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Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial.
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| Zeitschriftentitel: | Journal of Clinical Oncology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , |
| In: | Journal of Clinical Oncology, 35, 2017, 4_suppl, S. 281-281 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Clinical Oncology (ASCO)
|
| Schlagwörter: |
| author_facet |
Striefler, Jana Kaethe Sinn, Marianne Jöhrens, Korinna Pelzer, Uwe Blaeker, Hendrik Jühling, Anja Sinn, Bruno Valentin Oettle, Helmut Wislocka, Lilianna Bischoff, Sven Denkert, Carsten Riess, Hanno Lohneis, Philipp Striefler, Jana Kaethe Sinn, Marianne Jöhrens, Korinna Pelzer, Uwe Blaeker, Hendrik Jühling, Anja Sinn, Bruno Valentin Oettle, Helmut Wislocka, Lilianna Bischoff, Sven Denkert, Carsten Riess, Hanno Lohneis, Philipp |
|---|---|
| author |
Striefler, Jana Kaethe Sinn, Marianne Jöhrens, Korinna Pelzer, Uwe Blaeker, Hendrik Jühling, Anja Sinn, Bruno Valentin Oettle, Helmut Wislocka, Lilianna Bischoff, Sven Denkert, Carsten Riess, Hanno Lohneis, Philipp |
| spellingShingle |
Striefler, Jana Kaethe Sinn, Marianne Jöhrens, Korinna Pelzer, Uwe Blaeker, Hendrik Jühling, Anja Sinn, Bruno Valentin Oettle, Helmut Wislocka, Lilianna Bischoff, Sven Denkert, Carsten Riess, Hanno Lohneis, Philipp Journal of Clinical Oncology Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. Cancer Research Oncology |
| author_sort |
striefler, jana kaethe |
| spelling |
Striefler, Jana Kaethe Sinn, Marianne Jöhrens, Korinna Pelzer, Uwe Blaeker, Hendrik Jühling, Anja Sinn, Bruno Valentin Oettle, Helmut Wislocka, Lilianna Bischoff, Sven Denkert, Carsten Riess, Hanno Lohneis, Philipp 0732-183X 1527-7755 American Society of Clinical Oncology (ASCO) Cancer Research Oncology http://dx.doi.org/10.1200/jco.2017.35.4_suppl.281 <jats:p> 281 </jats:p><jats:p> Background: The role of T lymphocytes, frequently found in the tumor microenvironment, on development and behavior of several solid tumors is well recognized. Studies on breast cancer and colon carcinoma showed the prognostic and predictive impact of tumor infiltrating T lymphocytes (TILs) while there are no similar studies on pancreatic cancer (PC) until now. Methods: We evaluated the prognostic effect of CD8 and CD103 positive TILs in a cohort of PC patients in the CONKO-001 study treated with adjuvant Gemcitabine or observed only. In 165 formalin-fixed paraffin-embedded (FFPE) tissue samples suitable for tissue microarray construction, CD 8 und CD 103 positive TILs were identified by immunohistochemical staining and counted manually; a ratio of intraepithelial to total CD 103 positive TILs was calculated. Results: The mean number of CD8 positive TILs was 69, a high number ( > 42 TILs) of CD8 positive lymphocytes was significantly associated with longer disease-free (DFS) and overall survival (OS) in the overall study population (high vs low median DFS 12.8 vs 7.4 months; p = 0.007, median OS 26.7 vs 18.1 months; p = 0.018). Furthermore, a ratio of intraepithelial to total CD103 positive lymphocytes < 0.3 was associated with significantly improved DFS and OS in the overall study population (high vs low median DFS 6.5 vs 11.8 months; p = 0.031, median OS 16.6 vs 24.7 months; p = 0.009). Conclusions: Our results suggest that the presence of TILs is important for prognosis in resected PC. We showed for the first time a prognostic effect of CD 8 and CD 103 expressing lymphocytes in PC. Therefore, we suggest further analysis of lymphocyte populations in this dismal entity. </jats:p> Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. Journal of Clinical Oncology |
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| title |
Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. |
| title_unstemmed |
Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. |
| title_full |
Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. |
| title_fullStr |
Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. |
| title_full_unstemmed |
Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. |
