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Kisspeptin Resets the Hypothalamic GnRH Clock in Men
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| Zeitschriftentitel: | The Journal of Clinical Endocrinology & Metabolism |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | The Journal of Clinical Endocrinology & Metabolism, 96, 2011, 6, S. E908-E915 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Endocrine Society
|
| Schlagwörter: |
| author_facet |
Chan, Yee-Ming Butler, James P. Pinnell, Nancy E. Pralong, François P. Crowley, William F. Ren, Chen Chan, Kenneth K. Seminara, Stephanie B. Chan, Yee-Ming Butler, James P. Pinnell, Nancy E. Pralong, François P. Crowley, William F. Ren, Chen Chan, Kenneth K. Seminara, Stephanie B. |
|---|---|
| author |
Chan, Yee-Ming Butler, James P. Pinnell, Nancy E. Pralong, François P. Crowley, William F. Ren, Chen Chan, Kenneth K. Seminara, Stephanie B. |
| spellingShingle |
Chan, Yee-Ming Butler, James P. Pinnell, Nancy E. Pralong, François P. Crowley, William F. Ren, Chen Chan, Kenneth K. Seminara, Stephanie B. The Journal of Clinical Endocrinology & Metabolism Kisspeptin Resets the Hypothalamic GnRH Clock in Men Biochemistry (medical) Clinical Biochemistry Endocrinology Biochemistry Endocrinology, Diabetes and Metabolism |
| author_sort |
chan, yee-ming |
| spelling |
Chan, Yee-Ming Butler, James P. Pinnell, Nancy E. Pralong, François P. Crowley, William F. Ren, Chen Chan, Kenneth K. Seminara, Stephanie B. 0021-972X 1945-7197 The Endocrine Society Biochemistry (medical) Clinical Biochemistry Endocrinology Biochemistry Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1210/jc.2010-3046 <jats:sec> <jats:title>Context:</jats:title> <jats:p>Reproduction in all mammals is controlled by a hypothalamic clock that produces periodic secretory pulses of GnRH, but how the timing of these pulses is determined is poorly understood. The neuropeptide kisspeptin potently and selectively stimulates the secretion of GnRH. Although this property of kisspeptin is well described, the effects of kisspeptin on endogenous GnRH pulse generation remain largely unexplored.</jats:p> </jats:sec> <jats:sec> <jats:title>Objective:</jats:title> <jats:p>The objective of the study was to detail the effects of kisspeptin on GnRH secretion, as reflected by LH secretion, in men.</jats:p> </jats:sec> <jats:sec> <jats:title>Participants:</jats:title> <jats:p>Thirteen healthy adult men participated in the study.</jats:p> </jats:sec> <jats:sec> <jats:title>Intervention:</jats:title> <jats:p>The intervention was the administration of a single iv bolus of the C-terminal decapeptide of kisspeptin (amino acids 112–121 of the parent protein).</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Kisspeptin induced an immediate LH pulse, regardless of the timing of the previous endogenous pulse. The kisspeptin-induced pulses were on average larger than endogenous pulses (amplitude 5.0 ± 1.0 vs. 2.1 ± 0.3 mIU/ml, P = 0.02). Comparison of the morphology of kisspeptin-induced LH pulses in healthy men with that of GnRH-induced LH pulses in men with isolated GnRH deficiency suggests that a single iv bolus of kisspeptin triggered sustained GnRH release lasting approximately 17 min. Furthermore, kisspeptin reset the GnRH pulse generator, as it not only induced an immediate LH pulse but also delayed the next endogenous pulse by an interval approximating the normal interpulse interval.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>As the first known agent capable of resetting the hypothalamic GnRH pulse generator, kisspeptin can be used as a physiological tool for studying GnRH pulse generation and opens a door to understanding the mechanisms of biological clocks in general.</jats:p> </jats:sec> Kisspeptin Resets the Hypothalamic GnRH Clock in Men The Journal of Clinical Endocrinology & Metabolism |
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The Endocrine Society, 2011 |
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The Endocrine Society, 2011 |
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| title |
Kisspeptin Resets the Hypothalamic GnRH Clock in Men |
| title_unstemmed |
Kisspeptin Resets the Hypothalamic GnRH Clock in Men |
| title_full |
Kisspeptin Resets the Hypothalamic GnRH Clock in Men |
| title_fullStr |
Kisspeptin Resets the Hypothalamic GnRH Clock in Men |
| title_full_unstemmed |
Kisspeptin Resets the Hypothalamic GnRH Clock in Men |
| title_short |
Kisspeptin Resets the Hypothalamic GnRH Clock in Men |
| title_sort |
kisspeptin resets the hypothalamic gnrh clock in men |
