Eintrag weiter verarbeiten
Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography.
Gespeichert in:
| Zeitschriftentitel: | Journal of Clinical Oncology |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Journal of Clinical Oncology, 38, 2020, 15_suppl, S. e24060-e24060 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Clinical Oncology (ASCO)
|
| Schlagwörter: |
| author_facet |
Zingarelli, Roman Aras, Mandar A Bibby, Dwight Fang, Qizhi Daud, Adil Schiller, Nelson B Tsai, Katy K. Zingarelli, Roman Aras, Mandar A Bibby, Dwight Fang, Qizhi Daud, Adil Schiller, Nelson B Tsai, Katy K. |
|---|---|
| author |
Zingarelli, Roman Aras, Mandar A Bibby, Dwight Fang, Qizhi Daud, Adil Schiller, Nelson B Tsai, Katy K. |
| spellingShingle |
Zingarelli, Roman Aras, Mandar A Bibby, Dwight Fang, Qizhi Daud, Adil Schiller, Nelson B Tsai, Katy K. Journal of Clinical Oncology Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. Cancer Research Oncology |
| author_sort |
zingarelli, roman |
| spelling |
Zingarelli, Roman Aras, Mandar A Bibby, Dwight Fang, Qizhi Daud, Adil Schiller, Nelson B Tsai, Katy K. 0732-183X 1527-7755 American Society of Clinical Oncology (ASCO) Cancer Research Oncology http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e24060 <jats:p> e24060 </jats:p><jats:p> Background: Immune checkpoint inhibitors (ICI) effect durable responses in cancer patients (pts). Myocarditis is rare but fatigue is commonly reported, and whether ICI-induced fatigue is due to subclinical cardiac toxicity is unknown. We hypothesized that pts on ICI develop changes on rest and stress echocardiogram (echo) that correlate with fatigue. Methods: A prospective observational study was performed to monitor cardiac function in pts receiving ICI. Our cohort consisted of pts (n = 10) with stage III/IV melanoma, ECOG 0-1, deemed safe to exercise, without unstable cardiac symptoms. ICI-naïve pts received anti-PD1 alone or in combination with anti-CTLA-4, in adjuvant or metastatic setting. Rest transthoracic echo and dynamic staged exercise stress echo testing was conducted at baseline (prior to ICI) and at 3 and 6 months (mo) following ICI. Various echo parameters at rest and stress were compared. irAEs were detailed and surveys administered at baseline and post-follow up. Results: 10 pts (9 men, mean age 56 yrs) completed baseline cardiac testing of whom 7 completed follow up testing at 6 mo (6 anti-PD1 monotherapy, 1 metastatic combination therapy). Of these 7 pts, 5 (71%) reported increased fatigue per CTCAE at 3 or 6 mo follow up and all 7 had irAEs (3 rash, 1 colitis, 1 diarrhea, 1 hypophysitis, 1 arthralgia, 1 xerostomia). Among resting echo parameters, left ventricular outflow tract velocity time integral (LVOT VTI) was significantly reduced at 6 mo compared to baseline (22.6 ± 3.4 vs 20.0 ± 2.5, p = 0.0047), albeit still within normal range. No other resting echo parameters changed. Among exercise echo parameters, there was no difference in METs achieved, time of exercise, blood pressure or heart rate between time points. Of note, of 7 subjects who completed 6 mo testing, 2 (29%) were unable to achieve previous peak stage of exercise during testing. Conclusions: Though no echo parameter significantly correlating with fatigue was reported, nearly one-third of a small cohort of pts were unable to achieve peak exercise 6 mo after starting ICI. This combined with the statistical reduction in LVOT VTI suggests functional limitation and warrants further study. Post-follow up surveys are pending and may further inform issues important in ICI survivorship. [Table: see text] </jats:p> Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. Journal of Clinical Oncology |
| doi_str_mv |
10.1200/jco.2020.38.15_suppl.e24060 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTIwMC9qY28uMjAyMC4zOC4xNV9zdXBwbC5lMjQwNjA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTIwMC9qY28uMjAyMC4zOC4xNV9zdXBwbC5lMjQwNjA |
