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Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement
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| Zeitschriftentitel: | Brazilian Dental Journal |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Brazilian Dental Journal, 28, 2017, 3, S. 287-295 |
| Format: | E-Article |
| Sprache: | Unbestimmt |
| veröffentlicht: |
FapUNIFESP (SciELO)
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| Schlagwörter: |
| author_facet |
Moraes, Paola Castro de Marques, Isabela Cristina de Souza Basso, Fernanda Gonçalves Rossetto, Hebert Luis Pires-de-Souza, Fernanda de Carvalho Panzeri Costa, Carlos Alberto de Souza Garcia, Lucas da Fonseca Roberti Moraes, Paola Castro de Marques, Isabela Cristina de Souza Basso, Fernanda Gonçalves Rossetto, Hebert Luis Pires-de-Souza, Fernanda de Carvalho Panzeri Costa, Carlos Alberto de Souza Garcia, Lucas da Fonseca Roberti |
|---|---|
| author |
Moraes, Paola Castro de Marques, Isabela Cristina de Souza Basso, Fernanda Gonçalves Rossetto, Hebert Luis Pires-de-Souza, Fernanda de Carvalho Panzeri Costa, Carlos Alberto de Souza Garcia, Lucas da Fonseca Roberti |
| spellingShingle |
Moraes, Paola Castro de Marques, Isabela Cristina de Souza Basso, Fernanda Gonçalves Rossetto, Hebert Luis Pires-de-Souza, Fernanda de Carvalho Panzeri Costa, Carlos Alberto de Souza Garcia, Lucas da Fonseca Roberti Brazilian Dental Journal Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement General Dentistry |
| author_sort |
moraes, paola castro de |
| spelling |
Moraes, Paola Castro de Marques, Isabela Cristina de Souza Basso, Fernanda Gonçalves Rossetto, Hebert Luis Pires-de-Souza, Fernanda de Carvalho Panzeri Costa, Carlos Alberto de Souza Garcia, Lucas da Fonseca Roberti 0103-6440 FapUNIFESP (SciELO) General Dentistry http://dx.doi.org/10.1590/0103-6440201601454 <jats:p>Abstract Innovative biomaterials can provide a promising new direction for the treatment of bone defects, stimulating a proper repair process, with no damage to adjacent tissues. The purpose of this in vivo study was to evaluate the biocompatibility and the osteoinductive capacity of chitosan-collagen biomembrane and scaffold containing calcium aluminate cement. Eighteen New Zealand white rabbits (Oryctolagus cuniculus) were distributed according to the experimental times of analysis (7, 15 and 30 days). Four bone defects were created in the rabbits calvaria, which were individually filled with the biomembrane, scaffold, blood clot (negative control) and autologous bone (positive control). Histopathological analysis was performed using optical microscope at 32´, 64´, 125´ and 320´ magnifications. Cell response to inflammation and new bone tissue formation was quantified using a score system. The biomembrane group presented greater inflammatory response at 15 days, with significant difference to autologous bone group (p<0.05). There was no statistically significant difference for foreign body type reaction among groups (p>0.05). Concerning new bone formation, linear closure of the defect area was observed more evidently in the group with autologous bone. The scaffold group presented similar results compared with the autologous bone group at 30 days (p>0.05). Both tested biomaterials presented similar biocompatibility compared with the control groups. In addition, the biomembrane and scaffold presented similar osteoinductive capacity, stimulating bone repair process in the course of the experimental time intervals.</jats:p> Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement Brazilian Dental Journal |
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| title |
Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement |
| title_unstemmed |
Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement |
| title_full |
Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement |
| title_fullStr |
Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement |
| title_full_unstemmed |
Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement |
| title_short |
Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement |
| title_sort |
repair of bone defects with chitosan-collagen biomembrane and scaffold containing calcium aluminate cement |
| topic |
General Dentistry |
| url |
http://dx.doi.org/10.1590/0103-6440201601454 |
| publishDate |
2017 |
| physical |
287-295 |
| description |
<jats:p>Abstract Innovative biomaterials can provide a promising new direction for the treatment of bone defects, stimulating a proper repair process, with no damage to adjacent tissues. The purpose of this in vivo study was to evaluate the biocompatibility and the osteoinductive capacity of chitosan-collagen biomembrane and scaffold containing calcium aluminate cement. Eighteen New Zealand white rabbits (Oryctolagus cuniculus) were distributed according to the experimental times of analysis (7, 15 and 30 days). Four bone defects were created in the rabbits calvaria, which were individually filled with the biomembrane, scaffold, blood clot (negative control) and autologous bone (positive control). Histopathological analysis was performed using optical microscope at 32´, 64´, 125´ and 320´ magnifications. Cell response to inflammation and new bone tissue formation was quantified using a score system. The biomembrane group presented greater inflammatory response at 15 days, with significant difference to autologous bone group (p<0.05). There was no statistically significant difference for foreign body type reaction among groups (p>0.05). Concerning new bone formation, linear closure of the defect area was observed more evidently in the group with autologous bone. The scaffold group presented similar results compared with the autologous bone group at 30 days (p>0.05). Both tested biomaterials presented similar biocompatibility compared with the control groups. In addition, the biomembrane and scaffold presented similar osteoinductive capacity, stimulating bone repair process in the course of the experimental time intervals.</jats:p> |
