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Thyroid Hormone Transporters
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| Zeitschriftentitel: | Endocrine Reviews |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Endocrine Reviews, 41, 2020, 2, S. 146-201 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Endocrine Society
|
| Schlagwörter: |
| author_facet |
Groeneweg, Stefan van Geest, Ferdy S Peeters, Robin P Heuer, Heike Visser, W Edward Groeneweg, Stefan van Geest, Ferdy S Peeters, Robin P Heuer, Heike Visser, W Edward |
|---|---|
| author |
Groeneweg, Stefan van Geest, Ferdy S Peeters, Robin P Heuer, Heike Visser, W Edward |
| spellingShingle |
Groeneweg, Stefan van Geest, Ferdy S Peeters, Robin P Heuer, Heike Visser, W Edward Endocrine Reviews Thyroid Hormone Transporters Endocrinology Endocrinology, Diabetes and Metabolism |
| author_sort |
groeneweg, stefan |
| spelling |
Groeneweg, Stefan van Geest, Ferdy S Peeters, Robin P Heuer, Heike Visser, W Edward 0163-769X 1945-7189 The Endocrine Society Endocrinology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1210/endrev/bnz008 <jats:title>Abstract</jats:title> <jats:p>Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion transporting polypeptide (OATP) 1C1, and SLC17A4 are currently known as transporters displaying the highest specificity toward thyroid hormones. Structure-function studies using homology modeling and mutational screens have led to better understanding of the molecular basis of thyroid hormone transport. Mutations in MCT8 and in OATP1C1 have been associated with clinical disorders. Different animal models have provided insight into the functional role of thyroid hormone transporters, in particular MCT8. Different treatment strategies for MCT8 deficiency have been explored, of which thyroid hormone analogue therapy is currently applied in patients. Future studies may reveal the identity of as-yet-undiscovered thyroid hormone transporters. Complementary studies employing animal and human models will provide further insight into the role of transporters in health and disease.</jats:p> Thyroid Hormone Transporters Endocrine Reviews |
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The Endocrine Society, 2020 |
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The Endocrine Society, 2020 |
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Endocrine Reviews |
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| title |
Thyroid Hormone Transporters |
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Thyroid Hormone Transporters |
| title_full |
Thyroid Hormone Transporters |
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Thyroid Hormone Transporters |
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Thyroid Hormone Transporters |
| title_short |
Thyroid Hormone Transporters |
| title_sort |
thyroid hormone transporters |
| topic |
Endocrinology Endocrinology, Diabetes and Metabolism |
| url |
http://dx.doi.org/10.1210/endrev/bnz008 |
| publishDate |
2020 |
| physical |
146-201 |
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<jats:title>Abstract</jats:title>
<jats:p>Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion transporting polypeptide (OATP) 1C1, and SLC17A4 are currently known as transporters displaying the highest specificity toward thyroid hormones. Structure-function studies using homology modeling and mutational screens have led to better understanding of the molecular basis of thyroid hormone transport. Mutations in MCT8 and in OATP1C1 have been associated with clinical disorders. Different animal models have provided insight into the functional role of thyroid hormone transporters, in particular MCT8. Different treatment strategies for MCT8 deficiency have been explored, of which thyroid hormone analogue therapy is currently applied in patients. Future studies may reveal the identity of as-yet-undiscovered thyroid hormone transporters. Complementary studies employing animal and human models will provide further insight into the role of transporters in health and disease.</jats:p> |
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| author | Groeneweg, Stefan, van Geest, Ferdy S, Peeters, Robin P, Heuer, Heike, Visser, W Edward |
| author_facet | Groeneweg, Stefan, van Geest, Ferdy S, Peeters, Robin P, Heuer, Heike, Visser, W Edward, Groeneweg, Stefan, van Geest, Ferdy S, Peeters, Robin P, Heuer, Heike, Visser, W Edward |
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| description | <jats:title>Abstract</jats:title> <jats:p>Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion transporting polypeptide (OATP) 1C1, and SLC17A4 are currently known as transporters displaying the highest specificity toward thyroid hormones. Structure-function studies using homology modeling and mutational screens have led to better understanding of the molecular basis of thyroid hormone transport. Mutations in MCT8 and in OATP1C1 have been associated with clinical disorders. Different animal models have provided insight into the functional role of thyroid hormone transporters, in particular MCT8. Different treatment strategies for MCT8 deficiency have been explored, of which thyroid hormone analogue therapy is currently applied in patients. Future studies may reveal the identity of as-yet-undiscovered thyroid hormone transporters. Complementary studies employing animal and human models will provide further insight into the role of transporters in health and disease.</jats:p> |
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| physical | 146-201 |
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| series | Endocrine Reviews |
| source_id | 49 |
| spelling | Groeneweg, Stefan van Geest, Ferdy S Peeters, Robin P Heuer, Heike Visser, W Edward 0163-769X 1945-7189 The Endocrine Society Endocrinology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1210/endrev/bnz008 <jats:title>Abstract</jats:title> <jats:p>Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion transporting polypeptide (OATP) 1C1, and SLC17A4 are currently known as transporters displaying the highest specificity toward thyroid hormones. Structure-function studies using homology modeling and mutational screens have led to better understanding of the molecular basis of thyroid hormone transport. Mutations in MCT8 and in OATP1C1 have been associated with clinical disorders. Different animal models have provided insight into the functional role of thyroid hormone transporters, in particular MCT8. Different treatment strategies for MCT8 deficiency have been explored, of which thyroid hormone analogue therapy is currently applied in patients. Future studies may reveal the identity of as-yet-undiscovered thyroid hormone transporters. Complementary studies employing animal and human models will provide further insight into the role of transporters in health and disease.</jats:p> Thyroid Hormone Transporters Endocrine Reviews |
| spellingShingle | Groeneweg, Stefan, van Geest, Ferdy S, Peeters, Robin P, Heuer, Heike, Visser, W Edward, Endocrine Reviews, Thyroid Hormone Transporters, Endocrinology, Endocrinology, Diabetes and Metabolism |
| title | Thyroid Hormone Transporters |
| title_full | Thyroid Hormone Transporters |
| title_fullStr | Thyroid Hormone Transporters |
| title_full_unstemmed | Thyroid Hormone Transporters |
| title_short | Thyroid Hormone Transporters |
| title_sort | thyroid hormone transporters |
| title_unstemmed | Thyroid Hormone Transporters |
| topic | Endocrinology, Endocrinology, Diabetes and Metabolism |
| url | http://dx.doi.org/10.1210/endrev/bnz008 |