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Cell-mediated bioresorption of sintered carbonate apatite in rabbits
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| Zeitschriftentitel: | The Journal of Bone and Joint Surgery. British volume |
|---|---|
| Personen und Körperschaften: | , , |
| In: | The Journal of Bone and Joint Surgery. British volume, 85-B, 2003, 1, S. 142-147 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
British Editorial Society of Bone & Joint Surgery
|
| Schlagwörter: |
| author_facet |
Hasegawa, M. Doi, Y Uchida, A. Hasegawa, M. Doi, Y Uchida, A. |
|---|---|
| author |
Hasegawa, M. Doi, Y Uchida, A. |
| spellingShingle |
Hasegawa, M. Doi, Y Uchida, A. The Journal of Bone and Joint Surgery. British volume Cell-mediated bioresorption of sintered carbonate apatite in rabbits Orthopedics and Sports Medicine Surgery |
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hasegawa, m. |
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Hasegawa, M. Doi, Y Uchida, A. 0301-620X 2044-5377 British Editorial Society of Bone & Joint Surgery Orthopedics and Sports Medicine Surgery http://dx.doi.org/10.1302/0301-620x.85b1.13414 <jats:p> Bone apatite contains carbonate and is therefore not pure hydroxyapatite. We have successfully developed sintered carbonate apatite (CA) with a concentration of carbonate of 6 weight% and have evaluated its osteoconductive and bioresorption characteristics. Cylindrical porous sintered CA and sintered hydroxyapatite (HA) measuring 4 × 4 mm with a porosity of 20% were implanted into surgically-created bone defects in the knees of rabbits. The animals were killed after 1, 3, 6 and 12 months. The defects were evaluated by microfocus CT and histology. </jats:p><jats:p> Bone growth into and around both materials increased. Newly-formed bone was placed in direct contact with both. Osteoclast-like cells resorbed only CA, and were coupled with osteoblasts. The porosity of sintered CA increased, indicating bioresorption, whereas that of sintered HA did not increase. Our findings indicate that sintered CA may be useful as a bioresorbable bone substitute. </jats:p> Cell-mediated bioresorption of sintered carbonate apatite in rabbits The Journal of Bone and Joint Surgery. British volume |
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| title |
Cell-mediated bioresorption of sintered carbonate apatite in rabbits |
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Cell-mediated bioresorption of sintered carbonate apatite in rabbits |
| title_full |
Cell-mediated bioresorption of sintered carbonate apatite in rabbits |
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Cell-mediated bioresorption of sintered carbonate apatite in rabbits |
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Cell-mediated bioresorption of sintered carbonate apatite in rabbits |
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Cell-mediated bioresorption of sintered carbonate apatite in rabbits |
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cell-mediated bioresorption of sintered carbonate apatite in rabbits |
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Orthopedics and Sports Medicine Surgery |
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http://dx.doi.org/10.1302/0301-620x.85b1.13414 |
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2003 |
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142-147 |
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<jats:p> Bone apatite contains carbonate and is therefore not pure hydroxyapatite. We have successfully developed sintered carbonate apatite (CA) with a concentration of carbonate of 6 weight% and have evaluated its osteoconductive and bioresorption characteristics. Cylindrical porous sintered CA and sintered hydroxyapatite (HA) measuring 4 × 4 mm with a porosity of 20% were implanted into surgically-created bone defects in the knees of rabbits. The animals were killed after 1, 3, 6 and 12 months. The defects were evaluated by microfocus CT and histology. </jats:p><jats:p> Bone growth into and around both materials increased. Newly-formed bone was placed in direct contact with both. Osteoclast-like cells resorbed only CA, and were coupled with osteoblasts. The porosity of sintered CA increased, indicating bioresorption, whereas that of sintered HA did not increase. Our findings indicate that sintered CA may be useful as a bioresorbable bone substitute. </jats:p> |
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| author | Hasegawa, M., Doi, Y, Uchida, A. |
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| description | <jats:p> Bone apatite contains carbonate and is therefore not pure hydroxyapatite. We have successfully developed sintered carbonate apatite (CA) with a concentration of carbonate of 6 weight% and have evaluated its osteoconductive and bioresorption characteristics. Cylindrical porous sintered CA and sintered hydroxyapatite (HA) measuring 4 × 4 mm with a porosity of 20% were implanted into surgically-created bone defects in the knees of rabbits. The animals were killed after 1, 3, 6 and 12 months. The defects were evaluated by microfocus CT and histology. </jats:p><jats:p> Bone growth into and around both materials increased. Newly-formed bone was placed in direct contact with both. Osteoclast-like cells resorbed only CA, and were coupled with osteoblasts. The porosity of sintered CA increased, indicating bioresorption, whereas that of sintered HA did not increase. Our findings indicate that sintered CA may be useful as a bioresorbable bone substitute. </jats:p> |
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| spelling | Hasegawa, M. Doi, Y Uchida, A. 0301-620X 2044-5377 British Editorial Society of Bone & Joint Surgery Orthopedics and Sports Medicine Surgery http://dx.doi.org/10.1302/0301-620x.85b1.13414 <jats:p> Bone apatite contains carbonate and is therefore not pure hydroxyapatite. We have successfully developed sintered carbonate apatite (CA) with a concentration of carbonate of 6 weight% and have evaluated its osteoconductive and bioresorption characteristics. Cylindrical porous sintered CA and sintered hydroxyapatite (HA) measuring 4 × 4 mm with a porosity of 20% were implanted into surgically-created bone defects in the knees of rabbits. The animals were killed after 1, 3, 6 and 12 months. The defects were evaluated by microfocus CT and histology. </jats:p><jats:p> Bone growth into and around both materials increased. Newly-formed bone was placed in direct contact with both. Osteoclast-like cells resorbed only CA, and were coupled with osteoblasts. The porosity of sintered CA increased, indicating bioresorption, whereas that of sintered HA did not increase. Our findings indicate that sintered CA may be useful as a bioresorbable bone substitute. </jats:p> Cell-mediated bioresorption of sintered carbonate apatite in rabbits The Journal of Bone and Joint Surgery. British volume |
| spellingShingle | Hasegawa, M., Doi, Y, Uchida, A., The Journal of Bone and Joint Surgery. British volume, Cell-mediated bioresorption of sintered carbonate apatite in rabbits, Orthopedics and Sports Medicine, Surgery |
| title | Cell-mediated bioresorption of sintered carbonate apatite in rabbits |
| title_full | Cell-mediated bioresorption of sintered carbonate apatite in rabbits |
| title_fullStr | Cell-mediated bioresorption of sintered carbonate apatite in rabbits |
| title_full_unstemmed | Cell-mediated bioresorption of sintered carbonate apatite in rabbits |
| title_short | Cell-mediated bioresorption of sintered carbonate apatite in rabbits |
| title_sort | cell-mediated bioresorption of sintered carbonate apatite in rabbits |
| title_unstemmed | Cell-mediated bioresorption of sintered carbonate apatite in rabbits |
| topic | Orthopedics and Sports Medicine, Surgery |
| url | http://dx.doi.org/10.1302/0301-620x.85b1.13414 |