Eintrag weiter verarbeiten
Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes
Gespeichert in:
Zeitschriftentitel: | The Journal of Clinical Endocrinology & Metabolism |
---|---|
Personen und Körperschaften: | , , , |
In: | The Journal of Clinical Endocrinology & Metabolism, 103, 2018, 6, S. 2116-2125 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
The Endocrine Society
|
Schlagwörter: |
author_facet |
Berni, Thomas R Morgan, Christopher L Berni, Ellen R Rees, D Aled Berni, Thomas R Morgan, Christopher L Berni, Ellen R Rees, D Aled |
---|---|
author |
Berni, Thomas R Morgan, Christopher L Berni, Ellen R Rees, D Aled |
spellingShingle |
Berni, Thomas R Morgan, Christopher L Berni, Ellen R Rees, D Aled The Journal of Clinical Endocrinology & Metabolism Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes Biochemistry (medical) Clinical Biochemistry Endocrinology Biochemistry Endocrinology, Diabetes and Metabolism |
author_sort |
berni, thomas r |
spelling |
Berni, Thomas R Morgan, Christopher L Berni, Ellen R Rees, D Aled 0021-972X 1945-7197 The Endocrine Society Biochemistry (medical) Clinical Biochemistry Endocrinology Biochemistry Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1210/jc.2017-02667 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Context</jats:title> <jats:p>Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and subfertility, but the effects on mental health and child neurodevelopment are unclear.</jats:p> </jats:sec> <jats:sec> <jats:title>Objectives</jats:title> <jats:p>To determine if (1) there is an association between PCOS and psychiatric outcomes and (2) whether rates of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are higher in children of mothers with PCOS.</jats:p> </jats:sec> <jats:sec> <jats:title>Design</jats:title> <jats:p>Data were extracted from the Clinical Practice Research Datalink. Patients with PCOS were matched to two control sets (1:1) by age, body mass index, and primary care practice. Control set 2 was additionally matched on prior mental health status. Primary outcomes were the incidence of depression, anxiety, and bipolar disorder. Secondary outcomes were the prevalence of ADHD or ASD in the children.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Eligible patients (16,986) were identified; 16,938 and 16,355 were matched to control sets 1 and 2, respectively. Compared with control set 1, baseline prevalence was 23.1% vs 19.3% for depression, 11.5% vs 9.3% for anxiety, and 3.2% vs 1.5% for bipolar disorder (P &lt; 0.001). The hazard ratio for time to each endpoint was 1.26 (95% confidence interval 1.19 to 1.32), 1.20 (1.11 to 1.29), and 1.21 (1.03 to 1.42) for set 1 and 1.38 (1.30 to 1.45), 1.39 (1.29 to 1.51), and 1.44 (1.21 to 1.71) for set 2. The odds ratios for ASD and ADHD in children were 1.54 (1.12 to 2.11) and 1.64 (1.16 to 2.33) for set 1 and 1.76 (1.27 to 2.46) and 1.34 (0.96 to 1.89) for set 2.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>PCOS is associated with psychiatric morbidity and increased risk of ADHD and ASD in their children. Screening for mental health disorders should be considered during assessment.</jats:p> </jats:sec> Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes The Journal of Clinical Endocrinology & Metabolism |
doi_str_mv |
10.1210/jc.2017-02667 |
facet_avail |
Online Free |
finc_class_facet |
Medizin Biologie Chemie und Pharmazie |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTIxMC9qYy4yMDE3LTAyNjY3 |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTIxMC9qYy4yMDE3LTAyNjY3 |
institution |
DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 |
imprint |
The Endocrine Society, 2018 |
imprint_str_mv |
The Endocrine Society, 2018 |
issn |
0021-972X 1945-7197 |
issn_str_mv |
0021-972X 1945-7197 |
language |
English |
mega_collection |
The Endocrine Society (CrossRef) |
match_str |
berni2018polycysticovarysyndromeisassociatedwithadversementalhealthandneurodevelopmentaloutcomes |
publishDateSort |
2018 |
publisher |
The Endocrine Society |
recordtype |
ai |
record_format |
ai |
series |
The Journal of Clinical Endocrinology & Metabolism |
source_id |
49 |
title |
Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes |
title_unstemmed |
Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes |
title_full |
Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes |
title_fullStr |
Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes |
title_full_unstemmed |
Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes |
title_short |
Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes |
title_sort |
polycystic ovary syndrome is associated with adverse mental health and neurodevelopmental outcomes |
topic |
Biochemistry (medical) Clinical Biochemistry Endocrinology Biochemistry Endocrinology, Diabetes and Metabolism |