| topic |
Biochemistry (medical) Clinical Biochemistry Endocrinology Biochemistry Endocrinology, Diabetes and Metabolism |
| url |
http://dx.doi.org/10.1210/jc.2010-3046 |
| publishDate |
2011 |
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E908-E915 |
| description |
<jats:sec>
<jats:title>Context:</jats:title>
<jats:p>Reproduction in all mammals is controlled by a hypothalamic clock that produces periodic secretory pulses of GnRH, but how the timing of these pulses is determined is poorly understood. The neuropeptide kisspeptin potently and selectively stimulates the secretion of GnRH. Although this property of kisspeptin is well described, the effects of kisspeptin on endogenous GnRH pulse generation remain largely unexplored.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Objective:</jats:title>
<jats:p>The objective of the study was to detail the effects of kisspeptin on GnRH secretion, as reflected by LH secretion, in men.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Participants:</jats:title>
<jats:p>Thirteen healthy adult men participated in the study.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Intervention:</jats:title>
<jats:p>The intervention was the administration of a single iv bolus of the C-terminal decapeptide of kisspeptin (amino acids 112–121 of the parent protein).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results:</jats:title>
<jats:p>Kisspeptin induced an immediate LH pulse, regardless of the timing of the previous endogenous pulse. The kisspeptin-induced pulses were on average larger than endogenous pulses (amplitude 5.0 ± 1.0 vs. 2.1 ± 0.3 mIU/ml, P = 0.02). Comparison of the morphology of kisspeptin-induced LH pulses in healthy men with that of GnRH-induced LH pulses in men with isolated GnRH deficiency suggests that a single iv bolus of kisspeptin triggered sustained GnRH release lasting approximately 17 min. Furthermore, kisspeptin reset the GnRH pulse generator, as it not only induced an immediate LH pulse but also delayed the next endogenous pulse by an interval approximating the normal interpulse interval.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions:</jats:title>
<jats:p>As the first known agent capable of resetting the hypothalamic GnRH pulse generator, kisspeptin can be used as a physiological tool for studying GnRH pulse generation and opens a door to understanding the mechanisms of biological clocks in general.</jats:p>
</jats:sec> |
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| author | Chan, Yee-Ming, Butler, James P., Pinnell, Nancy E., Pralong, François P., Crowley, William F., Ren, Chen, Chan, Kenneth K., Seminara, Stephanie B. |
| author_facet | Chan, Yee-Ming, Butler, James P., Pinnell, Nancy E., Pralong, François P., Crowley, William F., Ren, Chen, Chan, Kenneth K., Seminara, Stephanie B., Chan, Yee-Ming, Butler, James P., Pinnell, Nancy E., Pralong, François P., Crowley, William F., Ren, Chen, Chan, Kenneth K., Seminara, Stephanie B. |
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| description | <jats:sec> <jats:title>Context:</jats:title> <jats:p>Reproduction in all mammals is controlled by a hypothalamic clock that produces periodic secretory pulses of GnRH, but how the timing of these pulses is determined is poorly understood. The neuropeptide kisspeptin potently and selectively stimulates the secretion of GnRH. Although this property of kisspeptin is well described, the effects of kisspeptin on endogenous GnRH pulse generation remain largely unexplored.</jats:p> </jats:sec> <jats:sec> <jats:title>Objective:</jats:title> <jats:p>The objective of the study was to detail the effects of kisspeptin on GnRH secretion, as reflected by LH secretion, in men.</jats:p> </jats:sec> <jats:sec> <jats:title>Participants:</jats:title> <jats:p>Thirteen healthy adult men participated in the study.</jats:p> </jats:sec> <jats:sec> <jats:title>Intervention:</jats:title> <jats:p>The intervention was the administration of a single iv bolus of the C-terminal decapeptide of kisspeptin (amino acids 112–121 of the parent protein).</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Kisspeptin induced an immediate LH pulse, regardless of the timing of the previous endogenous pulse. The kisspeptin-induced pulses were on average larger than endogenous pulses (amplitude 5.0 ± 1.0 vs. 2.1 ± 0.3 mIU/ml, P = 0.02). Comparison of the morphology of kisspeptin-induced LH pulses in healthy men with that of GnRH-induced LH pulses in men with isolated GnRH deficiency suggests that a single iv bolus of kisspeptin triggered sustained GnRH release lasting approximately 17 min. Furthermore, kisspeptin reset the GnRH pulse generator, as it not only induced an immediate LH pulse but also delayed the next endogenous pulse by an interval approximating the normal interpulse interval.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>As the first known agent capable of resetting the hypothalamic GnRH pulse generator, kisspeptin can be used as a physiological tool for studying GnRH pulse generation and opens a door to understanding the mechanisms of biological clocks in general.</jats:p> </jats:sec> |