| institution |
DE-Zi4 DE-Gla1 DE-15 DE-Pl11 DE-Rs1 DE-14 DE-105 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
American Society of Clinical Oncology (ASCO), 2020 |
| imprint_str_mv |
American Society of Clinical Oncology (ASCO), 2020 |
| issn |
0732-183X 1527-7755 |
| issn_str_mv |
0732-183X 1527-7755 |
| language |
English |
| mega_collection |
American Society of Clinical Oncology (ASCO) (CrossRef) |
| match_str |
zingarelli2020prospectiveinvestigationofimmunotherapyinducedfatiguebyrestandstressechocardiography |
| publishDateSort |
2020 |
| publisher |
American Society of Clinical Oncology (ASCO) |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of Clinical Oncology |
| source_id |
49 |
| title |
Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| title_unstemmed |
Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| title_full |
Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| title_fullStr |
Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| title_full_unstemmed |
Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| title_short |
Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| title_sort |
prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e24060 |
| publishDate |
2020 |
| physical |
e24060-e24060 |
| description |
<jats:p> e24060 </jats:p><jats:p> Background: Immune checkpoint inhibitors (ICI) effect durable responses in cancer patients (pts). Myocarditis is rare but fatigue is commonly reported, and whether ICI-induced fatigue is due to subclinical cardiac toxicity is unknown. We hypothesized that pts on ICI develop changes on rest and stress echocardiogram (echo) that correlate with fatigue. Methods: A prospective observational study was performed to monitor cardiac function in pts receiving ICI. Our cohort consisted of pts (n = 10) with stage III/IV melanoma, ECOG 0-1, deemed safe to exercise, without unstable cardiac symptoms. ICI-naïve pts received anti-PD1 alone or in combination with anti-CTLA-4, in adjuvant or metastatic setting. Rest transthoracic echo and dynamic staged exercise stress echo testing was conducted at baseline (prior to ICI) and at 3 and 6 months (mo) following ICI. Various echo parameters at rest and stress were compared. irAEs were detailed and surveys administered at baseline and post-follow up. Results: 10 pts (9 men, mean age 56 yrs) completed baseline cardiac testing of whom 7 completed follow up testing at 6 mo (6 anti-PD1 monotherapy, 1 metastatic combination therapy). Of these 7 pts, 5 (71%) reported increased fatigue per CTCAE at 3 or 6 mo follow up and all 7 had irAEs (3 rash, 1 colitis, 1 diarrhea, 1 hypophysitis, 1 arthralgia, 1 xerostomia). Among resting echo parameters, left ventricular outflow tract velocity time integral (LVOT VTI) was significantly reduced at 6 mo compared to baseline (22.6 ± 3.4 vs 20.0 ± 2.5, p = 0.0047), albeit still within normal range. No other resting echo parameters changed. Among exercise echo parameters, there was no difference in METs achieved, time of exercise, blood pressure or heart rate between time points. Of note, of 7 subjects who completed 6 mo testing, 2 (29%) were unable to achieve previous peak stage of exercise during testing. Conclusions: Though no echo parameter significantly correlating with fatigue was reported, nearly one-third of a small cohort of pts were unable to achieve peak exercise 6 mo after starting ICI. This combined with the statistical reduction in LVOT VTI suggests functional limitation and warrants further study. Post-follow up surveys are pending and may further inform issues important in ICI survivorship. [Table: see text] </jats:p> |
| container_issue |
15_suppl |
| container_start_page |
0 |
| container_title |
Journal of Clinical Oncology |
| container_volume |