url |
http://dx.doi.org/10.1210/jc.2017-02667 |
publishDate |
2018 |
physical |
2116-2125 |
description |
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Context</jats:title>
<jats:p>Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and subfertility, but the effects on mental health and child neurodevelopment are unclear.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Objectives</jats:title>
<jats:p>To determine if (1) there is an association between PCOS and psychiatric outcomes and (2) whether rates of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are higher in children of mothers with PCOS.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Design</jats:title>
<jats:p>Data were extracted from the Clinical Practice Research Datalink. Patients with PCOS were matched to two control sets (1:1) by age, body mass index, and primary care practice. Control set 2 was additionally matched on prior mental health status. Primary outcomes were the incidence of depression, anxiety, and bipolar disorder. Secondary outcomes were the prevalence of ADHD or ASD in the children.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>Eligible patients (16,986) were identified; 16,938 and 16,355 were matched to control sets 1 and 2, respectively. Compared with control set 1, baseline prevalence was 23.1% vs 19.3% for depression, 11.5% vs 9.3% for anxiety, and 3.2% vs 1.5% for bipolar disorder (P &lt; 0.001). The hazard ratio for time to each endpoint was 1.26 (95% confidence interval 1.19 to 1.32), 1.20 (1.11 to 1.29), and 1.21 (1.03 to 1.42) for set 1 and 1.38 (1.30 to 1.45), 1.39 (1.29 to 1.51), and 1.44 (1.21 to 1.71) for set 2. The odds ratios for ASD and ADHD in children were 1.54 (1.12 to 2.11) and 1.64 (1.16 to 2.33) for set 1 and 1.76 (1.27 to 2.46) and 1.34 (0.96 to 1.89) for set 2.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>PCOS is associated with psychiatric morbidity and increased risk of ADHD and ASD in their children. Screening for mental health disorders should be considered during assessment.</jats:p>
</jats:sec> |
container_issue |
6 |
container_start_page |
2116 |
container_title |
The Journal of Clinical Endocrinology & Metabolism |
container_volume |
103 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792348285965434886 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T18:08:44.269Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Polycystic+Ovary+Syndrome+Is+Associated+With+Adverse+Mental+Health+and+Neurodevelopmental+Outcomes&rft.date=2018-06-01&genre=article&issn=1945-7197&volume=103&issue=6&spage=2116&epage=2125&pages=2116-2125&jtitle=The+Journal+of+Clinical+Endocrinology+%26+Metabolism&atitle=Polycystic+Ovary+Syndrome+Is+Associated+With+Adverse+Mental+Health+and+Neurodevelopmental+Outcomes&aulast=Rees&aufirst=D+Aled&rft_id=info%3Adoi%2F10.1210%2Fjc.2017-02667&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792348285965434886 |
author | Berni, Thomas R, Morgan, Christopher L, Berni, Ellen R, Rees, D Aled |
author_facet | Berni, Thomas R, Morgan, Christopher L, Berni, Ellen R, Rees, D Aled, Berni, Thomas R, Morgan, Christopher L, Berni, Ellen R, Rees, D Aled |
author_sort | berni, thomas r |
container_issue | 6 |
container_start_page | 2116 |
container_title | The Journal of Clinical Endocrinology & Metabolism |
container_volume | 103 |
description | <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Context</jats:title> <jats:p>Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and subfertility, but the effects on mental health and child neurodevelopment are unclear.</jats:p> </jats:sec> <jats:sec> <jats:title>Objectives</jats:title> <jats:p>To determine if (1) there is an association between PCOS and psychiatric outcomes and (2) whether rates of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are higher in children of mothers with PCOS.</jats:p> </jats:sec> <jats:sec> <jats:title>Design</jats:title> <jats:p>Data were extracted from the Clinical Practice Research Datalink. Patients with PCOS were matched to two control sets (1:1) by age, body mass index, and primary care practice. Control set 2 was additionally matched on prior mental health status. Primary outcomes were the incidence of depression, anxiety, and bipolar disorder. Secondary outcomes were the prevalence of ADHD or ASD in the children.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Eligible patients (16,986) were identified; 16,938 and 16,355 were matched to control sets 1 and 2, respectively. Compared with control set 1, baseline prevalence was 23.1% vs 19.3% for depression, 11.5% vs 9.3% for anxiety, and 3.2% vs 1.5% for bipolar disorder (P &lt; 0.001). The hazard ratio for time to each endpoint was 1.26 (95% confidence interval 1.19 to 1.32), 1.20 (1.11 to 1.29), and 1.21 (1.03 to 1.42) for set 1 and 1.38 (1.30 to 1.45), 1.39 (1.29 to 1.51), and 1.44 (1.21 to 1.71) for set 2. The odds ratios for ASD and ADHD in children were 1.54 (1.12 to 2.11) and 1.64 (1.16 to 2.33) for set 1 and 1.76 (1.27 to 2.46) and 1.34 (0.96 to 1.89) for set 2.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>PCOS is associated with psychiatric morbidity and increased risk of ADHD and ASD in their children. Screening for mental health disorders should be considered during assessment.</jats:p> </jats:sec> |
