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Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease
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| Zeitschriftentitel: | Clinical and Translational Gastroenterology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Clinical and Translational Gastroenterology, 10, 2019, 3, S. e00015 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Huang, Shanshan Li, Li Ben-Horin, Shomron Mao, Ren Lin, Sinan Qiu, Yun Feng, Rui He, Yao Chen, Baili Zeng, Zhirong Chen, Minhu Zhang, Shenghong Huang, Shanshan Li, Li Ben-Horin, Shomron Mao, Ren Lin, Sinan Qiu, Yun Feng, Rui He, Yao Chen, Baili Zeng, Zhirong Chen, Minhu Zhang, Shenghong |
|---|---|
| author |
Huang, Shanshan Li, Li Ben-Horin, Shomron Mao, Ren Lin, Sinan Qiu, Yun Feng, Rui He, Yao Chen, Baili Zeng, Zhirong Chen, Minhu Zhang, Shenghong |
| spellingShingle |
Huang, Shanshan Li, Li Ben-Horin, Shomron Mao, Ren Lin, Sinan Qiu, Yun Feng, Rui He, Yao Chen, Baili Zeng, Zhirong Chen, Minhu Zhang, Shenghong Clinical and Translational Gastroenterology Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease Gastroenterology |
| author_sort |
huang, shanshan |
| spelling |
Huang, Shanshan Li, Li Ben-Horin, Shomron Mao, Ren Lin, Sinan Qiu, Yun Feng, Rui He, Yao Chen, Baili Zeng, Zhirong Chen, Minhu Zhang, Shenghong 2155-384X Ovid Technologies (Wolters Kluwer Health) Gastroenterology http://dx.doi.org/10.14309/ctg.0000000000000015 <jats:sec> <jats:title>OBJECTIVES:</jats:title> <jats:p>Mucosal healing (MH) is the goal of the “treat to target” strategy in Crohn's disease (CD), which seeks to prevent disability. However, evidence is limited regarding whether achieving MH can reduce disability in CD. We aimed to estimate the probability of disabling disease and to investigate the association between MH and disabling disease in CD.</jats:p> </jats:sec> <jats:sec> <jats:title>METHODS:</jats:title> <jats:p>This was a retrospective case-control study of 319 consecutive CD patients. The primary outcome was disabling disease occurrence (defined as surgery, hospitalizations, steroid dependency, or disease complications). The secondary endpoint was disabling disease recurrence. The Kaplan-Meier method and Cox proportional hazards model were used to calculate cumulative rates and for multivariate analysis, respectively.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS:</jats:title> <jats:p>Of 319 CD patients (median follow-up time: 42.4 months, interquartile range: 24.7–60.0 months), 105 (32.9%) progressed to disabling disease and 20 (6.3%) had the recurrence of disabling disease. The cumulative rates of disabling disease were 11.3%, 30.2%, and 44.9% at 1, 3, and 5 years, respectively, after diagnosis. MH was associated with a significantly lower frequency of surgery, new penetrating event, and new stenosis (<jats:italic toggle="yes">P</jats:italic> = 0.004, <jats:italic toggle="yes">P</jats:italic> = 0.001, <jats:italic toggle="yes">P</jats:italic> = 0.002, respectively). Univariate and multivariate analyses revealed that MH was an independent protective factor of disabling disease occurrence (hazard ratio: 0.166, 95% confidence interval: 0.084–0.329).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS:</jats:title> <jats:p>Disabling disease was common in Chinese CD patients and increased during follow-up. Moreover, MH was significantly associated with a reduced occurrence of disabling disease in CD.</jats:p> </jats:sec> Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease Clinical and Translational Gastroenterology |
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10.14309/ctg.0000000000000015 |
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Ovid Technologies (Wolters Kluwer Health), 2019 |
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Ovid Technologies (Wolters Kluwer Health), 2019 |
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| title |
Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease |
| title_unstemmed |
Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease |
| title_full |
Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease |
| title_fullStr |
Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease |
| title_full_unstemmed |
Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease |
| title_short |
Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease |
| title_sort |
mucosal healing is associated with the reduced disabling disease in crohn's disease |
| topic |
Gastroenterology |
| url |
http://dx.doi.org/10.14309/ctg.0000000000000015 |
| publishDate |
2019 |
| physical |
e00015 |
| description |
<jats:sec>
<jats:title>OBJECTIVES:</jats:title>
<jats:p>Mucosal healing (MH) is the goal of the “treat to target” strategy in Crohn's disease (CD), which seeks to prevent disability. However, evidence is limited regarding whether achieving MH can reduce disability in CD. We aimed to estimate the probability of disabling disease and to investigate the association between MH and disabling disease in CD.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>METHODS:</jats:title>
<jats:p>This was a retrospective case-control study of 319 consecutive CD patients. The primary outcome was disabling disease occurrence (defined as surgery, hospitalizations, steroid dependency, or disease complications). The secondary endpoint was disabling disease recurrence. The Kaplan-Meier method and Cox proportional hazards model were used to calculate cumulative rates and for multivariate analysis, respectively.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>RESULTS:</jats:title>
<jats:p>Of 319 CD patients (median follow-up time: 42.4 months, interquartile range: 24.7–60.0 months), 105 (32.9%) progressed to disabling disease and 20 (6.3%) had the recurrence of disabling disease. The cumulative rates of disabling disease were 11.3%, 30.2%, and 44.9% at 1, 3, and 5 years, respectively, after diagnosis. MH was associated with a significantly lower frequency of surgery, new penetrating event, and new stenosis (<jats:italic toggle="yes">P</jats:italic> = 0.004, <jats:italic toggle="yes">P</jats:italic> = 0.001, <jats:italic toggle="yes">P</jats:italic> = 0.002, respectively). Univariate and multivariate analyses revealed that MH was an independent protective factor of disabling disease occurrence (hazard ratio: 0.166, 95% confidence interval: 0.084–0.329).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>CONCLUSIONS:</jats:title>
<jats:p>Disabling disease was common in Chinese CD patients and increased during follow-up. Moreover, MH was significantly associated with a reduced occurrence of disabling disease in CD.</jats:p>
</jats:sec> |
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| author | Huang, Shanshan, Li, Li, Ben-Horin, Shomron, Mao, Ren, Lin, Sinan, Qiu, Yun, Feng, Rui, He, Yao, Chen, Baili, Zeng, Zhirong, Chen, Minhu, Zhang, Shenghong |
| author_facet | Huang, Shanshan, Li, Li, Ben-Horin, Shomron, Mao, Ren, Lin, Sinan, Qiu, Yun, Feng, Rui, He, Yao, Chen, Baili, Zeng, Zhirong, Chen, Minhu, Zhang, Shenghong, Huang, Shanshan, Li, Li, Ben-Horin, Shomron, Mao, Ren, Lin, Sinan, Qiu, Yun, Feng, Rui, He, Yao, Chen, Baili, Zeng, Zhirong, Chen, Minhu, Zhang, Shenghong |
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| description | <jats:sec> <jats:title>OBJECTIVES:</jats:title> <jats:p>Mucosal healing (MH) is the goal of the “treat to target” strategy in Crohn's disease (CD), which seeks to prevent disability. However, evidence is limited regarding whether achieving MH can reduce disability in CD. We aimed to estimate the probability of disabling disease and to investigate the association between MH and disabling disease in CD.</jats:p> </jats:sec> <jats:sec> <jats:title>METHODS:</jats:title> <jats:p>This was a retrospective case-control study of 319 consecutive CD patients. The primary outcome was disabling disease occurrence (defined as surgery, hospitalizations, steroid dependency, or disease complications). The secondary endpoint was disabling disease recurrence. The Kaplan-Meier method and Cox proportional hazards model were used to calculate cumulative rates and for multivariate analysis, respectively.