38 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792321469371383810 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T11:02:07.904Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Prospective+investigation+of+immunotherapy-induced+fatigue+by+rest+and+stress+echocardiography.&rft.date=2020-05-20&genre=article&issn=1527-7755&volume=38&issue=15_suppl&pages=e24060-e24060&jtitle=Journal+of+Clinical+Oncology&atitle=Prospective+investigation+of+immunotherapy-induced+fatigue+by+rest+and+stress+echocardiography.&aulast=Tsai&aufirst=Katy+K.&rft_id=info%3Adoi%2F10.1200%2Fjco.2020.38.15_suppl.e24060&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792321469371383810 |
| author | Zingarelli, Roman, Aras, Mandar A, Bibby, Dwight, Fang, Qizhi, Daud, Adil, Schiller, Nelson B, Tsai, Katy K. |
| author_facet | Zingarelli, Roman, Aras, Mandar A, Bibby, Dwight, Fang, Qizhi, Daud, Adil, Schiller, Nelson B, Tsai, Katy K., Zingarelli, Roman, Aras, Mandar A, Bibby, Dwight, Fang, Qizhi, Daud, Adil, Schiller, Nelson B, Tsai, Katy K. |
| author_sort | zingarelli, roman |
| container_issue | 15_suppl |
| container_start_page | 0 |
| container_title | Journal of Clinical Oncology |
| container_volume | 38 |
| description | <jats:p> e24060 </jats:p><jats:p> Background: Immune checkpoint inhibitors (ICI) effect durable responses in cancer patients (pts). Myocarditis is rare but fatigue is commonly reported, and whether ICI-induced fatigue is due to subclinical cardiac toxicity is unknown. We hypothesized that pts on ICI develop changes on rest and stress echocardiogram (echo) that correlate with fatigue. Methods: A prospective observational study was performed to monitor cardiac function in pts receiving ICI. Our cohort consisted of pts (n = 10) with stage III/IV melanoma, ECOG 0-1, deemed safe to exercise, without unstable cardiac symptoms. ICI-naïve pts received anti-PD1 alone or in combination with anti-CTLA-4, in adjuvant or metastatic setting. Rest transthoracic echo and dynamic staged exercise stress echo testing was conducted at baseline (prior to ICI) and at 3 and 6 months (mo) following ICI. Various echo parameters at rest and stress were compared. irAEs were detailed and surveys administered at baseline and post-follow up. Results: 10 pts (9 men, mean age 56 yrs) completed baseline cardiac testing of whom 7 completed follow up testing at 6 mo (6 anti-PD1 monotherapy, 1 metastatic combination therapy). Of these 7 pts, 5 (71%) reported increased fatigue per CTCAE at 3 or 6 mo follow up and all 7 had irAEs (3 rash, 1 colitis, 1 diarrhea, 1 hypophysitis, 1 arthralgia, 1 xerostomia). Among resting echo parameters, left ventricular outflow tract velocity time integral (LVOT VTI) was significantly reduced at 6 mo compared to baseline (22.6 ± 3.4 vs 20.0 ± 2.5, p = 0.0047), albeit still within normal range. No other resting echo parameters changed. Among exercise echo parameters, there was no difference in METs achieved, time of exercise, blood pressure or heart rate between time points. Of note, of 7 subjects who completed 6 mo testing, 2 (29%) were unable to achieve previous peak stage of exercise during testing. Conclusions: Though no echo parameter significantly correlating with fatigue was reported, nearly one-third of a small cohort of pts were unable to achieve peak exercise 6 mo after starting ICI. This combined with the statistical reduction in LVOT VTI suggests functional limitation and warrants further study. Post-follow up surveys are pending and may further inform issues important in ICI survivorship. [Table: see text] </jats:p> |
| doi_str_mv | 10.1200/jco.2020.38.15_suppl.e24060 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTIwMC9qY28uMjAyMC4zOC4xNV9zdXBwbC5lMjQwNjA |
| imprint | American Society of Clinical Oncology (ASCO), 2020 |
| imprint_str_mv | American Society of Clinical Oncology (ASCO), 2020 |
| institution | DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 0732-183X, 1527-7755 |
| issn_str_mv | 0732-183X, 1527-7755 |
| language | English |
| last_indexed | 2024-03-01T11:02:07.904Z |
