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Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog
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| Zeitschriftentitel: | Veterinary Pathology |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Veterinary Pathology, 44, 2007, 4, S. 518-520 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Bae, I.-H. Kim, Y. Pakhrin, B. You, M.-H. Hwang, C.-Y. Kim, J.-H. Kim, D.-Y. Bae, I.-H. Kim, Y. Pakhrin, B. You, M.-H. Hwang, C.-Y. Kim, J.-H. Kim, D.-Y. |
|---|---|
| author |
Bae, I.-H. Kim, Y. Pakhrin, B. You, M.-H. Hwang, C.-Y. Kim, J.-H. Kim, D.-Y. |
| spellingShingle |
Bae, I.-H. Kim, Y. Pakhrin, B. You, M.-H. Hwang, C.-Y. Kim, J.-H. Kim, D.-Y. Veterinary Pathology Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog General Veterinary |
| author_sort |
bae, i.-h. |
| spelling |
Bae, I.-H. Kim, Y. Pakhrin, B. You, M.-H. Hwang, C.-Y. Kim, J.-H. Kim, D.-Y. 0300-9858 1544-2217 SAGE Publications General Veterinary http://dx.doi.org/10.1354/vp.44-4-518 <jats:p>A 2-year-old intact female Golden Retriever presented due to rapidly progressing depression, ascites, dysuria, abdominal pain, and severe vaginal bleeding. At necropsy, the retroperitoneal space was expanded by multiple coalescing neoplastic nodules and the uterine wall was thickened with poorly defined neoplastic infiltrates. The urinary bladder was markedly thickened due to botryoid nodules exhibiting exophytic growth into the lumen. Metastases to lung, liver, kidney, and abdominal and thoracic lymph nodes were also noted. Microscopically, the genital tract and retroperitoneal masses were consistent with the alveolar subtype of rhabdomysarcoma, while the urinary bladder mass had characteristics of the embryonal subtype. Immunohistochemically, the neoplastic cells in all these tissue sites were intensely positive for desmin, sacromeric actin, and vimentin, while they were uniformly negative for cytokeratin and smooth muscle actin. Phosphotungstic acid hematoxylin stain revealed cross-striations in the cytoplasm of scattered neoplastic cells. Based on the gross findings, histopathology, and immunohistochemistry, genitourinary rhabdomyosarcoma with multisystemic metastases was made.</jats:p> Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog Veterinary Pathology |
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| title |
Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog |
| title_unstemmed |
Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog |
| title_full |
Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog |
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Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog |
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Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog |
| title_short |
Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog |
| title_sort |
genitourinary rhabdomyosarcoma with systemic metastasis in a young dog |
| topic |
General Veterinary |
| url |
http://dx.doi.org/10.1354/vp.44-4-518 |
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2007 |
| physical |
518-520 |
| description |
<jats:p>A 2-year-old intact female Golden Retriever presented due to rapidly progressing depression, ascites, dysuria, abdominal pain, and severe vaginal bleeding. At necropsy, the retroperitoneal space was expanded by multiple coalescing neoplastic nodules and the uterine wall was thickened with poorly defined neoplastic infiltrates. The urinary bladder was markedly thickened due to botryoid nodules exhibiting exophytic growth into the lumen. Metastases to lung, liver, kidney, and abdominal and thoracic lymph nodes were also noted. Microscopically, the genital tract and retroperitoneal masses were consistent with the alveolar subtype of rhabdomysarcoma, while the urinary bladder mass had characteristics of the embryonal subtype. Immunohistochemically, the neoplastic cells in all these tissue sites were intensely positive for desmin, sacromeric actin, and vimentin, while they were uniformly negative for cytokeratin and smooth muscle actin. Phosphotungstic acid hematoxylin stain revealed cross-striations in the cytoplasm of scattered neoplastic cells. Based on the gross findings, histopathology, and immunohistochemistry, genitourinary rhabdomyosarcoma with multisystemic metastases was made.</jats:p> |
