated with changes in synaptic functions, we used adult OVX rats to evaluate the consequences of short-term (7–10 d, OVX<jats:sub>Control</jats:sub>) and long-term (∼5 months, OVX<jats:sub>LT</jats:sub>) ovarian hormone loss, as well as subsequent<jats:italic>in vivo</jats:italic>E<jats:sub>2</jats:sub>treatment, on excitatory synaptic transmission at the hippocampal CA3–CA1 synapses important for learning and memory. The results show that ovarian hormone loss was associated with a marked decrease in synaptic strength. E<jats:sub>2</jats:sub>treatment increased synaptic strength in OVX<jats:sub>Control</jats:sub>but not OVX<jats:sub>LT</jats:sub>rats, demonstrating a change in the efficacy for E<jats:sub>2</jats:sub>5 months following OVX. E<jats:sub>2</jats:sub>also had a more rapid effect: within minutes of bath application, E<jats:sub>2</jats:sub>acutely increased synaptic strength in all groups except OVX<jats:sub>LT</jats:sub>rats that did not receive<jats:italic>in vivo</jats:italic>E<jats:sub>2</jats:sub>treatment. E<jats:sub>2</jats:sub>'s acute effect was mediated postsynaptically, and required Ca<jats:sup>2+</jats:sup>influx through the voltage-gated Ca<jats:sup>2+</jats:sup>channels. Despite E<jats:sub>2</jats:sub>'s acute effect, synaptic strength of OVX<jats:sub>LT</jats:sub>rats remained significantly lower than that of OVX<jats:sub>Control</jats:sub>rats. Thus, changes in CA3–CA1 synaptic transmission associated with ovarian hormone loss cannot be fully reversed with delayed E<jats:sub>2</jats:sub>treatment. Given that synaptic strength at CA3–CA1 synapses is related to the ability to learn hippocampus-dependent tasks, these findings provide additional insights for understanding cognitive impairment-associated long-term ovarian hormone loss and ineffectiveness for delayed E<jats:sub>2</jats:sub>treatment to maintain cognitive functions.</jats:p> Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses The Journal of Neuroscience |
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Society for Neuroscience, 2013 |
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2013 |
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The Journal of Neuroscience |
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49 |
| title |
Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses |
| title_unstemmed |
Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses |
| title_full |
Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses |
| title_fullStr |
Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses |
| title_full_unstemmed |
Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses |
| title_short |
Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses |
| title_sort |
ovarian hormone loss impairs excitatory synaptic transmission at hippocampal ca3–ca1 synapses |
| topic |
General Neuroscience |
| url |
http://dx.doi.org/10.1523/jneurosci.2001-13.2013 |
| publishDate |
2013 |
| physical |
16158-16169 |
| description |
<jats:p>Premature and long-term ovarian hormone loss following ovariectomy (OVX) is associated with cognitive impairment. This condition is prevented by estradiol (E<jats:sub>2</jats:sub>) therapy when initiated shortly following OVX but not after substantial delay. To determine whether these clinical findings are correlated with changes in synaptic functions, we used adult OVX rats to evaluate the consequences of short-term (7–10 d, OVX<jats:sub>Control</jats:sub>) and long-term (∼5 months, OVX<jats:sub>LT</jats:sub>) ovarian hormone loss, as well as subsequent<jats:italic>in vivo</jats:italic>E<jats:sub>2</jats:sub>treatment, on excitatory synaptic transmission at the hippocampal CA3–CA1 synapses important for learning and memory. The results show that ovarian hormone loss was associated with a marked decrease in synaptic strength. E<jats:sub>2</jats:sub>treatment increased synaptic strength in OVX<jats:sub>Control</jats:sub>but not OVX<jats:sub>LT</jats:sub>rats, demonstrating a change in the efficacy for E<jats:sub>2</jats:sub>5 months following OVX. E<jats:sub>2</jats:sub>also had a more rapid effect: within minutes of bath application, E<jats:sub>2</jats:sub>acutely increased synaptic strength in all groups except OVX<jats:sub>LT</jats:sub>rats that did not receive<jats:italic>in vivo</jats:italic>E<jats:sub>2</jats:sub>treatment. E<jats:sub>2</jats:sub>'s acute effect was mediated postsynaptically, and required Ca<jats:sup>2+</jats:sup>influx through the voltage-gated Ca<jats:sup>2+</jats:sup>channels. Despite E<jats:sub>2</jats:sub>'s acute effect, synaptic strength of OVX<jats:sub>LT</jats:sub>rats remained significantly lower than that of OVX<jats:sub>Control</jats:sub>rats. Thus, changes in CA3–CA1 synaptic transmission associated with ovarian hormone loss cannot be fully reversed with delayed E<jats:sub>2</jats:sub>treatment. Given that synaptic strength at CA3–CA1 synapses is related to the ability to learn hippocampus-dependent tasks, these findings provide additional insights for understanding cognitive impairment-associated long-term ovarian hormone loss and ineffectiveness for delayed E<jats:sub>2</jats:sub>treatment to maintain cognitive functions.</jats:p> |
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| author | Wu, Wendy W., Bryant, Damani N., Dorsa, Daniel M., Adelman, John P., Maylie, James |
| author_facet | Wu, Wendy W., Bryant, Damani N., Dorsa, Daniel M., Adelman, John P., Maylie, James, Wu, Wendy W., Bryant, Damani N., Dorsa, Daniel M., Adelman, John P., Maylie, James |
