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ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli
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| Zeitschriftentitel: | The Journal of Neuroscience |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , |
| In: | The Journal of Neuroscience, 33, 2013, 47, S. 18381-18395 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Society for Neuroscience
|
| Schlagwörter: |
| author_facet |
Lobo, Mary Kay Zaman, Samir Damez-Werno, Diane M. Koo, Ja Wook Bagot, Rosemary C. DiNieri, Jennifer A. Nugent, Alexandria Finkel, Eric Chaudhury, Dipesh Chandra, Ramesh Riberio, Efrain Rabkin, Jacqui Mouzon, Ezekiell Cachope, Roger Cheer, Joseph F. Han, Ming-Hu Dietz, David M. Self, David W. Hurd, Yasmin L. Vialou, Vincent Nestler, Eric J. Lobo, Mary Kay Zaman, Samir Damez-Werno, Diane M. Koo, Ja Wook Bagot, Rosemary C. DiNieri, Jennifer A. Nugent, Alexandria Finkel, Eric Chaudhury, Dipesh Chandra, Ramesh Riberio, Efrain Rabkin, Jacqui Mouzon, Ezekiell Cachope, Roger Cheer, Joseph F. Han, Ming-Hu Dietz, David M. Self, David W. Hurd, Yasmin L. Vialou, Vincent Nestler, Eric J. |
|---|---|
| author |
Lobo, Mary Kay Zaman, Samir Damez-Werno, Diane M. Koo, Ja Wook Bagot, Rosemary C. DiNieri, Jennifer A. Nugent, Alexandria Finkel, Eric Chaudhury, Dipesh Chandra, Ramesh Riberio, Efrain Rabkin, Jacqui Mouzon, Ezekiell Cachope, Roger Cheer, Joseph F. Han, Ming-Hu Dietz, David M. Self, David W. Hurd, Yasmin L. Vialou, Vincent Nestler, Eric J. |
| spellingShingle |
Lobo, Mary Kay Zaman, Samir Damez-Werno, Diane M. Koo, Ja Wook Bagot, Rosemary C. DiNieri, Jennifer A. Nugent, Alexandria Finkel, Eric Chaudhury, Dipesh Chandra, Ramesh Riberio, Efrain Rabkin, Jacqui Mouzon, Ezekiell Cachope, Roger Cheer, Joseph F. Han, Ming-Hu Dietz, David M. Self, David W. Hurd, Yasmin L. Vialou, Vincent Nestler, Eric J. The Journal of Neuroscience ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli General Neuroscience |
| author_sort |
lobo, mary kay |
| spelling |
Lobo, Mary Kay Zaman, Samir Damez-Werno, Diane M. Koo, Ja Wook Bagot, Rosemary C. DiNieri, Jennifer A. Nugent, Alexandria Finkel, Eric Chaudhury, Dipesh Chandra, Ramesh Riberio, Efrain Rabkin, Jacqui Mouzon, Ezekiell Cachope, Roger Cheer, Joseph F. Han, Ming-Hu Dietz, David M. Self, David W. Hurd, Yasmin L. Vialou, Vincent Nestler, Eric J. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.1875-13.2013 <jats:p>The transcription factor, ΔFosB, is robustly and persistently induced in striatum by several chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, and stress. However, very few studies have examined the degree of ΔFosB induction in the two striatal medium spiny neuron (MSN) subtypes. We make use of fluorescent reporter BAC transgenic mice to evaluate induction of ΔFosB in dopamine receptor 1 (D1) enriched and dopamine receptor 2 (D2) enriched MSNs in ventral striatum, nucleus accumbens (NAc) shell and core, and in dorsal striatum (dStr) after chronic exposure to several drugs of abuse including cocaine, ethanol, Δ(9)-tetrahydrocannabinol, and opiates; the antipsychotic drug, haloperidol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake inhibitor antidepressant, fluoxetine; and social defeat stress. Our findings demonstrate that chronic exposure to many stimuli induces ΔFosB in an MSN-subtype selective pattern across all three striatal regions. To explore the circuit-mediated induction of ΔFosB in striatum, we use optogenetics to enhance activity in limbic brain regions that send synaptic inputs to NAc; these regions include the ventral tegmental area and several glutamatergic afferent regions: medial prefrontal cortex, amygdala, and ventral hippocampus. These optogenetic conditions lead to highly distinct patterns of ΔFosB induction in MSN subtypes in NAc core and shell. Together, these findings establish selective patterns of ΔFosB induction in striatal MSN subtypes in response to chronic stimuli and provide novel insight into the circuit-level mechanisms of ΔFosB induction in striatum.</jats:p> ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli The Journal of Neuroscience |
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| title |
ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli |