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| author | Bae, I.-H., Kim, Y., Pakhrin, B., You, M.-H., Hwang, C.-Y., Kim, J.-H., Kim, D.-Y. |
| author_facet | Bae, I.-H., Kim, Y., Pakhrin, B., You, M.-H., Hwang, C.-Y., Kim, J.-H., Kim, D.-Y., Bae, I.-H., Kim, Y., Pakhrin, B., You, M.-H., Hwang, C.-Y., Kim, J.-H., Kim, D.-Y. |
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| description | <jats:p>A 2-year-old intact female Golden Retriever presented due to rapidly progressing depression, ascites, dysuria, abdominal pain, and severe vaginal bleeding. At necropsy, the retroperitoneal space was expanded by multiple coalescing neoplastic nodules and the uterine wall was thickened with poorly defined neoplastic infiltrates. The urinary bladder was markedly thickened due to botryoid nodules exhibiting exophytic growth into the lumen. Metastases to lung, liver, kidney, and abdominal and thoracic lymph nodes were also noted. Microscopically, the genital tract and retroperitoneal masses were consistent with the alveolar subtype of rhabdomysarcoma, while the urinary bladder mass had characteristics of the embryonal subtype. Immunohistochemically, the neoplastic cells in all these tissue sites were intensely positive for desmin, sacromeric actin, and vimentin, while they were uniformly negative for cytokeratin and smooth muscle actin. Phosphotungstic acid hematoxylin stain revealed cross-striations in the cytoplasm of scattered neoplastic cells. Based on the gross findings, histopathology, and immunohistochemistry, genitourinary rhabdomyosarcoma with multisystemic metastases was made.</jats:p> |
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| imprint | SAGE Publications, 2007 |
| imprint_str_mv | SAGE Publications, 2007 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
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| spelling | Bae, I.-H. Kim, Y. Pakhrin, B. You, M.-H. Hwang, C.-Y. Kim, J.-H. Kim, D.-Y. 0300-9858 1544-2217 SAGE Publications General Veterinary http://dx.doi.org/10.1354/vp.44-4-518 <jats:p>A 2-year-old intact female Golden Retriever presented due to rapidly progressing depression, ascites, dysuria, abdominal pain, and severe vaginal bleeding. At necropsy, the retroperitoneal space was expanded by multiple coalescing neoplastic nodules and the uterine wall was thickened with poorly defined neoplastic infiltrates. The urinary bladder was markedly thickened due to botryoid nodules exhibiting exophytic growth into the lumen. Metastases to lung, liver, kidney, and abdominal and thoracic lymph nodes were also noted. Microscopically, the genital tract and retroperitoneal masses were consistent with the alveolar subtype of rhabdomysarcoma, while the urinary bladder mass had characteristics of the embryonal subtype. Immunohistochemically, the neoplastic cells in all these tissue sites were intensely positive for desmin, sacromeric actin, and vimentin, while they were uniformly negative for cytokeratin and smooth muscle actin. Phosphotungstic acid hematoxylin stain revealed cross-striations in the cytoplasm of scattered neoplastic cells. Based on the gross findings, histopathology, and immunohistochemistry, genitourinary rhabdomyosarcoma with multisystemic metastases was made.</jats:p> Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog Veterinary Pathology |
| spellingShingle | Bae, I.-H., Kim, Y., Pakhrin, B., You, M.-H., Hwang, C.-Y., Kim, J.-H., Kim, D.-Y., Veterinary Pathology, Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog, General Veterinary |
| title | Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog |
| title_full | Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog |
| title_fullStr | Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog |
| title_full_unstemmed | Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog |
| title_short | Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog |
| title_sort | genitourinary rhabdomyosarcoma with systemic metastasis in a young dog |
| title_unstemmed | Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog |
| topic | General Veterinary |
| url | http://dx.doi.org/10.1354/vp.44-4-518 |