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| description | <jats:p>Premature and long-term ovarian hormone loss following ovariectomy (OVX) is associated with cognitive impairment. This condition is prevented by estradiol (E<jats:sub>2</jats:sub>) therapy when initiated shortly following OVX but not after substantial delay. To determine whether these clinical findings are correlated with changes in synaptic functions, we used adult OVX rats to evaluate the consequences of short-term (7–10 d, OVX<jats:sub>Control</jats:sub>) and long-term (∼5 months, OVX<jats:sub>LT</jats:sub>) ovarian hormone loss, as well as subsequent<jats:italic>in vivo</jats:italic>E<jats:sub>2</jats:sub>treatment, on excitatory synaptic transmission at the hippocampal CA3–CA1 synapses important for learning and memory. The results show that ovarian hormone loss was associated with a marked decrease in synaptic strength. E<jats:sub>2</jats:sub>treatment increased synaptic strength in OVX<jats:sub>Control</jats:sub>but not OVX<jats:sub>LT</jats:sub>rats, demonstrating a change in the efficacy for E<jats:sub>2</jats:sub>5 months following OVX. E<jats:sub>2</jats:sub>also had a more rapid effect: within minutes of bath application, E<jats:sub>2</jats:sub>acutely increased synaptic strength in all groups except OVX<jats:sub>LT</jats:sub>rats that did not receive<jats:italic>in vivo</jats:italic>E<jats:sub>2</jats:sub>treatment. E<jats:sub>2</jats:sub>'s acute effect was mediated postsynaptically, and required Ca<jats:sup>2+</jats:sup>influx through the voltage-gated Ca<jats:sup>2+</jats:sup>channels. Despite E<jats:sub>2</jats:sub>'s acute effect, synaptic strength of OVX<jats:sub>LT</jats:sub>rats remained significantly lower than that of OVX<jats:sub>Control</jats:sub>rats. Thus, changes in CA3–CA1 synaptic transmission associated with ovarian hormone loss cannot be fully reversed with delayed E<jats:sub>2</jats:sub>treatment. Given that synaptic strength at CA3–CA1 synapses is related to the ability to learn hippocampus-dependent tasks, these findings provide additional insights for understanding cognitive impairment-associated long-term ovarian hormone loss and ineffectiveness for delayed E<jats:sub>2</jats:sub>treatment to maintain cognitive functions.</jats:p> |
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| imprint_str_mv | Society for Neuroscience, 2013 |
| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
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| spelling | Wu, Wendy W. Bryant, Damani N. Dorsa, Daniel M. Adelman, John P. Maylie, James 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.2001-13.2013 <jats:p>Premature and long-term ovarian hormone loss following ovariectomy (OVX) is associated with cognitive impairment. This condition is prevented by estradiol (E<jats:sub>2</jats:sub>) therapy when initiated shortly following OVX but not after substantial delay. To determine whether these clinical findings are correlated with changes in synaptic functions, we used adult OVX rats to evaluate the consequences of short-term (7–10 d, OVX<jats:sub>Control</jats:sub>) and long-term (∼5 months, OVX<jats:sub>LT</jats:sub>) ovarian hormone loss, as well as subsequent<jats:italic>in vivo</jats:italic>E<jats:sub>2</jats:sub>treatment, on excitatory synaptic transmission at the hippocampal CA3–CA1 synapses important for learning and memory. The results show that ovarian hormone loss was associated with a marked decrease in synaptic strength. E<jats:sub>2</jats:sub>treatment increased synaptic strength in OVX<jats:sub>Control</jats:sub>but not OVX<jats:sub>LT</jats:sub>rats, demonstrating a change in the efficacy for E<jats:sub>2</jats:sub>5 months following OVX. E<jats:sub>2</jats:sub>also had a more rapid effect: within minutes of bath application, E<jats:sub>2</jats:sub>acutely increased synaptic strength in all groups except OVX<jats:sub>LT</jats:sub>rats that did not receive<jats:italic>in vivo</jats:italic>E<jats:sub>2</jats:sub>treatment. E<jats:sub>2</jats:sub>'s acute effect was mediated postsynaptically, and required Ca<jats:sup>2+</jats:sup>influx through the voltage-gated Ca<jats:sup>2+</jats:sup>channels. Despite E<jats:sub>2</jats:sub>'s acute effect, synaptic strength of OVX<jats:sub>LT</jats:sub>rats remained significantly lower than that of OVX<jats:sub>Control</jats:sub>rats. Thus, changes in CA3–CA1 synaptic transmission associated with ovarian hormone loss cannot be fully reversed with delayed E<jats:sub>2</jats:sub>treatment. Given that synaptic strength at CA3–CA1 synapses is related to the ability to learn hippocampus-dependent tasks, these findings provide additional insights for understanding cognitive impairment-associated long-term ovarian hormone loss and ineffectiveness for delayed E<jats:sub>2</jats:sub>treatment to maintain cognitive functions.</jats:p> Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses The Journal of Neuroscience |
| spellingShingle | Wu, Wendy W., Bryant, Damani N., Dorsa, Daniel M., Adelman, John P., Maylie, James, The Journal of Neuroscience, Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses, General Neuroscience |
| title | Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses |
| title_full | Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses |
| title_fullStr | Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses |
| title_full_unstemmed | Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses |
| title_short | Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses |
| title_sort | ovarian hormone loss impairs excitatory synaptic transmission at hippocampal ca3–ca1 synapses |
| title_unstemmed | Ovarian Hormone Loss Impairs Excitatory Synaptic Transmission at Hippocampal CA3–CA1 Synapses |
| topic | General Neuroscience |
| url | http://dx.doi.org/10.1523/jneurosci.2001-13.2013 |