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| imprint_str_mv | The Endocrine Society, 2011 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
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| publishDate | 2011 |
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| series | The Journal of Clinical Endocrinology & Metabolism |
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| spelling | Chan, Yee-Ming Butler, James P. Pinnell, Nancy E. Pralong, François P. Crowley, William F. Ren, Chen Chan, Kenneth K. Seminara, Stephanie B. 0021-972X 1945-7197 The Endocrine Society Biochemistry (medical) Clinical Biochemistry Endocrinology Biochemistry Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1210/jc.2010-3046 <jats:sec> <jats:title>Context:</jats:title> <jats:p>Reproduction in all mammals is controlled by a hypothalamic clock that produces periodic secretory pulses of GnRH, but how the timing of these pulses is determined is poorly understood. The neuropeptide kisspeptin potently and selectively stimulates the secretion of GnRH. Although this property of kisspeptin is well described, the effects of kisspeptin on endogenous GnRH pulse generation remain largely unexplored.</jats:p> </jats:sec> <jats:sec> <jats:title>Objective:</jats:title> <jats:p>The objective of the study was to detail the effects of kisspeptin on GnRH secretion, as reflected by LH secretion, in men.</jats:p> </jats:sec> <jats:sec> <jats:title>Participants:</jats:title> <jats:p>Thirteen healthy adult men participated in the study.</jats:p> </jats:sec> <jats:sec> <jats:title>Intervention:</jats:title> <jats:p>The intervention was the administration of a single iv bolus of the C-terminal decapeptide of kisspeptin (amino acids 112–121 of the parent protein).</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Kisspeptin induced an immediate LH pulse, regardless of the timing of the previous endogenous pulse. The kisspeptin-induced pulses were on average larger than endogenous pulses (amplitude 5.0 ± 1.0 vs. 2.1 ± 0.3 mIU/ml, P = 0.02). Comparison of the morphology of kisspeptin-induced LH pulses in healthy men with that of GnRH-induced LH pulses in men with isolated GnRH deficiency suggests that a single iv bolus of kisspeptin triggered sustained GnRH release lasting approximately 17 min. Furthermore, kisspeptin reset the GnRH pulse generator, as it not only induced an immediate LH pulse but also delayed the next endogenous pulse by an interval approximating the normal interpulse interval.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>As the first known agent capable of resetting the hypothalamic GnRH pulse generator, kisspeptin can be used as a physiological tool for studying GnRH pulse generation and opens a door to understanding the mechanisms of biological clocks in general.</jats:p> </jats:sec> Kisspeptin Resets the Hypothalamic GnRH Clock in Men The Journal of Clinical Endocrinology & Metabolism |
| spellingShingle | Chan, Yee-Ming, Butler, James P., Pinnell, Nancy E., Pralong, François P., Crowley, William F., Ren, Chen, Chan, Kenneth K., Seminara, Stephanie B., The Journal of Clinical Endocrinology & Metabolism, Kisspeptin Resets the Hypothalamic GnRH Clock in Men, Biochemistry (medical), Clinical Biochemistry, Endocrinology, Biochemistry, Endocrinology, Diabetes and Metabolism |
| title | Kisspeptin Resets the Hypothalamic GnRH Clock in Men |
| title_full | Kisspeptin Resets the Hypothalamic GnRH Clock in Men |
| title_fullStr | Kisspeptin Resets the Hypothalamic GnRH Clock in Men |
| title_full_unstemmed | Kisspeptin Resets the Hypothalamic GnRH Clock in Men |
| title_short | Kisspeptin Resets the Hypothalamic GnRH Clock in Men |
| title_sort | kisspeptin resets the hypothalamic gnrh clock in men |
| title_unstemmed | Kisspeptin Resets the Hypothalamic GnRH Clock in Men |
| topic | Biochemistry (medical), Clinical Biochemistry, Endocrinology, Biochemistry, Endocrinology, Diabetes and Metabolism |
| url | http://dx.doi.org/10.1210/jc.2010-3046 |