| title_unstemmed |
ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli |
| title_full |
ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli |
| title_fullStr |
ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli |
| title_full_unstemmed |
ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli |
| title_short |
ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli |
| title_sort |
δfosb induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli |
| topic |
General Neuroscience |
| url |
http://dx.doi.org/10.1523/jneurosci.1875-13.2013 |
| publishDate |
2013 |
| physical |
18381-18395 |
| description |
<jats:p>The transcription factor, ΔFosB, is robustly and persistently induced in striatum by several chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, and stress. However, very few studies have examined the degree of ΔFosB induction in the two striatal medium spiny neuron (MSN) subtypes. We make use of fluorescent reporter BAC transgenic mice to evaluate induction of ΔFosB in dopamine receptor 1 (D1) enriched and dopamine receptor 2 (D2) enriched MSNs in ventral striatum, nucleus accumbens (NAc) shell and core, and in dorsal striatum (dStr) after chronic exposure to several drugs of abuse including cocaine, ethanol, Δ(9)-tetrahydrocannabinol, and opiates; the antipsychotic drug, haloperidol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake inhibitor antidepressant, fluoxetine; and social defeat stress. Our findings demonstrate that chronic exposure to many stimuli induces ΔFosB in an MSN-subtype selective pattern across all three striatal regions. To explore the circuit-mediated induction of ΔFosB in striatum, we use optogenetics to enhance activity in limbic brain regions that send synaptic inputs to NAc; these regions include the ventral tegmental area and several glutamatergic afferent regions: medial prefrontal cortex, amygdala, and ventral hippocampus. These optogenetic conditions lead to highly distinct patterns of ΔFosB induction in MSN subtypes in NAc core and shell. Together, these findings establish selective patterns of ΔFosB induction in striatal MSN subtypes in response to chronic stimuli and provide novel insight into the circuit-level mechanisms of ΔFosB induction in striatum.</jats:p> |
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| author | Lobo, Mary Kay, Zaman, Samir, Damez-Werno, Diane M., Koo, Ja Wook, Bagot, Rosemary C., DiNieri, Jennifer A., Nugent, Alexandria, Finkel, Eric, Chaudhury, Dipesh, Chandra, Ramesh, Riberio, Efrain, Rabkin, Jacqui, Mouzon, Ezekiell, Cachope, Roger, Cheer, Joseph F., Han, Ming-Hu, Dietz, David M., Self, David W., Hurd, Yasmin L., Vialou, Vincent, Nestler, Eric J. |
| author_facet | Lobo, Mary Kay, Zaman, Samir, Damez-Werno, Diane M., Koo, Ja Wook, Bagot, Rosemary C., DiNieri, Jennifer A., Nugent, Alexandria, Finkel, Eric, Chaudhury, Dipesh, Chandra, Ramesh, Riberio, Efrain, Rabkin, Jacqui, Mouzon, Ezekiell, Cachope, Roger, Cheer, Joseph F., Han, Ming-Hu, Dietz, David M., Self, David W., Hurd, Yasmin L., Vialou, Vincent, Nestler, Eric J., Lobo, Mary Kay, Zaman, Samir, Damez-Werno, Diane M., Koo, Ja Wook, Bagot, Rosemary C., DiNieri, Jennifer A., Nugent, Alexandria, Finkel, Eric, Chaudhury, Dipesh, Chandra, Ramesh, Riberio, Efrain, Rabkin, Jacqui, Mouzon, Ezekiell, Cachope, Roger, Cheer, Joseph F., Han, Ming-Hu, Dietz, David M., Self, David W., Hurd, Yasmin L., Vialou, Vincent, Nestler, Eric J. |
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| description | <jats:p>The transcription factor, ΔFosB, is robustly and persistently induced in striatum by several chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, and stress. However, very few studies have examined the degree of ΔFosB induction in the two striatal medium spiny neuron (MSN) subtypes. We make use of fluorescent reporter BAC transgenic mice to evaluate induction of ΔFosB in dopamine receptor 1 (D1) enriched and dopamine receptor 2 (D2) enriched MSNs in ventral striatum, nucleus accumbens (NAc) shell and core, and in dorsal striatum (dStr) after chronic exposure to several drugs of abuse including cocaine, ethanol, Δ(9)-tetrahydrocannabinol, and opiates; the antipsychotic