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| author | Moraes, Paola Castro de, Marques, Isabela Cristina de Souza, Basso, Fernanda Gonçalves, Rossetto, Hebert Luis, Pires-de-Souza, Fernanda de Carvalho Panzeri, Costa, Carlos Alberto de Souza, Garcia, Lucas da Fonseca Roberti |
| author_facet | Moraes, Paola Castro de, Marques, Isabela Cristina de Souza, Basso, Fernanda Gonçalves, Rossetto, Hebert Luis, Pires-de-Souza, Fernanda de Carvalho Panzeri, Costa, Carlos Alberto de Souza, Garcia, Lucas da Fonseca Roberti, Moraes, Paola Castro de, Marques, Isabela Cristina de Souza, Basso, Fernanda Gonçalves, Rossetto, Hebert Luis, Pires-de-Souza, Fernanda de Carvalho Panzeri, Costa, Carlos Alberto de Souza, Garcia, Lucas da Fonseca Roberti |
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| description | <jats:p>Abstract Innovative biomaterials can provide a promising new direction for the treatment of bone defects, stimulating a proper repair process, with no damage to adjacent tissues. The purpose of this in vivo study was to evaluate the biocompatibility and the osteoinductive capacity of chitosan-collagen biomembrane and scaffold containing calcium aluminate cement. Eighteen New Zealand white rabbits (Oryctolagus cuniculus) were distributed according to the experimental times of analysis (7, 15 and 30 days). Four bone defects were created in the rabbits calvaria, which were individually filled with the biomembrane, scaffold, blood clot (negative control) and autologous bone (positive control). Histopathological analysis was performed using optical microscope at 32´, 64´, 125´ and 320´ magnifications. Cell response to inflammation and new bone tissue formation was quantified using a score system. The biomembrane group presented greater inflammatory response at 15 days, with significant difference to autologous bone group (p<0.05). There was no statistically significant difference for foreign body type reaction among groups (p>0.05). Concerning new bone formation, linear closure of the defect area was observed more evidently in the group with autologous bone. The scaffold group presented similar results compared with the autologous bone group at 30 days (p>0.05). Both tested biomaterials presented similar biocompatibility compared with the control groups. In addition, the biomembrane and scaffold presented similar osteoinductive capacity, stimulating bone repair process in the course of the experimental time intervals.</jats:p> |
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| spelling | Moraes, Paola Castro de Marques, Isabela Cristina de Souza Basso, Fernanda Gonçalves Rossetto, Hebert Luis Pires-de-Souza, Fernanda de Carvalho Panzeri Costa, Carlos Alberto de Souza Garcia, Lucas da Fonseca Roberti 0103-6440 FapUNIFESP (SciELO) General Dentistry http://dx.doi.org/10.1590/0103-6440201601454 <jats:p>Abstract Innovative biomaterials can provide a promising new direction for the treatment of bone defects, stimulating a proper repair process, with no damage to adjacent tissues. The purpose of this in vivo study was to evaluate the biocompatibility and the osteoinductive capacity of chitosan-collagen biomembrane and scaffold containing calcium aluminate cement. Eighteen New Zealand white rabbits (Oryctolagus cuniculus) were distributed according to the experimental times of analysis (7, 15 and 30 days). Four bone defects were created in the rabbits calvaria, which were individually filled with the biomembrane, scaffold, blood clot (negative control) and autologous bone (positive control). Histopathological analysis was performed using optical microscope at 32´, 64´, 125´ and 320´ magnifications. Cell response to inflammation and new bone tissue formation was quantified using a score system. The biomembrane group presented greater inflammatory response at 15 days, with significant difference to autologous bone group (p<0.05). There was no statistically significant difference for foreign body type reaction among groups (p>0.05). Concerning new bone formation, linear closure of the defect area was observed more evidently in the group with autologous bone. The scaffold group presented similar results compared with the autologous bone group at 30 days (p>0.05). Both tested biomaterials presented similar biocompatibility compared with the control groups. In addition, the biomembrane and scaffold presented similar osteoinductive capacity, stimulating bone repair process in the course of the experimental time intervals.</jats:p> Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement Brazilian Dental Journal |
| spellingShingle | Moraes, Paola Castro de, Marques, Isabela Cristina de Souza, Basso, Fernanda Gonçalves, Rossetto, Hebert Luis, Pires-de-Souza, Fernanda de Carvalho Panzeri, Costa, Carlos Alberto de Souza, Garcia, Lucas da Fonseca Roberti, Brazilian Dental Journal, Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement, General Dentistry |
| title | Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement |
| title_full | Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement |
| title_fullStr | Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement |
| title_full_unstemmed | Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement |
| title_short | Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement |
| title_sort | repair of bone defects with chitosan-collagen biomembrane and scaffold containing calcium aluminate cement |
| title_unstemmed | Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement |
| topic | General Dentistry |
| url | http://dx.doi.org/10.1590/0103-6440201601454 |