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS:</jats:title> <jats:p>Of 319 CD patients (median follow-up time: 42.4 months, interquartile range: 24.7–60.0 months), 105 (32.9%) progressed to disabling disease and 20 (6.3%) had the recurrence of disabling disease. The cumulative rates of disabling disease were 11.3%, 30.2%, and 44.9% at 1, 3, and 5 years, respectively, after diagnosis. MH was associated with a significantly lower frequency of surgery, new penetrating event, and new stenosis (<jats:italic toggle="yes">P</jats:italic> = 0.004, <jats:italic toggle="yes">P</jats:italic> = 0.001, <jats:italic toggle="yes">P</jats:italic> = 0.002, respectively). Univariate and multivariate analyses revealed that MH was an independent protective factor of disabling disease occurrence (hazard ratio: 0.166, 95% confidence interval: 0.084–0.329).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS:</jats:title> <jats:p>Disabling disease was common in Chinese CD patients and increased during follow-up. Moreover, MH was significantly associated with a reduced occurrence of disabling disease in CD.</jats:p> </jats:sec> |
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| imprint | Ovid Technologies (Wolters Kluwer Health), 2019 |
| imprint_str_mv | Ovid Technologies (Wolters Kluwer Health), 2019 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Huang, Shanshan Li, Li Ben-Horin, Shomron Mao, Ren Lin, Sinan Qiu, Yun Feng, Rui He, Yao Chen, Baili Zeng, Zhirong Chen, Minhu Zhang, Shenghong 2155-384X Ovid Technologies (Wolters Kluwer Health) Gastroenterology http://dx.doi.org/10.14309/ctg.0000000000000015 <jats:sec> <jats:title>OBJECTIVES:</jats:title> <jats:p>Mucosal healing (MH) is the goal of the “treat to target” strategy in Crohn's disease (CD), which seeks to prevent disability. However, evidence is limited regarding whether achieving MH can reduce disability in CD. We aimed to estimate the probability of disabling disease and to investigate the association between MH and disabling disease in CD.</jats:p> </jats:sec> <jats:sec> <jats:title>METHODS:</jats:title> <jats:p>This was a retrospective case-control study of 319 consecutive CD patients. The primary outcome was disabling disease occurrence (defined as surgery, hospitalizations, steroid dependency, or disease complications). The secondary endpoint was disabling disease recurrence. The Kaplan-Meier method and Cox proportional hazards model were used to calculate cumulative rates and for multivariate analysis, respectively.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS:</jats:title> <jats:p>Of 319 CD patients (median follow-up time: 42.4 months, interquartile range: 24.7–60.0 months), 105 (32.9%) progressed to disabling disease and 20 (6.3%) had the recurrence of disabling disease. The cumulative rates of disabling disease were 11.3%, 30.2%, and 44.9% at 1, 3, and 5 years, respectively, after diagnosis. MH was associated with a significantly lower frequency of surgery, new penetrating event, and new stenosis (<jats:italic toggle="yes">P</jats:italic> = 0.004, <jats:italic toggle="yes">P</jats:italic> = 0.001, <jats:italic toggle="yes">P</jats:italic> = 0.002, respectively). Univariate and multivariate analyses revealed that MH was an independent protective factor of disabling disease occurrence (hazard ratio: 0.166, 95% confidence interval: 0.084–0.329).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS:</jats:title> <jats:p>Disabling disease was common in Chinese CD patients and increased during follow-up. Moreover, MH was significantly associated with a reduced occurrence of disabling disease in CD.</jats:p> </jats:sec> Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease Clinical and Translational Gastroenterology |
| spellingShingle | Huang, Shanshan, Li, Li, Ben-Horin, Shomron, Mao, Ren, Lin, Sinan, Qiu, Yun, Feng, Rui, He, Yao, Chen, Baili, Zeng, Zhirong, Chen, Minhu, Zhang, Shenghong, Clinical and Translational Gastroenterology, Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease, Gastroenterology |
| title | Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease |
| title_full | Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease |
| title_fullStr | Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease |
| title_full_unstemmed | Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease |
| title_short | Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease |
| title_sort | mucosal healing is associated with the reduced disabling disease in crohn's disease |
| title_unstemmed | Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease |
| topic | Gastroenterology |
| url | http://dx.doi.org/10.14309/ctg.0000000000000015 |