drug, haloperidol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake inhibitor antidepressant, fluoxetine; and social defeat stress. Our findings demonstrate that chronic exposure to many stimuli induces ΔFosB in an MSN-subtype selective pattern across all three striatal regions. To explore the circuit-mediated induction of ΔFosB in striatum, we use optogenetics to enhance activity in limbic brain regions that send synaptic inputs to NAc; these regions include the ventral tegmental area and several glutamatergic afferent regions: medial prefrontal cortex, amygdala, and ventral hippocampus. These optogenetic conditions lead to highly distinct patterns of ΔFosB induction in MSN subtypes in NAc core and shell. Together, these findings establish selective patterns of ΔFosB induction in striatal MSN subtypes in response to chronic stimuli and provide novel insight into the circuit-level mechanisms of ΔFosB induction in striatum.</jats:p> |
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| spelling | Lobo, Mary Kay Zaman, Samir Damez-Werno, Diane M. Koo, Ja Wook Bagot, Rosemary C. DiNieri, Jennifer A. Nugent, Alexandria Finkel, Eric Chaudhury, Dipesh Chandra, Ramesh Riberio, Efrain Rabkin, Jacqui Mouzon, Ezekiell Cachope, Roger Cheer, Joseph F. Han, Ming-Hu Dietz, David M. Self, David W. Hurd, Yasmin L. Vialou, Vincent Nestler, Eric J. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.1875-13.2013 <jats:p>The transcription factor, ΔFosB, is robustly and persistently induced in striatum by several chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, and stress. However, very few studies have examined the degree of ΔFosB induction in the two striatal medium spiny neuron (MSN) subtypes. We make use of fluorescent reporter BAC transgenic mice to evaluate induction of ΔFosB in dopamine receptor 1 (D1) enriched and dopamine receptor 2 (D2) enriched MSNs in ventral striatum, nucleus accumbens (NAc) shell and core, and in dorsal striatum (dStr) after chronic exposure to several drugs of abuse including cocaine, ethanol, Δ(9)-tetrahydrocannabinol, and opiates; the antipsychotic drug, haloperidol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake inhibitor antidepressant, fluoxetine; and social defeat stress. Our findings demonstrate that chronic exposure to many stimuli induces ΔFosB in an MSN-subtype selective pattern across all three striatal regions. To explore the circuit-mediated induction of ΔFosB in striatum, we use optogenetics to enhance activity in limbic brain regions that send synaptic inputs to NAc; these regions include the ventral tegmental area and several glutamatergic afferent regions: medial prefrontal cortex, amygdala, and ventral hippocampus. These optogenetic conditions lead to highly distinct patterns of ΔFosB induction in MSN subtypes in NAc core and shell. Together, these findings establish selective patterns of ΔFosB induction in striatal MSN subtypes in response to chronic stimuli and provide novel insight into the circuit-level mechanisms of ΔFosB induction in striatum.</jats:p> ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli The Journal of Neuroscience |
| spellingShingle | Lobo, Mary Kay, Zaman, Samir, Damez-Werno, Diane M., Koo, Ja Wook, Bagot, Rosemary C., DiNieri, Jennifer A., Nugent, Alexandria, Finkel, Eric, Chaudhury, Dipesh, Chandra, Ramesh, Riberio, Efrain, Rabkin, Jacqui, Mouzon, Ezekiell, Cachope, Roger, Cheer, Joseph F., Han, Ming-Hu, Dietz, David M., Self, David W., Hurd, Yasmin L., Vialou, Vincent, Nestler, Eric J., The Journal of Neuroscience, ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli, General Neuroscience |
| title | ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli |
| title_full | ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli |
| title_fullStr | ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli |
| title_full_unstemmed | ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli |
| title_short | ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli |
| title_sort | δfosb induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli |
| title_unstemmed | ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli |
| topic | General Neuroscience |
| url | http://dx.doi.org/10.1523/jneurosci.1875-13.2013 |