| title_short |
Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. |
| title_sort |
influence of cytotoxic tumor-infiltrating t lymphocytes on outcome in resectable pancreatic cancer: results from the conko 001 trial. |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1200/jco.2017.35.4_suppl.281 |
| publishDate |
2017 |
| physical |
281-281 |
| description |
<jats:p> 281 </jats:p><jats:p> Background: The role of T lymphocytes, frequently found in the tumor microenvironment, on development and behavior of several solid tumors is well recognized. Studies on breast cancer and colon carcinoma showed the prognostic and predictive impact of tumor infiltrating T lymphocytes (TILs) while there are no similar studies on pancreatic cancer (PC) until now. Methods: We evaluated the prognostic effect of CD8 and CD103 positive TILs in a cohort of PC patients in the CONKO-001 study treated with adjuvant Gemcitabine or observed only. In 165 formalin-fixed paraffin-embedded (FFPE) tissue samples suitable for tissue microarray construction, CD 8 und CD 103 positive TILs were identified by immunohistochemical staining and counted manually; a ratio of intraepithelial to total CD 103 positive TILs was calculated. Results: The mean number of CD8 positive TILs was 69, a high number ( > 42 TILs) of CD8 positive lymphocytes was significantly associated with longer disease-free (DFS) and overall survival (OS) in the overall study population (high vs low median DFS 12.8 vs 7.4 months; p = 0.007, median OS 26.7 vs 18.1 months; p = 0.018). Furthermore, a ratio of intraepithelial to total CD103 positive lymphocytes < 0.3 was associated with significantly improved DFS and OS in the overall study population (high vs low median DFS 6.5 vs 11.8 months; p = 0.031, median OS 16.6 vs 24.7 months; p = 0.009). Conclusions: Our results suggest that the presence of TILs is important for prognosis in resected PC. We showed for the first time a prognostic effect of CD 8 and CD 103 expressing lymphocytes in PC. Therefore, we suggest further analysis of lymphocyte populations in this dismal entity. </jats:p> |
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| author | Striefler, Jana Kaethe, Sinn, Marianne, Jöhrens, Korinna, Pelzer, Uwe, Blaeker, Hendrik, Jühling, Anja, Sinn, Bruno Valentin, Oettle, Helmut, Wislocka, Lilianna, Bischoff, Sven, Denkert, Carsten, Riess, Hanno, Lohneis, Philipp |
| author_facet | Striefler, Jana Kaethe, Sinn, Marianne, Jöhrens, Korinna, Pelzer, Uwe, Blaeker, Hendrik, Jühling, Anja, Sinn, Bruno Valentin, Oettle, Helmut, Wislocka, Lilianna, Bischoff, Sven, Denkert, Carsten, Riess, Hanno, Lohneis, Philipp, Striefler, Jana Kaethe, Sinn, Marianne, Jöhrens, Korinna, Pelzer, Uwe, Blaeker, Hendrik, Jühling, Anja, Sinn, Bruno Valentin, Oettle, Helmut, Wislocka, Lilianna, Bischoff, Sven, Denkert, Carsten, Riess, Hanno, Lohneis, Philipp |
| author_sort | striefler, jana kaethe |
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| description | <jats:p> 281 </jats:p><jats:p> Background: The role of T lymphocytes, frequently found in the tumor microenvironment, on development and behavior of several solid tumors is well recognized. Studies on breast cancer and colon carcinoma showed the prognostic and predictive impact of tumor infiltrating T lymphocytes (TILs) while there are no similar studies on pancreatic cancer (PC) until now. Methods: We evaluated the prognostic effect of CD8 and CD103 positive TILs in a cohort of PC patients in the CONKO-001 study treated with adjuvant Gemcitabine or observed only. In 165 formalin-fixed paraffin-embedded (FFPE) tissue samples suitable for tissue microarray construction, CD 8 und CD 103 positive TILs were identified by immunohistochemical staining and counted manually; a ratio of intraepithelial to total CD 103 positive TILs was calculated. Results: The mean number of CD8 positive TILs was 69, a high number ( > 42 TILs) of CD8 positive lymphocytes was significantly associated with longer disease-free (DFS) and overall survival (OS) in the overall study population (high vs low median DFS 12.8 vs 7.4 