| match_str | zingarelli2020prospectiveinvestigationofimmunotherapyinducedfatiguebyrestandstressechocardiography |
| mega_collection | American Society of Clinical Oncology (ASCO) (CrossRef) |
| physical | e24060-e24060 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | American Society of Clinical Oncology (ASCO) |
| record_format | ai |
| recordtype | ai |
| series | Journal of Clinical Oncology |
| source_id | 49 |
| spelling | Zingarelli, Roman Aras, Mandar A Bibby, Dwight Fang, Qizhi Daud, Adil Schiller, Nelson B Tsai, Katy K. 0732-183X 1527-7755 American Society of Clinical Oncology (ASCO) Cancer Research Oncology http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e24060 <jats:p> e24060 </jats:p><jats:p> Background: Immune checkpoint inhibitors (ICI) effect durable responses in cancer patients (pts). Myocarditis is rare but fatigue is commonly reported, and whether ICI-induced fatigue is due to subclinical cardiac toxicity is unknown. We hypothesized that pts on ICI develop changes on rest and stress echocardiogram (echo) that correlate with fatigue. Methods: A prospective observational study was performed to monitor cardiac function in pts receiving ICI. Our cohort consisted of pts (n = 10) with stage III/IV melanoma, ECOG 0-1, deemed safe to exercise, without unstable cardiac symptoms. ICI-naïve pts received anti-PD1 alone or in combination with anti-CTLA-4, in adjuvant or metastatic setting. Rest transthoracic echo and dynamic staged exercise stress echo testing was conducted at baseline (prior to ICI) and at 3 and 6 months (mo) following ICI. Various echo parameters at rest and stress were compared. irAEs were detailed and surveys administered at baseline and post-follow up. Results: 10 pts (9 men, mean age 56 yrs) completed baseline cardiac testing of whom 7 completed follow up testing at 6 mo (6 anti-PD1 monotherapy, 1 metastatic combination therapy). Of these 7 pts, 5 (71%) reported increased fatigue per CTCAE at 3 or 6 mo follow up and all 7 had irAEs (3 rash, 1 colitis, 1 diarrhea, 1 hypophysitis, 1 arthralgia, 1 xerostomia). Among resting echo parameters, left ventricular outflow tract velocity time integral (LVOT VTI) was significantly reduced at 6 mo compared to baseline (22.6 ± 3.4 vs 20.0 ± 2.5, p = 0.0047), albeit still within normal range. No other resting echo parameters changed. Among exercise echo parameters, there was no difference in METs achieved, time of exercise, blood pressure or heart rate between time points. Of note, of 7 subjects who completed 6 mo testing, 2 (29%) were unable to achieve previous peak stage of exercise during testing. Conclusions: Though no echo parameter significantly correlating with fatigue was reported, nearly one-third of a small cohort of pts were unable to achieve peak exercise 6 mo after starting ICI. This combined with the statistical reduction in LVOT VTI suggests functional limitation and warrants further study. Post-follow up surveys are pending and may further inform issues important in ICI survivorship. [Table: see text] </jats:p> Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. Journal of Clinical Oncology |
| spellingShingle | Zingarelli, Roman, Aras, Mandar A, Bibby, Dwight, Fang, Qizhi, Daud, Adil, Schiller, Nelson B, Tsai, Katy K., Journal of Clinical Oncology, Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography., Cancer Research, Oncology |
| title | Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| title_full | Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| title_fullStr | Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| title_full_unstemmed | Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| title_short | Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| title_sort | prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| title_unstemmed | Prospective investigation of immunotherapy-induced fatigue by rest and stress echocardiography. |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e24060 |