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Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil
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| Zeitschriftentitel: | Revista da Sociedade Brasileira de Medicina Tropical |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Revista da Sociedade Brasileira de Medicina Tropical, 20, 1987, 3, S. 153-158 |
| Format: | E-Article |
| Sprache: | Unbestimmt |
| veröffentlicht: |
FapUNIFESP (SciELO)
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| Schlagwörter: |
| author_facet |
Meira, Domingos Alves Pellegrino Júnior, Jordão Marcondes-Machado, Jussara Tsuji, Kimiyoski Matsuoka, Elinda Satie Haida, Elizete Khoury, Albert Boutros El Meira, Domingos Alves Pellegrino Júnior, Jordão Marcondes-Machado, Jussara Tsuji, Kimiyoski Matsuoka, Elinda Satie Haida, Elizete Khoury, Albert Boutros El |
|---|---|
| author |
Meira, Domingos Alves Pellegrino Júnior, Jordão Marcondes-Machado, Jussara Tsuji, Kimiyoski Matsuoka, Elinda Satie Haida, Elizete Khoury, Albert Boutros El |
| spellingShingle |
Meira, Domingos Alves Pellegrino Júnior, Jordão Marcondes-Machado, Jussara Tsuji, Kimiyoski Matsuoka, Elinda Satie Haida, Elizete Khoury, Albert Boutros El Revista da Sociedade Brasileira de Medicina Tropical Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil Infectious Diseases Microbiology (medical) Parasitology |
| author_sort |
meira, domingos alves |
| spelling |
Meira, Domingos Alves Pellegrino Júnior, Jordão Marcondes-Machado, Jussara Tsuji, Kimiyoski Matsuoka, Elinda Satie Haida, Elizete Khoury, Albert Boutros El 0037-8682 FapUNIFESP (SciELO) Infectious Diseases Microbiology (medical) Parasitology http://dx.doi.org/10.1590/s0037-86821987000300005 <jats:p>In August 1983,85 inhabitants of the municipality of Humaitá, Amazonas State, Brazil were studied to determine the prevalence of antigens to HLA-A, -B, -C and DR. Thirty-eight were sick with malaria due to Plasmodium falciparum. All subjects were examined for splenomegaly, blood parasitaemia and antibodies to malaria. They constituted three groups: 1) 25 subjects native to the Amazon region who had never had malaria; 2) 38 Amazonian subjects who had malaria in the past or currently had an infection; 3) 22 patients with malaria who had acquired the infection in the Amazon Region but came from other regions of Brazil. Blood was taken from each person, the lymphocytes were separated and typed by the test of microlymphocytotoxicity. There was a high frequency of antigens that could not be identified in the groups studied which suggests the existence of a homozygote or phenotype not identified in the population. There was a high frequency of the phenotype Ag(W24) (44.7%) in group 2 when compared with group 1 (32%) or group 3 (9%). Also the individuals in group 2 showed an elevated frequency of antigen DR(4)80%) when compared with group 1 (36.6%) or group 3 (16.6%). These observations suggest the possibility of a genetic susceptibility to malaria among Amazonian residents and indicate a necessity for more extensive studies of the frequency of HLA antigens among inhabitants of this endemic malarial zone.</jats:p> Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil Revista da Sociedade Brasileira de Medicina Tropical |
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| title |
Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_unstemmed |
Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_full |
Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_fullStr |
Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_full_unstemmed |
Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_short |
Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_sort |
frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of humaitá county, amazonas state, brazil |
| topic |
Infectious Diseases Microbiology (medical) Parasitology |
| url |
http://dx.doi.org/10.1590/s0037-86821987000300005 |
| publishDate |
1987 |
| physical |
153-158 |
| description |
<jats:p>In August 1983,85 inhabitants of the municipality of Humaitá, Amazonas State, Brazil were studied to determine the prevalence of antigens to HLA-A, -B, -C and DR. Thirty-eight were sick with malaria due to Plasmodium falciparum. All subjects were examined for splenomegaly, blood parasitaemia and antibodies to malaria. They constituted three groups: 1) 25 subjects native to the Amazon region who had never had malaria; 2) 38 Amazonian subjects who had malaria in the past or currently had an infection; 3) 22 patients with malaria who had acquired the infection in the Amazon Region but came from other regions of Brazil. Blood was taken from each person, the lymphocytes were separated and typed by the test of microlymphocytotoxicity. There was a high frequency of antigens that could not be identified in the groups studied which suggests the existence of a homozygote or phenotype not identified in the population. There was a high frequency of the phenotype Ag(W24) (44.7%) in group 2 when compared with group 1 (32%) or group 3 (9%). Also the individuals in group 2 showed an elevated frequency of antigen DR(4)80%) when compared with group 1 (36.6%) or group 3 (16.6%). These observations suggest the possibility of a genetic susceptibility to malaria among Amazonian residents and indicate a necessity for more extensive studies of the frequency of HLA antigens among inhabitants of this endemic malarial zone.</jats:p> |