months; p = 0.007, median OS 26.7 vs 18.1 months; p = 0.018). Furthermore, a ratio of intraepithelial to total CD103 positive lymphocytes < 0.3 was associated with significantly improved DFS and OS in the overall study population (high vs low median DFS 6.5 vs 11.8 months; p = 0.031, median OS 16.6 vs 24.7 months; p = 0.009). Conclusions: Our results suggest that the presence of TILs is important for prognosis in resected PC. We showed for the first time a prognostic effect of CD 8 and CD 103 expressing lymphocytes in PC. Therefore, we suggest further analysis of lymphocyte populations in this dismal entity. </jats:p> |
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| imprint_str_mv | American Society of Clinical Oncology (ASCO), 2017 |
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| spelling | Striefler, Jana Kaethe Sinn, Marianne Jöhrens, Korinna Pelzer, Uwe Blaeker, Hendrik Jühling, Anja Sinn, Bruno Valentin Oettle, Helmut Wislocka, Lilianna Bischoff, Sven Denkert, Carsten Riess, Hanno Lohneis, Philipp 0732-183X 1527-7755 American Society of Clinical Oncology (ASCO) Cancer Research Oncology http://dx.doi.org/10.1200/jco.2017.35.4_suppl.281 <jats:p> 281 </jats:p><jats:p> Background: The role of T lymphocytes, frequently found in the tumor microenvironment, on development and behavior of several solid tumors is well recognized. Studies on breast cancer and colon carcinoma showed the prognostic and predictive impact of tumor infiltrating T lymphocytes (TILs) while there are no similar studies on pancreatic cancer (PC) until now. Methods: We evaluated the prognostic effect of CD8 and CD103 positive TILs in a cohort of PC patients in the CONKO-001 study treated with adjuvant Gemcitabine or observed only. In 165 formalin-fixed paraffin-embedded (FFPE) tissue samples suitable for tissue microarray construction, CD 8 und CD 103 positive TILs were identified by immunohistochemical staining and counted manually; a ratio of intraepithelial to total CD 103 positive TILs was calculated. Results: The mean number of CD8 positive TILs was 69, a high number ( > 42 TILs) of CD8 positive lymphocytes was significantly associated with longer disease-free (DFS) and overall survival (OS) in the overall study population (high vs low median DFS 12.8 vs 7.4 months; p = 0.007, median OS 26.7 vs 18.1 months; p = 0.018). Furthermore, a ratio of intraepithelial to total CD103 positive lymphocytes < 0.3 was associated with significantly improved DFS and OS in the overall study population (high vs low median DFS 6.5 vs 11.8 months; p = 0.031, median OS 16.6 vs 24.7 months; p = 0.009). Conclusions: Our results suggest that the presence of TILs is important for prognosis in resected PC. We showed for the first time a prognostic effect of CD 8 and CD 103 expressing lymphocytes in PC. Therefore, we suggest further analysis of lymphocyte populations in this dismal entity. </jats:p> Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. Journal of Clinical Oncology |
| spellingShingle | Striefler, Jana Kaethe, Sinn, Marianne, Jöhrens, Korinna, Pelzer, Uwe, Blaeker, Hendrik, Jühling, Anja, Sinn, Bruno Valentin, Oettle, Helmut, Wislocka, Lilianna, Bischoff, Sven, Denkert, Carsten, Riess, Hanno, Lohneis, Philipp, Journal of Clinical Oncology, Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial., Cancer Research, Oncology |
| title | Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. |
| title_full | Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. |
| title_fullStr | Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. |
| title_full_unstemmed | Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. |
| title_short | Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. |
| title_sort | influence of cytotoxic tumor-infiltrating t lymphocytes on outcome in resectable pancreatic cancer: results from the conko 001 trial. |
| title_unstemmed | Influence of cytotoxic tumor-infiltrating T lymphocytes on outcome in resectable pancreatic cancer: Results from the CONKO 001 trial. |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1200/jco.2017.35.4_suppl.281 |