doi_str_mv | 10.1210/jc.2017-02667 |
facet_avail | Online, Free |
finc_class_facet | Medizin, Biologie, Chemie und Pharmazie |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTIxMC9qYy4yMDE3LTAyNjY3 |
imprint | The Endocrine Society, 2018 |
imprint_str_mv | The Endocrine Society, 2018 |
institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
issn | 0021-972X, 1945-7197 |
issn_str_mv | 0021-972X, 1945-7197 |
language | English |
last_indexed | 2024-03-01T18:08:44.269Z |
match_str | berni2018polycysticovarysyndromeisassociatedwithadversementalhealthandneurodevelopmentaloutcomes |
mega_collection | The Endocrine Society (CrossRef) |
physical | 2116-2125 |
publishDate | 2018 |
publishDateSort | 2018 |
publisher | The Endocrine Society |
record_format | ai |
recordtype | ai |
series | The Journal of Clinical Endocrinology & Metabolism |
source_id | 49 |
spelling | Berni, Thomas R Morgan, Christopher L Berni, Ellen R Rees, D Aled 0021-972X 1945-7197 The Endocrine Society Biochemistry (medical) Clinical Biochemistry Endocrinology Biochemistry Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1210/jc.2017-02667 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Context</jats:title> <jats:p>Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and subfertility, but the effects on mental health and child neurodevelopment are unclear.</jats:p> </jats:sec> <jats:sec> <jats:title>Objectives</jats:title> <jats:p>To determine if (1) there is an association between PCOS and psychiatric outcomes and (2) whether rates of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are higher in children of mothers with PCOS.</jats:p> </jats:sec> <jats:sec> <jats:title>Design</jats:title> <jats:p>Data were extracted from the Clinical Practice Research Datalink. Patients with PCOS were matched to two control sets (1:1) by age, body mass index, and primary care practice. Control set 2 was additionally matched on prior mental health status. Primary outcomes were the incidence of depression, anxiety, and bipolar disorder. Secondary outcomes were the prevalence of ADHD or ASD in the children.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Eligible patients (16,986) were identified; 16,938 and 16,355 were matched to control sets 1 and 2, respectively. Compared with control set 1, baseline prevalence was 23.1% vs 19.3% for depression, 11.5% vs 9.3% for anxiety, and 3.2% vs 1.5% for bipolar disorder (P &lt; 0.001). The hazard ratio for time to each endpoint was 1.26 (95% confidence interval 1.19 to 1.32), 1.20 (1.11 to 1.29), and 1.21 (1.03 to 1.42) for set 1 and 1.38 (1.30 to 1.45), 1.39 (1.29 to 1.51), and 1.44 (1.21 to 1.71) for set 2. The odds ratios for ASD and ADHD in children were 1.54 (1.12 to 2.11) and 1.64 (1.16 to 2.33) for set 1 and 1.76 (1.27 to 2.46) and 1.34 (0.96 to 1.89) for set 2.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>PCOS is associated with psychiatric morbidity and increased risk of ADHD and ASD in their children. Screening for mental health disorders should be considered during assessment.</jats:p> </jats:sec> Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes The Journal of Clinical Endocrinology & Metabolism |
spellingShingle | Berni, Thomas R, Morgan, Christopher L, Berni, Ellen R, Rees, D Aled, The Journal of Clinical Endocrinology & Metabolism, Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes, Biochemistry (medical), Clinical Biochemistry, Endocrinology, Biochemistry, Endocrinology, Diabetes and Metabolism |
title | Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes |
title_full | Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes |
title_fullStr | Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes |
title_full_unstemmed | Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes |
title_short | Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes |
title_sort | polycystic ovary syndrome is associated with adverse mental health and neurodevelopmental outcomes |
title_unstemmed | Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes |
topic | Biochemistry (medical), Clinical Biochemistry, Endocrinology, Biochemistry, Endocrinology, Diabetes and Metabolism |
url | http://dx.doi.org/10.1210/jc.2017-02667 |