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| description | <jats:p>In August 1983,85 inhabitants of the municipality of Humaitá, Amazonas State, Brazil were studied to determine the prevalence of antigens to HLA-A, -B, -C and DR. Thirty-eight were sick with malaria due to Plasmodium falciparum. All subjects were examined for splenomegaly, blood parasitaemia and antibodies to malaria. They constituted three groups: 1) 25 subjects native to the Amazon region who had never had malaria; 2) 38 Amazonian subjects who had malaria in the past or currently had an infection; 3) 22 patients with malaria who had acquired the infection in the Amazon Region but came from other regions of Brazil. Blood was taken from each person, the lymphocytes were separated and typed by the test of microlymphocytotoxicity. There was a high frequency of antigens that could not be identified in the groups studied which suggests the existence of a homozygote or phenotype not identified in the population. There was a high frequency of the phenotype Ag(W24) (44.7%) in group 2 when compared with group 1 (32%) or group 3 (9%). Also the individuals in group 2 showed an elevated frequency of antigen DR(4)80%) when compared with group 1 (36.6%) or group 3 (16.6%). These observations suggest the possibility of a genetic susceptibility to malaria among Amazonian residents and indicate a necessity for more extensive studies of the frequency of HLA antigens among inhabitants of this endemic malarial zone.</jats:p> |
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| spelling | Meira, Domingos Alves Pellegrino Júnior, Jordão Marcondes-Machado, Jussara Tsuji, Kimiyoski Matsuoka, Elinda Satie Haida, Elizete Khoury, Albert Boutros El 0037-8682 FapUNIFESP (SciELO) Infectious Diseases Microbiology (medical) Parasitology http://dx.doi.org/10.1590/s0037-86821987000300005 <jats:p>In August 1983,85 inhabitants of the municipality of Humaitá, Amazonas State, Brazil were studied to determine the prevalence of antigens to HLA-A, -B, -C and DR. Thirty-eight were sick with malaria due to Plasmodium falciparum. All subjects were examined for splenomegaly, blood parasitaemia and antibodies to malaria. They constituted three groups: 1) 25 subjects native to the Amazon region who had never had malaria; 2) 38 Amazonian subjects who had malaria in the past or currently had an infection; 3) 22 patients with malaria who had acquired the infection in the Amazon Region but came from other regions of Brazil. Blood was taken from each person, the lymphocytes were separated and typed by the test of microlymphocytotoxicity. There was a high frequency of antigens that could not be identified in the groups studied which suggests the existence of a homozygote or phenotype not identified in the population. There was a high frequency of the phenotype Ag(W24) (44.7%) in group 2 when compared with group 1 (32%) or group 3 (9%). Also the individuals in group 2 showed an elevated frequency of antigen DR(4)80%) when compared with group 1 (36.6%) or group 3 (16.6%). These observations suggest the possibility of a genetic susceptibility to malaria among Amazonian residents and indicate a necessity for more extensive studies of the frequency of HLA antigens among inhabitants of this endemic malarial zone.</jats:p> Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil Revista da Sociedade Brasileira de Medicina Tropical |
| spellingShingle | Meira, Domingos Alves, Pellegrino Júnior, Jordão, Marcondes-Machado, Jussara, Tsuji, Kimiyoski, Matsuoka, Elinda Satie, Haida, Elizete, Khoury, Albert Boutros El, Revista da Sociedade Brasileira de Medicina Tropical, Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil, Infectious Diseases, Microbiology (medical), Parasitology |
| title | Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_full | Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_fullStr | Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_full_unstemmed | Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_short | Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| title_sort | frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of humaitá county, amazonas state, brazil |
| title_unstemmed | Frequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazil |
| topic | Infectious Diseases, Microbiology (medical), Parasitology |
| url | http://dx.doi.org/10.1590/s0037-86821987000300005 |